Comprehensive Summary Cross-electrophile couplings(XEC),a crucial subset of cross-coupling reactions,center on the formation of robust C—C bonds through the union of two electrophiles.Usually,such reactions have prim...Comprehensive Summary Cross-electrophile couplings(XEC),a crucial subset of cross-coupling reactions,center on the formation of robust C—C bonds through the union of two electrophiles.Usually,such reactions have primarily been catalyzed by transition metals.However,with the steady advancements in photochemical and electrochemical technologies,XEC reactions have significantly progressed and broadened their scope,allowing for the utilization of a wider array of tolerable functional groups,thus revealing vast application prospects.This review aims to systematically summarize the current prevalent types of electrophiles and delve into their specific application examples within XEC reactions involving electrophiles with identical functional groups.Specifically,XECs between the same type of halides have received considerable attention,whereas carboxylic acids and alcohols are still in the early stages of investigation.Furthermore,certain other common electrophiles remain unexplored in this context.Moreover,this review underscores the remarkable contributions of photochemistry and electrochemistry in the field of XEC reactions,aiming to provide valuable insights and inspiration for researchers.Also,this review hopes to spark further interest in XEC reactions,thereby fueling the continuous development and advancement of this exciting area of research.展开更多
基金the Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202001338 and KJQN202101340)the Natural Science Foundation Project of CQ CSTSC(cstc2020jcyj-msxmX0733 and cstc2021jcyj-bsh0233).
文摘Comprehensive Summary Cross-electrophile couplings(XEC),a crucial subset of cross-coupling reactions,center on the formation of robust C—C bonds through the union of two electrophiles.Usually,such reactions have primarily been catalyzed by transition metals.However,with the steady advancements in photochemical and electrochemical technologies,XEC reactions have significantly progressed and broadened their scope,allowing for the utilization of a wider array of tolerable functional groups,thus revealing vast application prospects.This review aims to systematically summarize the current prevalent types of electrophiles and delve into their specific application examples within XEC reactions involving electrophiles with identical functional groups.Specifically,XECs between the same type of halides have received considerable attention,whereas carboxylic acids and alcohols are still in the early stages of investigation.Furthermore,certain other common electrophiles remain unexplored in this context.Moreover,this review underscores the remarkable contributions of photochemistry and electrochemistry in the field of XEC reactions,aiming to provide valuable insights and inspiration for researchers.Also,this review hopes to spark further interest in XEC reactions,thereby fueling the continuous development and advancement of this exciting area of research.
