Background:The isometric steady-state following active lengthening is associated with greater torque production and lower activation,as measured by electromyographic activity(EMG),in comparison with a purely isometric...Background:The isometric steady-state following active lengthening is associated with greater torque production and lower activation,as measured by electromyographic activity(EMG),in comparison with a purely isometric contraction(ISO)at the same joint angle.This phenomenon is termed residual force enhancement(RFE).While there has been a great deal of research investigating the basic mechanisms of RFE,little work has been performed to understand the everyday relevance of RFE.The purpose of this study was to investigate whether neuromuscular control strategies differ between ISO and RFE by measuring torque steadiness of the human ankle plantar flexors.Methods:Following ISO maximal voluntary contractions in 12 males(25±4 years),an active lengthening contraction was performed at 15°/s over a 30°ankle excursion,ending at the same joint angle as ISO(5°dorsiflexion;RFE).Surface EMG of the tibialis anterior and soleus muscles was recorded during all tasks.Torque steadiness was determined as the standard deviation(SD)and coefficient of variation(CV)of the torque trace in the ISO and RFE condition during activation-matching(20%and 60%integrated EMG)and torque-matching(20%and 60%maximal voluntary contraction)experiments.Two-tailed,paired t tests were used,within subjects,to determine the presence of RFE/activation reduction(AR)and whether there was a difference in torque steadiness between ISO and RFE conditions.Results:During the maximal and submaximal conditions,there was 5%-9%RFE with a 9%-11%AR(p<0.05),respectively,with no difference in antagonist coactivation between RFE and ISO(p>0.05).There were no differences in SD and CV of the torque trace for the 20%and60%activation-matching or the 60%and maximal torque-matching trials in either the RFE or ISO condition(p>0.05).During the 20%torquematching trial,there were~37%higher values for SD and CV in the RFE as compared with the ISO condition(p<0.05).A significant moderate-to-strong negative relationship was identified between the reduction in torque steadiness following active lengthening and the accompanying AR(p<0.05).Conclusion:It appears that while the RFE-associated AR provides some improved neuromuscular economy,this comes at the cost of increased torque fluctuations in the isometric steady-state following active lengthening during submaximal contractions.展开更多
To establish the relationship among reservoir characteristics and rock physical parameters,we construct the well-bore rock physical models firstly,considering the influence factors,such as mineral composition,shale co...To establish the relationship among reservoir characteristics and rock physical parameters,we construct the well-bore rock physical models firstly,considering the influence factors,such as mineral composition,shale content,porosity,fluid type and saturation.Then with analyzing the change rules of elastic parameters along with the above influence factors and the cross-plots among elastic parameters,the sensitive elastic parameters of tight sandstone reservoir are determined,and the rock physics template of sweet spot is constructed to guide pre-stack seismic inversion.The results show that velocity ratio and Poisson impedance are the most sensitive elastic parameters to indicate the lithologic and gas-bearing properties of sweet spot in tight sandstone reservoir.The high-quality sweet spot is characterized by the lower velocity ratio and Poisson impedance.Finally,the actual seismic data are selected to predict the sweet spots in tight sandstone gas reservoirs,so as to verify the validity of the rock physical simulation results.The significant consistency between the relative logging curves and inversion results in different wells implies that the utilization of well-bore rock physical simulation can guide the prediction of sweet spot in tight sandstone gas reservoirs.展开更多
In this paper,for a bounded C2 domain,we prove the existence and uniqueness of positive classical solutions to the Dirichlet problem for the steady relativistic heat equation with a class of restricted positive C2 bou...In this paper,for a bounded C2 domain,we prove the existence and uniqueness of positive classical solutions to the Dirichlet problem for the steady relativistic heat equation with a class of restricted positive C2 boundary data.We have a non-existence result,which is the justification for taking into account the restricted boundary data.There is a smooth positive boundary datum that precludes the existence of the positive classical solution.展开更多
