The purpose of this study is to investigate effects of gastrodin and sodium nitroprusside on circulatory mechanics and hemodynamics.The modified Windkessel model was used to calculate arterial vascular compliance and ...The purpose of this study is to investigate effects of gastrodin and sodium nitroprusside on circulatory mechanics and hemodynamics.The modified Windkessel model was used to calculate arterial vascular compliance and inertance of blood flow in the arterial vessels.Blood pressure,cardiac output,peripheral resistance,inertance of blood flow in the arterial vessels,and proximal and distal compliance etc in 20 dogs were measured and calculated before and after gastrodin and sodium nitroprusside ad-ministration.The results show that gastrodin is efficient in decreasing the blood pres-sure(P<0.001)and peripheral resistance(P<0.01),and increasing the proximal(P<0.05)and distal arterial vascular compliance(P<0.01),and inertance of blood flow in the arterial vessels(P=0.054).Sodium nitroprusside strongly de·eases bloood pres-sure and peripheral resistance(P<0.001),and increases distal arterial compliance(P<0.001)and inertance of blood flow in the arterial vessels(P<0.01).Comparing with sodium nitropursside,gastrodin is moderate in reducing blood pressure,but it reduces systolic blood pressure is relatively stronger than it does diastolic blood pressure.Fur-thermore,gastrodin is stronger than sodium nitroprusside and some of other vasodila-tors in increasing proximal arterial compliance,i.e.,gastrodin has the beneficial ef-fect of improving arterial vascular,particularly aorta and large artery,elasticity.Gas-trodin,as a traditional Chinese medicine,can be used to cure the elderly hypertension.展开更多
文摘The purpose of this study is to investigate effects of gastrodin and sodium nitroprusside on circulatory mechanics and hemodynamics.The modified Windkessel model was used to calculate arterial vascular compliance and inertance of blood flow in the arterial vessels.Blood pressure,cardiac output,peripheral resistance,inertance of blood flow in the arterial vessels,and proximal and distal compliance etc in 20 dogs were measured and calculated before and after gastrodin and sodium nitroprusside ad-ministration.The results show that gastrodin is efficient in decreasing the blood pres-sure(P<0.001)and peripheral resistance(P<0.01),and increasing the proximal(P<0.05)and distal arterial vascular compliance(P<0.01),and inertance of blood flow in the arterial vessels(P=0.054).Sodium nitroprusside strongly de·eases bloood pres-sure and peripheral resistance(P<0.001),and increases distal arterial compliance(P<0.001)and inertance of blood flow in the arterial vessels(P<0.01).Comparing with sodium nitropursside,gastrodin is moderate in reducing blood pressure,but it reduces systolic blood pressure is relatively stronger than it does diastolic blood pressure.Fur-thermore,gastrodin is stronger than sodium nitroprusside and some of other vasodila-tors in increasing proximal arterial compliance,i.e.,gastrodin has the beneficial ef-fect of improving arterial vascular,particularly aorta and large artery,elasticity.Gas-trodin,as a traditional Chinese medicine,can be used to cure the elderly hypertension.
