BACKGROUND Prion diseases are a group of degenerative nerve diseases that are caused by infectious prion proteins or gene mutations.In humans,prion diseases result from mutations in the prion protein gene(PRNP).Only a...BACKGROUND Prion diseases are a group of degenerative nerve diseases that are caused by infectious prion proteins or gene mutations.In humans,prion diseases result from mutations in the prion protein gene(PRNP).Only a limited number of cases involving a specific PRNP mutation at codon 196(E196A)have been reported.The coexistence of Korsakoff syndrome in patients with Creutzfeldt-Jakob disease(CJD)caused by E196A mutation has not been documented in the existing literature.CASE SUMMARY A 61-year-old Chinese man initially presented with Korsakoff syndrome,followed by rapid-onset dementia,visual hallucinations,akinetic mutism,myoclonus,and hyperthermia.The patient had no significant personal or familial medical history.Magnetic resonance imaging of the brain revealed extensive hyperintense signals in the cortex,while positron emission tomography/computed tomography showed a diffuse reduction in cerebral cortex metabolism.Routine biochemical and microorganism testing of the cerebrospinal fluid(CSF)yielded normal results.Tests for thyroid function,human immunodeficiency virus,syphilis,vitamin B1 and B12 levels,and autoimmune rheumatic disorders were normal.Blood and CSF tests for autoimmune encephalitis and autoantibody-associated paraneoplastic syndrome yielded negative results.A test for 14-3-3 protein in the CSF yielded negative results.Whole-genome sequencing revealed a diseasecausing mutation in PRNP.The patient succumbed to the illness 11 months after the initial symptom onset.CONCLUSION Korsakoff syndrome,typically associated with alcohol intoxication,also manifests in CJD patients.Individuals with CJD along with PRNP E196A mutation may present with Korsakoff syndrome.展开更多
p.Tyr329fs is a cytochrome P450c17 mutation among Chinese individuals.However,data on 17-α-hydroxylase deficiency caused by cytochrome P450c17 p.Tyr329fs homozygous mutation are lacking.This paper is a case report of...p.Tyr329fs is a cytochrome P450c17 mutation among Chinese individuals.However,data on 17-α-hydroxylase deficiency caused by cytochrome P450c17 p.Tyr329fs homozygous mutation are lacking.This paper is a case report of three patients homozygous for p.Tyr329fs who were diagnosed with 17-α-hydroxylase deficiency between 2005 and 2019.CASE SUMMARY Case 1 presented with hypertension,hypokalemia,sexual infantilism and delayed bone age.The patient had a 46,XY karyotype,was homozygous for p.Tyr329fs and was recently treated with dexamethasone 0.375 mg qn.Case 2 presented with hypokalemia,sexual infantilism,osteoporosis and delayed bone age.The patient had a 46,XY karyotype,was homozygous for p.Tyr329fs and was treated with dexamethasone 0.75 mg qn at the last follow-up.Serum potassium and blood pressure could be maintained within normal range for cases 1 and 2.Case 3 presented with amenorrhea,sexual infantilism,osteopenia and delayed bone age.The patient had a 46,XX karyotype,was homozygous for p.Tyr329fs and was treated with dexamethasone 0.75 mg qn and progynova 1 mg qd.Outpatient follow-up revealed an adrenocorticotropic hormone(8 AM)of<5.00 pg/mL.CONCLUSION The homozygous p.Tyr329fs mutation usually manifests as a combined deficiency,and definitive diagnosis depends primarily on genetic testing.展开更多
With the trust and support by WFO and its members,Foundry Institution of Chinese Mechanical Engineering Society (FICMES) will host the 69th World Foundry Congress (WFC2010). We cordially invite you to participate ... With the trust and support by WFO and its members,Foundry Institution of Chinese Mechanical Engineering Society (FICMES) will host the 69th World Foundry Congress (WFC2010). We cordially invite you to participate in the 69th WFC to be held on October 16-20,2010,in Hangzhou,China.……展开更多
)The 2008 IEEE World Congress on Computational Intelligence (WCCI 2008) will be held at the HongKong Convention and Exhibition Centre during June 1-6, 2008. WCCI 2008 will be the fifth milestone inthis series with a g...)The 2008 IEEE World Congress on Computational Intelligence (WCCI 2008) will be held at the HongKong Convention and Exhibition Centre during June 1-6, 2008. WCCI 2008 will be the fifth milestone inthis series with a glorious history from WCCI 1994 in Orlando, WCCI 1998 in Anchorage, WCCI 2002in Honolulu, to WCCI 2006 in Vancouver. Sponsored by the IEEE Computational Intelligence Society,展开更多
