选择性凝血因子XI抑制剂在血栓性疾病治疗中的临床研究进展

血栓性疾病是当今社会的一个重要医疗问题,动脉内血栓形成是引起心肌梗死、缺血性脑卒中、急性肢体缺血的最常见原因,静脉内血栓则可能导致肢体缺血坏死及肺栓塞等严重后果,这些疾病每年共导致全球1000多万人死亡,占所有疾病死亡的50%以上,在过去的20年内,这一比例更是增加了25%~35%[1]。目前,抗凝剂是预防和治疗血栓形成的主要手段之一。

Linguistic landscape and its impacts on place-making in mountain destination:A case of Mogan Mountain Town of Huzhou City,China

The place and placeness are believed to be a crucial perspective for comprehending the transformative dynamics of tourist destinations in the context of globalization and the rapid development of the tourism industry.As the material carrier of language,linguistic landscape is an intermediary for people to endow emotions and personalities into the place,becoming an effective path for exploring the place-making in a certain area.Mogan Mountain is a famous national tourist resort,which is located in Mogan Mountain Town,Deqing County,Huzhou City,China.This is a good case area for studying the relationship between linguistic landscape and placemaking in tourist destinations.There are two theories that form the theoretical foundation of the study,namely the place and the geosemiotics.Firstly,the results showed the overall style of the linguistic landscape.Multilingual labelling(52.7%),official signs(55.3%),and standardized Chinese characters predominantly shaped the linguistic landscape,with English and other languages being complementary.Secondly,from the perspective of three dimensions of the geosemiotics framework,such as inscription,language preference,and placement position,we conduct a comprehensive semiotic analysis of the linguistic landscape,which encompasses diverse facets such as fonts,materials,shifts in state,text vectors,and symmetrical arrangements.Finally,we explore the influence of linguistic landscapes on the place-making of Mogan Mountain through the dimensions of location,locale,and sense of place.The information on linguistic landscapes indicates the geographical location.These linguistic landscapes play an important role in constructing the language order,nostalgic atmosphere,exotic atmosphere,and elegant and tasteful lifestyle of the public space in Mogan Mountain.Readers of linguistic landscapes,including tourists and residents,generate and identify with the unique sense of place in Mogan Mountain.These linguistic landscapes construct the destination placeness of Mogan Mountain that combines both foreign and nostalgic styles,and the integration of Chinese and Western cultures.It will help promote the image positioning of tourism destinations and have practical guiding significance for the tourism planning,landscape-making,language management,and other aspects of tourism destinations.

Assessing Flexible Places for Adaptive Urban Design:A New Method and the Case of Cittaducale

Each place has its own peculiarities,determining that the resilience and adaptation to diverse types of risks will be different,requiring different time and methods for mitigation as well.The coexistence of several risks determines further resolution difficulties as commonly,since risks are sudden and unforeseen,there is a tendency to treat the last risk more carefully,neglecting the previous one even if it is just as important.Most of the methodologies used to analyse areas affected by different risks are aimed at focusing in particular on seismic risks without considering those relating to intangible aspects linked to the identity of the places or aspects related to urban health and liveability.And,more in general,in relation to design aspects,urban methodologies do not consider all the results of the analyses,maybe for the difficulty deriving from translating the complexity of collected data in project interventions.Starting from these premises,the objective of the article,elaborated within the SISMI and PRIN 2020 research projects is to propose an original methodology capable of analysing the places affected by multiple risks and planning its resilience attentive to its cultural resources and to its liveability.To this end,the proposed method will be aimed at creating flexible and adaptive places and the case-study of Cittaducale will be illustrated.Criticalities and qualities of this place affected by an earthquake in 2016 will be reported and project interventions to transform its risks into opportunities will be shown.

