Systematic measurement and spatiotemporal evolution of agricultural versatility in China

In this study,the entropy weight method was used to measure the agricultural versatility of 30 provinces in China(excluding Tibet,Hong Kong,Macao,and Taiwan)from 2008 to 2019.In addition,the Theil index method and kernel density estimation were used to analyze the spatiotemporal characteristics of the agricultural versatility in each province.The results show that the agricultural product supply and social security functions rapidly developed,but the economic development was weak.From 2008 to 2019,the total functional index of agriculture increased by 6.74%;the functional index of the agricultural product supply,social security,and ecological services increased by 12.72%,5.53%,and 2.05%,respectively;and the functional index of economic development decreased by 1.32%.The development of agricultural multifunctions in China is regionally heterogeneous.Based on the Theil index method,the differences in the agricultural functions of the three regions are mainly due to intragroup differences.The contribution of intragroup differences of the eight economic regions is significantly lower than that of the three regions.However,intragroup differences dominate the agricultural product supply,economic development,and social security functions and intergroup differences control the ecological service function.The kernel density estimation curve shows that the overall agricultural functional evaluation index increased,among which the agricultural product supply function increased the most.

Plant peroxisomes:Small organelles with versatility and complexity

Peroxisomes are small,highly dynamic,and multifunctional organelles in eukaryotes.Essential to plant survival,peroxisomes house various crucial metabolic activities,such as degradation of hydrogen peroxide(H2O2),lipid metabolism,photorespiration,and hormone biosynthesis and catabolism,and remodel their proteome in response to developmental and environmental changes(Hu et al.2012;Pan and Hu 2018).The four reviews and three research articles in this special issue on plant peroxisomes provide new insights into the diverse roles and dynamics of these structurally simple but functionally complicated organelles,raising exciting new questions for future investigations.

Versatile and controlled quantum teleportation network

A quantum teleportation network involving multiple users is essential for future quantum internet.So far,controlled quantum teleportation has been demonstrated in a three-user network.However,versatile and controlled quantum teleportation network involving more users is in demand,which satisfies different combinations of users for practical requirements.Here we propose a highly versatile and controlled teleportation network that can switch among various combinations of different users.We use a single continuous-variable six-partite Greenberger-Horne-Zeilinger(GHZ)state to realize such a task by choosing the different measurement and feedback operations.The controlled teleportation network,which includes one sub-network,two sub-networks and three sub-networks,can be realized for different application of user combinations.Furthermore,the coherent feedback control(CFC)can manipulate and improve the teleportation performance.Our approach is flexible and scalable,and would provide a versatile platform for demonstrations of complex quantum communication and quantum computing protocols.

间充质干细胞命运的调控机制

Mesenchymal intricate stem cells(MSCs)represent a versatile population of multipotent progenitor cells with remarkable capacity for selfrenewal and differentiation[1].The fate commitment of MSCs is orchestrated by a complex interplay of intrinsic and extrinsic factors,encompassing signaling pathways,transcriptional regulators,epigenetic modifiers,and microenvironmental cues[2-5].

Leggings: The new fashion staple

Leggings have been a staple in the fashion industry for decades,consistently remaining one of the most popular and versatile items of clothing.They have achieved viral status and continue to be a highly sought-after fashion item,transcending age and cultural barriers.The body-hugging style of leggings has remained in vogue,attracting young people of all ages and backgrounds.With their enduring popularity,it’s likely that leggings will remain a fashion staple for years to come.