An efficient data-driven approach for predicting steady airfoil flows is proposed based on the Fourier neural operator(FNO),which is a new framework of neural networks.Theoretical reasons and experimental results are ...An efficient data-driven approach for predicting steady airfoil flows is proposed based on the Fourier neural operator(FNO),which is a new framework of neural networks.Theoretical reasons and experimental results are provided to support the necessity and effectiveness of the improvements made to the FNO,which involve using an additional branch neural operator to approximate the contribution of boundary conditions to steady solutions.The proposed approach runs several orders of magnitude faster than the traditional numerical methods.The predictions for flows around airfoils and ellipses demonstrate the superior accuracy and impressive speed of this novel approach.Furthermore,the property of zero-shot super-resolution enables the proposed approach to overcome the limitations of predicting airfoil flows with Cartesian grids,thereby improving the accuracy in the near-wall region.There is no doubt that the unprecedented speed and accuracy in forecasting steady airfoil flows have massive benefits for airfoil design and optimization.展开更多
Fixed-point fast sweeping WENO methods are a class of efficient high-order numerical methods to solve steady-state solutions of hyperbolic partial differential equations(PDEs).The Gauss-Seidel iterations and alternati...Fixed-point fast sweeping WENO methods are a class of efficient high-order numerical methods to solve steady-state solutions of hyperbolic partial differential equations(PDEs).The Gauss-Seidel iterations and alternating sweeping strategy are used to cover characteristics of hyperbolic PDEs in each sweeping order to achieve fast convergence rate to steady-state solutions.A nice property of fixed-point fast sweeping WENO methods which distinguishes them from other fast sweeping methods is that they are explicit and do not require inverse operation of nonlinear local systems.Hence,they are easy to be applied to a general hyperbolic system.To deal with the difficulties associated with numerical boundary treatment when high-order finite difference methods on a Cartesian mesh are used to solve hyperbolic PDEs on complex domains,inverse Lax-Wendroff(ILW)procedures were developed as a very effective approach in the literature.In this paper,we combine a fifthorder fixed-point fast sweeping WENO method with an ILW procedure to solve steadystate solution of hyperbolic conservation laws on complex computing regions.Numerical experiments are performed to test the method in solving various problems including the cases with the physical boundary not aligned with the grids.Numerical results show highorder accuracy and good performance of the method.Furthermore,the method is compared with the popular third-order total variation diminishing Runge-Kutta(TVD-RK3)time-marching method for steady-state computations.Numerical examples show that for most of examples,the fixed-point fast sweeping method saves more than half CPU time costs than TVD-RK3 to converge to steady-state solutions.展开更多
In Li and Ren(Int.J.Numer.Methods Fluids 70:742–763,2012),a high-order k-exact WENO finite volume scheme based on secondary reconstructions was proposed to solve the two-dimensional time-dependent Euler equations in ...In Li and Ren(Int.J.Numer.Methods Fluids 70:742–763,2012),a high-order k-exact WENO finite volume scheme based on secondary reconstructions was proposed to solve the two-dimensional time-dependent Euler equations in a polygonal domain,in which the high-order numerical accuracy and the oscillations-free property can be achieved.In this paper,the method is extended to solve steady state problems imposed in a curved physical domain.The numerical framework consists of a Newton type finite volume method to linearize the nonlinear governing equations,and a geometrical multigrid method to solve the derived linear system.To achieve high-order non-oscillatory numerical solutions,the classical k-exact reconstruction with k=3 and the efficient secondary reconstructions are used to perform the WENO reconstruction for the conservative variables.The non-uniform rational B-splines(NURBS)curve is used to provide an exact or a high-order representation of the curved wall boundary.Furthermore,an enlarged reconstruction patch is constructed for every element of mesh to significantly improve the convergence to steady state.A variety of numerical examples are presented to show the effectiveness and robustness of the proposed method.展开更多