终末期肝病模型-XI评分对急性心肌梗死冠状动脉支架植入术后患者预后的预测价值

目的 探讨终末期肝病模型-XI(MELD-XI)评分对急性心肌梗死患者冠状动脉支架植入术后的预后的预测价值。方法 回顾性收集2021年1月至2022年12月于内蒙古医科大学附属医院收治的急性心肌梗死患者226例,根据入院时MELD-XI评分,将患者分为高MELD-XI评分组和低MELD-XI评分组,每组各113例。比较两组患者近、远期预后。结果 与低MELD-XI评分组比较,高MELD-XI评分组患者左室射血分数(LVEF)显著降低[(51.67±7.91)%vs.(60.91±5.91)%],(P<0.001);N末端脑钠肽前体(NT-proBNP)显著增高(822.87±462.38) vs.(701.84±338.21)ng/L,(P=0.026)。与低MELD-XI评分组比较,高MELD-XI评分组患者不良结局事件的发生率显著增高(16.81%vs. 6.19%,P=0.012)。MELD-XI评分对急性心肌梗死冠状动脉支架植入术后不良结局事件具有一定的预测价值,曲线下面积为0.732,95%CI:0.671~0.798,(P<0.001)。结论 MELD-XI对于预测急性心肌梗死患者预后具有一定的参考价值。

Making the World a Better Place for All

In bidding farewell to 2023,Chinese President Xi Jinping’s New Year message,with its commitment to advance Chinese modernization,deliver a better life for the people,and build a community with a shared future for mankind,effectively ushered in a new year brimming with hope.

System and Realization Path of Xi Jinping's Eco-poverty Alleviation Concept under the Vision of Green Development

Since the 18 th National Congress of the Communist Party of China,General Secretary Xi Jinping delivered a series of speeches on ecological environment and poverty governance,forming the Xi Jinping's eco-poverty alleviation ideology.In this paper,the Xi Jinping's eco-poverty alleviation ideology is taken as the research object.Using the methods of literature analysis and comparative analysis,the origin of eco-poverty alleviation theory is explored from the common prosperity theory and the theory of ecological capital,and the practice foundation is found out from practical cases.The relationship between the ecological damage and poverty is systematically analyzed,and the mechanism of ecological poverty is explored in detail.The basic connotation of Xi Jinping's eco-poverty alleviation is expounded,and it consists of three parts:guiding ideology layer,implementation layer,and guarantee layer.By perfecting and innovating the market mechanism,social management mechanism,performance evaluation mechanism,integration mechanism with other poverty alleviation methods,and ecological immigration mechanism of ecological poverty,the realization of Xi Jinping's eco-poverty alleviation concept could be guaranteed.

Analysis of the Appealing Structure in Hemingway’s“A Clean,Well-lighted Place”

In the novel“A Clean,Well-lighted Place”,Hemingway tells the story of two waiters in a Spanish caféjust before closing time,talking about an old man who drank heavily in the caféevery night and lived a wealthy life but still wants to commit suicide.Using the iceberg principle,Hemingway purposely omits the plot,characterization of the story,and uses symbolism and repetition to describe people’s different attitudes facing the spiritual emptiness after the war,breaking the readers’expectations,and inspiring them to explore the meaning of individual life.Therefore,based on Wolfgang Iser and Zhu Liyuan’s appealing structure theory,this paper will analyze the appealing structure in“A Clean,Well-lighted Place”at three levels:meaning construction,rhetorical techniques,and thoughts and themes.It is hoped that readers can find a new way to interpret the short story,better understand the author’s creative ideas and dig deeper into the connotation of the work.

English Translation of Chinese Natural Ecological Discourse:A Corpus-based Case Study on Xi Jinping:The Governance of China

Amid the increasingly severe global natural eco-environment,it is necessary to build a natural ecological civilization by constructing an ecological civilization discourse.Against this background,this study compiles a corpus of natural ecological discourse in the English translation of Xi Jinping:The Governance of China(short for Xi).By using Wordsmith and AntConc,this study explores the linguistic features of the ecological discourse in English translation of Xi in the following dimensions,including high-frequency words,keywords,word collocations,concordance lines.This study aims to analyze the concepts and attitudes towards natural ecology,so as to provide certain valuable insights for the construction of China’s discourse on natural ecological civilization.The study found that the natural ecology discourse involving in the English translation of Xi turned out to be ecologically beneficial.

达芬奇机器人(Xi)辅助下直肠前切除术(NOSES-Ⅳ式)

达芬奇机器人(Xi)系统联合经自然腔道取标本(NOSES)在直肠癌手术中的应用日益成熟和普遍.二者的结合充分发挥了各自的优势,将层面的游离,淋巴的清扫,血管的解剖,神经的保护和无菌、微创理念贯穿始终.因此,机器人下的手术操作,规范的手术流程,经自然腔道取标本的微创模式,为程序化的直肠癌根治手术带来了新的进步.