四川大白菜细菌性软腐病新病原菌Pectobacterium versatile的鉴定

为明确引起四川理县大白菜软腐病的病原菌种类,从理县梭罗沟村田间采集具有典型软腐症状的大白菜病样,采用组织分离、致病力测定、生理生化分析、形态学和分子生物学方法进行鉴定。结果表明,分离获得的5株细菌在NA培养基上形成的菌落呈圆形、半透明、乳白色、中心突起、边缘平滑,在半选择性培养基CVP上培养48 h后产生凹陷。5株菌均能使大白菜、胡萝卜、马铃薯和芹菜的离体组织腐烂,接种于白菜苗后叶片呈湿腐萎蔫症状。通过大白菜叶柄接种部位形成的病斑长径来比较菌株致病力强弱,各菌株的致病力有显著差异。基于看家基因pgi、rpoS、mdh、proA、mtlD和icdA(NCBI登录号为OL963562~OL963571)的多基因联合系统发育树,分离菌株与Pectobacterium versatile聚为一簇,dnaX-leuS-recA(NCBI登录号为OL963572~OL963576)的多位点序列分析(MLSA)进一步支持以上结果,且准确性更高。分离菌株的生理生化特征与P.versatile模式菌株一致,综上将其鉴定为P.versatile。这是我国首次报道P.versatile引起大白菜软腐病。

The role of TGF-beta3 in cartilage development and osteoarthritis

Articular cartilage serves as a low-friction,load-bearing tissue without the support with blood vessels,lymphatics and nerves,making its repair a big challenge.Transforming growth factor-beta 3(TGF-β3),a vital member of the highly conserved TGF-βsuperfamily,plays a versatile role in cartilage physiology and pathology.TGF-β3 influences the whole life cycle of chondrocytes and mediates a series of cellular responses,including cell survival,proliferation,migration,and differentiation.Since TGF-β3 is involved in maintaining the balance between chondrogenic differentiation and chondrocyte hypertrophy,its regulatory role is especially important to cartilage development.Increased TGF-β3 plays a dual role:in healthy tissues,it can facilitate chondrocyte viability,but in osteoarthritic chondrocytes,it can accelerate the progression of disease.Recently,TGF-β3 has been recognized as a potential therapeutic target for osteoarthritis(OA)owing to its protective effect,which it confers by enhancing the recruitment of autologous mesenchymal stem cells(MSCs)to damaged cartilage.However,the biological mechanism of TGF-β3 action in cartilage development and OA is not well understood.In this review,we systematically summarize recent progress in the research on TGF-β3 in cartilage physiology and pathology,providing up-to-date strategies for cartilage repair and preventive treatment.

Efficient large fragment deletion in plants:double pairs of sgRNAs are better than dual sgRNAs

Dear Editor,Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)is a powerful and versatile gene editing system that has been extensively utilized in various animals and plants,which holds enormous potential and value for scientific research and breeding.However,single-targeted CRISPR can only induce a few base deletions,insertions,or substitution.Ideally,thesemutations result in premature termination of the protein encoded by the target gene,leading to a loss of function[1].

Cannabis sativa: origin and history, glandular trichome development, and cannabinoid biosynthesis

Is Cannabis a boon or bane?Cannabis sativa has long been a versatile crop for fiber extraction(industrial hemp),traditional Chinese medicine(hemp seeds),and recreational drugs(marijuana).Cannabis faced global prohibition in the twentieth century because of the psychoactive properties of △^(9)-tetrahydrocannabinol;however,recently,the perspective has changed with the recognition of additional therapeutic values,particularly the pharmacological potential of cannabidiol.A comprehensive understanding of the underlying mechanism of cannabinoid biosynthesis is necessary to cultivate and promote globally the medicinal application of Cannabis resources.Here,we comprehensively review the historical usage of Cannabis,biosynthesis of trichome-specific cannabinoids,regulatory network of trichome development,and synthetic biology of cannabinoids.This review provides valuable insights into the efficient biosynthesis and green production of cannabinoids,and the development and utilization of novel Cannabis varieties.

Giant Tunneling Magnetoresistance in Spin-Filter Magnetic Tunnel Junctions Based on van der Waals A-Type Antiferromagnet CrSBr

Two-dimensional van der Waals magnetic materials have demonstrated great potential for new-generation high-performance and versatile spintronic devices.Among them,magnetic tunnel junctions(MTJs)based on A-type antiferromagnets,such as CrI_(3),possess record-high tunneling magnetoresistance(TMR)because of the spin filter effect of each insulating unit ferromagnetic layer.However,the relatively low working temperature and the instability of the chromium halides hinder applications of this system.Using a different technical scheme,we fabricated the MTJs based on an air-stable A-type antiferromagnet,CrSBr,and observed a giant TMR of up to 47000%at 5 K.Meanwhile,because of a relatively high Néel temperature of CrSBr,a sizable TMR of about 50%was observed at 130 K,which makes a big step towards spintronic devices at room temperature.Our results reveal the potential of realizing magnetic information storage in CrSBr-based spin-filter MTJs.