The World Journal of Gastroenterology Editorial Board consists of 685members,representing a team of worldwide experts in gastroenterologyand hepatology.They are from 52 countries including:Albania(1),Argentina(1),Aust...The World Journal of Gastroenterology Editorial Board consists of 685members,representing a team of worldwide experts in gastroenterologyand hepatology.They are from 52 countries including:Albania(1),Argentina(1),Australia(16).Austria(7),Belarus(1),Belgium(11),Brazil(1),Bulgaria(1),Canada(10),China(58),Croatia(2),Czech(1),Denmark(5),Egypt(3),Finland(1),France(27).Germany(71),Greece(1),Hungary(1).Iceland(1),India(6),Iran(2),Ireland(2),Israel(5),Italy(51),Japan(137),Lebanon(2),Lithuania(1),Macedonia(1),Malaysia(3),Mexico(2),Monaco(1),Netherlands(15),New Zealand(1),Nigeria(1),Norway(2),Pakistan(1),Poland(6),Portugal(1),Russia(3),Singapore(3),Slovakia(1),South Africa(1),South Korea(9),Spain(27),Sweden(6),Switzerland(8),Turkey(7),United Arab Emirates(1),United Kingdom(37).United States(121),Yugoslavia(1).展开更多
More than 20000 representatives and tourists from 170 countries and regions participated in the World Festival of International. Youth which opened on July 1 in Pyongyang.
On January 4, United States planes shot down two Libyan jet fighters over the Mediterranean Sea. This is the first fighting between the US and Libya since US jets bombed Tripoli in 1986. But on January 12, the United ...On January 4, United States planes shot down two Libyan jet fighters over the Mediterranean Sea. This is the first fighting between the US and Libya since US jets bombed Tripoli in 1986. But on January 12, the United States, Britain and France, in a rare triple veto, blocked a Security Council resolution to deplore the shooting down of two Libyan jets by US navy fighters. President Fidel Castro of Cuba announced on January 4 in Havana that the first 3000 Cuban troops to be withdrawn from展开更多
The European Union summit ended on December 16 in Madrid. European leaders set their seal on a drive to make Europe a global power ready for challenges of the next century with a new currency and a new list of members...The European Union summit ended on December 16 in Madrid. European leaders set their seal on a drive to make Europe a global power ready for challenges of the next century with a new currency and a new list of members. The US federal government partially shut down for the second time in a month on December 16, with President Bill展开更多
Russian President Boris Yeltsin, after an emphatic election victory, made a plea on July 4 for national reconciliation. With over 99 per cent of the vote counted, Yeltsin had 53. 70 per cent to Zyuganov’s 40.41 per c...Russian President Boris Yeltsin, after an emphatic election victory, made a plea on July 4 for national reconciliation. With over 99 per cent of the vote counted, Yeltsin had 53. 70 per cent to Zyuganov’s 40.41 per cent. The 65-year-old persident’s victory will return him to展开更多
Struggling to rebuild a mission near collapse,the UN Security Council voted on June 16 toenlarge its force in Bosnia to include up to12500 heavily armed troops.
On August 5, US President Bill Clinton signed into law a bill to punish foreign companies that invest in oil and gas projects in Iran or Libya. The law, which sparked vehement protests from European countries, was des...On August 5, US President Bill Clinton signed into law a bill to punish foreign companies that invest in oil and gas projects in Iran or Libya. The law, which sparked vehement protests from European countries, was designed to discourage investment in Iran and Libya. On August 14, Iran’s Parliament Speaker Ali Akbar Nateq-nouri vowed to take stance against US domination展开更多
Organizer,date and venueThe Second World Conference on Digestology will beheld in the Beijing International Convention Center,Beijing,China on September 8-11,2000 by World Journal ofGastroenterology and World Chinese ...Organizer,date and venueThe Second World Conference on Digestology will beheld in the Beijing International Convention Center,Beijing,China on September 8-11,2000 by World Journal ofGastroenterology and World Chinese Journal of Digestologyand the Committee of World Digestology Network(http://www.wd.org.cn).About 2000 participants are expected toattend the meeting.展开更多
Organizer,date and venueThe Second World Conference on Digestology will beheld in the Beijing International Convention Center,Beijing,China on September 8-11,2000 by World Journal ofGastroenterology and World Chinese ...Organizer,date and venueThe Second World Conference on Digestology will beheld in the Beijing International Convention Center,Beijing,China on September 8-11,2000 by World Journal ofGastroenterology and World Chinese Journal of Digestologyand the Committee of World Digestology Network (http://www.wd.org.cn).About 2000 participants are expected toattend the meeting.展开更多
On June 2, US President Bill Clinton renewedthe Most-Favoured Nation trade status for Chinafor another year on the recommendation of USSecretary of State Warren Christopher.
