In this paper, the axial-flux permanent magnet driver is modeledand analyzed in a simple and novel way under three-dimensional cylindricalcoordinates. The inherent three-dimensional characteristics of the deviceare co...In this paper, the axial-flux permanent magnet driver is modeledand analyzed in a simple and novel way under three-dimensional cylindricalcoordinates. The inherent three-dimensional characteristics of the deviceare comprehensively considered, and the governing equations are solved bysimplifying the boundary conditions. The axial magnetization of the sectorshapedpermanent magnets is accurately described in an algebraic form bythe parameters, which makes the physical meaning more explicit than thepurely mathematical expression in general series forms. The parameters of theBessel function are determined simply and the magnetic field distribution ofpermanent magnets and the air-gap is solved. Furthermore, the field solutionsare completely analytical, which provides convenience and satisfactoryaccuracy for modeling a series of electromagnetic performance parameters,such as the axial electromagnetic force density, axial electromagnetic force,and electromagnetic torque. The correctness and accuracy of the analyticalmodels are fully verified by three-dimensional finite element simulations and a15 kW prototype and the results of calculations, simulations, and experimentsunder three methods are highly consistent. The influence of several designparameters on magnetic field distribution and performance is studied and discussed.The results indicate that the modeling method proposed in this papercan calculate the magnetic field distribution and performance accurately andrapidly, which affords an important reference for the design and optimizationof axial-flux permanent magnet drivers.展开更多
Natural slopes usually display complicated exposed rock surfaces that are characterized by complex and substantial terrain undulation and ubiquitous undesirable phenomena such as vegetation cover and rockfalls.This st...Natural slopes usually display complicated exposed rock surfaces that are characterized by complex and substantial terrain undulation and ubiquitous undesirable phenomena such as vegetation cover and rockfalls.This study presents a systematic outcrop research of fracture pattern variations in a complicated rock slope,and the qualitative and quantitative study of the complex phenomena impact on threedimensional(3D)discrete fracture network(DFN)modeling.As the studies of the outcrop fracture pattern have been so far focused on local variations,thus,we put forward a statistical analysis of global variations.The entire outcrop is partitioned into several subzones,and the subzone-scale variability of fracture geometric properties is analyzed(including the orientation,the density,and the trace length).The results reveal significant variations in fracture characteristics(such as the concentrative degree,the average orientation,the density,and the trace length)among different subzones.Moreover,the density of fracture sets,which is approximately parallel to the slope surface,exhibits a notably higher value compared to other fracture sets across all subzones.To improve the accuracy of the DFN modeling,the effects of three common phenomena resulting from vegetation and rockfalls are qualitatively analyzed and the corresponding quantitative data processing solutions are proposed.Subsequently,the 3D fracture geometric parameters are determined for different areas of the high-steep rock slope in terms of the subzone dimensions.The results show significant variations in the same set of 3D fracture parameters across different regions with density differing by up to tenfold and mean trace length exhibiting differences of 3e4 times.The study results present precise geological structural information,improve modeling accuracy,and provide practical solutions for addressing complex outcrop issues.展开更多
The thermal evolution of the Earth’s interior and its dynamic effects are the focus of Earth sciences.However,the commonly adopted grid-based temperature solver is usually prone to numerical oscillations,especially i...The thermal evolution of the Earth’s interior and its dynamic effects are the focus of Earth sciences.However,the commonly adopted grid-based temperature solver is usually prone to numerical oscillations,especially in the presence of sharp thermal gradients,such as when modeling subducting slabs and rising plumes.This phenomenon prohibits the correct representation of thermal evolution and may cause incorrect implications of geodynamic processes.After examining several approaches for removing these numerical oscillations,we show that the Lagrangian method provides an ideal way to solve this problem.In this study,we propose a particle-in-cell method as a strategy for improving the solution to the energy equation and demonstrate its effectiveness in both one-dimensional and three-dimensional thermal problems,as well as in a global spherical simulation with data assimilation.We have implemented this method in the open-source finite-element code CitcomS,which features a spherical coordinate system,distributed memory parallel computing,and data assimilation algorithms.展开更多
We combined domestic ground-based and satellite magnetic measurements to create a regional three-dimensional surface Spline(3DSS)gradient model of the main geomagnetic field over the Chinese continent.To improve the p...We combined domestic ground-based and satellite magnetic measurements to create a regional three-dimensional surface Spline(3DSS)gradient model of the main geomagnetic field over the Chinese continent.To improve the precision of the model,we considered the data gap between the ground and satellite data.We compared and analyzed the results of the Taylor polynomial,surface Spline,and CHAOS-6(the CHAMP,?rsted and SAC-C model of Earth’s magnetic field)gradient models.Results showed that the gradients in the south-north and east-west directions of the four models were consistent.The 3DSS model was able to express not only gradients at different altitudes,but also average gradients inside the research area.The two Spline models were able to capture more information on gradient anomalies than were the fitted models.Strong local anomalies were observed in northern Xinjiang,Beijing,and the junction area between Jiangsu and Zhejiang,and the total intensity F decreased whereas the altitude increased.The gradient decreased by 21.69%in the south-north direction and increased by 11.78%in the east-west direction.In addition,the altitude gradient turned from negative to positive while the altitude increased.The Spline model and the two fitted models differed mainly in the field sources they expressed and the modeling theory.展开更多
