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基于Y-shaped路网的早高峰拼车定价策略
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作者 贺冬冬 仲秋雁 曲毅 《系统工程学报》 CSCD 北大核心 2023年第5期706-722,共17页
针对交通资源配置有限导致的早高峰通勤拥堵问题,借鉴共享经济理论,引入拼车出行概念,充分考虑通勤者出行方式和Y-shaped路网特点,建立了基于通勤者出行效益的拼车定价模型.模型结合费用补偿机制,讨论了以平台利润最大化和系统负效用最... 针对交通资源配置有限导致的早高峰通勤拥堵问题,借鉴共享经济理论,引入拼车出行概念,充分考虑通勤者出行方式和Y-shaped路网特点,建立了基于通勤者出行效益的拼车定价模型.模型结合费用补偿机制,讨论了以平台利润最大化和系统负效用最小化为目标的拼车定价策略,并给出了定价策略有效的阈值条件.研究结果表明,当通勤者都参与到拼车服务中时,拼车平台利润和交通系统负效用在其相应拼车定价策略下均能达到最优值,并且以交通系统负效用最小化为目标的拼车定价策略能消除Y-shaped路网中瓶颈处的交通拥堵. 展开更多
关键词 动态拼车 y-shaped瓶颈模型 拼车定价 早高峰通勤
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Gastrotracheal fistula:Treatment with a covered self-expanding Y-shaped metallic stent 被引量:2
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作者 Fei Wang Hong Yu +4 位作者 Ming-Hui Zhu Quan-Peng Li Xian-Xiu Ge Jun-Jie Nie Lin Miao 《World Journal of Gastroenterology》 SCIE CAS 2015年第3期1032-1035,共4页
A 67-year-old man had a sev-ere cough and pulmonary infection for 1 wk before seeking evaluation at our hospital.He had undergone esophagectomy with gastric pull-up and radiotherapy for esophageal cancer 3 years previ... A 67-year-old man had a sev-ere cough and pulmonary infection for 1 wk before seeking evaluation at our hospital.He had undergone esophagectomy with gastric pull-up and radiotherapy for esophageal cancer 3 years previously.After admission to our hospital,gastroscopy and bronchoscopy revealed a fistulous communication between the posterior tracheal wallnear the carina and the upper residual stomach.We measured the diameter of the trachea and bronchus and determined the site and size of the fistula using multislice computed tomography and gastroscopy.A covered self-expanding Y-shaped metallic stent was implanted into the trachea and bronchus.Subsequently,the fistula was closed completely.The patient tolerated the stent well and had good palliation of his symptoms. 展开更多
关键词 Gastrotracheal FISTULA y-shaped metallic STENT ESO
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Y-shaped block copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide) synthesized by ATRP 被引量:2
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作者 Xin De Tang Xiao Chao Liang Nian Feng Han 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第11期1353-1356,共4页
Novel Y-shaped block copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide), PEG-b-(PNIPAM)2, were successfully synthesized through atom transfer radical polymerization (ATRP). A difunctional macr... Novel Y-shaped block copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide), PEG-b-(PNIPAM)2, were successfully synthesized through atom transfer radical polymerization (ATRP). A difunctional macroinitiator was prepared by esterification of 2,2-dichloroacetyl chloride with poly(ethylene glycol) monomethyl ether (PEG). The copolymers were obtained via the ATRP ofN-isopropylacrylamide (NIPAM) at 30℃ with CuCl/Me6TREN as a catalyst system and DMF/H2O (v/v = 3:1) mixture as solvent. The resulting copolymers were characterized by gel permeation chromatography (GPC) and ^1H NMR. These block copolymers show controllable molecular weights and narrow molecular weight distributions (PDI 〈 1.15). Their phase transition temperatures and the corresponding enthalpy changes in aqueous solution were measured by differential scanning calorimetry (DSC). As a result, the phase transition temperature of PEG45-b-(PNIPAM55)2 is higher than that of PNIPAM, however, the corresponding enthalpy change is much lower, indicating the significant influence of the macromolecular composition and architecture on the phase transition. 展开更多
