Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer’s disease mice

Amyloid beta(Aβ)monomers aggregate to form fibrils and amyloid plaques,which are critical mechanisms in the pathogenesis of Alzheimer’s disease(AD).Given the important role of Aβ1-42 aggregation in plaque formation,leading to brain lesions and cognitive impairment,numerous studies have aimed to reduce Aβaggregation and slow AD progression.The diphenylalanine(FF)sequence is critical for amyloid aggregation,and magnetic fields can affect peptide alignment due to the diamagnetic anisotropy of aromatic rings.In this study,we examined the effects of a moderate-intensity rotating magnetic field(RMF)on Aβaggregation and AD pathogenesis.Results indicated that the RMF directly inhibited Aβamyloid fibril formation and reduced Aβ-induced cytotoxicity in neural cells in vitro.Using the AD mouse model APP/PS1,RMF restored motor abilities to healthy control levels and significantly alleviated cognitive impairments,including exploration and spatial and non-spatial memory abilities.Tissue examinations demonstrated that RMF reduced amyloid plaque accumulation,attenuated microglial activation,and reduced oxidative stress in the APP/PS1 mouse brain.These findings suggest that RMF holds considerable potential as a non-invasive,high-penetration physical approach for AD treatment.

Remarks about External Forces Acting on Earth’s Rotation Axis

It is well known that a variation in the direction of Earth’s rotation axis is a real astronomical phenomenon, named nutation. It is interesting if a variation of this axis can take place only in intensity, in the simplest theoretical case of only two rigid body dynamics. This paper presents two positions of the Moon during its monthly orbit, where a sudden variation of Earth’s rotation axis in intensity can take place. The duration of this phenomenon is limited in time, maybe an instant or a day, and then a vortex can appear.

Anomalies identification of Earth’s rotation rate time series (2012-2017) for possible correlation with strong earthquakes occurrence

The analysis of the Earth’s rotation rate time series,from January 1,2012 till December 31,2017,is performed using two different time series analysis methods,both based on signal decomposition joined with forecasting approach.Anomalies in the time series are detected making the comparison between the raw signal and the forecasting one at the 95% confidence interval.The two methods show consistent results and the best is selected according to the evaluation of the prediction uncertainty.Both methods highlight correlations between detected anomalies in the Earth’s rotation rate time series and the world’s earthquakes occurrence with magnitude≥7 and/or number of events≥150 per day,within a time interval of ±10 days from each earthquake event.This study brings an innovation in the analysis of such time series and helps to better understand the extent of this relationship.

Strain data recorded in Xinjiang and their bearing on Tianshan’s uplift/shortening and Tarim basin’s rotation

Based on the continuous strain data recorded in Xinjiang since 1985, we discuss the mechanisms of Tianshan＇ s uplift and Tarim basin＇ s clockwise rotation. The results indicate ： 1 ） The principal - compression directions in Tianshan are nearly NS, and their intersection angles with regional structures and mountains are nearly perpendicular, which is in accordance with Tianshan＇ s uplift and crustal shortening. 2）The principal compressions around Tarim basin tend to facilitate the regional faults＇ left-lateral strike-slip movements and the basin＇ s clockwise rotation. These phenomena of uplift/shortening and rotation are fundamentally the re- suits of India plate＇ s northward push on Euro-Asia plate, and the associated Pamir arc ＇ s rapid northward movement and regional blocks＇ interaction.

Relationships between Earth’s Rotation or Revolution and Geographical Extent of the Global Surface Monsoons

Monsoon seasons, occasionally also known as wet seasons or trade-wind littoral seasons, are found in the regions where there is a complete seasonal reversal of the prevailing surface winds. Accompanying these shifts in the prevailing surface winds are modulations in rainfall activity. Given the fact that our knowledge of the monsoons is mainly based on the interpretation of the mean values of precipitation, cloudiness and winds;relationships between earth’s rotation or revolution and geographical extent of the global surface monsoons deserve to be highlighted. In the abundant literary and audiovisual production devoted to monsoons worldwide and despite the fact that everyone agrees with physical law which shows that Coriolis force acts to the right in the northern hemisphere (to the left in the southern hemisphere), there is no reference to the relationship between Coriolis force (due to earth’s rotation) effects on troposphere general circulation and geographical extent of the global surface monsoons. Furthermore knowing that the ITCZ oscillations on either side of the equators (due to earth’s revolution) determine the seasons (mainly winter and summer), it is clear that earth’s revolution also plays a crucial role in the seasonal reversal of the prevailing surface winds observed in the regions where monsoons are found. Our main objective is to provide a rational answer to the question: what is a monsoon?

