Thirty-seven males with non-alcoholic staatohepatitis (NASH) (aged 39 - 62) were included in the study. Clinical, biochemical and instrumental studies were used to verify the diagnosis. The control group was comprised...Thirty-seven males with non-alcoholic staatohepatitis (NASH) (aged 39 - 62) were included in the study. Clinical, biochemical and instrumental studies were used to verify the diagnosis. The control group was comprised of thirty-three males of comparable age and without confirmed signs of liver diseases and other pathology of inner organs. Dielectrophoresis was applied to evaluate the structural-and-functional erythrocytic parameters. The patients with NASH erythrocytes tended to differ in their much lower amplitude deformation, polarizability, capacity of erythrocytic membranes, pace of translational motion of cells towards electrodes and much higher levels of overall indices of rigidity, viscosity, electroconductivity, destruction and aggregation as compared to the control group (p < 0.001 - 0.05). We discovered cases of correlation of erythrocytic parameters with biochemical findings reflecting inflammatory and cytolytic syndrome, cholestasis, protein-synthesizing liver function as well as markers of metabolic syndrome (BMI, changes in arterial blood pressure, the degree of disturbances in carbohydrate metabolism, atherogenic dyslipidemia) and microalbuminuria. Aggravation of microcirculatory disturbances leading to an increase of fibrogenes is induced by changes in the properties of erythrocytes under NASH suggests the administration of a number of therapeutic techniques which could improve the status of the parameters of red blood cells. This study aims to evaluate the peculiarities of electric and viscoelastic behavior of erythrocytes in patients with primary NASH in order to determine additional methods of treatment for this disease.展开更多
Viscoelastic parameters are becoming more important and their inversion algorithms are studied by many researchers. Genetic algorithms are random, self-adaptive, robust, and heuristic with global search and convergenc...Viscoelastic parameters are becoming more important and their inversion algorithms are studied by many researchers. Genetic algorithms are random, self-adaptive, robust, and heuristic with global search and convergence abilities. Based on the direct VSP wave equation, a genetic algorithm （GA） is introduced to determine the viscoelastic parameters. First, the direct wave equation in frequency is expressed as a function of complex velocity and then the complex velocities estimated by GA inversion. Since the phase velocity and Q-factor both are functions of complex velocity, their values can be computed easily. However, there are so many complex velocities that it is difficult to invert them directly. They can be rewritten as a function of Co and C∞ to reduce the number of parameters during the inversion process. Finally, a theoretical model experiment proves that our algorithm is exact and effective.展开更多
文摘Thirty-seven males with non-alcoholic staatohepatitis (NASH) (aged 39 - 62) were included in the study. Clinical, biochemical and instrumental studies were used to verify the diagnosis. The control group was comprised of thirty-three males of comparable age and without confirmed signs of liver diseases and other pathology of inner organs. Dielectrophoresis was applied to evaluate the structural-and-functional erythrocytic parameters. The patients with NASH erythrocytes tended to differ in their much lower amplitude deformation, polarizability, capacity of erythrocytic membranes, pace of translational motion of cells towards electrodes and much higher levels of overall indices of rigidity, viscosity, electroconductivity, destruction and aggregation as compared to the control group (p < 0.001 - 0.05). We discovered cases of correlation of erythrocytic parameters with biochemical findings reflecting inflammatory and cytolytic syndrome, cholestasis, protein-synthesizing liver function as well as markers of metabolic syndrome (BMI, changes in arterial blood pressure, the degree of disturbances in carbohydrate metabolism, atherogenic dyslipidemia) and microalbuminuria. Aggravation of microcirculatory disturbances leading to an increase of fibrogenes is induced by changes in the properties of erythrocytes under NASH suggests the administration of a number of therapeutic techniques which could improve the status of the parameters of red blood cells. This study aims to evaluate the peculiarities of electric and viscoelastic behavior of erythrocytes in patients with primary NASH in order to determine additional methods of treatment for this disease.
文摘Viscoelastic parameters are becoming more important and their inversion algorithms are studied by many researchers. Genetic algorithms are random, self-adaptive, robust, and heuristic with global search and convergence abilities. Based on the direct VSP wave equation, a genetic algorithm （GA） is introduced to determine the viscoelastic parameters. First, the direct wave equation in frequency is expressed as a function of complex velocity and then the complex velocities estimated by GA inversion. Since the phase velocity and Q-factor both are functions of complex velocity, their values can be computed easily. However, there are so many complex velocities that it is difficult to invert them directly. They can be rewritten as a function of Co and C∞ to reduce the number of parameters during the inversion process. Finally, a theoretical model experiment proves that our algorithm is exact and effective.