Design Strategies for Cellular Nanosponges as Medical Countermeasures

The interest in using therapeutic nanoparticles to bind with harmful molecules or pathogens and subsequently neutralize their bioactivity has grown tremendously.Among various nanomedicine platforms,cell membrane-coated nanoparticles,namely,“cellular nanosponges,”stand out for their broadspectrum neutralization capability challenging to achieve in traditional countermeasure technologies.Such ability is attributable to their cellular function-based rather than target structure-based working principle.Integrating cellular nanosponges with various synthetic substrates further makes their applications exceptionally versatile and adaptive.This review discusses the latest cellular nanosponge technology focusing on how the structure–function relationship in different designs has led to versatile and potent medical countermeasures.Four design strategies are discussed,including harnessing native cell membrane functions for biological neutralization,functionalizing cell membrane coatings to enhance neutralization capabilities,combining cell membranes and functional cores for multimodal neutralization,and integrating cellular nanosponges with hydrogels for localized applications.Examples in each design strategy are selected,and the discussion is to highlight their structure–function relationships in complex disease settings.The review may inspire additional design strategies for cellular nanosponges and fulfill even broader medical applications.

Micro Calcification Detection in Mammogram Images Using Contiguous Convolutional Neural Network Algorithm

The mortality rate decreases as the early detection of Breast Cancer(BC)methods are emerging very fast,and when the starting stage of BC is detected,it is curable.The early detection of the disease depends on the image processing techniques,and it is used to identify the disease easily and accurately,especially the micro calcifications are visible on mammography when they are 0.1 mm or bigger,and cancer cells are about 0.03 mm,which is crucial for identifying in the BC area.To achieve this micro calcification in the BC images,it is necessary to focus on the four main steps presented in this work.There are three significant stages of the process assigned to find the BC using a thermal image;the image processing procedures are described below.In the first stage of the process,the Gaussian filter technique is implemented to magnify the screening image.During the second stage,BC detection is separated from the pre-processed image.The Proposed Versatile K-means clustering(VKC)algorithm with segmentation is used to identify the BC detection form of the screening image.The centroids are then recalculated using proposed VKC,which takes the mean of all data points allocated to that centroid’s cluster,lowering the overall intracluster variance in comparison to the prior phase.The“means”in K-means refers to the process of averaging the data and determining a new centroid.This process eliminates unnecessary areas of interest.First,the mammogram screening image information is taken from the patient and begins with the Contiguous Convolutional Neural Network(CCNN)method.The proposed CCNN is used to classify the Micro calcification in the BC spot using the feature values is the fourth stage of the process.The assess the presence of high-definition digital infrared thermography technology and knowledge base and suggests that future diagnostic and treatment services in breast cancer imaging will be developed.The use of sophisticated CCNN techniques in thermography is being developed to attain a greater level of consistency.The implemented(CCNN)technique’s performance is examined with different classification parameters like Recall,Precision,F-measure and accuracy.Finally,the Breast Cancer stages will be classified based on the true positive and true negative values.

Courtside to Catwalk--Surging demand for sports fashion in China captures consumer interest

A mid the ever-changing tides of fashion,Arc’teryx,a high-performance outdoor equipment brand known for leading innovations in outdoor apparel tech and once beloved by middleaged outdoor enthusiasts,has now secured a place as social currency for Chinese trendsetters.Salomon,once associated with the“ugly shoe”aesthetic exclusive to mountaineers,has become a coveted fashion essential,commanding premium prices driven by fervent demand.In addition,as the Lululemon brand evolves from its body-conscious fit origins for yoga enthusiasts to a versatile wardrobe staple for commuters.