Objective To evaluate the predictive validity of IRIS™(Intuitive Surgical®,Sunnyvale,CA,USA)as a planning tool for robot-assisted partial nephrectomy(RAPN)by assessing the degree of overlap with intraoperative ex...Objective To evaluate the predictive validity of IRIS™(Intuitive Surgical®,Sunnyvale,CA,USA)as a planning tool for robot-assisted partial nephrectomy(RAPN)by assessing the degree of overlap with intraoperative execution.Methods Thirty-one patients scheduled for RAPN by four experienced urologists were enrolled in a prospective study.Prior to surgery,urologists reviewed the IRIS™three-dimensional model on an iphone Operating System(iOS)app and completed a questionnaire outlining their surgical plan including surgical approach,and ischemia technique as well as confidence in executing this plan.Postoperatively,questionnaires assessing the procedural approach,clinical utility,efficiency,and effectiveness of IRIS™were completed.The degree of overlap between the preoperative and intraoperative questionnaires and between the planned approach and actual execution of the procedure was analyzed.Questionnaires were answered on a 5-point Likert scale and scores of 4 or greater were considered positive.Results Mean age was 65.1 years with a mean tumor size of 27.7 mm(interquartile range 17.5-44.0 mm).Hilar tumors consisted of 32.3%;48.4%of patients had R.E.N.A.L.nephrometry scores of 7-9.On preoperative questionnaires,the surgeons reported that in 67.7%cases they were confident that they can perform the procedure successfully,and on intraoperative questionnaires,the surgeons reported that in 96.8%cases IRIS™helped achieve good spatial sensation of the anatomy.There was a high degree of overlap between preoperative and intraoperative questionnaires for the surgical approach,interpreting anatomical details and clinical utility.When comparing plans for selective or off-clamp,the preoperative plan was executed in 90.0%of cases intraoperatively.Conclusion A high degree of overlap between the preoperative surgical approach and intraoperative RAPN execution was found using IRIS™.This is the first study to evaluate the predictive accuracy of IRIS™during RAPN by comparing preoperative plan and intraoperative execution.展开更多
The study of water resources at watershed scale is widely adopted as approach to manage, assess and simulate these important natural resources. The development of remote sensing and GIS techniques has allowed the use ...The study of water resources at watershed scale is widely adopted as approach to manage, assess and simulate these important natural resources. The development of remote sensing and GIS techniques has allowed the use of spatially and physically based hydrologic models to simulate as simply and realistically as possible the functioning of watershed systems. Indeed, the major constraint that has hindered the expansion use of these tools was the unavailability or scarcity of data especially in the developing countries. In this context, the objective of this study is to model the hydrology in the Bouregreg basin, located at the north-central of Morocco, using the Soil and Water Assessment Tool (SWAT) in order to understand and determine the different watershed hydrological processes. Thus, it aims to simulate the stream flow, establish the water balance and estimate the monthly volume inflow to SMBA dam situated at the basin outlet. The ArcSWAT interface implemented in the ArcGIS software was used to delineate the basin and its sub-components, combine the data layers and edit the model database. The model parameters were analyzed, ranked and adjusted for hydrologic modeling purposes using daily temporal data series. They were calibrated using an auto-calibration method based on a Shuffled Complex Evolution Algorithm from 1989 to 1997 and validated from 1998 to 2005. Based on statistical indicators, the evaluation indicates that SWAT model had a good performance for both calibration and validation periods in Bouregreg Watershed. In fact, the model showed a good correlation between the observed and simulated monthly average river discharge with R2 and Nash coefficient of about 0.8. The water balance components were correctly estimated and the SMBA dam inflow was successfully reproduced with R2 of 0.9. These results revealed that if properly calibrated, SWAT model can be used efficiently in semi-arid regions to support water management policies.展开更多
Three-dimensional(3D)culture systems are becoming increasingly popular due to their ability to mimic tissue-like structures more effectively than the monolayer cultures.In cancer and stem cell research,the natural cel...Three-dimensional(3D)culture systems are becoming increasingly popular due to their ability to mimic tissue-like structures more effectively than the monolayer cultures.In cancer and stem cell research,the natural cell characteristics and architectures are closely mimicked by the 3D cell models.Thus,the 3D cell cultures are promising and suitable systems for various proposes,ranging from disease modeling to drug target identification as well as potential therapeutic substances that may transform our lives.This review provides a comprehensive compendium of recent advancements in culturing cells,in particular cancer and stem cells,using 3D culture techniques.The major approaches highlighted here include cell spheroids,hydrogel embedding,bioreactors,scaffolds,and bioprinting.In addition,the progress of employing 3D cell culture systems as a platform for cancer and stem cell research was addressed,and the prominent studies of 3D cell culture systems were discussed.展开更多
This paper outlines a methodology to estimate monthly precipitation surfaces at 1-kin resolution for the Upper Shiyang River watershed (USRW) in northwest China. Generation of precipitation maps is based on the appl...This paper outlines a methodology to estimate monthly precipitation surfaces at 1-kin resolution for the Upper Shiyang River watershed (USRW) in northwest China. Generation of precipitation maps is based on the application of a four-variable genetic algorithm (GA) trained on 10 years of weather and ancillary data, i.e., surface air temperature, relative humidity, Digital Elevation Model-derived estimates of elevation, and time of year collected at 29 weather stations in west-central Gansu and northern Qinghai province. An observed-to-GA predicted data comparison of 10 years of precipitation collected at the 29 weather stations showed that about 84% of the variability in observed values could be explained by the trained GA, including variability in two independent datasets. Point-comparisons of observed and modeled precipitation along an elevation-rainfall gradient demonstrated near-similar spatiotemporal patterns. A precipitation surface for USRW for July, 2005, was developed with the trained GA and input surfaces of surface air temperature and relative humidity generated from Moderate Resolution Imaging Spectroradiometer sensor (MODIS) products of land surface temperature. Spatial tendencies in predicted maximum and minimum values of surface air temperature, relative humidity, and precipitation within a 2-kin radius circle around selected weather stations were in close agreement with the values measured at the weather stations.展开更多
Controlling soil erosion and the transport and deposition of suspended sediment to receiving waters, especially in relation to the modifying influences of, and interplay between, climate and land-use alterations, is e...Controlling soil erosion and the transport and deposition of suspended sediment to receiving waters, especially in relation to the modifying influences of, and interplay between, climate and land-use alterations, is essential for effective watershed management. The Atlantic Canada—New England region is expected to experience elevated rainfall erosivity due to climate change over the next century. Using the projected higher precipitation amounts of 5% and 10% for future scenarios of 5 and 25 years for the region, and a spatially-explicit, integrated (GIS, RUSLE) model for a rural watershed in Nova Scotia, predicted increases in total erosion rates of 4.9 and 9.9%, respectively. Modelled scenarios altering buffer strips based on either consistent or slope-variable widths between 30 m (the legal requirement) to 90 m were found to correspond to reductions in predicted total watershed erosion rates from 11% to 32%. Assuming and extending the 1:1 concordance between projected precipitation and estimated soil erosion for this particular watershed into the more distant future of 26 to 55 years, suggests that the 25% increase in soil erosion predicted over this period would have to be offset by expanding the protective buffer strips to a consistent width of 70 m. Adoption of such a protective management scheme would subsume 19% of the terrestrial area of the study watershed and thus consequent reductions in land available for agricultural production and timber harvest.展开更多