关键词 y-shaped Block copolymer Poly(ethylene glycol) Poly(N-isopropylacrylamide) Atom transfer radical polymerization (ATRP)
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Deformation and defects in hydroforming of Y-shaped tubes
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作者 程东明 滕步刚 +1 位作者 郭斌 苑世剑 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2008年第2期206-210,共5页
Hydroforming process of a Y-shaped stainless steel tube was investigated through numerical simulation and experiments. The forming process and reasons of typical defects were analyzed with three different loading path... Hydroforming process of a Y-shaped stainless steel tube was investigated through numerical simulation and experiments. The forming process and reasons of typical defects were analyzed with three different loading paths. Thickness distribution of formed Y-shaped tube was obtained. It is shown by numerical and experimental results that the transition regions are depressed in the forming condition of low inner pressure and wrinkles occur, while fracture occurs in the forming condition of high inner pressure. After forming, the thickness in left transition fillet region is the largest, that in fight transition fillet region is thinner, and the thinnest thickness is at the top of the protrusion. The original thickness line is below the top of the protrusion. The thinning area occurs above this line, while the thickening area is below this line. The maximum thinning rate is significantly increased as the calibration pressure increases, while the maximum thickening rate remains almost unchanged. 展开更多
关键词 HYDROFORMING y-shaped tube loading path DEFECTS thickness
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Binary collision approximation for solitary waves in a Y-shaped granular chain
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作者 陈琼 杨先清 +2 位作者 赵新印 王振辉 赵跃民 《Chinese Physics B》 SCIE EI CAS CSCD 2013年第1期350-355,共6页
We implement a binary collision approximation to study solitary wave propagation in a two-dimensional double Y- shaped granular chain. The solitary wave was transmitted and reflected when it met the interface of the b... We implement a binary collision approximation to study solitary wave propagation in a two-dimensional double Y- shaped granular chain. The solitary wave was transmitted and reflected when it met the interface of the bifurcated branches of the Y-shaped granular chains. We obtain the analytic results of the ratios of the transmitted and reflected speeds to the incident speed of the solitary wave, the maximum force between the two neighbor beads in a solitary wave, and the total time taken by the pulse to pass through each branch. All of the analytic results are in good agreement with the experimental observations from Daraio et al. [Phys. Rev. E 82 036603 (2010)]. Moreover, we also discuss the delay effects on the arrival of split pulses, and predict the recombination of the split waves traveling in branches in the final stem of asymmetric systems. The prediction of pulse recombination is verified by our numerical results. 展开更多