Variations of the Earth＇s rotation rate and cyclic processes in geodynamics

The authors analyzed the relationship between variations of the Earth＇s rotation rate and the geodynamic processes within the Earth＇s body, including seismic activity, The rotation rate of a planet determines its uniaxial compression along the axis of rotation and the areas of various surface elements of the body. The Earth＇s ellipticity variations, caused naturally by the rotation rate variations, are manifested in vertical components of precise GPS measurements. Comparative analysis of these variations is considered in view of modern theoretical ideas concerning the Earth＇s figure. The results justify further research that is of interest for improvement of space svstems and technologiesi.

The g-factors and magnetic rotation in ^(82)Rb

The g-factors of the intra-band states 12, 13, 14, 15 in a magnetic-rotational band built on the 11 state in S2Rb are measured for the first time by using a transient magnetic field-ion implantation perturbed angular distribution （TMF-IMPAD） method. The magnetic-rotational band in ^82Rb is populated by the ^60Ni（27A1,4pn）^82Rb reaction, and the time-integral Larmor precessions are measured after recoil implantation into a polarized Fe foil. The calculation of g-factors is also carried out in terms of a semi-classical model of independent particle angular momentum coupling on the basis of the four-quasiparticle configuration π（99/2）^2 Оπ（p3/2, f5/2） О v （g9/2）. The measured and calculated g-factors are in good agreement with each other. The g-factors and deduced shear angles decrease with the increase of spin along the band. This clearly illustrates the shear effect of a step-by-step alignment of the valence protons and neutrons in magnetic rotation. The semi-classical calculation also shows that the alignment of the valence neutron angular momentum is faster than that of the valence protons, which results in a decrease of g-factors with increasing spin. The present results provide solid evidence of the shear mechanism of magnetic rotation.

Effects of rotation and gravity on an electro-magneto-thermoelastic medium with diffusion and voids by using the Lord-Shulman and dual-phase-lag models

The effects of rotation and gravity on an electro-magneto-thermoelastic medium with diffusion and voids in a generalized thermoplastic half-space are studied by using the Lord-Shulman (L-S) model and the dual-phase-lag (DPL) model. The analytical solutions for the displacements, stresses, temperature, diffusion concentration, and volume fraction field with different values of the magnetic field, the rotation, the gravity, and the initial stress are obtained and portrayed graphically. The results indicate that the effects of gravity, rotation, voids, diffusion, initial stress, and electromagnetic field are very pronounced on the physical properties of the material.

Revolving scheme for solving a cascade of Abel equations in dynamics of planar satellite rotation

The main objective for this research was the analytical exploration of the dynamics of planar satellite rotation during the motion of an elliptical orbit around a planet. First, we revisit the results of J. Wisdom et al. （1984）, in which, by the elegant change of variables （considering the true anomaly f as the independent variable）, the governing equation of satellite rotation takes the form of an Abel ordinary differential equation （ODE） of the second kind, a sort of generalization of the Riccati ODE. We note that due to the special character of solutions of a Riccati-type ODE, there exists the possibility of sudden jumping in the magnitude of the solution at some moment of time. In the physical sense, this jumping of the Riccati-type solutions of the governing ODE could be associated with the effect of sudden acceleration[deceleration in the satellite rotation around the chosen principle axis at a definite moment of parametric time. This means that there exists not only a chaotic satellite rotation regime （as per the results of J. Wisdom et al. （1984））, but a kind of gradient catastrophe （Arnold, 1992） could occur during the satellite rotation process. We especially note that if a gradient catastrophe could occur, this does not mean that it must occur： such a possibility depends on the initial conditions. In addition, we obtained asymptotical solutions that manifest a quasi-periodic character even with the strong simplifying assumptions e → 0, p -- 1, which reduce the governing equation of J. Wisdom et al. （1984） to a kind of Beletskii＇s equation.

