An experimental research of Weining granule in treating gastric precancerous lesions

Objective： To investigate potential therapeutic effects and mechanism of Weining granule in the treatment of gastric precancerous lesions. Methods： Sixty rats were randomly assigned to a blank group or a model group or to receive retinoic acid or high-, medium- or low- dose of Weining granule. General conditions of the animals were observed before and after treatment. Changes in gastric mucosal pathohistology, telomerase activity, proliferation index （PI） and apoptosis index （AI） were measured. Results： General conditions, including activity and eating, were improved in all Weining-granule-treated groups with the numbers of rats having intestinal metaplasia （IM）, atypical hyperplasia （ATP） or positive telomerase activity being significantly lower than those in the model group （P 〈 0.05 or P 〈 0.01）. Compared with the model group, all doses of Weining granule significantly decreased PI （P 〈 0.01） and increased AI （P 〈 0.05）. Conclusion： Weining granule may provide a therapeutic benefit for the treatment of gastric precancerous lesions by inhibiting telomerase activity and proliferation of gastric cancer cells and by accelerating their apoptosis.

Geochronology,Geochemistry,and Sr-Nd-Hf Isotopes of the Diorite Porphyrites from the Weining Beishan Area,Ningxia Hui Autonomous Region:Constraints on Their Source and Tectonic Implications

The Weining Beishan area of Ningxia Hui Autonomous Region is located at on the western edge of the Helanshan tectonic belt,which is a tectonic joint among Alxa Block,Ordos Block,and North Qilian orogenic belt.However,the tectonic evolution of this area remains unclear due to the lack of magmatic information.This paper conducted researches on geochronology,geochemistry,and Sr-Nd-Hf isotopes of the diorite porphyrites exposed in the Weining Beishan area.The zircon U-Pb dating yields two ages of 145.0±1.1 and 146.2±1.5 Ma,and the whole-rock geochemical data indicate that the diorite porphyrites are metaluminous to weakly peraluminous and high-K calc-alkaline series.The characteristics of highly initial^(87)Sr/^(86)Sr ratios(0.70816 to 0.71047),negativeε_(Nd)(t)(−8.9 to−8.4),and negativeε_(Hf)(t)(−13.8 to−21.2)indicate that the diorite porphyrites originated from partial melting of the middle-lower ancient crust related to the North China Craton.Combined with the regional geology,we suggested that partial melting was triggered by a tectonic activity of deep faults cutting through the crust under the regional stress transformation from compressing to extension during the Late Jurassic–Early Cretaceous,which is probably related to the westward subduction of the Paleo-Pacific Plate.

A clinical study of Weining Granules in the treatment of gastric precancerous lesions

OBJECTIVE:To investigate the clinical effects of Weining Granules on gastric precancerous lesions(GPLs).METHODS:120 patients with GPLs were randomly assigned in a 1:1 ratio to receive Weining Granules(trial group) or the comparator Weifuchun tablets(control group) for 6 months.Outcomes were compared between the two groups including:overall response;gastroscopically-determined response;pathologically-confirmed response;eradication of Helicobacter pylori(HP);microvessel density(MVD) in the gastric mucosa;expression of vascular endothelial growth factor(VEGF);interleukin 2(IL-2);interleukin 6(IL-6);T lymphocyte subsets;immunoglobulins;symptom scores;quality of life(QOL);and adverse reactions.RESULTS:Patients in the trial group had a significantly higher(P<0.05) overall response rate(81.7%) as compared with those in the control group(63.3%).Relative to treatment with Weifuchun tablets treatment with Weining Granules resulted in a significant improvement(P<0.05) in the scores for gastric pain,distension and stuffiness in the hypochondrium,and anorexia.As compared with the tablets the Granules were associated with a significantly higher overall gastroscopically-determined response rate(78.3%;P<0.05).Pathological examination of tissue samples indicated that 61.7% of patients receiving the granules were cured with an overall response rate of 75.5%;these rates were significantly higher than in the control group(P<0.05).In comparison with patients receiving the tablets,those given the granules were significantly more likely to have their HP eradicated(75.0% vs.51.4%;P<0.05).Improvements in MVD,VEGF,CD4+,CD4+/CD8+,IL-2,IL-6 and IgG were significantly greater with the Weining Granules than with the Weifuchun tablets(P<0.05 or P<0.01).After follow-up of 1 year,17.5% of patients in the trial group relapsed as compared with 39.5% in the control group(P<0.05).Relative to the control group,the trial group showed significantly greater improvements in physical,psychological and social relationships,and in environmental domains(P<0.05 or P<0.01).No significant adverse reactions were observed during treatment.CONCLUSION:The Weining Granules appear to be effective in improving the gastric precancerous state and the main symptoms,in inhibiting angiogenesis,enhancing immune function and QOL,and in reducing 1-year relapses.In addition,this preparation seems to be associated with a low risk of adverse events,making it a safe and efficacious option for the treatment of GPLs.

