Objective: The objective of this study was to explore the medication rules and academic ideas of Professor Wang Yu-Ying in the treatment of climacteric syndrome(CLS) and to predict new prescriptions. Materials and Met...Objective: The objective of this study was to explore the medication rules and academic ideas of Professor Wang Yu-Ying in the treatment of climacteric syndrome(CLS) and to predict new prescriptions. Materials and Methods: The characteristics of frequency, clustering, four properties, and five flavors were analyzed, and new prescriptions were predicted through an artificial intelligence(AI)-based method. The potential pathways of new prescriptions were explored through network pharmacology-based analysis. Results: The top 16 medicinals used by Professor Wang Yu-Ying in the treatment of CLS included Danggui, Longgu, Muli, Fuling, Chuanxiong, Gancao, Xiangfu, and Tusizi. The AI method was applied to predict the basic prescription for treating CLS: Danggui 15 g, Duanlonggu 30 g, Duanmuli 30 g, Fuling 28 g, Chuanxiong 10 g, Gancao 6 g, Xiangfu 12 g, Tusizi 14 g, etc., Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses showed that the pathogenesis of CLS might be related to the estrogen pathway, involving typical steroid responses. Conclusions: This study summarized Professor Wang's medication experience in the treatment of CLS based on the data mining of clinical diagnoses and treatment cases. The AI method was used to predict the new prescription of CLS treatment, which was found to be reasonable by network pharmacology studies on its multi-target and multi-pathway mechanisms.展开更多
Prof.C.C.Ting,Nobel Laureate and Foreign Member of the Chinese Academy of Sciences(CAS),during his visit to the CAS Institute of High Energy Physics(IHEP)in Beijing,attended the High Energy Physics Forum held by IHEP....Prof.C.C.Ting,Nobel Laureate and Foreign Member of the Chinese Academy of Sciences(CAS),during his visit to the CAS Institute of High Energy Physics(IHEP)in Beijing,attended the High Energy Physics Forum held by IHEP.After giving a lecture reviewing his experiences in experimental particle physics,he had an open talk with the audience together with CAS Member Prof.WANG Yifang,the Director of IHEP and one of his former PhD students.Here we recorded Ting and WANG’s responses to some questions from the listeners.展开更多
Wang Yangming was a prominent thinker and politician with significant national influence during the Ming Dynasty.He has been a key subject of study in the realms of China’s ideological history,academic history,and po...Wang Yangming was a prominent thinker and politician with significant national influence during the Ming Dynasty.He has been a key subject of study in the realms of China’s ideological history,academic history,and political history.His travels to various regions have been the subject of valuable research.While the contribution of Wang Yangming in Guangxi has historically been less extensive compared to his contributions in places such as Zhejiang,Guizhou,and Jiangxi,it has shown gradual improvement over the past 50 years.Particularly,there has been an expanding and deepening exploration of the wisdom and impact he left during his governance of Guangxi.展开更多
文摘Objective: The objective of this study was to explore the medication rules and academic ideas of Professor Wang Yu-Ying in the treatment of climacteric syndrome(CLS) and to predict new prescriptions. Materials and Methods: The characteristics of frequency, clustering, four properties, and five flavors were analyzed, and new prescriptions were predicted through an artificial intelligence(AI)-based method. The potential pathways of new prescriptions were explored through network pharmacology-based analysis. Results: The top 16 medicinals used by Professor Wang Yu-Ying in the treatment of CLS included Danggui, Longgu, Muli, Fuling, Chuanxiong, Gancao, Xiangfu, and Tusizi. The AI method was applied to predict the basic prescription for treating CLS: Danggui 15 g, Duanlonggu 30 g, Duanmuli 30 g, Fuling 28 g, Chuanxiong 10 g, Gancao 6 g, Xiangfu 12 g, Tusizi 14 g, etc., Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses showed that the pathogenesis of CLS might be related to the estrogen pathway, involving typical steroid responses. Conclusions: This study summarized Professor Wang's medication experience in the treatment of CLS based on the data mining of clinical diagnoses and treatment cases. The AI method was used to predict the new prescription of CLS treatment, which was found to be reasonable by network pharmacology studies on its multi-target and multi-pathway mechanisms.
文摘Prof.C.C.Ting,Nobel Laureate and Foreign Member of the Chinese Academy of Sciences(CAS),during his visit to the CAS Institute of High Energy Physics(IHEP)in Beijing,attended the High Energy Physics Forum held by IHEP.After giving a lecture reviewing his experiences in experimental particle physics,he had an open talk with the audience together with CAS Member Prof.WANG Yifang,the Director of IHEP and one of his former PhD students.Here we recorded Ting and WANG’s responses to some questions from the listeners.
文摘Wang Yangming was a prominent thinker and politician with significant national influence during the Ming Dynasty.He has been a key subject of study in the realms of China’s ideological history,academic history,and political history.His travels to various regions have been the subject of valuable research.While the contribution of Wang Yangming in Guangxi has historically been less extensive compared to his contributions in places such as Zhejiang,Guizhou,and Jiangxi,it has shown gradual improvement over the past 50 years.Particularly,there has been an expanding and deepening exploration of the wisdom and impact he left during his governance of Guangxi.
