Objective The experiment is to study the protective effects of Xinkang Injection on ADR-induced toxin myocarditisin mice.Methods The test of Xinkang Injection on ADR-induced toxin myocarditisin mice.Firstly,the animal...Objective The experiment is to study the protective effects of Xinkang Injection on ADR-induced toxin myocarditisin mice.Methods The test of Xinkang Injection on ADR-induced toxin myocarditisin mice.Firstly,the animal of obnormal,weight and death rate.Secondly,the influnences of cardiogram of ADR-induced toxin myocarditisin mice.Thirdly,the influnences of lactate dehydrogenase(LDH),creatine kinase(CK)and glutamic oxaloacetic transaminasw(GOT)of ADR-induced toxin myocarditisin mice.Fouthly,the influnences of changes of cardioc pathological mechanism of ADR-induced toxin myocarditisin mice.Fifthly,the influnces of the caidioc ultrastructural of ADR-induced toxin myocarditisin mice.Results Firstly,to ADR-induced toxin myocarditisin mice,the weight of middle dose and high dose of Xinkang injection had declined obviosly which contrast with the constraction model mice team.In the mean time,the weight of Xinkang injection team had obviosly changde which contrast with contrastion mice team(P<0.01).Secondly,to ADR-induced toxin myocarditisin mice,the middle dose and high dose of Xinkang injection have obviosly withstand Q abnormal cardiogram,in the meantime,Xinkang injection team had obviosly changde contrast with the contrastion model mice(P<0.01).Thirdly,to ADR-induced toxin myocarditisin mice,The activity of lactate dehydrogenase(LDH),creatine kinase(CK)and glutamic oxaloacetic transaminasw(GOT)were differently measured.The middle dose and high dose of Xinkang injection team can obviously declined the activity of LDH and CK(P<0.01).Fouthly,to ADR-induced toxin myocarditisin mice,the low dose,the middle dose and high dose of Xinkang injection team can contrast with injured on toxic myocarditisin mice cardioc.Fifthly,to ADR-induced toxin myocarditisin mice,the low dose,the middle dose and high dose of Xinkang injection team have effect of allevite the injection of the cardioc ulteasteuctural of ADR-induced toxin myocarditisin mice.Conclusions Xinkang injection can protect the ADR-induced toxin myocarditisin mice.展开更多
ABSTRCAT Objective: The effect of prevention and treatment of Xinkang oral liquid (心康口服液, XKOL) on experimental coxsackievirus B 3 (CVB 3) myocarditis mice model were investigated. Methods: The mice were ino...ABSTRCAT Objective: The effect of prevention and treatment of Xinkang oral liquid (心康口服液, XKOL) on experimental coxsackievirus B 3 (CVB 3) myocarditis mice model were investigated. Methods: The mice were inoculated intraperitoneally with 0.3 ml of 10 5 TCID 50 of CVB 3 to induce acute viral myocarditis model. These mice were divided into model control group (Group A), prevention high dosage group (Group B) and prevention low dosage group (Group C), treatment high dosage group (Group D) and treatment low dosage group (Group E), respectively. In addition, XKOL control group (Group F) and normal control group (Group G) were not infected with CVB 3 intraperitoneally. The administration of XKOL in Group B and C began 2 days before virus infection. All animals were sacrificed on day 20 for evaluation. Results: Histological examination showed extensive myocardial necrosis and cell infiltration in most of Group A mice, but necrosis and cell infiltration were less severe in Group B,C,D and E mice. Thymus weight in Group B,C,D and E mice were heavier and less cell depletion occurred than those in Group A. Conclussion: The XKOL could effectively inhibit myocardial CVB 3 replication, reduce the myocardial inflammatory response, lower incidence rate of myocarditis and prevent the disease associated lymphoid organ atrophy in this animal models.展开更多
文摘Objective The experiment is to study the protective effects of Xinkang Injection on ADR-induced toxin myocarditisin mice.Methods The test of Xinkang Injection on ADR-induced toxin myocarditisin mice.Firstly,the animal of obnormal,weight and death rate.Secondly,the influnences of cardiogram of ADR-induced toxin myocarditisin mice.Thirdly,the influnences of lactate dehydrogenase(LDH),creatine kinase(CK)and glutamic oxaloacetic transaminasw(GOT)of ADR-induced toxin myocarditisin mice.Fouthly,the influnences of changes of cardioc pathological mechanism of ADR-induced toxin myocarditisin mice.Fifthly,the influnces of the caidioc ultrastructural of ADR-induced toxin myocarditisin mice.Results Firstly,to ADR-induced toxin myocarditisin mice,the weight of middle dose and high dose of Xinkang injection had declined obviosly which contrast with the constraction model mice team.In the mean time,the weight of Xinkang injection team had obviosly changde which contrast with contrastion mice team(P<0.01).Secondly,to ADR-induced toxin myocarditisin mice,the middle dose and high dose of Xinkang injection have obviosly withstand Q abnormal cardiogram,in the meantime,Xinkang injection team had obviosly changde contrast with the contrastion model mice(P<0.01).Thirdly,to ADR-induced toxin myocarditisin mice,The activity of lactate dehydrogenase(LDH),creatine kinase(CK)and glutamic oxaloacetic transaminasw(GOT)were differently measured.The middle dose and high dose of Xinkang injection team can obviously declined the activity of LDH and CK(P<0.01).Fouthly,to ADR-induced toxin myocarditisin mice,the low dose,the middle dose and high dose of Xinkang injection team can contrast with injured on toxic myocarditisin mice cardioc.Fifthly,to ADR-induced toxin myocarditisin mice,the low dose,the middle dose and high dose of Xinkang injection team have effect of allevite the injection of the cardioc ulteasteuctural of ADR-induced toxin myocarditisin mice.Conclusions Xinkang injection can protect the ADR-induced toxin myocarditisin mice.
文摘ABSTRCAT Objective: The effect of prevention and treatment of Xinkang oral liquid (心康口服液, XKOL) on experimental coxsackievirus B 3 (CVB 3) myocarditis mice model were investigated. Methods: The mice were inoculated intraperitoneally with 0.3 ml of 10 5 TCID 50 of CVB 3 to induce acute viral myocarditis model. These mice were divided into model control group (Group A), prevention high dosage group (Group B) and prevention low dosage group (Group C), treatment high dosage group (Group D) and treatment low dosage group (Group E), respectively. In addition, XKOL control group (Group F) and normal control group (Group G) were not infected with CVB 3 intraperitoneally. The administration of XKOL in Group B and C began 2 days before virus infection. All animals were sacrificed on day 20 for evaluation. Results: Histological examination showed extensive myocardial necrosis and cell infiltration in most of Group A mice, but necrosis and cell infiltration were less severe in Group B,C,D and E mice. Thymus weight in Group B,C,D and E mice were heavier and less cell depletion occurred than those in Group A. Conclussion: The XKOL could effectively inhibit myocardial CVB 3 replication, reduce the myocardial inflammatory response, lower incidence rate of myocarditis and prevent the disease associated lymphoid organ atrophy in this animal models.