Combined distal tibial rotational osteotomy and proximal growth plate modulation for treatment of infantile Blount's disease

Infantile Blount's disease is a condition that causes genu varum and internal tibial torsion. Treatment options include observation, orthotics, corrective osteotomy, elevation of the medial tibial plateau, resection of a physeal bar, lateral hemi-epiphysiodesis, and guided growth of the proximal tibial physis. Each of these treatment options has its disadvantages. Treating the coronal deformity alone(genu varum) will result in persistence of the internal tibial torsion(the axial deformity). In this report, we describe the combination of lateral growth modulation and distal tibial external rotation osteotomy to correct all the elements of the disease. This has not been described before for treatment of Blount's disease. Both coronal and axial deformities were corrected in this patient. We propose this combination(rather than the lateral growth modulation alone) as the method of treatment for early stages of Blount's disease as it corrects both elements of the disease and in the same time avoids the complications of proximal tibial osteotomy.

Rotational Eustasy as Understood in Physics

Global sea level has today become widely understood merely in terms of glacial eustasy and thermal expansion. Although this is good in theory, it is not enough to explain observational facts in nature. We know that the 17th century was characterized by cold climate, Little Ice Age conditions, and low solar activity during the Maunder Grand Solar Minimum. In contrast, the 18th century was characterized by warm climate conditions and a Grand Solar Maximum (with the Polar front located north of Svalbard). In terms of glacial eustasy, one would expect to find a low sea level in the 17th century and a high sea level in the 18th century. This is not the case in the equatorial regions, however. In the Indian Ocean and the Pacific, there was a 60 - 70 cm higher sea level in the 17th century, and a sea level well below the present one in the 18th century. This can only be understood in terms of “rotational eustasy”. This is a novel concept, here for the first time addressed with respect to physical interpretation. It is shown that planetary beat affects Earth’s rate of rotation and that this leads to oscillations of the equatorial water bulge with amplitudes of up to ±70 cm.

Generalized geometry theory on constrained rotating relativistic Birkhoffian systems

This paper focuses on studying the generalized geometry theory of constrained rotating relativistic Birkhoffian systems. Based on the fact that relativistic rotating inertia is embedded in the Birkhoffian systems, the Pfaff action of rotating relativistic Birkhoffian systems was defined. The Pfaff-Birkhoff principles and Birkhoff＇s equations of the constrained rotating relativistic systems were obtained. The geometrical description, the exact properties and their forms on R T^＊M for the constrained rotating relativistic Birkhoffian systems are given. The global analyses of the autonomous, semi-autonomous and non-autonomous constrained relativistic Birkhoff＇s equations as well as the geometrical properties of energy change for the constrained rotating relativistic Birkhoffian systems were also conducted.

Synthesis of Silver Sulf ide Quantum Dots Via the Liquid–Liquid Interface Reaction in a Rotating Packed Bed Reactor

We developed the high-gravity coupled liquid-liquid interface reaction technique on the basis of the rotating packed bed(RPB)reactor for the continuous and ultrafast synthesis of silver sulfide(Ag2S)quantum dots(QDs)with near-infrared(NIR)luminescence.The formation of Ag2S QDs occurs at the interface of microdroplets,and the average size of Ag2S QDs was 4.5 nm with a narrow size distribution.Ag2S QDs can disperse well in various organic solvents and exhibit NIR luminescence with a peak wavelength at 1270 nm under 980-nm laser excitation.The mechanism of the process intensification was revealed by both the computational fluid dynamics simulation and fluorescence imaging,and the mechanism is attributed to the small and uniform droplet formation in the RPB reactor.This study provides a novel approach for the continuous and ultrafast synthesis of NIR Ag2S QDs for potential scale-up.

“Snake”: New Object of Hypothetical Venusian Fauna

On March 1 and 5, 1982, experiments in television photography instrumented by the landers VENERA-13 and 14 returned panoramas of the Venus surface at the landing site. Over the past 31 years, no similar missions have been sent to Venus. In connection with the renewed interest in what was occurring during the experiment and to the discovery of manifestations of possible life revealed on some of the pictures, the panoramas were re-examined.?Analysis of treated once again VENERA-14 panoramic images revealed a?“snake”?object about 40 cm in size possessing apparent terramorphic features. The snake’s body stands out with its honeycomb, spotty surface against the stone plates close by. The “snake”?can be included into the list of the most significant findings of the hypothetical Venusian fauna. Apart from that, of interest is a?“dove”?object, although details of its structure cannot be discerned. The snake’s body show slow movements, which is another evidence of the Venusian fauna’s very slow style of activity, which appears to be associated with its energy constraints, and that is more likely, with the properties of its internal medium. The terramorphic features of the fauna, if they are confirmed, may point out outstandingly important and yet undiscovered general laws of the animated nature.

