The Wugong Mts. region may have experienced three stages of metamorphism in Early Paleo-zoic, which may be closely related to the generations of regional deformation. The first stage ismedium-pressure metamorphism, th...The Wugong Mts. region may have experienced three stages of metamorphism in Early Paleo-zoic, which may be closely related to the generations of regional deformation. The first stage ismedium-pressure metamorphism, the second medium- and high-pressure one with stress on high-pressure metamorphism, and the third low-pressure and high-temperature metamorphism. Theregion, as a whole, is a Caledonian medium-high pressure metamorphic belt.展开更多
目的探讨蜈蚣败毒饮对银屑病HaCaT细胞凋亡相关基因Bcl-2、核因子-κB(NF-κB)m RNA表达的影响。方法实验大鼠随机分为空白对照组、西药对照组、中药对照组和蜈蚣败毒饮低、中、高剂量组,分别给予生理盐水、甲氨蝶呤混悬液、复方青黛胶...目的探讨蜈蚣败毒饮对银屑病HaCaT细胞凋亡相关基因Bcl-2、核因子-κB(NF-κB)m RNA表达的影响。方法实验大鼠随机分为空白对照组、西药对照组、中药对照组和蜈蚣败毒饮低、中、高剂量组,分别给予生理盐水、甲氨蝶呤混悬液、复方青黛胶囊混悬液和蜈蚣败毒饮低、中、高剂量浓缩液灌胃,制备相应的药物血清,将其分别作用于HaCaT细胞中培养传代,采用RT-PCR法检测不同药物血清对目的基因表达的干预作用。结果各组药物血清均能够降低HaCaT细胞Bcl-2、NF-κB m RNA的表达,蜈蚣败毒饮高剂量组和西药对照组的作用效果最为明显,且蜈蚣败毒饮各剂量组呈现出一定的量效关系。结论蜈蚣败毒饮可能通过降低Bcl-2、NF-κB m RNA的表达促进了HaCaT细胞凋亡,调控T细胞相关因子降低免疫反应,从而发挥抗银屑病样的作用。展开更多
文摘The Wugong Mts. region may have experienced three stages of metamorphism in Early Paleo-zoic, which may be closely related to the generations of regional deformation. The first stage ismedium-pressure metamorphism, the second medium- and high-pressure one with stress on high-pressure metamorphism, and the third low-pressure and high-temperature metamorphism. Theregion, as a whole, is a Caledonian medium-high pressure metamorphic belt.
文摘目的探讨蜈蚣败毒饮对银屑病HaCaT细胞凋亡相关基因Bcl-2、核因子-κB(NF-κB)m RNA表达的影响。方法实验大鼠随机分为空白对照组、西药对照组、中药对照组和蜈蚣败毒饮低、中、高剂量组,分别给予生理盐水、甲氨蝶呤混悬液、复方青黛胶囊混悬液和蜈蚣败毒饮低、中、高剂量浓缩液灌胃,制备相应的药物血清,将其分别作用于HaCaT细胞中培养传代,采用RT-PCR法检测不同药物血清对目的基因表达的干预作用。结果各组药物血清均能够降低HaCaT细胞Bcl-2、NF-κB m RNA的表达,蜈蚣败毒饮高剂量组和西药对照组的作用效果最为明显,且蜈蚣败毒饮各剂量组呈现出一定的量效关系。结论蜈蚣败毒饮可能通过降低Bcl-2、NF-κB m RNA的表达促进了HaCaT细胞凋亡,调控T细胞相关因子降低免疫反应,从而发挥抗银屑病样的作用。