杜梨LRR-XI-a亚家族的鉴定及调控腐烂病抗性的成员筛选

为探究LRR-XI-a基因家族在杜梨免疫系统中的作用机制,基于GDR数据库的杜梨基因组数据鉴定了杜梨LRR-XI-a家族成员,经进化特征、基因重复事件和表达模式分析筛选了响应腐烂病信号的成员,并结合果实瞬时表达和抗性基因表达分析对部分成员的功能进行了初步分析。结果表明,杜梨LRR-XI-a基因家族包含91个成员,进化上可分为6个亚组。基因重复分析结果表明,杜梨中GroupⅠ成员数的迅速增加可能由串联复制(TD)和全基因组复制(WGD)共同导致,而GroupⅥ成员的增加仅由WGD所致。顺式作用元件分析结果表明,杜梨LRR-XI-a亚组Ⅱ和Ⅵ可能主要参与杜梨对非生物逆境信号的响应,而其余4个亚组同时参与对生物和非生物逆境信号的响应。表达分析结果表明,LRR-XI-4和LRR-XI-5在腐烂病侵染后呈不同程度的上调表达,其中LRR-XI-5上调表达量可达对照的586倍以上。果实瞬时表达分析结果表明,过表达LRR-XI-4和LRR-XI-5降低了梨果实对腐烂病的抗性,抑制了JA信号通路基因的表达,但激活了超敏反应响应基因的表达。综上,基因重复导致杜梨LRR-XI-a家族成员发生迅速增加;LRR-XI-a家族成员响应不同的生物胁迫和非生物胁迫;LRR-XI-4和LRR-XI-5通过激活超敏反应(HR)相关基因的表达负调控腐烂病抗性,可作为后期腐烂病抗性研究的候选基因。本研究结果为后续开展梨抗病机理研究和分子育种奠定了基础。

达芬奇Xi系统机器人辅助后腹腔镜肾上腺切除术治疗肾上腺肿瘤的疗效观察

目的 探讨达芬奇Xi系统机器人辅助后腹腔镜肾上腺切除术治疗肾上腺肿瘤的临床效果。方法 选取2019年1月至2022年1月河北省唐山市人民医院收治并经病理确诊的肾上腺肿瘤患者97例进行回顾性研究,根据治疗方法分为机器人手术组46例(采用达芬奇Xi系统机器人辅助后腹腔镜肾上腺切除术治疗)和传统腹腔镜手术组51例(采用传统后腹腔镜肾上腺切除术治疗)。比较两组手术相关指标,统计两组并发症情况、随访情况。结果 两组术中出血量、手术时间比较,差异无显著性(P>0.05);与传统腹腔镜手术组相比,机器人手术组肿瘤直径较大,中转开腹率、术后出血率降低,术后止痛剂使用次数更少,术后引流时间、术后住院时间、下床活动时间及术后胃肠功能恢复时间明显缩短,住院费用有所增加,差异有显著性(P<0.05)。与传统腹腔镜手术组相比较,机器人手术组术中并发症发生率明显降低,差异有显著性(P<0.05),而两组术后并发症发生率、术后血压改善情况、肿瘤复发率、是否需长期口服激素差异无显著性(P>0.05)。结论 达芬奇Xi系统机器人辅助后腹腔镜肾上腺切除术治疗肾上腺肿瘤,手术创伤小,术中并发症发生率低,患者恢复快,且不增加手术时间。

从Place连接Space助推“机械原理”一流课程建设

基于教学实践,从教学内容、教学组织和双向评价这三个关键维度出发,分别在先进理论和现代设计方法、大规模在线教育和工程实践及教师评价“学”的过程和学生评价“教”的过程等重要方向建立连接,使课程体系从有限容量的线性place占位扩展到大容量现代化教学的多方向space占位。建设结果表明,多方向的space课程体系既能解决学生学习过程中的主动性、积极性问题,又能助推课程自身迭代,促使“机械原理”始终处于一流课程的领先地位。

A Parallel Indexing Cam Mechanism with Internal Placed Followers

A new type of parallel indexing cam mechanism is discovered.The composition of the cam profile is proposed and the formulas of the mechanism parameters are established by synthesis of its configuration and size.The equations for working pro- file and pressure angle of the cam are derived based on the inverse model and the derivative of pitch curve of cams.An example is given and demonstrates that it is available to design the new mechanism using the derived expressions.