The traditional fuzzy logic system (FLS) can only model and control the process in two-dimensional nature. Many of real-world systems are of multidimensional features, such as, thermal and fluid processes with spati...The traditional fuzzy logic system (FLS) can only model and control the process in two-dimensional nature. Many of real-world systems are of multidimensional features, such as, thermal and fluid processes with spatiotemporal dynamics, biological systems, or decision-making processes that contain stochastic and imprecise uncertainties. These types of systems are difficult for the traditional FLS to model and control because they require a third dimension for spatial or probabilistic information. The type-2 fuzzy set provides the possibility to develop a three-dimensional fuzzy logic system for modeling and controlling these processes in three-dimensional nature.展开更多
Mathematical models of the quantity and quality of water in hydrographic basins enable simulation of a wide variety of processes, including the production of water and sediments, and the dynamics of point and nonpoint...Mathematical models of the quantity and quality of water in hydrographic basins enable simulation of a wide variety of processes, including the production of water and sediments, and the dynamics of point and nonpoint sources of pollution. These models have become increasingly complex, requiring large amounts of input data, which can increase the uncertainty of the results of simulations. For this reason, it is essential to perform calibration and validation procedures. The objective of this work was to conduct sensitivity analysis and calibration of a distributed hydrological model (SWAT) applied to the flows of water in the watershed of the Poxim River. Satisfactory performance of the model was indicated by the values obtained for the Nash-Sutcliffe efficiency coefficient (0.77), the percent bias (5.05), the root mean square error (0.48), and the ratio of the RMSE to the standard deviation of the observations (RSR) (0.49). The set of parameters identified here could be used for the simulation and evaluation of other scenarios.展开更多
The mitigation potential of reforestation for offsetting the deleterious effects of increased flooding and soil erosion projected to occur in Atlantic Canada through future climate change was investigated. Modelling d...The mitigation potential of reforestation for offsetting the deleterious effects of increased flooding and soil erosion projected to occur in Atlantic Canada through future climate change was investigated. Modelling determined a strong but non-linear relationship between extent of vegetative cover and runoff volume and discharge rate for a Nova Scotian watershed, suggesting that reforestation will reduce, but not completely prevent, flooding. Predicted erosion rates were found to be progressively reduced in relation to the extent of upland reforestation. Of three scenarios examined in which 60%, 65%, and 85% of the entire watershed are randomly reforested, only the latter would reduce the elevated erosion expected to occur through climate change back to present-day existing levels. Additional modelling revealed that comparable mitigation of soil erosion can ensue through implementation of 70 m streamside buffer strips, which would only take up 19% of the total surface area. Prioritizing riparian zones for reforestation will therefore subsume less of the overall productive land area and therefore enact a less severe socio-economic impact on agriculture and forestry.展开更多
An optimized device structure for reducing the RESET current of phase-change random access memory (PCRAM) with blade-type like (BTL) phase change layer is proposed. The electrical thermal analysis of the BTL cell ...An optimized device structure for reducing the RESET current of phase-change random access memory (PCRAM) with blade-type like (BTL) phase change layer is proposed. The electrical thermal analysis of the BTL cell and the blade heater contactor structure by three-dimensional finite element modeling are compared with each other during RESET operation. The simulation results show that the programming region of the phase change layer in the BTL cell is much smaller, and thermal electrical distributions of the BTL cell are more concentrated on the TiN/GST interface. The results indicate that the BTL cell has the superiorities of increasing the heating efficiency, decreasing the power consumption and reducing the RESET current from 0.67mA to 0.32mA. Therefore, the BTL cell will be appropriate for high performance PCRAM device with lower power consumption and lower RESET current.展开更多
In the past decades,physical modeling has been widely used in hydrogeology for teaching,studying and exhibition purposes.Most of these models are used to illustrate hydrogeological profiles,but few can depict three-di...In the past decades,physical modeling has been widely used in hydrogeology for teaching,studying and exhibition purposes.Most of these models are used to illustrate hydrogeological profiles,but few can depict three-dimensional groundwater flows,making it impossible to validate groundwater flows simulated by numerical methods with physical modeling.展开更多
Land use changes such as deforestation,increase in cropping or grazing areas and built-up land, likely modify the water balance and land surface behavior in the Himalayan watersheds.An integrated approach of hydrologi...Land use changes such as deforestation,increase in cropping or grazing areas and built-up land, likely modify the water balance and land surface behavior in the Himalayan watersheds.An integrated approach of hydrological and hydraulic modeling was adopted for comparative analysis of hydrological pattern in three Himalayan watersheds i.e.Khanpur,Rawal and Simly situated in the Northern territory of Pakistan.The rainfall-runoff model SWAT- Soil and water assessment tool and Hydro CAD were calibrated for the selected watersheds.The correlation analysis of the precipitation data of two climate stations i.e.Murree and Islamabad, with the discharge data of three rivers was utilized to select best suitable input precipitation data for Hydro CAD rainfall-runoff modeling.The peak flood hydrograph were generated using Hydro CAD runoff to optimize the basin parameters like CN, runoff volume, peak flows of the three watersheds.The hydrological response of the Rawal watershed was studied as a case study to different scenarios of land use change using SWAT model.The scenario of high deforestation indicated a decline of about 6.3% in the groundwater recharge tostream while increase of 7.1% in the surface runoff has been observed under the scenario of growth in urbanization in the recent decades.The integrated modeling approach proved helpful in investigating the hydrological behavior under changing environment at watershed level in the Himalayan region.展开更多