Protective effect and mechanisms of Weining granule on N-methyl-N’-nitro-N-nitrosoguanidine-induced gastric cancer in rats

OBJECTIVE:To investigate the protective effect and molecular mechanisms of Weining granule on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastric cancer in rats.METHODS:A total of sixty healthy male wistar rats were randomly divided into five groups,including control group (CG),gastric cancer model group (MG),low-dose Weining granule treated group (LWT),medium-dose Weining granule treated group (MWT),and high-dose Weining granule treated group (HWT).Except the control group,the other groups were treated with MNNG to establish a rat model of gastric cancer.Low-dose Weining granule treated group,medium-dose Weining granule treated group,and high-dose Weining granule treated group were fed 9.0,18.0 and 36.0 g/kg Weining granule,respectively.Histopathologic and molecular biologic technology were adopted to determine the protective effect of Weining granule on MNNG-induced gastric cancer in rats.The pathological changes of gastrointestinal tissue were observed.Meanwhile,the differential expression of proliferation,apoptosis and angiogenesis markers were determined,including proliferating cell nuclear antigen (PCNA),pokemon,cyclin D1,B-cell lymphoma-2 (Bcl-2),caspase-3,phosphatase and tensin homolog (PTEN) and vascular endothelial growth factor (VEGF).RESULTS.:After the MNNG treated,the pathological changes of stomach tissue were improved noticeably,including the intestinal metaplasia and atypic hyperplasia.The experiment was completed in.58 rats (96.67%).As compared with gastric cancer model group,the general states of rats were improved significantly after treated with different dose Weining granule.Moreover,treatment with different doses of Weining granule could inhibit the protein and mRNA expression of PCNA,pokemon,cyclin D1,Bcl-2,and VEGF,while increase caspase-3 and PTEN (P < 0.01).CONCLUSION:Weining granule could improve gastric cancer by suppressing cell proliferation,promoting tumor cell apoptosis,and inhibiting angiogenesis.

两种根管弯曲度测量方法的比较研究

目的对Schneider法和Weine法测量根管弯曲度的可靠性进行研究。方法由三位检查者分别用Schneider法和Weine法测量51个弯曲前磨牙根管的弯曲度。结果三位检查者用同种方法测得的数据间均无显著差异(P>0.05),两种方法之间存在线性相关关系(P=0.0001)。结论以Schneider法和Weine法测量根管弯曲程度是可靠的。

两种根管弯曲度测量法间数学关系的推导

目的:研究2种根管弯曲度测量法测值(Schneider法的测值为θS,Weine法的测值为θW)间的数学关系。方法:将弯曲根管长轴简化为依次由相切的线段(长度为l1)、圆弧(半径为r、圆心角为θ)、线段(长度为l2)组成的连线,根据2测量法确定简化弯曲根管长轴测量角时不同的定点、连线方式,推导θS、θW间的函数方程以及与l1、l2、r、θ间的数学关系,分析方程与函数图形的特征。结果:θS与θW间存在以下数学关系:(1)tanθS=(1-cosθW+ksinθW)/(sinθW+kcosθW),k=l2/r;(2)θW/2≤θS≤θW。k取不同值时函数曲线的形态具有不同的特点。θW在0,π的区间内,θS与θW间呈近似的线性关系;k越大,θS越接近θW,k越小,θS越接近θW/2。结论:Schneider法与Weine法测值间存在着复杂的函数关系,根管根尖部直段的长度(l2)与弯曲段曲率半径(r)之比值是影响2种方法测值间差异的重要因素。

一种推导黑体温度变换的简易新方法

近一个世纪以来,对黑体相对论温度变换的讨论一直在进行着。其中最具代表性的变换是在上世纪六十年代,由R.N.Bracewell等人以从实验发现的3K宇宙背景辐射为基础、从与实验符合很好的Plank黑体辐射公式出发。

上颌前磨牙根管弯曲度的测量

目的测量上颌前磨牙根管的弯曲度。方法从临床采集需要进行根管治疗的病例,从中随机挑选上颌第一、二前磨牙各50牙。根管治疗过程中RVG数字成像系统采用平行光投照技术拍摄正位插针根尖片(插入#10 K锉)。图像分析软件ImagePro Plus 6.0测量根管弯曲度(分别用Schneider法和Weine法)。结果 Schneider法测得上颌第一、二前磨牙根管在近远中向弯曲度均值为14.02±7.46°及16.56±8.65°;Weine法为20.90±11.51°及24.83±12.85°,两牙位间差异均无统计学意义(P>0.05);2方法测值间存在高度的相关性(相关系数r=0.95;P=0.000),并基本符合这样的规律:Schneider法测值小于Weine法测值,但大于后者的1/2。结论掌握上颌前磨牙根管弯曲的特点对于根管预备取得成功具有重要的价值。

A New Method of Measurement of the True Temperature and Emissivity of Non-Black Body Using One Component of Wien’s Spectrum of Thermal Radiation

It is shown that the measurement of only one component of the Wein’s spectrum of thermal radiation in range λT ≤ 3000 (&deg;C μm) is sufficient to estimate the true temperature and spectral emissivity of the selected component with sufficient accuracy, although more than one hundred years this statement was considered as incorrect. The proposed method is based on the formation of the linear dependence of the logarithm of the emissivity of not real wavelengths and artificially generated “virtual” spectral components.

初论魏宁格对维特根斯坦《逻辑哲学论》的思想影响

研究者解读《逻辑哲学论》时偏执于重构论证,使得《逻辑哲学论》的解读遇到困境,并与维特根斯坦的初衷相偏离。维特根斯坦认为,其只是复制了名单人物的思想,而魏宁格就是名单人物之一。通过质疑冯·赖特对“1931年维氏列出的名单”的传统解读,以《性与性格》与《逻辑哲学论》的关系为切入点,对二者哲学思想进行比较研究,可以说明,魏宁格的思想对维特根斯坦的《逻辑哲学论》产生了巨大的影响,这些影响包括对哲学看法的影响,对“要理解某一事物,就要站在某一事物之外”这个前提的影响,对“伦理、逻辑、世界”三者关系的看法所产生的影响,对意志主义与唯我论的影响。这些影响不仅对理解《逻辑哲学论》显得十分重要,而且透过它们,还可以了解魏宁格被人淡忘的哲学思想,重拾魏宁格的思想价值。