Journey of the Chameleon Filmmaker

A versatile filmmaker who has been dedicated to directing a wide range of short films.AT the Shanghai International Advertising Festival (SHIAF) 2021 held in July 2021, director Wang Yucheng was the recipient of three shining trophies.Behind the scenes, he is a low-key person who is dedicated to creating advertisements and short films. He has won the nickname“chameleon director”for his passion of finding ways to exhibit a different style in each video, so as to make the artwork fit the theme and impress every audience.

可编程逻辑阵列分段递进优化布局算法研究

为了提高FPGA（Field Programmable Gate Array）的布通率并优化电路的连线长度,在模拟退火算法的基础上,该文提出一种新的FPGA布局算法。该算法在不同的温度区间采用不同的评价函数,高温阶段采用半周长法进行快速优化布局,低温阶段在评价函数中加入变量因子并进行适度的回火处理,以此来优化布局。实验表明,该算法提高了布通率,优化了连线长度,与最具代表性的VPR（Versatile Place and Route）布局算法相比布线通道宽度提高了近6%,电路总的连线长度降低了4-23%。

Low-Dimensional Halide Perovskites and Their Advanced Optoelectronic Applications

Metal halide perovskites are crystalline materials originally developed out of scientific curiosity. They have shown great potential as active materials in optoelectronic applications. In the last 6 years, their certified photovoltaic efficiencies have reached 22.1%. Compared to bulk halide perovskites, low-dimensional ones exhibited novel physical properties. The photoluminescence quantum yields of perovskite quantum dots are close to 100%. The external quantum efficiencies and current efficiencies of perovskite quantum dot light-emitting diodes have reached 8% and 43 cd A^(-1),respectively, and their nanowire lasers show ultralow-threshold room-temperature lasing with emission tunability and ease of synthesis. Perovskite nanowire photodetectors reached a responsivity of 10 A W^(-1)and a specific normalized detectivity of the order of 10^(12 )Jones. Different from most reported reviews focusing on photovoltaic applications, we summarize the rapid progress in the study of low-dimensional perovskite materials, as well as their promising applications in optoelectronic devices. In particular, we review the wide tunability of fabrication methods and the state-of-the-art research outputs of low-dimensional perovskite optoelectronic devices. Finally, the anticipated challenges and potential for this exciting research are proposed.

Novel HBD-Containing Zn (dobdc) (datz) as efficiently heterogeneous catalyst for CO_(2) chemical conversion under mild conditions

A novel Zn-based metal–organic framework Zn(dobdc)(datz)[Zn_(2)(H2dobdc)(datz)2$1.5DMF]with plentiful hydrogen bond donors(HBD)groups was facilely synthesized from mixed ligands.The dual activation of metal Zn sites and HBD groups for epoxides by forming Zn–O adduct and hydrogen bonds facilitated the ring-opening of epoxide substrate,which is critical for the subsequent CO_(2) fixation.Also,the existence of micropores and N-rich units in Zn(dobdc)(datz)afforded affinity towards CO_(2),which is beneficial to further improvement on catalytic CO_(2) conversion performance.Satisfactorily,Zn(dobdc)(datz)/Bu4NBr system was proved efficient heterogeneous catalyst for the CO_(2) cycloaddition with epoxides,and 98%propylene carbonate yield was obtained under mild conditions(80C,1.5 MPa and solvent-free).In addition,Zn(dobdc)(datz)/Bu4NBr exhibited remarkable versatility to different epoxides and could be completely recycled over six runs with high catalytic activity.The highly stable,easily recycle and solvent-free Zn-based MOF reported here displays eco-friendly and efficient performance to CO_(2)conversion.