Three-dimensional modeling of virtual hoisting machinery is the critical works to structure the system of virtual construction, and the foundation to realize intelligent and interactive virtual hoisting. Aimed at enha...Three-dimensional modeling of virtual hoisting machinery is the critical works to structure the system of virtual construction, and the foundation to realize intelligent and interactive virtual hoisting. Aimed at enhancing the requests of image quality and stability of the virtual construction scene, taking a tower crane for example. We studied the technology of three-dimensional modeling and optimization of a virtual tower crane, and a method named two-stage model optimization was put forward. This depended on the modeling stage using Solidworks and 3DS Max and the performance optimization stage in EON. The practice of software development indicates that the proposed methods of three-dimensional modeling and optimization could satisfy the performance request of virtual construction system and be popularized to other virtual system.展开更多
Water shortage is a chronic problem in arid Northwest China.The rapid population growth and expanding urbanization as well as potential climate change impacts are likely to worsen the situation,threatening domestic,ir...Water shortage is a chronic problem in arid Northwest China.The rapid population growth and expanding urbanization as well as potential climate change impacts are likely to worsen the situation,threatening domestic,irrigation,and industrial supplies and even the survival of the ecosystems in Northwest China.This paper describes the preliminary work of adapting the Distributed Large Basin Runoff Model(DLBRM) to the Heihe watershed(the second largest inland river in arid Northwestern China,with a drainage area of 128,000 km2) for understanding distribution of glacial-snow melt,groundwater,surface runoff,and evapotranspi-ration,and for assessing hydrological impacts of climate change and glacial recession on water supply in the middle and lower reaches of the watershed.Preliminary simulation results show that the Qilian Mountain in the upper reach area produces most runoff in the Heihe watershed.The simulated daily river flows during the period of 1990-2000 indicate that the Heihe River dis-charges about 1×109 m3 of water from the middle reach(at Zhengyixia Station) to lower reach,with surface runoff and interflow contributing 51 and 49 percent respectively.The sandy lower soil zone in the middle reach has the highest evapotranspiration rate and also contributes nearly half of the river flow.Work underway focuses on the DLBRM model improvement and incorporation of the climate change and management scenarios to the hydrological simulations in the watershed.展开更多
Metastasis is the leading cause of most cancer deaths, as opposed to dysregulated cell growth of the primary tumor. Molecular mechanisms of metastasis have been studied for decades and the findings have evolved our un...Metastasis is the leading cause of most cancer deaths, as opposed to dysregulated cell growth of the primary tumor. Molecular mechanisms of metastasis have been studied for decades and the findings have evolved our understanding of the progression of malignancy. However, most of the molecular mechanisms fail to address the causes of cancer and its evolutionary origin, demonstrating an inability to find a solution for complete cure of cancer. After being a neglected area of tumor biology for quite some time, recently several studies have focused on the impact of the tumor microenvironment on cancer growth. The importance of the tumor microenvironment is gradually gaining attention, particularly from the per- spective of biophysics. In vitro three-dimensional (3-D) metastatic models are an indispensable platform for investigating the tumor microenvironment, as they mimic the in vivo tumor tissue. In 3-D metastatic in vitro models, static factors such as the mechanical properties, biochemical factors, as well as dynamic factors such as cell-cell, cell-ECM interactions, and fluid shear stress can be studied quantitatively. With increasing focus on basic cancer research and drug development, the in vitro 3-D models offer unique advantages in fundamental and clinical biomedical studies.展开更多
Central nervous system(CNS)tumors are a variety of distinct neoplasms that present multiple challenges in terms of treatment and prognosis.Glioblastoma,the most common primary tumor in adults,is associated with poor s...Central nervous system(CNS)tumors are a variety of distinct neoplasms that present multiple challenges in terms of treatment and prognosis.Glioblastoma,the most common primary tumor in adults,is associated with poor survival and remains one of the least treatable neoplasms.These tumors are highly heterogenous and complex in their nature.Due to this complexity,traditional cell culturing techniques and methods do not provide an ideal recapitulating model for the study of these tumors’behavior in vivo.Two-dimensional models lack the spatial arrangement,the heterogeneity in cell types,and the microenvironment that play a large role in tumor cell behavior and response to treatment.Recently,scientists have turned towards three-dimensional culturing methods,namely spheroids and organoids,as they have been shown to recapitulate tumors in a more faithful manner to their in vivo counterparts.Moreover,tumor-on-a-chip systems have lately been employed in CNS tumor modeling and have shown great potential in both studying the pathophysiology and therapeutic testing.In this review,we will discuss the current available literature on in vitro threedimensional culturing models in CNS tumors,in addition to presenting their advantages and current limitations.We will also elaborate on the future implications of these models and their benefit in the clinical setting.展开更多
Yingqiong basin is a proven hydrocarbon-rich basin in South China Sea. There are a number of large exploration prospects in high temperature and over-pressured formations, especially in Yacheng Block of Qiongdongnan b...Yingqiong basin is a proven hydrocarbon-rich basin in South China Sea. There are a number of large exploration prospects in high temperature and over-pressured formations, especially in Yacheng Block of Qiongdongnan basin and Dongfang District of Yinggehai Basin. Owing to good exploration situation, we have already achieved proven geological reserves over 1000 × 108 m3. In recent years, a few drilled HPHT wells have confirmed that pressure predicted by conventional method was wildly inaccurate. From the view of regional stress, the accuracy of the pressure prediction will be substantially improved. Accurate pressure prediction and three-dimensional pressure modeling which are based on three-dimensional lithology modeling are the cornerstone to achieve exploration breakthrough. In this paper, the use of the triple constraint trend lithology model broke through the traditional method of seismic lithology prediction only by means of impedance threshold value. Compared with actual data and prediction, it confirms that three-dimensional pressure modeling method is reasonable and effective, and has a wide prospect of application.展开更多
基金supported by the National Natural Science Foundation of China under Grant[52077027]Liaoning Province Science and Technology Major Project[No.2020JH1/10100020].