Neuropathy is nerve damage that can cause chronic neuropathic pain, which is challenging to cure and has a significant financial burden. Exercise therapies, including High-Intensity Interval Training (HIIT) and steady...Neuropathy is nerve damage that can cause chronic neuropathic pain, which is challenging to cure and has a significant financial burden. Exercise therapies, including High-Intensity Interval Training (HIIT) and steady-state cardio, are being explored as potential treatments for neuropathic pain. This systematic review compares the effectiveness of HIIT and steady-state cardio for improving function in neurological patients. This article provides an overview of the systematic review conducted on the effects of exercise on neuropathic patients, with a focus on high-intensity interval training (HIIT) and steady-state cardio. The authors conducted a comprehensive search of various databases, identified relevant studies based on predetermined inclusion criteria, and used the EPPI automation application to process the data. The final selection of studies was based on validity and relevance, with redundant articles removed. The article reviews four studies that compare high-intensity interval training (HIIT) to moderate-intensity continuous training (MICT) on various health outcomes. The studies found that HIIT can improve aerobic fitness, cerebral blood flow, and brain function in stroke patients;lower diastolic blood pressure more than MICT and improve insulin sensitivity and skeletal muscle mitochondrial content in obese individuals, potentially helping with the prevention and management of type 2 diabetes. In people with multiple sclerosis, acute exercise can decrease the plasma neurofilament light chain while increasing the flow of the kynurenine pathway. The available clinical and preclinical data suggest that further study on high-intensity interval training (HIIT) and its potential to alleviate neuropathic pain is justified. Randomized controlled trials are needed to investigate the type, intensity, frequency, and duration of exercise, which could lead to consensus and specific HIIT-based advice for patients with neuropathies.展开更多
目的探讨多种听力学检测方法在听性脑干反应(ABR)最大输出未引出患儿的听力学诊断中的应用价值。方法回顾性分析69例(138耳)ABR最大强度未引出患儿的临床资料,年龄42天到5岁,平均1岁6个月,鼓室导抗图均为A型或正向单峰,声反射均未引出,...目的探讨多种听力学检测方法在听性脑干反应(ABR)最大输出未引出患儿的听力学诊断中的应用价值。方法回顾性分析69例(138耳)ABR最大强度未引出患儿的临床资料,年龄42天到5岁,平均1岁6个月,鼓室导抗图均为A型或正向单峰,声反射均未引出,影像学检查内耳无畸形。69例患儿均进行ABR、耳蜗微音电位(CM)、畸变产物耳声发射(DPOAE)和听性稳态反应(ASSR)测试。结果69例138耳中,8例16耳(11.59%)记录到CM,其中10耳(7.25%)记录到DPOAE,0.5、1、2、4 kHz ASSR反应阈值分别为83.2±13.1、82.9±13.0、75.3±12.4、63.1±9.1 dB nHL,结合其他检查结果诊断为听神经病。余61例(122耳)CM和DPOAE均未引出,0.5、1、2、4 kHz的ASSR引出率分别为82.3%、81.9%、76.9%、60.2%,其中20耳ASSR各频率均未引出,102耳至少一个频率引出,0.5、1、2、4 kHz ASSR反应阈分别为93.2±6.1、99.8±7.0、105.4±5.4、108.2±9.8 dB nHL,诊断为极重度感音神经性聋。结论对于ABR最大输出强度未引出的患儿,CM和/或DPOAE引出且ASSR各频率反应阈低于感音神经性聋患儿,有助于听神经病的诊断;CM和DPOAE均未引出有助于极重度感音神经性聋的诊断,ASSR测试有助于评估其残余听力。展开更多
基金supported by the Natural Sciences and Engineering Research Council of Canada
文摘Background:The isometric steady-state following active lengthening is associated with greater torque production and lower activation,as measured by electromyographic activity(EMG),in comparison with a purely isometric contraction(ISO)at the same joint angle.This phenomenon is termed residual force enhancement(RFE).While there has been a great deal of research investigating the basic mechanisms of RFE,little work has been performed to understand the everyday relevance of RFE.The purpose of this study was to investigate whether neuromuscular control strategies differ between ISO and RFE by measuring torque steadiness of the human ankle plantar flexors.Methods:Following ISO maximal voluntary contractions in 12 males(25±4 years),an active lengthening contraction was performed at 15°/s over a 30°ankle excursion,ending at the same joint angle as ISO(5°dorsiflexion;RFE).Surface EMG of the tibialis anterior and soleus muscles was recorded during all tasks.Torque steadiness was determined as the standard deviation(SD)and coefficient of variation(CV)of the torque trace in the ISO and RFE condition during activation-matching(20%and 60%integrated EMG)and torque-matching(20%and 60%maximal voluntary contraction)experiments.Two-tailed,paired t tests were used,within subjects,to determine the presence of RFE/activation reduction(AR)and whether there was a difference in torque steadiness between ISO and RFE conditions.Results:During the maximal and submaximal conditions,there was 5%-9%RFE with a 9%-11%AR(p<0.05),respectively,with no difference in antagonist coactivation between RFE and ISO(p>0.05).There were no differences in SD and CV of the torque trace for the 20%and60%activation-matching or the 60%and maximal torque-matching trials in either the RFE or ISO condition(p>0.05).During the 20%torquematching trial,there were~37%higher values for SD and CV in the RFE as compared with the ISO condition(p<0.05).A significant moderate-to-strong negative relationship was identified between the reduction in torque steadiness following active lengthening and the accompanying AR(p<0.05).Conclusion:It appears that while the RFE-associated AR provides some improved neuromuscular economy,this comes at the cost of increased torque fluctuations in the isometric steady-state following active lengthening during submaximal contractions.