关键词 y-shaped granule chain solitary wave binary collision approximation
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Evaluation of ultimate bearing capacity of Y-shaped vibro-pile
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作者 王新泉 陈永辉 +2 位作者 林飞 卢孝益 张霆 《Journal of Central South University》 SCIE EI CAS 2008年第S2期186-194,共9页
Based on Mindlin stress solution, a numerical computational method was proposed to calculate the stresses in the ground induced by side friction and the resistance of Y-shaped vibro-pile. The improved Terzaghi's a... Based on Mindlin stress solution, a numerical computational method was proposed to calculate the stresses in the ground induced by side friction and the resistance of Y-shaped vibro-pile. The improved Terzaghi's and ЪерезанцевВГ's methods for ultimate bearing capacity evaluation were proposed by considering the stress strength induced by friction resistance at pile head level of Y-pile. A new method to calculate the ultimate bearing capacity of Y-pile was also proposed based on the assumptions of soil failure mode at the tip of Y-pile and the use of Mohr-Coulomb soil yield criterion and Vesic compressive correction coefficient with the induced stresses in the ground. Based on the comparisons with the field static load test results, it is found that the improved Terzaghi's method gives higher ultimate capacity, while the other two methods shows good agreement with the field results. 展开更多
关键词 y-shaped vibro-pile circular PILE MINDLIN stress solution ULTIMATE bearing capacity of PILE TIP static loading test
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Transfer characteristics of dynamic biochemical signals in non-reversing pulsatile flows in a shallow Y-shaped microfluidic channel: signal filtering and nonlinear amplitude-frequency modulation
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作者 Zongzheng CHEN Weimo YUAN +4 位作者 A.R.AZIZ Zhengming GAO Depei ZENG Bo LIU Kairong QIN 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2017年第10期1481-1496,共16页
The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are ana- lyzed. The results show that the mixing micro-channel acts a... The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are ana- lyzed. The results show that the mixing micro-channel acts as a low-pass filter, and the biochemical signals are nonlinearly modulated by the pulsatile flows, which depend on the biochemical signal frequency, the flow signal frequency, and the biochemical signal transporting distance. It is concluded that, the transfer characteristics of the dynamic biochemical signals, which are transported in the time-varying flows, should be carefully considered for better loading biochemical signals on the cells cultured on the bottom of the microfluidic channel. 展开更多
关键词 shallow y-shaped microfluidic channel dynamic biochemical signal non-reversing pulsatile flow nonlinear amplitude-frequency modulation Taylor-Aris disper-sion
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Y-Shaped Intra-Scleral Fixated Lens versus Retro-Pupillary Iris Claw Lens in the Treatment of Aphakia