文摘In this paper, the axial-flux permanent magnet driver is modeledand analyzed in a simple and novel way under three-dimensional cylindricalcoordinates. The inherent three-dimensional characteristics of the deviceare comprehensively considered, and the governing equations are solved bysimplifying the boundary conditions. The axial magnetization of the sectorshapedpermanent magnets is accurately described in an algebraic form bythe parameters, which makes the physical meaning more explicit than thepurely mathematical expression in general series forms. The parameters of theBessel function are determined simply and the magnetic field distribution ofpermanent magnets and the air-gap is solved. Furthermore, the field solutionsare completely analytical, which provides convenience and satisfactoryaccuracy for modeling a series of electromagnetic performance parameters,such as the axial electromagnetic force density, axial electromagnetic force,and electromagnetic torque. The correctness and accuracy of the analyticalmodels are fully verified by three-dimensional finite element simulations and a15 kW prototype and the results of calculations, simulations, and experimentsunder three methods are highly consistent. The influence of several designparameters on magnetic field distribution and performance is studied and discussed.The results indicate that the modeling method proposed in this papercan calculate the magnetic field distribution and performance accurately andrapidly, which affords an important reference for the design and optimizationof axial-flux permanent magnet drivers.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFC3080200)the National Natural Science Foundation of China(Grant No.42022053)the China Postdoctoral Science Foundation(Grant No.2023M731264).
文摘Natural slopes usually display complicated exposed rock surfaces that are characterized by complex and substantial terrain undulation and ubiquitous undesirable phenomena such as vegetation cover and rockfalls.This study presents a systematic outcrop research of fracture pattern variations in a complicated rock slope,and the qualitative and quantitative study of the complex phenomena impact on threedimensional(3D)discrete fracture network(DFN)modeling.As the studies of the outcrop fracture pattern have been so far focused on local variations,thus,we put forward a statistical analysis of global variations.The entire outcrop is partitioned into several subzones,and the subzone-scale variability of fracture geometric properties is analyzed(including the orientation,the density,and the trace length).The results reveal significant variations in fracture characteristics(such as the concentrative degree,the average orientation,the density,and the trace length)among different subzones.Moreover,the density of fracture sets,which is approximately parallel to the slope surface,exhibits a notably higher value compared to other fracture sets across all subzones.To improve the accuracy of the DFN modeling,the effects of three common phenomena resulting from vegetation and rockfalls are qualitatively analyzed and the corresponding quantitative data processing solutions are proposed.Subsequently,the 3D fracture geometric parameters are determined for different areas of the high-steep rock slope in terms of the subzone dimensions.The results show significant variations in the same set of 3D fracture parameters across different regions with density differing by up to tenfold and mean trace length exhibiting differences of 3e4 times.The study results present precise geological structural information,improve modeling accuracy,and provide practical solutions for addressing complex outcrop issues.
基金the National Supercomputer Center in Tianjin for their patient assistance in providing the compilation environment.We thank the editor,Huajian Yao,for handling the manuscript and Mingming Li and another anonymous reviewer for their constructive comments.The research leading to these results has received funding from National Natural Science Foundation of China projects(Grant Nos.92355302 and 42121005)Taishan Scholar projects(Grant No.tspd20210305)others(Grant Nos.XDB0710000,L2324203,XK2023DXC001,LSKJ202204400,and ZR2021ZD09).
文摘The thermal evolution of the Earth’s interior and its dynamic effects are the focus of Earth sciences.However,the commonly adopted grid-based temperature solver is usually prone to numerical oscillations,especially in the presence of sharp thermal gradients,such as when modeling subducting slabs and rising plumes.This phenomenon prohibits the correct representation of thermal evolution and may cause incorrect implications of geodynamic processes.After examining several approaches for removing these numerical oscillations,we show that the Lagrangian method provides an ideal way to solve this problem.In this study,we propose a particle-in-cell method as a strategy for improving the solution to the energy equation and demonstrate its effectiveness in both one-dimensional and three-dimensional thermal problems,as well as in a global spherical simulation with data assimilation.We have implemented this method in the open-source finite-element code CitcomS,which features a spherical coordinate system,distributed memory parallel computing,and data assimilation algorithms.
基金the support of the National Natural Science Foundation of China(Nos.41974073,41404053)the Macao Foundation and the pre-research project of Civil Aerospace Technologies(Nos.D020308 and D020303)+2 种基金funded by the National Space Administration of Chinathe opening fund of the State Key Laboratory of Lunar and Planetary Sciences(Macao University of Science and Technology,Macao Science and Technology Development Fund No.119/2017/A3)the Specialized Research Fund for State Key Laboratories,and the NUIST-UoR International Research Institute。
文摘We combined domestic ground-based and satellite magnetic measurements to create a regional three-dimensional surface Spline(3DSS)gradient model of the main geomagnetic field over the Chinese continent.To improve the precision of the model,we considered the data gap between the ground and satellite data.We compared and analyzed the results of the Taylor polynomial,surface Spline,and CHAOS-6(the CHAMP,?rsted and SAC-C model of Earth’s magnetic field)gradient models.Results showed that the gradients in the south-north and east-west directions of the four models were consistent.The 3DSS model was able to express not only gradients at different altitudes,but also average gradients inside the research area.The two Spline models were able to capture more information on gradient anomalies than were the fitted models.Strong local anomalies were observed in northern Xinjiang,Beijing,and the junction area between Jiangsu and Zhejiang,and the total intensity F decreased whereas the altitude increased.The gradient decreased by 21.69%in the south-north direction and increased by 11.78%in the east-west direction.In addition,the altitude gradient turned from negative to positive while the altitude increased.The Spline model and the two fitted models differed mainly in the field sources they expressed and the modeling theory.
