This study aimed to exploit a new virtual block method to spare normal lung tissue in VMAT planning for patients with locally advanced non-small cell lung cancer(LA-NSCLC).The previous method was used to manually rest...This study aimed to exploit a new virtual block method to spare normal lung tissue in VMAT planning for patients with locally advanced non-small cell lung cancer(LA-NSCLC).The previous method was used to manually restrict the angle of the beam passing through,which ignored the location and shape of large targets that varied between different slices and did not block the beamlets precisely.Unlike the previous method,this new virtual block method was used to block the beamlets when necessary by closing the multi-leaf collimator(MLC)at prerequisite angles.The algorithm for closing the MLC depended on the thickness of the beamlets passing through the lungs and avoided only the entrance radiation beamlet.Moreover,this block can be automatically contoured.A retrospective study was performed to compare the VMAT plans with and without the virtual block method for 17 LANSCLC patients,named the block plan(B-plan)/non-block plan(N-plan).All cases were selected in this study because of the large tumor size and unmet dose constraints of the lungs.In addition to the maximum dose constraint for the virtual block,B-plans adopted identical optimization parameters to N-plans for each patient.These two types of plans were compared in terms of dosimetric indices and plan scores.The results were statistically analyzed using the Wilcoxon nonparametric signed-rank test.B-plans have advantages in the following dosimetric metrics that have statistical significance(p<0.05):(1)lower V_(5)/V_(10)/D_(mean)/normal tissue complication probability(NTCP)of total lungs;(2)reductions in V_(5)/V_(10)for the contralateral lung;(3)decrease in Dmean/V_(40)of the heart;(4)decrease in esophagus V_(40);(5)reductions in Dmean,V_(5)/V_(10) of normal tissue.B-plans(82.51±7.07)achieved higher-quality scores than N-plans(80.74±7.22).The new virtual block spared the lungs as well as other normal structures in VMAT planning for LA-NSCLC.Thus,the block method may decrease the risk of radiation-related toxicity in patients.展开更多
We performed on paleomagnetic investigation of the Upper Cretaceous red sandstones collected from Fujiau and Guangdong provinces. Significant characteristic directions were isolated by principal comPonent analysis fro...We performed on paleomagnetic investigation of the Upper Cretaceous red sandstones collected from Fujiau and Guangdong provinces. Significant characteristic directions were isolated by principal comPonent analysis from 22 of 25 and 9 of 14 sampling sites iu Fujian and Guangdong,respectively. Maximum concentration of global mean directions every province is achieved at 70 %and complete (100 % ) untilting for Fujian and Guangdong, respectively. We regarded these mean directions as the Late Cretaceous paleomagnetic directions and calculated virtual geomagnetic poles (VGPs); Fujian, Lat. /Lon. = 79. 4°N/210. 3°E (α95= 5. 1°) and Guangdong, Lat. /Lon. = 80. 1°N/193. 4°E (α95=8. 0°). These two VGPs are nearly equal to each other and to a mean VGP from Sichuan Province reported previously. This observation suggests no relative movement among three regions, Fujian, Guangdong and Sichuan, since the Late Cretaceous. Two VGPs from this study are significantly different from previously reported VGPs from the same regions. Further systematic paleomagnetic works are needed to clarify this difference of VGP Positions.展开更多
基金supported by the National Natural Science Foundation of China(No.12105368).
文摘This study aimed to exploit a new virtual block method to spare normal lung tissue in VMAT planning for patients with locally advanced non-small cell lung cancer(LA-NSCLC).The previous method was used to manually restrict the angle of the beam passing through,which ignored the location and shape of large targets that varied between different slices and did not block the beamlets precisely.Unlike the previous method,this new virtual block method was used to block the beamlets when necessary by closing the multi-leaf collimator(MLC)at prerequisite angles.The algorithm for closing the MLC depended on the thickness of the beamlets passing through the lungs and avoided only the entrance radiation beamlet.Moreover,this block can be automatically contoured.A retrospective study was performed to compare the VMAT plans with and without the virtual block method for 17 LANSCLC patients,named the block plan(B-plan)/non-block plan(N-plan).All cases were selected in this study because of the large tumor size and unmet dose constraints of the lungs.In addition to the maximum dose constraint for the virtual block,B-plans adopted identical optimization parameters to N-plans for each patient.These two types of plans were compared in terms of dosimetric indices and plan scores.The results were statistically analyzed using the Wilcoxon nonparametric signed-rank test.B-plans have advantages in the following dosimetric metrics that have statistical significance(p<0.05):(1)lower V_(5)/V_(10)/D_(mean)/normal tissue complication probability(NTCP)of total lungs;(2)reductions in V_(5)/V_(10)for the contralateral lung;(3)decrease in Dmean/V_(40)of the heart;(4)decrease in esophagus V_(40);(5)reductions in Dmean,V_(5)/V_(10) of normal tissue.B-plans(82.51±7.07)achieved higher-quality scores than N-plans(80.74±7.22).The new virtual block spared the lungs as well as other normal structures in VMAT planning for LA-NSCLC.Thus,the block method may decrease the risk of radiation-related toxicity in patients.
基金National Key Research and Development Program of China(No.2020YFB1707700)Fundamental Research Funds for the Central Universities,China(No.20D111201)。
文摘基于计算机视觉的虚拟试衣(virtual try-on,VITON)技术是指将试穿服装按照模特图像特征进行扭曲并合成到模特图像中,以替换原有服装部分。当前的虚拟试衣技术主要存在两个问题:保留模特图像头部、下装和背景等原有特征不足;扭曲后的试穿服装与模特图像匹配度不高。针对这两个问题,提出一种原有特征保持虚拟试衣网络(original feature preserving virtual try-on network,OFP-VTON),由语义分割图生成、试穿服装扭曲和试穿图像合成三部分组成。在试穿服装扭曲阶段通过使网络学习模特图像中所穿服装的扭曲映射,以更好地约束试穿服装扭曲;在试穿图像合成阶段提取并保留模特图像原有特征,并引入感受野模块(receptive field block,RFB)以尽可能保留试穿服装特征。在公开的VITON数据集上的定性与定量实验表明,OFP-VTON能更好地保留原有特征,扭曲后的试穿服装与模特图像匹配度高。
文摘We performed on paleomagnetic investigation of the Upper Cretaceous red sandstones collected from Fujiau and Guangdong provinces. Significant characteristic directions were isolated by principal comPonent analysis from 22 of 25 and 9 of 14 sampling sites iu Fujian and Guangdong,respectively. Maximum concentration of global mean directions every province is achieved at 70 %and complete (100 % ) untilting for Fujian and Guangdong, respectively. We regarded these mean directions as the Late Cretaceous paleomagnetic directions and calculated virtual geomagnetic poles (VGPs); Fujian, Lat. /Lon. = 79. 4°N/210. 3°E (α95= 5. 1°) and Guangdong, Lat. /Lon. = 80. 1°N/193. 4°E (α95=8. 0°). These two VGPs are nearly equal to each other and to a mean VGP from Sichuan Province reported previously. This observation suggests no relative movement among three regions, Fujian, Guangdong and Sichuan, since the Late Cretaceous. Two VGPs from this study are significantly different from previously reported VGPs from the same regions. Further systematic paleomagnetic works are needed to clarify this difference of VGP Positions.