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作者 Ahmed Mohamed Morshed Mahmoud Nasr Aldeeb +1 位作者 Adel Kamal Abdeen Salah Mohamed Almosalamy 《Open Journal of Ophthalmology》 2019年第2期105-124,共20页
Background: Many reasons can lead to an aphakia without adequate capsular support for implantation of a posterior chamber intraocular lens (IOL), such as intraoperative unintentional rupture of posterior capsule durin... Background: Many reasons can lead to an aphakia without adequate capsular support for implantation of a posterior chamber intraocular lens (IOL), such as intraoperative unintentional rupture of posterior capsule during phacoemulsification, planned intracapsular cataract extraction, ocular trauma and lens dislocation due to congenital and acquired causes. Purpose: To compare Y-shaped intra-scleral fixation of a posterior chamber IOL with retro pupillary fixation of an iris-claw intraocular lens (IOL) for Aphakic eyes without sufficient capsular support as respects safety, visual recovery and complications of both methods. Patients and Methods: One hundred Aphakic eyes were arbitrarily distributed between two groups. Group A included 50 eyes treated with retropupillary fixation of iris claw lens and group B included 50 eyes treated with Y-shaped intra-scleral fixation technique. Preoperative, intraoperative and postoperative data were analysed including best corrected visual acuity (BCVA), intraocular pressure (IOP), surgical time, intraoperative problems, IOL malposition and postoperative complications. Following up on patients was carried out for at least six months. Results: The mean duration of surgery was 21 ± 5.3 min in group A and was 53.4 ± 6.9 min in group B (p-value 0.05). IOL tilt was found in 0 (0%) eyes in group A and in 5 (10%) eyes in group B (p 0.05). Conclusion: The results of our study indicated that both methods are satisfactory in correcting aphakia without sufficient capsular support as regards postoperative best corrected visual acuity (BCVA);however the surgical technique of retropupillary iris claw lens is easier, shorter, with low intra- and postoperative complications and safer than those used for intra-scleral fixation of IOL. But for eyes which lack both iris and capsular support, a scleral fixation of a posterior chamber IOL remains the only option. 展开更多
关键词 APHAKIA Iris-Claw Intraocular LENS (IOL) y-shaped INTRA Scleral Fixation
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Comparison of lag screws and double Y-shaped miniplates in the fixation of anterior mandibular fractures
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作者 Lydia Melek 《World Journal of Methodology》 2021年第3期88-94,共7页
BACKGROUNDMandibular fractures constitute about 80.79% of maxillofacial injuries inAlexandria University, either as isolated mandibular fractures or as a part ofpanfacial fractures. The combination of symphyseal and p... BACKGROUNDMandibular fractures constitute about 80.79% of maxillofacial injuries inAlexandria University, either as isolated mandibular fractures or as a part ofpanfacial fractures. The combination of symphyseal and parasymphyseal fracturesrepresent 47.09% of the total mandibular fractures.AIMTo compare the effectiveness of lag screws vs double Y-shaped miniplates