达芬奇Xi机器人在单侧腋窝入路免充气甲状腺手术中的临床应用分析

背景和目的:2007年,Kang等第1次将机器人手术应用于甲状腺,之后机器人甲状腺手术在全球范围内开展。因安全性、肿瘤治疗的根治性和美容性不断得到验证,腋窝入路比例在国内正在快速增长。本研究通过对比分析使用达芬奇Xi机器人完成的95例单侧腋窝入路免充气甲状腺手术与91例传统手术治疗cN0期甲状腺微小乳头状癌(papillary thyroid microcarcinoma,PTMC)的临床疗效,探讨达芬奇Xi机器人单侧腋窝入路手术治疗PTMC的优势及临床应用价值。方法:回顾性分析2020年3月—2021年11月复旦大学附属肿瘤医院头颈外科收治的186例cN0期单侧单灶PTMC患者的临床数据,根据手术方式分为机器人组(95例)和开放组(91例),分析比较两组患者的一般临床资料、手术结果、术后并发症、切口满意度、学习曲线及手术费用等情况。结果:两组患者在性别、年龄、是否合并桥本甲状腺炎、肿瘤直径及病灶位置方面差异无统计学意义(P>0.05)。机器人组手术时间[(126.65±34.76)min]长于开放组[(60.99±21.12)min],在经历36例手术后手术时间可达稳定水平。手术费用[(47940.66±4404.30)元]高于开放组[(15807.73±2295.35)元]。在术中出血量[机器人组:(20.48±18.83)mL;开放组:(16.15±13.95)mL]、清扫淋巴结个数[机器人组:(2.61±2.77)枚;开放组:(2.97±2.20)枚]和检出阳性淋巴结个数[机器人组:(1.01±1.61)枚;开放组:(0.78±1.36)枚]方面差异无统计学意义(P>0.05)。机器人组术后暂时性声嘶(1.10%)低于开放组(2.20%),但差异无统计学意义(P>0.05)。机器人组术后切口满意度(非常满意87.4%,比较满意11.6%)高于开放组(非常满意71.4%,比较满意26.4%),差异有统计学意义(P<0.05)。结论:达芬奇Xi机器人单侧腋窝入路免充气甲状腺手术不仅具有良好的美容效果,较高的患者满意度,而且学习曲线短,术中出血量、淋巴结检测情况及术后并发症发生情况与传统手术相当。

Protection and Renovation Strategies for Ancient Town Architectural Space Design from the Perspective of Place Spirit Theory:A Case Study of Hekou Ancient Town,Yanshan County of Jiangxi Province

The protection and renovation of ancient town space design has been widely concerned by all walks of society and professionals of all disciplines.However,in the process of design protection and renovation,there are various serious problems such as lack of the core functions are weak,loss of historical context protection,and disappearance of architectural space design features.As an important commercial transportation hub town in the Ming and Qing Dynasties,Hekou Ancient Town has become increasingly weak.From the perspective of the place spirit(Genius Loci)theory,this paper followed the design principle of"use function enhancement,spatial feature extension and life situation experience",and elaborated the strategies of space protection and renovation of Hekou Ancient Town design from three aspects:spatial pattern,landscape restoration and landscape node reconstruction,in the hope of enhancing the depth of the inheritance and development of the spiritual culture of ancient towns in China.

Relationship between Dining Place, Iodine Source, and Iodine Nutrition in School-Age Children: A Cross-Sectional Study in China

Objective This study assesses the impact of iodine-rich processed foods and dining places on the iodine nutritional status of children.Methods School-aged children(SAC) in seven provinces in China were selected by school-based multistage sampling. Urinary iodine, salt iodine, and thyroid volume(TVOL) were determined. Questionnaires were used to investigate dining places and iodine-rich processed foods. The water iodine was from the2017 national survey. Multi-factor regression analysis was used to find correlations between variables.Results Children ate 78.7% of their meals at home, 15.1% at school canteens, and 6.1% at other places.The percentage of daily iodine intake from water, iodized salt, iodine-rich processed foods, and cooked food were 1.0%, 79.2%, 1.5%, and 18.4%, respectively. The salt iodine was correlated with the urinary iodine and TVOL, respectively(r = 0.999 and-0.997, P < 0.05). The iodine intake in processed foods was weakly correlated with the TVOL(r = 0.080, P < 0.01). Non-iodized salt used in processed foods or diets when eating out had less effect on children’s iodine nutrition status.Conclusion Iodized salt remains the primary source of daily iodine intake of SAC, and processed food has less effect on iodine nutrition. Therefore, for children, iodized salt should be a compulsory supplement in their routine diet.