考虑风电功率序列时间相关性的电力系统动态经济调度

随着高比例可再生能源大规模接入电力系统,其不确定性对经济调度带来了巨大的挑战。针对含风电电力系统经济调度问题,提出了考虑风电功率序列时间相关性的数据筛选方法,并利用versatile-copula分布实现风电功率序列时间相关性建模,以此为基础提出了考虑随机变量相关性的机会约束与风电成本高低估代价计算方法,建立了考虑风电功率序列时间相关性的动态经济调度模型。通过对目标函数和约束条件的转化与分析,将随机优化模型转化为线性约束问题,并利用逐次线性化算法实现准确求解。最后,在含风电的IEEE-30节点和IEEE-118节点算例系统中进行仿真计算,验证了所提考虑风电功率序列时间相关性的调度方法在数据筛选、拟合精度、经济性等方面的有效性。

ZBP1(DAI/DLM-1) promotes osteogenic differentiation while inhibiting adipogenic differentiation in mesenchymal stem cells through a positive feedback loop of Wnt/β-catenin signaling

The lineage specification of mesenchymal stem/stromal cells(MSCs) is tightly regulated by a wide range of factors. Recently, the versatile functions of ZBP1(also known as DAI or DLM-1) have been reported in the blood circulation and immune systems.However, the biological function of ZBP1 during the lineage specification of MSCs is still unknown. In the present study, we found that ZBP1 was upregulated during osteogenesis but downregulated during adipogenesis in mouse bone marrow-derived MSCs(m BMSCs). ZBP1 was highly expressed in osteoblasts but expressed at a relatively low level in marrow adipocytes. Knockdown of ZBP1 inhibited alkaline phosphataseactivity, extracellular matrix mineralization, and osteogenesis-related gene expression in vitro and reduced ectopic bone formation in vivo. Knockdown of ZBP1 also promoted adipogenesis in MSCs in vitro. Conversely, the overexpression of ZBP1 increased the osteogenesis but suppressed the adipogenesis of MSCs. When the expression of ZBP1 was rescued, the osteogenic capacity of ZBP1-depleted m BMSCs was restored at both the molecular and phenotypic levels.Furthermore, we demonstrated that ZBP1, a newly identified target of Wnt/β-catenin signaling, was required for β-catenin translocation into nuclei. Collectively, our results indicate that ZBP1 is a novel regulator of bone and fat transdifferentiation via Wnt/β-catenin signaling.

A versatile nano-TiO_(2) decorated gel separator with derived multi-scale nanofibers towards dendrite-blocking and polysulfide-inhibiting lithium-metal batteries

In this study,a versatile fluorine-bearing gel membrane with multi-scale nanofibers was rationally designed and synthesized via facile one-step blend electrospinning of nano-titanium dioxide(TiO_(2))particles and fluorinated poly-m-phenyleneisophthalamide(PMIA)polymer solution.The prepared multiscale TiO_(2)-assisted gel separator presented relatively high porosity,small aperture,giving rise to superior affinity to electrolyte and sufficient active sites to accelerate lithium ions migration.Meanwhile,the asfabricated multifunctional GPE also rendered outstanding heat-resistance and well-distributed lithiumions flux,and the mutual overlaps between the coarse fibers and the fine fibers within the multi-scale nanofiber membrane provided a strong skeleton support,which in turn laid a solid footing stone for high-security and dendrite-proof batteries.Particularly,the nano-TiO_(2) particles within PMIA membrane acted as"gatekeepers",which can not only resist the growth of lithium dendrites,but also intercept the dissolved polysulfide on cathode side.Based on these merits,the gel PMIA-based lithium cobalt(LCO)/lithium battery obtained the remarkably improved rate capability and cycle performances on account of superior ionic conductivity,steady anodic stability window and weakened polarization behavior.Meanwhile,the resultant lithium-sulfur cell also delivered the outstanding cycling stability with the aid of the greatly prevented"shuttle effect"of dissolved lithium polysulfides based on the physical trapping and chemical binding of the prepared GPE to polysulfides species.This work proved that the addition of functional inorganic nanoparticles similar with TiO_(2) in multi-scale gel PMIA membrane can enhance the lithium ions transport capability,resist the growth of lithium dendrites as well as inhibit the shuttle effect of polysulfides,which would prompt a great development for dendrite-blocking and polysulfideinhibiting lithium-metal cells.