in thefixation of anterior mandibular fractures.METHODSThis study is a prospective randomized controlled clinical trial, performed onsixteen patients with anterior mandibular fractures. Patients were divided equallyinto two groups, each consisting of eight patients. Group 1: Underwent openreduction and internal fixation using two lag screws. Group 2: Underwent openreduction and internal fixation using double Y-shaped plates. The followingparameters were assessed: operating time in minutes, pain using a visual analogscale, edema, surgical wound healing for signs and symptoms of infection,occlusion status and stability, maximal mouth opening, and sensory nervefunction. Cone beam computed tomography was performed at 3 and 6 mo tomeasure bone density and assess the progression of fracture healing.RESULTSThe study included 13 males (81.3%) and 3 females (18.8%) aged 26 to 45 years(mean age was 35.69 ± 6.01 years). The cause of trauma was road traffic accidentsin 10 patients (62.5%), interpersonal violence in 3 patients (18.8%) and othercauses in 3 patients (18.8%). The fractures comprised 10 parasymphyseal fractures(62.5%) and 6 symphyseal fractures (37.5%). The values of all parameters were comparable in both groups with no statistically significant difference except forthe mean bone density at 3 mo postoperatively which was 946.38 ± 66.29 in group 1 and 830.36 ± 95.53 in group 2 (P = 0.015).CONCLUSIONBoth lag screws and double Y-shaped miniplates provide favorable means offixation for mandibular fractures in the anterior region. Fractures fixed with lagscrews show greater mean bone density at 3 mo post-operation, indicative ofhigher primary stability and faster early bone healing. Further studies with largersample sizes are required to verify these conclusions. 展开更多
关键词 Anterior mandibular fractures Symphyseal fracture Parasymphyseal fracture MINIPLATES Lag screws Double y-shaped plates
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Coverless Image Steganography System Based on Maze Game Generation
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作者 Al Hussien Seddik Saad Mohammed S.Reda +4 位作者 GamalM.Behery Ahmed A.El-harby Mohammed Baz Mohamed Abouhawwash Ahmed Ismail Ebada 《Intelligent Automation & Soft Computing》 2023年第11期125-138,共14页
The trend of digital information transformation has become a topic of interest.Many data are threatening;thus,protecting such data from attackers is considered an essential process.Recently,a new methodology for data ... The trend of digital information transformation has become a topic of interest.Many data are threatening;thus,protecting such data from attackers is considered an essential process.Recently,a new methodology for data concealing has been suggested by researchers called coverless steganography.Coverless steganography can be accomplished either by building an image database to match its image subblocks with the secret message to obtain the stego image or by generating an image.This paper proposes a coverless image steganography system based on pure image generation using secret message bits with a capacity higher than the other traditional systems.The system uses the secret message to generate the stego image in the form of one of the Intelligence Quotient(IQ)games,the