大型立式离心泵反转全特性曲线S区研究

随着化石燃料的快速消耗和产生的环境污染,许多公用事业已将其发电来源改为可再生能源。我国大型清洁可再生能源基地的集约化开发以及国家电网的智能化建设,需要大量的电站来进行电网调节。大型离心泵是一种用于大规模调水的通用机械,作为叶片式水力机械,它本身也具有可逆运行的能力。现有的大型离心泵机组,可实现反转发电的功能。本文以某大型立式离心泵为研究对象,在试验研究的基础上开展了水泵反转作水轮机S区数值模拟,对S区中的稳定区、近飞逸区、近零流量区以及反水泵区共四个特殊运行工况的压力、速度以及湍动能等特性进行了分析,对利用现有的水库与水力机械辅助低碳电网运行具有重要意义。

Differences in Male Climacteric Symptoms and Lifestyle Depending on the Duration of Working among Rotating Night Shift Workers

Background: There are various health problems in rotating shift workers. There have been few studies on the associations of male climacteric symptoms with duration of working and lifestyle. Objective: The aim of this study was to determine the differences in male climacteric symptoms depending on the number of working years and to determine whether lifestyle habits differ depending on the number of working years in rotating shift workers. Methods: We collected participant’s data from the manufacturing companies in Japan during the period from March to May in 2017. We conducted a self-administered questionnaire survey in 1561 male rotating night shift workers. Male climacteric symptoms were evaluated by using the Aging Males’ Symptoms (AMS) rating scale. We analyzed 636 rotating shift workers aged over 40 years old whose all AMS data was collected. Results: A significant difference in psychological AMS score was found between men who had worked for 10 - 19 years (9.4 ± 3.9) and men who had worked for more than 40 years (7.6 ± 3.0) (p = 0.011). Sexual functional AMS score significantly differed depending on the number of working years (less than 10 years: 8.1 ± 3.9, 10 - 19 years: 9.8 ± 4.1, 20 - 29 years: 7.9 ± 3.3, 30 - 39 years: 9.3 ± 3.5, more than 40 years: 9.3 ± 3.5) (p < 0.001). The proportion of workers with a balanced meal intake was significantly lower in men who had worked for less than 10 years and the proportions of such workers were significantly higher in men who had worked for 10 - 19 years and for more than 40 years. The proportions of men who did not drink alcohol were high in men who had worked for less than 10 years and 20 - 29 years and low in men who had worked more than 30 years. Conclusion: Psychological AMS score and sexual functional AMS score are significantly different among the 5 groups according to the number of working years on rotating shift. In addition, well-balanced diet on day shift and reduction of alcohol drinking is a related-factor for long-term rotating night shift workers.

Quasi-Radial Modes of Pulsating Neutron Stars: Numerical Results for General-Relativistic Rigidly Rotating Polytropic Models

In this paper we compute general-relativistic polytropic models simulating rigidly rotating, pulsating neutron stars. These relativistic compact objects, with a radius of ~10 km and mass between ~1.4 and 3.2 solar masses, are closely related to pulsars. We emphasize on computing the change in the pulsation eigenfrequencies owing to a rigid rotation, which, in turn, is a decisive issue for studying stability of such objects. In our computations, we keep rotational perturbation terms of up to second order in the angular velocity.

Hall Effects on Unsteady MHD Three Dimensional Flow through a Porous Medium in a Rotating Parallel Plate Channel with Effect of Inclined Magnetic Field

In this paper, we make an initial value investigation of the unsteady flow of incompressible viscous fluid between two rigid non-conducting rotating parallel plates bounded by a porous medium under the influence of a uniform magnetic field of strength H0 inclined at an angle of inclination α with normal to the boundaries taking hall current into account. The perturbations are created by a constant pressure gradient along the plates in addition to the non-torsional oscillations of the upper plate while the lower plate is at rest. The flow in the porous medium is governed by the Brinkman’s equations. The exact solution of the velocity in the porous medium consists of steady state and transient state. The time required for the transient state to decay is evaluated in detail and the ultimate quasi-steady state solution has been derived analytically. Its behaviour is computationally discussed with reference to the various governing parameters. The shear stresses on the boundaries are also obtained analytically and their behaviour is computationally discussed.