基金supported by the National Key R&D Program of China(Grant No.2018YFC1405900)the Major Projects of National Science and Technology(Grant Nos.2016ZX05011-002,2016ZX05027-002-005)+3 种基金the National Natural Science Foundation of China(Grant No.41806073)the Natural Science Foundation of Shandong Province(Grant No.ZR2017BD014)Shandong Provincial Key Laboratory of Depositional Mineralization and Sedimentary Minerals,Shandong University of Science and Technology(Grant No.DMSM2017042)the Fundamental Research Funds for the Central Universities(Grant No.201964016)
文摘To establish the relationship among reservoir characteristics and rock physical parameters,we construct the well-bore rock physical models firstly,considering the influence factors,such as mineral composition,shale content,porosity,fluid type and saturation.Then with analyzing the change rules of elastic parameters along with the above influence factors and the cross-plots among elastic parameters,the sensitive elastic parameters of tight sandstone reservoir are determined,and the rock physics template of sweet spot is constructed to guide pre-stack seismic inversion.The results show that velocity ratio and Poisson impedance are the most sensitive elastic parameters to indicate the lithologic and gas-bearing properties of sweet spot in tight sandstone reservoir.The high-quality sweet spot is characterized by the lower velocity ratio and Poisson impedance.Finally,the actual seismic data are selected to predict the sweet spots in tight sandstone gas reservoirs,so as to verify the validity of the rock physical simulation results.The significant consistency between the relative logging curves and inversion results in different wells implies that the utilization of well-bore rock physical simulation can guide the prediction of sweet spot in tight sandstone gas reservoirs.
基金supported by the National NaturalScience Foundation of China(11971069 and 12126307)。
文摘In this paper,for a bounded C2 domain,we prove the existence and uniqueness of positive classical solutions to the Dirichlet problem for the steady relativistic heat equation with a class of restricted positive C2 boundary data.We have a non-existence result,which is the justification for taking into account the restricted boundary data.There is a smooth positive boundary datum that precludes the existence of the positive classical solution.
文摘An efficient data-driven approach for predicting steady airfoil flows is proposed based on the Fourier neural operator(FNO),which is a new framework of neural networks.Theoretical reasons and experimental results are provided to support the necessity and effectiveness of the improvements made to the FNO,which involve using an additional branch neural operator to approximate the contribution of boundary conditions to steady solutions.The proposed approach runs several orders of magnitude faster than the traditional numerical methods.The predictions for flows around airfoils and ellipses demonstrate the superior accuracy and impressive speed of this novel approach.Furthermore,the property of zero-shot super-resolution enables the proposed approach to overcome the limitations of predicting airfoil flows with Cartesian grids,thereby improving the accuracy in the near-wall region.There is no doubt that the unprecedented speed and accuracy in forecasting steady airfoil flows have massive benefits for airfoil design and optimization.
基金Research was supported by the NSFC Grant 11872210Research was supported by the NSFC Grant 11872210 and Grant No.MCMS-I-0120G01+1 种基金Research supported in part by the AFOSR Grant FA9550-20-1-0055NSF Grant DMS-2010107.
文摘Fixed-point fast sweeping WENO methods are a class of efficient high-order numerical methods to solve steady-state solutions of hyperbolic partial differential equations(PDEs).The Gauss-Seidel iterations and alternating sweeping strategy are used to cover characteristics of hyperbolic PDEs in each sweeping order to achieve fast convergence rate to steady-state solutions.A nice property of fixed-point fast sweeping WENO methods which distinguishes them from other fast sweeping methods is that they are explicit and do not require inverse operation of nonlinear local systems.Hence,they are easy to be applied to a general hyperbolic system.To deal with the difficulties associated with numerical boundary treatment when high-order finite difference methods on a Cartesian mesh are used to solve hyperbolic PDEs on complex domains,inverse Lax-Wendroff(ILW)procedures were developed as a very effective approach in the literature.In this paper,we combine a fifthorder fixed-point fast sweeping WENO method with an ILW procedure to solve steadystate solution of hyperbolic conservation laws on complex computing regions.Numerical experiments are performed to test the method in solving various problems including the cases with the physical boundary not aligned with the grids.Numerical results show highorder accuracy and good performance of the method.Furthermore,the method is compared with the popular third-order total variation diminishing Runge-Kutta(TVD-RK3)time-marching method for steady-state computations.Numerical examples show that for most of examples,the fixed-point fast sweeping method saves more than half CPU time costs than TVD-RK3 to converge to steady-state solutions.