maze.Firstly,a full grid is generated with several specific rows and columns determined from the number of bits of the secret message.Then,these bits are fed to the full grid to form the maze game stego image.Finally,the generated maze game stego image is sent to the recipient.The experimental results,using the Bit Error Rate(BER),were conducted,and confirmed the strength of this system represented by a high capacity,perfect performance,robustness,and stronger hiding system compared with existing coverless steganography systems. 展开更多
关键词 Coverless data hiding digital image steganography intelligence quotient games maze game
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电针“天枢”与“天枢”配伍“上巨虚”对肠易激综合征大鼠行为学和结肠功能的影响 被引量:1
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作者 刘婷婷 张擎宇 +5 位作者 赵香顺 石运来 于燕南 王正文 陈少宗 杨添淞 《中国中医基础医学杂志》 CAS CSCD 2024年第2期245-250,共6页
目的观察并比较电针“天枢”与“天枢”配伍“上巨虚”对肠易激综合征(irritable bowel syndrome,IBS)模型大鼠情绪和结肠功能影响,初步探讨天枢配伍上巨虚是否存在协同或叠加效应。方法雄性Wistar大鼠分为空白组(10只)和造模组(45只),... 目的观察并比较电针“天枢”与“天枢”配伍“上巨虚”对肠易激综合征(irritable bowel syndrome,IBS)模型大鼠情绪和结肠功能影响,初步探讨天枢配伍上巨虚是否存在协同或叠加效应。方法雄性Wistar大鼠分为空白组(10只)和造模组(45只),采用慢性和急性应激相结合方法连续干预10 d制备模型,将制备成功IBS模型大鼠随机分为模型组(8只)、天枢组(8只)、天枢配伍上巨虚组(8只);天枢组、天枢配伍上巨虚组连续电针干预治疗14 d;干预结束后,分别对各组大鼠进行高架十字迷宫实验、结肠痛敏阈值测定,检测血清5-羟色胺(5-hydroxytryptamine,5-HT)含量以及结肠5-羟色胺4受体(5-hydroxytryptamine 4 receptor,5-HT 4 R)蛋白表达。结果与模型组比较,电针天枢组、电针天枢配伍上巨虚组进入开放臂(open arm entry,OE)次数百分比和开臂停留时间(open arm time,OT)百分比增加(P<0.01);结肠痛敏阈值显著升高(P<0.01);血清5-HT含量减少(P<0.05);结肠5-HT 4 R蛋白相对表达量增加(P<0.05)。两电针组之间比较,OE%、OT%、结肠痛敏阈值、血清5-HT含量以及结肠5-HT 4 R蛋白相对表达量的差异无统计学意义。结论电针“天枢”与“天枢”配伍“上巨虚”均能调节大鼠情绪心理行为的异常和改善结肠功能紊乱症状,但电针“天枢”配伍“上巨虚”相较于电针“天枢”未表现明显的穴位协同或叠加效应。 展开更多
关键词 肠易激综合征 天枢配伍上巨虚 高架十字迷宫 结肠功能
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经颅磁声电刺激对健康与帕金森病大鼠神经回路中beta振荡的影响 被引量:1
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作者 张帅 由胜男 +2 位作者 杜文静 王磊 徐桂芝 《中国组织工程研究》 CAS 北大核心 2024年第16期2519-2526,共8页
背景:经颅磁声电刺激是一种基于磁声耦合电效应的无创、高精度脑神经聚焦刺激方法,可调节神经节律振荡活动,从而影响大脑的运动、认知等功能。目的:探究经颅磁声电刺激对健康与帕金森病大鼠神经回路中beta振荡的影响。方法:①动物实验:... 背景:经颅磁声电刺激是一种基于磁声耦合电效应的无创、高精度脑神经聚焦刺激方法,可调节神经节律振荡活动,从而影响大脑的运动、认知等功能。目的:探究经颅磁声电刺激对健康与帕金森病大鼠神经回路中beta振荡的影响。方法:①动物实验:采用随机数字表法将24只Wistar大鼠随机分为4组,每组6只:正常对照组不进行任何干预;正常刺激组大脑前额叶皮质接受经颅磁声电刺激(空间峰值脉冲平均强度为13.33 W/cm^(2),基波频率为0.4 MHz,基波周期数为1000,脉冲重复频率为200 Hz);模型对照组、模型刺激组通过腹腔注射1-甲基-4-苯基-1,2,3,6-四氢吡啶建立帕金森病模型,造模成功后,模型对照组大脑前额叶皮质接受经颅磁声电假刺激,模型刺激组大脑前额叶皮质接受经颅磁声电刺激,每天刺激时长2.0 min,刺激结束停留8-10 min后,采集大鼠执行T迷宫过程中局部场电位信号并同时记录行为学正确率,对比分析各组局部场电位信号能量的时频分布情况和行为差异,当大鼠正确率连续3 d高于80%后停止刺激实验和T迷宫实验。②建模仿真实验:构建经颅磁声电刺激下皮质-基底神经节回路模型,分别改变超声发射周期(5,10,20 ms)、超声发射占空比(30%,50%,90%)和感应电流密度(20,50,100μA/cm^(2)),比较不同刺激参数下健康与帕金森病大鼠beta振荡的功率谱密度值。结果与结论:①动物实验:正常对照组大鼠的空间学习能力强于模型对照组(P<0.001),正常刺激组大鼠的空间学习能力强于正常对照组(P<0.05),模型刺激组大鼠的空间学习能力强于模型对照组(P<0.01);正常对照组beta振荡能量分布较为集中,正常刺激组较正常对照组beta振荡信号能量有所降低,模型对照组与模型刺激组beta振荡能量广泛分布且能量值显著高于正常对照组、正常刺激组,并且模型刺激组beta振荡信号能量明显低于模型对照组;②建模仿真实验:不加刺激时,健康大鼠beta频段功率谱密度峰值(30 dB)显著低于帕金森病大鼠(55 dB);施加经颅磁声电刺激后,两组大鼠beta频段功率谱密度值普遍降低;beta频段功率谱密度峰值与超声发射周期呈正相关、与感应电流密度呈负相关,当超声发射占空比为50%时功率谱密度峰值最低;③结果表明:经颅磁声电刺激可抑制健康与帕金森病大鼠的beta振荡,进而改善大鼠的运动功能与决策认知功能。 展开更多
关键词 经颅磁声电刺激 皮质-基底神经节回路 beta振荡 帕金森病 局部场电位 T迷宫 神经调控
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二甲双胍对小鼠脑缺血再灌注损伤后认知功能的影响及其机制
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作者 彭志锋 马国英 +1 位作者 杨靖辉 刘颖 《山西医科大学学报》 CAS 2024年第5期589-593,共5页
