目的 探讨济泰片治疗轻度海洛因依赖者稽延性戒断症状的有效性和安全性,为降低轻度海洛因依赖者的复吸率提供参考。方法 在河南省新乡市第一强制隔离戒毒所选取符合《精神障碍诊断与统计手册(第4版)》(DSM-IV)诊断标准的轻度海洛因依赖...目的 探讨济泰片治疗轻度海洛因依赖者稽延性戒断症状的有效性和安全性,为降低轻度海洛因依赖者的复吸率提供参考。方法 在河南省新乡市第一强制隔离戒毒所选取符合《精神障碍诊断与统计手册(第4版)》(DSM-IV)诊断标准的轻度海洛因依赖者81例,采用随机数字表法分为济泰片组( n =40)和对照组( n =41)。济泰片组接受济泰片治疗,对照组给予济泰模拟片,两组均治疗24周。采用海洛因依赖稽延性戒断症状评定量表(RSPWSHA)评定疗效,采用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表17项版(HAMD-17)及海洛因渴求问卷(HCQ)评定焦虑、抑郁症状和心理渴求程度,治疗期间监测药物不良反应、生命体征和实验室检查指标评估安全性。结果 济泰片组和对照组RSPWSHA、HAMA、HAMD-17 及HCQ总评分随治疗时间延长而降低( P <0.05),RSPWSHA总评分减分率随治疗时间延长而增加( P <0.05)。治疗8周后两组HCQ评分和治疗24周后两组HAMD-17总评分比较差异有统计学意义( P <0.05),其他各治疗时点两组各量表评分比较差异均无统计学意义( P 均>0.05)。结论 济泰片治疗轻度海洛因依赖者稽延性戒断症状可能疗效不明确。展开更多
Objective:Xin-Ke-Shu(XKS),a patent drug,used to treat coronary artery diseases in China for many years.Previous research indicates that XKS has similar therapeutic effect as atorvastatin(AS)against atherosclerotic in ...Objective:Xin-Ke-Shu(XKS),a patent drug,used to treat coronary artery diseases in China for many years.Previous research indicates that XKS has similar therapeutic effect as atorvastatin(AS)against atherosclerotic in rabbits.However,biochemical assays demonstrate that XKS could have a different therapeutic mechanism from AS.The aim of this study is to explore the mechanism of XKS therapeutic effect,especially those different from AS.Materials and Methods:~1H nuclear magnetic resonance-based metabonomics were applied to profile the low-molecular-weight polar metabolites in the plasma of rabbits fed a high cholesterol diet.Results:Seven of the eleven pathological biomarkers related to atherosclerosis in rabbits were mediated by XKS treatment,namely low-density lipoprotein/very-low-density lipoprotein LDL/VLDL),lactate,citrate,phosphatidylcholine,glutamine,creatinine,and methionine,as well as two characteristic metabolites of pyruvate and α-glucose.These metabolites involved lipid,energy,and amino acid metabolism,and all could be considered XKS treatment targets.However,AS only affected the metabolic disorders associated with LDL/VLDL and phosphatidylcholine,which is mainly target lipid metabolism.Conclusions:This study indicates that the anti-atherosclerosis effects of AS mainly involve reducing blood–lipid levels,but those of XKS involve a multitargeted activity.展开更多
文摘目的 探讨济泰片治疗轻度海洛因依赖者稽延性戒断症状的有效性和安全性,为降低轻度海洛因依赖者的复吸率提供参考。方法 在河南省新乡市第一强制隔离戒毒所选取符合《精神障碍诊断与统计手册(第4版)》(DSM-IV)诊断标准的轻度海洛因依赖者81例,采用随机数字表法分为济泰片组( n =40)和对照组( n =41)。济泰片组接受济泰片治疗,对照组给予济泰模拟片,两组均治疗24周。采用海洛因依赖稽延性戒断症状评定量表(RSPWSHA)评定疗效,采用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表17项版(HAMD-17)及海洛因渴求问卷(HCQ)评定焦虑、抑郁症状和心理渴求程度,治疗期间监测药物不良反应、生命体征和实验室检查指标评估安全性。结果 济泰片组和对照组RSPWSHA、HAMA、HAMD-17 及HCQ总评分随治疗时间延长而降低( P <0.05),RSPWSHA总评分减分率随治疗时间延长而增加( P <0.05)。治疗8周后两组HCQ评分和治疗24周后两组HAMD-17总评分比较差异有统计学意义( P <0.05),其他各治疗时点两组各量表评分比较差异均无统计学意义( P 均>0.05)。结论 济泰片治疗轻度海洛因依赖者稽延性戒断症状可能疗效不明确。
基金financially supported by National Natural Science Foundation of China(No.81473332)
文摘Objective:Xin-Ke-Shu(XKS),a patent drug,used to treat coronary artery diseases in China for many years.Previous research indicates that XKS has similar therapeutic effect as atorvastatin(AS)against atherosclerotic in rabbits.However,biochemical assays demonstrate that XKS could have a different therapeutic mechanism from AS.The aim of this study is to explore the mechanism of XKS therapeutic effect,especially those different from AS.Materials and Methods:~1H nuclear magnetic resonance-based metabonomics were applied to profile the low-molecular-weight polar metabolites in the plasma of rabbits fed a high cholesterol diet.Results:Seven of the eleven pathological biomarkers related to atherosclerosis in rabbits were mediated by XKS treatment,namely low-density lipoprotein/very-low-density lipoprotein LDL/VLDL),lactate,citrate,phosphatidylcholine,glutamine,creatinine,and methionine,as well as two characteristic metabolites of pyruvate and α-glucose.These metabolites involved lipid,energy,and amino acid metabolism,and all could be considered XKS treatment targets.However,AS only affected the metabolic disorders associated with LDL/VLDL and phosphatidylcholine,which is mainly target lipid metabolism.Conclusions:This study indicates that the anti-atherosclerosis effects of AS mainly involve reducing blood–lipid levels,but those of XKS involve a multitargeted activity.