文摘Objective To evaluate the predictive validity of IRIS™(Intuitive Surgical®,Sunnyvale,CA,USA)as a planning tool for robot-assisted partial nephrectomy(RAPN)by assessing the degree of overlap with intraoperative execution.Methods Thirty-one patients scheduled for RAPN by four experienced urologists were enrolled in a prospective study.Prior to surgery,urologists reviewed the IRIS™three-dimensional model on an iphone Operating System(iOS)app and completed a questionnaire outlining their surgical plan including surgical approach,and ischemia technique as well as confidence in executing this plan.Postoperatively,questionnaires assessing the procedural approach,clinical utility,efficiency,and effectiveness of IRIS™were completed.The degree of overlap between the preoperative and intraoperative questionnaires and between the planned approach and actual execution of the procedure was analyzed.Questionnaires were answered on a 5-point Likert scale and scores of 4 or greater were considered positive.Results Mean age was 65.1 years with a mean tumor size of 27.7 mm(interquartile range 17.5-44.0 mm).Hilar tumors consisted of 32.3%;48.4%of patients had R.E.N.A.L.nephrometry scores of 7-9.On preoperative questionnaires,the surgeons reported that in 67.7%cases they were confident that they can perform the procedure successfully,and on intraoperative questionnaires,the surgeons reported that in 96.8%cases IRIS™helped achieve good spatial sensation of the anatomy.There was a high degree of overlap between preoperative and intraoperative questionnaires for the surgical approach,interpreting anatomical details and clinical utility.When comparing plans for selective or off-clamp,the preoperative plan was executed in 90.0%of cases intraoperatively.Conclusion A high degree of overlap between the preoperative surgical approach and intraoperative RAPN execution was found using IRIS™.This is the first study to evaluate the predictive accuracy of IRIS™during RAPN by comparing preoperative plan and intraoperative execution.
文摘The study of water resources at watershed scale is widely adopted as approach to manage, assess and simulate these important natural resources. The development of remote sensing and GIS techniques has allowed the use of spatially and physically based hydrologic models to simulate as simply and realistically as possible the functioning of watershed systems. Indeed, the major constraint that has hindered the expansion use of these tools was the unavailability or scarcity of data especially in the developing countries. In this context, the objective of this study is to model the hydrology in the Bouregreg basin, located at the north-central of Morocco, using the Soil and Water Assessment Tool (SWAT) in order to understand and determine the different watershed hydrological processes. Thus, it aims to simulate the stream flow, establish the water balance and estimate the monthly volume inflow to SMBA dam situated at the basin outlet. The ArcSWAT interface implemented in the ArcGIS software was used to delineate the basin and its sub-components, combine the data layers and edit the model database. The model parameters were analyzed, ranked and adjusted for hydrologic modeling purposes using daily temporal data series. They were calibrated using an auto-calibration method based on a Shuffled Complex Evolution Algorithm from 1989 to 1997 and validated from 1998 to 2005. Based on statistical indicators, the evaluation indicates that SWAT model had a good performance for both calibration and validation periods in Bouregreg Watershed. In fact, the model showed a good correlation between the observed and simulated monthly average river discharge with R2 and Nash coefficient of about 0.8. The water balance components were correctly estimated and the SMBA dam inflow was successfully reproduced with R2 of 0.9. These results revealed that if properly calibrated, SWAT model can be used efficiently in semi-arid regions to support water management policies.
文摘Three-dimensional(3D)culture systems are becoming increasingly popular due to their ability to mimic tissue-like structures more effectively than the monolayer cultures.In cancer and stem cell research,the natural cell characteristics and architectures are closely mimicked by the 3D cell models.Thus,the 3D cell cultures are promising and suitable systems for various proposes,ranging from disease modeling to drug target identification as well as potential therapeutic substances that may transform our lives.This review provides a comprehensive compendium of recent advancements in culturing cells,in particular cancer and stem cells,using 3D culture techniques.The major approaches highlighted here include cell spheroids,hydrogel embedding,bioreactors,scaffolds,and bioprinting.In addition,the progress of employing 3D cell culture systems as a platform for cancer and stem cell research was addressed,and the prominent studies of 3D cell culture systems were discussed.
基金funded by the Chinese Meteorological Administration (CMA),the Gansu Provincial Meteorological Bureau (GMB),under the direction of the Lanzhou Regional Climate Centre(Natural Science Foundation of China under Grant No.40830957)the Faculty of Forestry and Environmental Management,University of New Brunswick
文摘This paper outlines a methodology to estimate monthly precipitation surfaces at 1-kin resolution for the Upper Shiyang River watershed (USRW) in northwest China. Generation of precipitation maps is based on the application of a four-variable genetic algorithm (GA) trained on 10 years of weather and ancillary data, i.e., surface air temperature, relative humidity, Digital Elevation Model-derived estimates of elevation, and time of year collected at 29 weather stations in west-central Gansu and northern Qinghai province. An observed-to-GA predicted data comparison of 10 years of precipitation collected at the 29 weather stations showed that about 84% of the variability in observed values could be explained by the trained GA, including variability in two independent datasets. Point-comparisons of observed and modeled precipitation along an elevation-rainfall gradient demonstrated near-similar spatiotemporal patterns. A precipitation surface for USRW for July, 2005, was developed with the trained GA and input surfaces of surface air temperature and relative humidity generated from Moderate Resolution Imaging Spectroradiometer sensor (MODIS) products of land surface temperature. Spatial tendencies in predicted maximum and minimum values of surface air temperature, relative humidity, and precipitation within a 2-kin radius circle around selected weather stations were in close agreement with the values measured at the weather stations.