目的探讨二甲双胍对脑缺血再灌注(I/R)小鼠认知功能的影响及其机制。方法采用随机数字表法将40只雄性C57BL/6小鼠[(23±2)g,7~8周龄]分为4组:sham组、I/R组、I/R+100 mg/kg二甲双胍组(低剂量组)和I/R+200 mg/kg二甲双胍组(高剂量组)... 目的探讨二甲双胍对脑缺血再灌注(I/R)小鼠认知功能的影响及其机制。方法采用随机数字表法将40只雄性C57BL/6小鼠[(23±2)g,7~8周龄]分为4组:sham组、I/R组、I/R+100 mg/kg二甲双胍组(低剂量组)和I/R+200 mg/kg二甲双胍组(高剂量组),每组10只。脑缺血组小鼠采用大脑中动脉阻断(MCAO)60 min后再灌注7 d,sham组除不插入细丝阻断外,其余手术步骤相同;低剂量组和高剂量组小鼠在脑缺血再灌注后4 h,每天分别用100,200 mg/kg二甲双胍溶液灌胃,持续7 d。采用Morris水迷宫实验评价小鼠学习和记忆相关指标;采用干湿质量法评估小鼠脑水肿情况;采用HE染色评估小鼠神经元形态变化;采用ELISA试剂盒检测小鼠脑组织脑源性神经营养因子(BDNF)含量和超氧化物歧化酶(SOD)活性。结果与sham组相比,I/R组小鼠自发交替正确率降低,逃避潜伏期增加,目标象限时间降低,穿越平台次数降低(均P<0.05);脑组织含水量增加(P<0.05);BDNF含量和SOD活性均降低(P<0.05);脑组织中变性神经元数量增多。与I/R组相比,低剂量组小鼠目标象限时间增加(P<0.05);高剂量组小鼠自发交替正确率增加(P<0.05),逃避潜伏期降低(P<0.05),目标象限时间增加(P<0.05),穿越平台次数增加(P<0.05),脑组织含水量降低(P<0.05),BDNF含量和SOD活性增加(P<0.05),神经元变性减少。结论200 mg/kg二甲双胍后处理可改善脑缺血再灌注小鼠认知功能,可能与脑水肿减轻、神经元变性改善、脑内BDNF含量和SOD活性增加有关。 展开更多
关键词 二甲双胍 缺血再灌注 水迷宫 脑源性神经营养因子 超氧化物歧化酶 小鼠
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体外循环手术同期改良迷宫射频消融治疗心脏疾病合并持续性心房颤动的临床研究
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作者 李晖 刘长城 李海洋 《心肺血管病杂志》 CAS 2024年第6期618-622,共5页
目的:探究体外循环手术同期改良迷宫心房颤动射频消融术(COX-Maze IV,CMIV)治疗心脏疾病合并持续性心房颤动的有效性和对左心房功能的影响。方法:回顾性分析2016年1月至2023年8月,我科治疗的235例持续性心房颤动合并其他需体外循环手术... 目的:探究体外循环手术同期改良迷宫心房颤动射频消融术(COX-Maze IV,CMIV)治疗心脏疾病合并持续性心房颤动的有效性和对左心房功能的影响。方法:回顾性分析2016年1月至2023年8月,我科治疗的235例持续性心房颤动合并其他需体外循环手术患者的临床资料,患者均接受同期改良CMIV手术。男性68例、女性167例,评均年龄(51.5±6.7)岁,心房颤动病程中位数4年。术后随访12个月,观察患者窦性心律恢复及左心房功能恢复情况。结果:235例患者均顺利完成手术,出院前心房颤动转为窦性心律或交界性心律占206例(90.0%),194例(84.7%)恢复左心房功能,平均A波速度(37.6±11.4)cm/s。术后12个月随访,维持窦性心律及左心房功能恢复患者分别占82.7%和80.1%。结论:体外循环手术同期改良CMIV治疗心脏疾病合并持续性心房颤动是有效的,且有助于左心房功能恢复。 展开更多
关键词 心房颤动 改良迷宫房颤射频消融手术 左心房功能 体外循环手术
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文冠果油对雄性小鼠记忆能力的影响
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作者 陆昕 李显玉 +6 位作者 陶超 胡奇 杨素芝 乌志颜 徐嘉 齐长永 张静姝 《中国油脂》 CAS CSCD 北大核心 2024年第4期28-31,39,共5页
为了对文冠果油相关产品的开发提供数据支撑,将健康雄性小鼠分为4个组,即对照组(玉米油)、文冠果油低剂量组〔2.1 g/(kg·d)〕、文冠果油中剂量组〔4.2 g/(kg·d)〕和文冠果油高剂量组〔12.5 g/(kg·d)〕,分别经口给予小鼠... 为了对文冠果油相关产品的开发提供数据支撑,将健康雄性小鼠分为4个组,即对照组(玉米油)、文冠果油低剂量组〔2.1 g/(kg·d)〕、文冠果油中剂量组〔4.2 g/(kg·d)〕和文冠果油高剂量组〔12.5 g/(kg·d)〕,分别经口给予小鼠灌胃1个月后,测定小鼠体质量,并进行跳台试验、避暗试验、水迷宫试验以评价文冠果油对雄性小鼠记忆能力的影响,试验结束后测定小鼠海马和大脑皮质组织匀浆中多巴胺(DA)、5-羟色胺(5-HT)、去甲肾上腺素(NE)、乙酰胆碱(ACh)含量及乙酰胆碱酯酶(AChE)活性,探讨文冠果油对小鼠记忆能力的影响机制。结果表明:经过1个月的灌胃试验,各组小鼠体质量及其增长率均无显著差异;文冠果油组小鼠跳台试验、避暗试验、水迷宫试验均为阳性;文冠果油高剂量组小鼠海马和大脑皮质组织匀桨中5-HT、ACh、NE、DA含量明显升高,AChE活性明显降低。综上,文冠果油具有改善小鼠记忆的功能,且是通过改善单胺类神经递质和胆碱能神经递质的代谢发挥作用的。 展开更多
关键词 文冠果油 神经酸 记忆能力 跳台试验 避暗试验 水迷宫试验
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塔河油田良里塔格组迷宫型岩溶洞穴系统发育特征
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作者 张长建 蒋林 +2 位作者 汪彦 曾清勇 马雪健 《新疆石油地质》 CAS CSCD 北大核心 2024年第5期522-532,共11页
为了明确塔河油田上奥陶统良里塔格组迷宫型岩溶洞穴系统的样式和结构,利用古地貌恢复、古水系刻画、测井地层对比、构造断裂解析、地震属性刻画等方法,进行了塔河油田11区的古水文地貌恢复、岩溶层组格架构建、岩溶洞穴识别和成因模式... 为了明确塔河油田上奥陶统良里塔格组迷宫型岩溶洞穴系统的样式和结构,利用古地貌恢复、古水系刻画、测井地层对比、构造断裂解析、地震属性刻画等方法,进行了塔河油田11区的古水文地貌恢复、岩溶层组格架构建、岩溶洞穴识别和成因模式分析。结果表明:塔河油田南部加里东运动中期Ⅱ幕古地貌西北高、东南低,发育北北西—南南东向树枝状地表深切沟谷,良里塔格组发育近水平状分布、闭合管道结构及溶蚀强度较高的迷宫型岩溶洞穴系统;良里塔格组岩溶洞穴系统与澳大利亚Judbarra地区Bullita洞穴系统成因相似,属于典型的表生岩溶扩散下渗型迷宫型岩溶洞穴系统;上奥陶统恰尔巴克组泥岩段为隔水层,控制了良里塔格组迷宫型岩溶洞穴系统的侧向溶蚀作用;沟通地表水系的断裂为岩溶水主要下渗溶蚀通道,随着区域基准面下降,岩溶水沿断裂下渗进入中奥陶统,中奥陶统一间房组形成断溶体。塔河油田加里东运动中期Ⅱ幕表生岩溶“双层”迷宫型岩溶洞穴系统的认识对上奥陶统油藏开发具有重要意义。 展开更多
关键词 塔河油田 奥陶系 加里东运动中期 迷宫型岩溶洞穴系统 断溶体 古地貌 古水系