Retired senior Chinese leader Chen Yun died atage 90 of an illness at 14:04 on April 10 inBeijing. An Organization of African Unity missionarrived in Burundi on April 12, seeking topromote reconciliatton in a nation r...Retired senior Chinese leader Chen Yun died atage 90 of an illness at 14:04 on April 10 inBeijing. An Organization of African Unity missionarrived in Burundi on April 12, seeking topromote reconciliatton in a nation racked byethnic bloodshed and to head off any massslaughter on a scale similar to Rwanda.展开更多
Russian President Boris Yeltsin arrived in Beijing on December 17 on a visit to China. Speaking to reporters at Beijing airport upon arrival, Yeltsin said it is only natural that Russia and China, which share a 4000-k...Russian President Boris Yeltsin arrived in Beijing on December 17 on a visit to China. Speaking to reporters at Beijing airport upon arrival, Yeltsin said it is only natural that Russia and China, which share a 4000-kilometre border, should seek to develop their friendship and co-operation. Yeltsin and Chinese President Yang Shangkun signed the joint declaration on the basic principles governing bilateral relations in Beijing on December 18 after separate talks in the morning between Yeltsin and Chinese Premier Li Peng and Communist Party General Secretary Jiang Zemin.展开更多
India’s ruling Congress closed ranks on May21 behind Prime Minister P.V. Narasimha Rao,calling a dissident gathering which triggered aparty split "illegal and unconstitutional". Aftera meeting on May 20, th...India’s ruling Congress closed ranks on May21 behind Prime Minister P.V. Narasimha Rao,calling a dissident gathering which triggered aparty split "illegal and unconstitutional". Aftera meeting on May 20, the Congress WorkingCommittee condemned "in the strongest terms thewhole charade put up by the disgruntled andexpelled leaders and reposes its full faith in展开更多
Published by The WJG Press and Elsevier Inc．,PO Box 23451 Beijing 100023,China Fax:+86-(0)10-85381893 E-mail:wjg@wjgnet．com http://www．wjgnet．com The World Journal of Gastroenterology Editorial Board consists of 5...Published by The WJG Press and Elsevier Inc．,PO Box 23451 Beijing 100023,China Fax:+86-(0)10-85381893 E-mail:wjg@wjgnet．com http://www．wjgnet．com The World Journal of Gastroenterology Editorial Board consists of 519 members,representing a team of worldwide experts in gastroenterology and hepatology．They are from 51 countries,including Albania(1),Algeria(1),Argentina(1),Australia(8), Austria(5),Belarus(1),Belgium(6),Brazil(1),Bulgaria(1),Canada(7),China(50),Costa Rica(1),Croatia(1),Denmark(6), Egypt(1),Finland(1),France(18),Germany(35),Greece(2),Hungary(2),Iceland(1),India(5),Iran(1),Ireland(1),Israel(2),Italy(41),Japan(132),Lithuania(1),Macedonia(1),Malaysia(3),Monaco(1),Netherlands(13),Norway(2),Pakistan(1),Philippines(1),Poland(2),Portugal(1),Russia(3),Singapore(2),Slovakia(1),South Africa(2),South Korea(6),Spain(20), Sri Lanka(1),Swaziland(1),Sweden(4),Switzerland(4),Turkey(3),United Kingdom(20),United States(90),Yugoslavia(1)． HONORARY EDITORS-IN-CHIEF Ke-Ji Chen,Professor Xiyuan Hospital,Chinese Tranditional Medicine University,Beijing 100091,China. kjchen@public．bta．net．展开更多
文摘BACKGROUND Prion diseases are a group of degenerative nerve diseases that are caused by infectious prion proteins or gene mutations.In humans,prion diseases result from mutations in the prion protein gene(PRNP).Only a limited number of cases involving a specific PRNP mutation at codon 196(E196A)have been reported.The coexistence of Korsakoff syndrome in patients with Creutzfeldt-Jakob disease(CJD)caused by E196A mutation has not been documented in the existing literature.CASE SUMMARY A 61-year-old Chinese man initially presented with Korsakoff syndrome,followed by rapid-onset dementia,visual hallucinations,akinetic mutism,myoclonus,and hyperthermia.The patient had no significant personal or familial medical history.Magnetic resonance imaging of the brain revealed extensive hyperintense signals in the cortex,while positron emission tomography/computed tomography showed a diffuse reduction in cerebral cortex metabolism.Routine biochemical and microorganism testing of the cerebrospinal fluid(CSF)yielded normal results.Tests for thyroid function,human immunodeficiency virus,syphilis,vitamin B1 and B12 levels,and autoimmune rheumatic disorders were normal.Blood and CSF tests for autoimmune encephalitis and autoantibody-associated paraneoplastic syndrome yielded negative results.A test for 14-3-3 protein in the CSF yielded negative results.Whole-genome sequencing revealed a diseasecausing mutation in PRNP.The patient succumbed to the illness 11 months after the initial symptom onset.CONCLUSION Korsakoff syndrome,typically associated with alcohol intoxication,also manifests in CJD patients.Individuals with CJD along with PRNP E196A mutation may present with Korsakoff syndrome.