文摘Controlling soil erosion and the transport and deposition of suspended sediment to receiving waters, especially in relation to the modifying influences of, and interplay between, climate and land-use alterations, is essential for effective watershed management. The Atlantic Canada—New England region is expected to experience elevated rainfall erosivity due to climate change over the next century. Using the projected higher precipitation amounts of 5% and 10% for future scenarios of 5 and 25 years for the region, and a spatially-explicit, integrated (GIS, RUSLE) model for a rural watershed in Nova Scotia, predicted increases in total erosion rates of 4.9 and 9.9%, respectively. Modelled scenarios altering buffer strips based on either consistent or slope-variable widths between 30 m (the legal requirement) to 90 m were found to correspond to reductions in predicted total watershed erosion rates from 11% to 32%. Assuming and extending the 1:1 concordance between projected precipitation and estimated soil erosion for this particular watershed into the more distant future of 26 to 55 years, suggests that the 25% increase in soil erosion predicted over this period would have to be offset by expanding the protective buffer strips to a consistent width of 70 m. Adoption of such a protective management scheme would subsume 19% of the terrestrial area of the study watershed and thus consequent reductions in land available for agricultural production and timber harvest.
基金supported by the National 973 Fundamental Research Program of China (No.2005CB724102,2006CB705404)
文摘The traditional fuzzy logic system (FLS) can only model and control the process in two-dimensional nature. Many of real-world systems are of multidimensional features, such as, thermal and fluid processes with spatiotemporal dynamics, biological systems, or decision-making processes that contain stochastic and imprecise uncertainties. These types of systems are difficult for the traditional FLS to model and control because they require a third dimension for spatial or probabilistic information. The type-2 fuzzy set provides the possibility to develop a three-dimensional fuzzy logic system for modeling and controlling these processes in three-dimensional nature.
文摘Mathematical models of the quantity and quality of water in hydrographic basins enable simulation of a wide variety of processes, including the production of water and sediments, and the dynamics of point and nonpoint sources of pollution. These models have become increasingly complex, requiring large amounts of input data, which can increase the uncertainty of the results of simulations. For this reason, it is essential to perform calibration and validation procedures. The objective of this work was to conduct sensitivity analysis and calibration of a distributed hydrological model (SWAT) applied to the flows of water in the watershed of the Poxim River. Satisfactory performance of the model was indicated by the values obtained for the Nash-Sutcliffe efficiency coefficient (0.77), the percent bias (5.05), the root mean square error (0.48), and the ratio of the RMSE to the standard deviation of the observations (RSR) (0.49). The set of parameters identified here could be used for the simulation and evaluation of other scenarios.
文摘The mitigation potential of reforestation for offsetting the deleterious effects of increased flooding and soil erosion projected to occur in Atlantic Canada through future climate change was investigated. Modelling determined a strong but non-linear relationship between extent of vegetative cover and runoff volume and discharge rate for a Nova Scotian watershed, suggesting that reforestation will reduce, but not completely prevent, flooding. Predicted erosion rates were found to be progressively reduced in relation to the extent of upland reforestation. Of three scenarios examined in which 60%, 65%, and 85% of the entire watershed are randomly reforested, only the latter would reduce the elevated erosion expected to occur through climate change back to present-day existing levels. Additional modelling revealed that comparable mitigation of soil erosion can ensue through implementation of 70 m streamside buffer strips, which would only take up 19% of the total surface area. Prioritizing riparian zones for reforestation will therefore subsume less of the overall productive land area and therefore enact a less severe socio-economic impact on agriculture and forestry.
基金Supported by the Strategic Priority Research Program of the Chinese Academy of Sciences under Grant No XDA09020402the National Integrate Circuit Research Program of China under Grant No 2009ZX02023-003+1 种基金the National Natural Science Foundation of China under Grant Nos 61261160500,61376006,61401444 and 61504157the Science and Technology Council of Shanghai under Grant Nos 14DZ2294900,15DZ2270900 and 14ZR1447500
文摘An optimized device structure for reducing the RESET current of phase-change random access memory (PCRAM) with blade-type like (BTL) phase change layer is proposed. The electrical thermal analysis of the BTL cell and the blade heater contactor structure by three-dimensional finite element modeling are compared with each other during RESET operation. The simulation results show that the programming region of the phase change layer in the BTL cell is much smaller, and thermal electrical distributions of the BTL cell are more concentrated on the TiN/GST interface. The results indicate that the BTL cell has the superiorities of increasing the heating efficiency, decreasing the power consumption and reducing the RESET current from 0.67mA to 0.32mA. Therefore, the BTL cell will be appropriate for high performance PCRAM device with lower power consumption and lower RESET current.
基金supported by the State Key Program of National Natural Science of China(Grant No.41130637)
文摘In the past decades,physical modeling has been widely used in hydrogeology for teaching,studying and exhibition purposes.Most of these models are used to illustrate hydrogeological profiles,but few can depict three-dimensional groundwater flows,making it impossible to validate groundwater flows simulated by numerical methods with physical modeling.
文摘Land use changes such as deforestation,increase in cropping or grazing areas and built-up land, likely modify the water balance and land surface behavior in the Himalayan watersheds.An integrated approach of hydrological and hydraulic modeling was adopted for comparative analysis of hydrological pattern in three Himalayan watersheds i.e.Khanpur,Rawal and Simly situated in the Northern territory of Pakistan.The rainfall-runoff model SWAT- Soil and water assessment tool and Hydro CAD were calibrated for the selected watersheds.The correlation analysis of the precipitation data of two climate stations i.e.Murree and Islamabad, with the discharge data of three rivers was utilized to select best suitable input precipitation data for Hydro CAD rainfall-runoff modeling.The peak flood hydrograph were generated using Hydro CAD runoff to optimize the basin parameters like CN, runoff volume, peak flows of the three watersheds.The hydrological response of the Rawal watershed was studied as a case study to different scenarios of land use change using SWAT model.The scenario of high deforestation indicated a decline of about 6.3% in the groundwater recharge tostream while increase of 7.1% in the surface runoff has been observed under the scenario of growth in urbanization in the recent decades.The integrated modeling approach proved helpful in investigating the hydrological behavior under changing environment at watershed level in the Himalayan region.