基金the Scientific Research Fund of Beijing Normal University(Grant No.28704-111032105)the Start-up Research Fund from BNU-HKBU United International College(Grant No.R72021112)+2 种基金The research of Guanghui Hu was partially supported by the FDCT of the Macao S.A.R.(0082/2020/A2)the National Natural Science Foundation of China(Grant Nos.11922120,11871489)the Multi-Year Research Grant(2019-00154-FST)of University of Macao,and a Grant from Department of Science and Technology of Guangdong Province(2020B1212030001).
文摘In Li and Ren(Int.J.Numer.Methods Fluids 70:742–763,2012),a high-order k-exact WENO finite volume scheme based on secondary reconstructions was proposed to solve the two-dimensional time-dependent Euler equations in a polygonal domain,in which the high-order numerical accuracy and the oscillations-free property can be achieved.In this paper,the method is extended to solve steady state problems imposed in a curved physical domain.The numerical framework consists of a Newton type finite volume method to linearize the nonlinear governing equations,and a geometrical multigrid method to solve the derived linear system.To achieve high-order non-oscillatory numerical solutions,the classical k-exact reconstruction with k=3 and the efficient secondary reconstructions are used to perform the WENO reconstruction for the conservative variables.The non-uniform rational B-splines(NURBS)curve is used to provide an exact or a high-order representation of the curved wall boundary.Furthermore,an enlarged reconstruction patch is constructed for every element of mesh to significantly improve the convergence to steady state.A variety of numerical examples are presented to show the effectiveness and robustness of the proposed method.
文摘Neuropathy is nerve damage that can cause chronic neuropathic pain, which is challenging to cure and has a significant financial burden. Exercise therapies, including High-Intensity Interval Training (HIIT) and steady-state cardio, are being explored as potential treatments for neuropathic pain. This systematic review compares the effectiveness of HIIT and steady-state cardio for improving function in neurological patients. This article provides an overview of the systematic review conducted on the effects of exercise on neuropathic patients, with a focus on high-intensity interval training (HIIT) and steady-state cardio. The authors conducted a comprehensive search of various databases, identified relevant studies based on predetermined inclusion criteria, and used the EPPI automation application to process the data. The final selection of studies was based on validity and relevance, with redundant articles removed. The article reviews four studies that compare high-intensity interval training (HIIT) to moderate-intensity continuous training (MICT) on various health outcomes. The studies found that HIIT can improve aerobic fitness, cerebral blood flow, and brain function in stroke patients;lower diastolic blood pressure more than MICT and improve insulin sensitivity and skeletal muscle mitochondrial content in obese individuals, potentially helping with the prevention and management of type 2 diabetes. In people with multiple sclerosis, acute exercise can decrease the plasma neurofilament light chain while increasing the flow of the kynurenine pathway. The available clinical and preclinical data suggest that further study on high-intensity interval training (HIIT) and its potential to alleviate neuropathic pain is justified. Randomized controlled trials are needed to investigate the type, intensity, frequency, and duration of exercise, which could lead to consensus and specific HIIT-based advice for patients with neuropathies.
文摘目的探讨多种听力学检测方法在听性脑干反应(ABR)最大输出未引出患儿的听力学诊断中的应用价值。方法回顾性分析69例(138耳)ABR最大强度未引出患儿的临床资料,年龄42天到5岁,平均1岁6个月,鼓室导抗图均为A型或正向单峰,声反射均未引出,影像学检查内耳无畸形。69例患儿均进行ABR、耳蜗微音电位(CM)、畸变产物耳声发射(DPOAE)和听性稳态反应(ASSR)测试。结果69例138耳中,8例16耳(11.59%)记录到CM,其中10耳(7.25%)记录到DPOAE,0.5、1、2、4 kHz ASSR反应阈值分别为83.2±13.1、82.9±13.0、75.3±12.4、63.1±9.1 dB nHL,结合其他检查结果诊断为听神经病。余61例(122耳)CM和DPOAE均未引出,0.5、1、2、4 kHz的ASSR引出率分别为82.3%、81.9%、76.9%、60.2%,其中20耳ASSR各频率均未引出,102耳至少一个频率引出,0.5、1、2、4 kHz ASSR反应阈分别为93.2±6.1、99.8±7.0、105.4±5.4、108.2±9.8 dB nHL,诊断为极重度感音神经性聋。结论对于ABR最大输出强度未引出的患儿,CM和/或DPOAE引出且ASSR各频率反应阈低于感音神经性聋患儿,有助于听神经病的诊断;CM和DPOAE均未引出有助于极重度感音神经性聋的诊断,ASSR测试有助于评估其残余听力。