基金Anhui Province Central Guided Local Science and Technology Development Funding Project,No.2017070802D147Anhui Province Key Clinical Specialist Construction Fund.
文摘p.Tyr329fs is a cytochrome P450c17 mutation among Chinese individuals.However,data on 17-α-hydroxylase deficiency caused by cytochrome P450c17 p.Tyr329fs homozygous mutation are lacking.This paper is a case report of three patients homozygous for p.Tyr329fs who were diagnosed with 17-α-hydroxylase deficiency between 2005 and 2019.CASE SUMMARY Case 1 presented with hypertension,hypokalemia,sexual infantilism and delayed bone age.The patient had a 46,XY karyotype,was homozygous for p.Tyr329fs and was recently treated with dexamethasone 0.375 mg qn.Case 2 presented with hypokalemia,sexual infantilism,osteoporosis and delayed bone age.The patient had a 46,XY karyotype,was homozygous for p.Tyr329fs and was treated with dexamethasone 0.75 mg qn at the last follow-up.Serum potassium and blood pressure could be maintained within normal range for cases 1 and 2.Case 3 presented with amenorrhea,sexual infantilism,osteopenia and delayed bone age.The patient had a 46,XX karyotype,was homozygous for p.Tyr329fs and was treated with dexamethasone 0.75 mg qn and progynova 1 mg qd.Outpatient follow-up revealed an adrenocorticotropic hormone(8 AM)of<5.00 pg/mL.CONCLUSION The homozygous p.Tyr329fs mutation usually manifests as a combined deficiency,and definitive diagnosis depends primarily on genetic testing.
文摘 With the trust and support by WFO and its members,Foundry Institution of Chinese Mechanical Engineering Society (FICMES) will host the 69th World Foundry Congress (WFC2010). We cordially invite you to participate in the 69th WFC to be held on October 16-20,2010,in Hangzhou,China.……
文摘)The 2008 IEEE World Congress on Computational Intelligence (WCCI 2008) will be held at the HongKong Convention and Exhibition Centre during June 1-6, 2008. WCCI 2008 will be the fifth milestone inthis series with a glorious history from WCCI 1994 in Orlando, WCCI 1998 in Anchorage, WCCI 2002in Honolulu, to WCCI 2006 in Vancouver. Sponsored by the IEEE Computational Intelligence Society,
文摘The World Journal of Gastroenterology Editorial Board consists of 685members,representing a team of worldwide experts in gastroenterologyand hepatology.They are from 52 countries including:Albania(1),Argentina(1),Australia(16).Austria(7),Belarus(1),Belgium(11),Brazil(1),Bulgaria(1),Canada(10),China(58),Croatia(2),Czech(1),Denmark(5),Egypt(3),Finland(1),France(27).Germany(71),Greece(1),Hungary(1).Iceland(1),India(6),Iran(2),Ireland(2),Israel(5),Italy(51),Japan(137),Lebanon(2),Lithuania(1),Macedonia(1),Malaysia(3),Mexico(2),Monaco(1),Netherlands(15),New Zealand(1),Nigeria(1),Norway(2),Pakistan(1),Poland(6),Portugal(1),Russia(3),Singapore(3),Slovakia(1),South Africa(1),South Korea(9),Spain(27),Sweden(6),Switzerland(8),Turkey(7),United Arab Emirates(1),United Kingdom(37).United States(121),Yugoslavia(1).
文摘More than 20000 representatives and tourists from 170 countries and regions participated in the World Festival of International. Youth which opened on July 1 in Pyongyang.