From Hai Yao, Yang Yao to Xi Yao: Sinification of Material Medical from the West

In ancient China, Daoist philosophers developed the concepts of qi(energy), Wu Xing(five elements), and yin(feminine, dark, negative) and yang(masculine, bright, positive) opposite forces between 200 and 600 BCE. Based on these philosophies, Zhen Jiu(acupuncture), Ben Cao(materia medica), and the practice of Qi Gong(energy optimization movements) evolved as the three interrelated therapeutic regimens of Chinese medicine(Note 1). Since the time of Zhang Qian, who discovered China's western regions in the 1st century BCE, Hai Yao(the exotic elements of materia medica from the maritime Silk Road countries), had been transmitted from the ancient land and maritime routes of the Silk Road to China in the past two millennia(Note 2). Since the late 17th century, the English East India Company, later called the British East India Company, introduced Yang Yao(opium) to the Manchu Qing Empire to balance a growing trade deficit for tea export from China to the British Empire. After the First Opium War ended in 1842, enterprising expatriate chemists and druggists in the treaty ports imported Xi Yao(modern medicines from the Western world) for sale to the merchant navy and the local market. From the second half of the 19th century onwards, both Hai Yao and Xi Yao have become a fully integrated part of modern China's armamentarium for the Chinese medicine and Western hospitals and retail pharmacy sectors. This paper articulates the journey of adoption of exotic elements of materia medica from the ancient land and sea routes of the Silk Road, including the western regions and the rest of the world in the past two millennia. Opium traders, ship surgeons, medical and pharmaceutical missionaries, enterprising traders, and policymakers together transformed Ben Cao into Xi Yao during the late Manchu Qing dynasty and the early Nationalist Era.

Analysis of the Development of the Commercial Space Around Metro Stations in Urban Core Areas Based on Place Making: A Case Study of Chunxi Road Metro Station in Chengdu

The metro is the most efficient and convenient public transport system in modern cities. For urban core areas in China, in which the metro was built later, there was more consideration for meeting the traffic needs of cities. However, there are few studies of collaborative planning for metro stations and their surrounding space. Thus, there is an urgent need to conduct research on collaborative planning for metro stations and their surrounding commercial space in urban core areas. Unlike conventional methods of integrated design of stations and cities, this paper, based on the theory of place spirit, took Chunxi Road Metro Station in Chengdu and its surrounding commercial space for example. It explored the pattern and characteristics of the place in the commercial space around the metro station, analyzed the strategies of cultural and commercial integration, as well as architecture, street, landscape and other aspects of the design method in the space, and explored the strategies of place-making and infiltration, providing a reference point for the development and place-making of the commercial space around metro stations in urban core areas.

Axial Load Capacity of Cast in Place Piles from SPT and CPTU Data

This paper aims to deal with the assessment of axial load capacity for cast in place pile foundations, which are made by the earth drill method, by using the data taken from Standard Penetration Tests (SPTs) and Piezocone Penetration Tests (CPTUs). These tests were carried out as part of the investigation program for P.N.G. Terminal-Power Plant, near Semani beach, in Hoxhara marsh, in the western part of Albania. The design of axial load capacity of piles is based on empirical formula using SPT and CPTU values. This study presents the results of axial load capacity analysis of cast in place piles by different analytical calculation methods, which are based on in situ tests results, and also referring to the Building Standard Law of Japan. In the end of our work, differences between calculations methods by using different in situ tests results are shown in tables and graphs.

A Corpus-based Study on the Existing Comments of the Literature Works:Hemingway’s A Clean,Well-Lighted Place

In recent years,the application of computer-aided technology of corpus linguistics to the quantitative analysis of literary texts has increasingly become a powerful supplement to the traditional text analysis of literary works.With the help of corpus linguistics,this paper aims to offer proof to the existing comments on Hemingway’s A Clean,Well-Lighted Place from an empirical perspective.And issues like its concise writing style,nihilistic theme,narrative plot and the character image analysis will be discussed.