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左旋精氨酸和氯化胆碱改善Aβ1-42诱导的痴呆大鼠学习记忆能力
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作者 刘丽霞 王浩玉 祁文秀 《神经解剖学杂志》 CAS CSCD 北大核心 2024年第3期327-333,共7页
目的:探讨中枢神经元型一氧化氮合酶(nNOS)和α7烟碱型乙酰胆碱受体(α7nAChR)在大鼠前额叶皮质和海马的表达变化以及对Aβ诱导的痴呆大鼠行为学的影响。方法:40只成年雄性SD大鼠均经侧脑室注射凝集态Aβ1-42制备痴呆模型,药物处理组分... 目的:探讨中枢神经元型一氧化氮合酶(nNOS)和α7烟碱型乙酰胆碱受体(α7nAChR)在大鼠前额叶皮质和海马的表达变化以及对Aβ诱导的痴呆大鼠行为学的影响。方法:40只成年雄性SD大鼠均经侧脑室注射凝集态Aβ1-42制备痴呆模型,药物处理组分别注射一氧化氮(NO)前体左旋精氨酸(L-Arg)和(或)α7nAChR激动剂氯化胆碱(CC)。通过Y迷宫实验检测大鼠的空间学习和记忆功能,用免疫组织化学染色、Western Blot检测大鼠前额叶皮质和海马nNOS或α7nAChR的表达。结果:Aβ+L-Arg组或Aβ+CC组与Aβ+NS组比较,大鼠学习和记忆达标次数均减少(P<0.05或P<0.01),同时前额叶皮质和海马nNOS和α7nAChR表达均增加(P<0.05或P<0.01);与Aβ+L-Arg组或Aβ+CC组比较,联合用药的Aβ+L-Arg+CC组大鼠前额叶皮质和海马nNOS和α7nAChR表达水平均升高(P<0.05或P<0.01),同时学习和记忆达标次数均减少(P<0.05或P<0.01)。结论:侧脑室联合注入L-Arg和CC可明显提高二者在单独应用时对痴呆大鼠nNOS和α7nAChR表达的上调作用及认知功能障碍的改善效果。推测,中枢nNOS与烟碱系统的协同作用更有利于提高痴呆大鼠的认知功能。 展开更多
关键词 阿尔茨海默病 神经元型一氧化氮合酶 Α7烟碱型乙酰胆碱受体 Y-迷宫 学习和记忆 大鼠
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陈皮提取物对APP/PS-1双转基因阿尔茨海默病小鼠学习记忆功能的影响
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作者 颜仁梁 李威 《福建医药杂志》 CAS 2024年第3期107-110,共4页
目的探讨陈皮提取物对APP/PS-1双转基因阿尔茨海默病(AD)小鼠学习记忆功能的影响.方法选用APP/PS-1双转基因AD小鼠16只,随机分为模型对照组和供试品组,8只/组,另取8只C57小鼠为正常对照组,正常对照组和模型对照组分别灌胃等量的生理盐水... 目的探讨陈皮提取物对APP/PS-1双转基因阿尔茨海默病(AD)小鼠学习记忆功能的影响.方法选用APP/PS-1双转基因AD小鼠16只,随机分为模型对照组和供试品组,8只/组,另取8只C57小鼠为正常对照组,正常对照组和模型对照组分别灌胃等量的生理盐水,供试品组灌胃陈皮提取物的生理盐水溶解液,灌胃体积为10mL/kg,1次/d,连续18d.第11天到第16天,进行Morris水迷宫的定位航行实验及空间探索实验.第17天到第18天,进行5min避暗实验.结果在Morris水迷宫实验中,与正常对照组比较,模型对照组定位航行第2天、第3天、第5天的潜伏期增加(P<0.05);与模型对照组比较,供试品组第5天的潜伏期降低(P<0.05).空间探索阶段,各组的目标象限路程百分比、时间百分比及站台穿越次数差异无统计学意义(P>0.05).在避暗实验中各组的错误潜伏期、错误次数及错误率差异均无统计学意义(P>0.05).结论陈皮提取物对APP/PS-1双转基因AD小鼠的空间学习、记忆能力有一定的改善作用. 展开更多
关键词 陈皮提取物 APP/PS-1双转基因AD小鼠 MORRIS水迷宫实验 避暗实验
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nNOS-CAPON偶联抑制剂的合成及抗焦虑研究
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作者 顾莉洁 《化学试剂》 CAS 2024年第10期99-104,共6页
合成nNOS-CAPON偶联抑制剂并评价其抗焦虑作用。根据nNOS-CPAON蛋白结构域配体结合部位的结构特点设计并合成了一系列缬氨酸类化合物,通过评价化合物抑制nNOS-CAPON蛋白相互作用(PPI)的活性来筛选化合物,并通过高架十字迷宫实验验证其... 合成nNOS-CAPON偶联抑制剂并评价其抗焦虑作用。根据nNOS-CPAON蛋白结构域配体结合部位的结构特点设计并合成了一系列缬氨酸类化合物,通过评价化合物抑制nNOS-CAPON蛋白相互作用(PPI)的活性来筛选化合物,并通过高架十字迷宫实验验证其抗焦虑作用。设计并合成了两个系列共15个化合物,其中N-8具有较好的PPI抑制作用,且在高架十字迷宫实验中显著增加小鼠在开臂的停留时间,具有较强的抗焦虑作用。研究丰富了nNOS-CAPON偶联抑制剂的结构类型,并验证了该类型化合物的抗焦虑作用。 展开更多
关键词 nNOS-CAPON偶联抑制剂 抗焦虑 缬氨酸类化合物 PPI抑制作用 高架十字迷宫实验
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紫斑牡丹花粉对D-半乳糖致衰老模型小鼠的影响 被引量:1
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作者 彭腾腾 王信 +3 位作者 李海燕 尹盼盼 范彬 石晓峰 《中国药理学通报》 CAS CSCD 北大核心 2024年第4期730-739,共10页
目的探究紫斑牡丹花粉对D-半乳糖致衰老小鼠学习记忆力及氧化应激损伤的影响。方法60只C57BL/6小鼠随机分为空白组、模型组、阳性组、紫斑牡丹花粉组(750、1500、3000 mg·kg^(-1)),采用颈背部皮下注射D-半乳糖(500 mg·kg^(-1... 目的探究紫斑牡丹花粉对D-半乳糖致衰老小鼠学习记忆力及氧化应激损伤的影响。方法60只C57BL/6小鼠随机分为空白组、模型组、阳性组、紫斑牡丹花粉组(750、1500、3000 mg·kg^(-1)),采用颈背部皮下注射D-半乳糖(500 mg·kg^(-1)),制备亚急性衰老模型。Morris水迷宫评估小鼠学习记忆力;HE、DAPI染色评估肝、脑组织细胞损伤情况;ELISA法检测小鼠血清、肝脑组织内MDA、T-AOC、GSH-Px、SOD、CAT及γ-H2AX、SA-β-Gal水平。结果水迷宫实验结果表明,紫斑牡丹花粉能明显提高衰老小鼠的学习记忆力。组织染色结果表明,紫斑牡丹花粉对D-半乳糖致衰老小鼠肝脑组织细胞损伤具有保护作用,且高剂量组作用最为明显。ELISA结果显示,与模型组比较,紫斑牡丹花粉各剂量组的MDA、γ-H2AX、SA-β-Gal水平降低,T-AOC、GSH-Px、SOD、CAT水平升高。结论紫斑牡丹花粉能改善D-半乳糖致衰老模型小鼠的学习记忆力,提高衰老小鼠体内抗氧化酶活性和清除自由基、脂质过氧化物的能力,保护肝脑脏器组织细胞免受氧化损伤,提示其具有潜在的延缓衰老的作用。 展开更多
关键词 紫斑牡丹花粉 D-半乳糖 氧化应激 抗衰老 MORRIS水迷宫 HE染色 DAPI染色
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