文摘On January 4, United States planes shot down two Libyan jet fighters over the Mediterranean Sea. This is the first fighting between the US and Libya since US jets bombed Tripoli in 1986. But on January 12, the United States, Britain and France, in a rare triple veto, blocked a Security Council resolution to deplore the shooting down of two Libyan jets by US navy fighters. President Fidel Castro of Cuba announced on January 4 in Havana that the first 3000 Cuban troops to be withdrawn from
文摘The European Union summit ended on December 16 in Madrid. European leaders set their seal on a drive to make Europe a global power ready for challenges of the next century with a new currency and a new list of members. The US federal government partially shut down for the second time in a month on December 16, with President Bill
文摘Russian President Boris Yeltsin, after an emphatic election victory, made a plea on July 4 for national reconciliation. With over 99 per cent of the vote counted, Yeltsin had 53. 70 per cent to Zyuganov’s 40.41 per cent. The 65-year-old persident’s victory will return him to
文摘Struggling to rebuild a mission near collapse,the UN Security Council voted on June 16 toenlarge its force in Bosnia to include up to12500 heavily armed troops.
文摘On August 5, US President Bill Clinton signed into law a bill to punish foreign companies that invest in oil and gas projects in Iran or Libya. The law, which sparked vehement protests from European countries, was designed to discourage investment in Iran and Libya. On August 14, Iran’s Parliament Speaker Ali Akbar Nateq-nouri vowed to take stance against US domination
文摘Organizer,date and venueThe Second World Conference on Digestology will beheld in the Beijing International Convention Center,Beijing,China on September 8-11,2000 by World Journal ofGastroenterology and World Chinese Journal of Digestologyand the Committee of World Digestology Network(http://www.wd.org.cn).About 2000 participants are expected toattend the meeting.
文摘Organizer,date and venueThe Second World Conference on Digestology will beheld in the Beijing International Convention Center,Beijing,China on September 8-11,2000 by World Journal ofGastroenterology and World Chinese Journal of Digestologyand the Committee of World Digestology Network (http://www.wd.org.cn).About 2000 participants are expected toattend the meeting.
文摘On June 2, US President Bill Clinton renewedthe Most-Favoured Nation trade status for Chinafor another year on the recommendation of USSecretary of State Warren Christopher.
文摘Retired senior Chinese leader Chen Yun died atage 90 of an illness at 14:04 on April 10 inBeijing. An Organization of African Unity missionarrived in Burundi on April 12, seeking topromote reconciliatton in a nation racked byethnic bloodshed and to head off any massslaughter on a scale similar to Rwanda.
文摘Russian President Boris Yeltsin arrived in Beijing on December 17 on a visit to China. Speaking to reporters at Beijing airport upon arrival, Yeltsin said it is only natural that Russia and China, which share a 4000-kilometre border, should seek to develop their friendship and co-operation. Yeltsin and Chinese President Yang Shangkun signed the joint declaration on the basic principles governing bilateral relations in Beijing on December 18 after separate talks in the morning between Yeltsin and Chinese Premier Li Peng and Communist Party General Secretary Jiang Zemin.
文摘India’s ruling Congress closed ranks on May21 behind Prime Minister P.V. Narasimha Rao,calling a dissident gathering which triggered aparty split "illegal and unconstitutional". Aftera meeting on May 20, the Congress WorkingCommittee condemned "in the strongest terms thewhole charade put up by the disgruntled andexpelled leaders and reposes its full faith in
文摘Published by The WJG Press and Elsevier Inc．,PO Box 23451 Beijing 100023,China Fax:+86-(0)10-85381893 E-mail:wjg@wjgnet．com http://www．wjgnet．com The World Journal of Gastroenterology Editorial Board consists of 519 members,representing a team of worldwide experts in gastroenterology and hepatology．They are from 51 countries,including Albania(1),Algeria(1),Argentina(1),Australia(8), Austria(5),Belarus(1),Belgium(6),Brazil(1),Bulgaria(1),Canada(7),China(50),Costa Rica(1),Croatia(1),Denmark(6), Egypt(1),Finland(1),France(18),Germany(35),Greece(2),Hungary(2),Iceland(1),India(5),Iran(1),Ireland(1),Israel(2),Italy(41),Japan(132),Lithuania(1),Macedonia(1),Malaysia(3),Monaco(1),Netherlands(13),Norway(2),Pakistan(1),Philippines(1),Poland(2),Portugal(1),Russia(3),Singapore(2),Slovakia(1),South Africa(2),South Korea(6),Spain(20), Sri Lanka(1),Swaziland(1),Sweden(4),Switzerland(4),Turkey(3),United Kingdom(20),United States(90),Yugoslavia(1)． HONORARY EDITORS-IN-CHIEF Ke-Ji Chen,Professor Xiyuan Hospital,Chinese Tranditional Medicine University,Beijing 100091,China. kjchen@public．bta．net．