基金supported by Special Project of Scientific Research of Education Department of Shaanxi Provincial Government under Grant No.11JK0967
文摘Three-dimensional modeling of virtual hoisting machinery is the critical works to structure the system of virtual construction, and the foundation to realize intelligent and interactive virtual hoisting. Aimed at enhancing the requests of image quality and stability of the virtual construction scene, taking a tower crane for example. We studied the technology of three-dimensional modeling and optimization of a virtual tower crane, and a method named two-stage model optimization was put forward. This depended on the modeling stage using Solidworks and 3DS Max and the performance optimization stage in EON. The practice of software development indicates that the proposed methods of three-dimensional modeling and optimization could satisfy the performance request of virtual construction system and be popularized to other virtual system.
基金support for this research is provided by the International Partnership Project of the Chinese Academy of Sciences, "The Basic Research for Water Issues of Inland River Basin in Arid Region" (CXTD-Z2005-2)Scherer Endowment Fund of Western Michigan University Department of Geography
文摘Water shortage is a chronic problem in arid Northwest China.The rapid population growth and expanding urbanization as well as potential climate change impacts are likely to worsen the situation,threatening domestic,irrigation,and industrial supplies and even the survival of the ecosystems in Northwest China.This paper describes the preliminary work of adapting the Distributed Large Basin Runoff Model(DLBRM) to the Heihe watershed(the second largest inland river in arid Northwestern China,with a drainage area of 128,000 km2) for understanding distribution of glacial-snow melt,groundwater,surface runoff,and evapotranspi-ration,and for assessing hydrological impacts of climate change and glacial recession on water supply in the middle and lower reaches of the watershed.Preliminary simulation results show that the Qilian Mountain in the upper reach area produces most runoff in the Heihe watershed.The simulated daily river flows during the period of 1990-2000 indicate that the Heihe River dis-charges about 1×109 m3 of water from the middle reach(at Zhengyixia Station) to lower reach,with surface runoff and interflow contributing 51 and 49 percent respectively.The sandy lower soil zone in the middle reach has the highest evapotranspiration rate and also contributes nearly half of the river flow.Work underway focuses on the DLBRM model improvement and incorporation of the climate change and management scenarios to the hydrological simulations in the watershed.
基金supported by the National Basic Research Program of China(Grant No.2013CB837200)the National Natural Science Foundation of China(Grant No.11474345)the Beijing Natural Science Foundation,China(Grant No.7154221)
文摘Metastasis is the leading cause of most cancer deaths, as opposed to dysregulated cell growth of the primary tumor. Molecular mechanisms of metastasis have been studied for decades and the findings have evolved our understanding of the progression of malignancy. However, most of the molecular mechanisms fail to address the causes of cancer and its evolutionary origin, demonstrating an inability to find a solution for complete cure of cancer. After being a neglected area of tumor biology for quite some time, recently several studies have focused on the impact of the tumor microenvironment on cancer growth. The importance of the tumor microenvironment is gradually gaining attention, particularly from the per- spective of biophysics. In vitro three-dimensional (3-D) metastatic models are an indispensable platform for investigating the tumor microenvironment, as they mimic the in vivo tumor tissue. In 3-D metastatic in vitro models, static factors such as the mechanical properties, biochemical factors, as well as dynamic factors such as cell-cell, cell-ECM interactions, and fluid shear stress can be studied quantitatively. With increasing focus on basic cancer research and drug development, the in vitro 3-D models offer unique advantages in fundamental and clinical biomedical studies.
文摘Central nervous system(CNS)tumors are a variety of distinct neoplasms that present multiple challenges in terms of treatment and prognosis.Glioblastoma,the most common primary tumor in adults,is associated with poor survival and remains one of the least treatable neoplasms.These tumors are highly heterogenous and complex in their nature.Due to this complexity,traditional cell culturing techniques and methods do not provide an ideal recapitulating model for the study of these tumors’behavior in vivo.Two-dimensional models lack the spatial arrangement,the heterogeneity in cell types,and the microenvironment that play a large role in tumor cell behavior and response to treatment.Recently,scientists have turned towards three-dimensional culturing methods,namely spheroids and organoids,as they have been shown to recapitulate tumors in a more faithful manner to their in vivo counterparts.Moreover,tumor-on-a-chip systems have lately been employed in CNS tumor modeling and have shown great potential in both studying the pathophysiology and therapeutic testing.In this review,we will discuss the current available literature on in vitro threedimensional culturing models in CNS tumors,in addition to presenting their advantages and current limitations.We will also elaborate on the future implications of these models and their benefit in the clinical setting.
文摘Yingqiong basin is a proven hydrocarbon-rich basin in South China Sea. There are a number of large exploration prospects in high temperature and over-pressured formations, especially in Yacheng Block of Qiongdongnan basin and Dongfang District of Yinggehai Basin. Owing to good exploration situation, we have already achieved proven geological reserves over 1000 × 108 m3. In recent years, a few drilled HPHT wells have confirmed that pressure predicted by conventional method was wildly inaccurate. From the view of regional stress, the accuracy of the pressure prediction will be substantially improved. Accurate pressure prediction and three-dimensional pressure modeling which are based on three-dimensional lithology modeling are the cornerstone to achieve exploration breakthrough. In this paper, the use of the triple constraint trend lithology model broke through the traditional method of seismic lithology prediction only by means of impedance threshold value. Compared with actual data and prediction, it confirms that three-dimensional pressure modeling method is reasonable and effective, and has a wide prospect of application.