Bipolar disorder presents significant challenges in clinical management, characterized by recurrent episodes of depression and mania often accompanied by impairment in functioning. This study investigates the efficacy...Bipolar disorder presents significant challenges in clinical management, characterized by recurrent episodes of depression and mania often accompanied by impairment in functioning. This study investigates the efficacy of pharmacological interventions and rehabilitation strategies to improve patient outcomes and quality of life. Utilizing a randomized controlled trial with multiple treatment arms, participants will receive pharmacotherapy, polypharmacotherapy, rehabilitation interventions, or combination treatments. Outcome measures will be assessed using standardized scales, including the Hamilton Depression Scale, Yale-Brown Obsessive Compulsive Scale (Y-BOCS), and Mania Scale. Preliminary data suggest improvements in symptom severity and functional outcomes with combination treatments. This research aims to inform clinical practice, guide treatment decisions, and ultimately enhance the quality of care for individuals living with bipolar disorder. Findings will be disseminated through peer-reviewed journals and scientific conferences to advance knowledge in this field.展开更多
Objective:To evaluate the reliability and validity of the MSCPOR used in China.Methods:45 subjects with OCD,35 subjects with phobias and 35 subjects with anxiety were selected as patient group,and 44 healthy persons w...Objective:To evaluate the reliability and validity of the MSCPOR used in China.Methods:45 subjects with OCD,35 subjects with phobias and 35 subjects with anxiety were selected as patient group,and 44 healthy persons were selected as control group.All subjects were rated according to the Chinese version of the MSCPOR,the Yale-Brown Obsessive Compulsive Scale(Y-BOCS)and the Hamilton Anxiety Scale(HAMA).Two or three weeks after the first rating,16 health persons were re=rated by MSCPOR;12 patients were re-rated with MSCPOR,Y-BOCS and HAMA.15 subjects were rated with MSCPOR and scored by two independent raters at the same time.Results:Test-retest reliability was 0.72～0.99;the homogeneity reliability(Chronbach’s α )in the OCD group were 0.82～0.88 and in phobias group 0.78～0.82;Spearman correlation coefficients were 0.35～0.94 in OCD group and 0.30～0.84 in phobias group;the inter-rater reliability(kappa index) were 0.53～1.For validity,correlation coefficients( γ )among different dimension of MSCPOR in OCD group was 0.36～0.92 and 0.10～0.80 in phobias group.Spearman correlation coefficients between MSCPOR vs Y-BOCS scores and MSCPOR vs HAMA were 0.62 and 0.41～0.44.The results of discriminate analysis showed that diagnosis error for MSCPOR was 40.1%.Conclusion:The reliability and validity of MSCPOR used in China were satisfactory;MSCPOR isn’t a suitable instrument for diagnosis but good for symptom assessment.展开更多
基金supported by grants from National Natural Science Foundation of China(81171280)Biomedical Engineering Cross Research Foundation of Shanghai Jiao Tong University(YG2013MS65)
文摘Bipolar disorder presents significant challenges in clinical management, characterized by recurrent episodes of depression and mania often accompanied by impairment in functioning. This study investigates the efficacy of pharmacological interventions and rehabilitation strategies to improve patient outcomes and quality of life. Utilizing a randomized controlled trial with multiple treatment arms, participants will receive pharmacotherapy, polypharmacotherapy, rehabilitation interventions, or combination treatments. Outcome measures will be assessed using standardized scales, including the Hamilton Depression Scale, Yale-Brown Obsessive Compulsive Scale (Y-BOCS), and Mania Scale. Preliminary data suggest improvements in symptom severity and functional outcomes with combination treatments. This research aims to inform clinical practice, guide treatment decisions, and ultimately enhance the quality of care for individuals living with bipolar disorder. Findings will be disseminated through peer-reviewed journals and scientific conferences to advance knowledge in this field.
文摘Objective:To evaluate the reliability and validity of the MSCPOR used in China.Methods:45 subjects with OCD,35 subjects with phobias and 35 subjects with anxiety were selected as patient group,and 44 healthy persons were selected as control group.All subjects were rated according to the Chinese version of the MSCPOR,the Yale-Brown Obsessive Compulsive Scale(Y-BOCS)and the Hamilton Anxiety Scale(HAMA).Two or three weeks after the first rating,16 health persons were re=rated by MSCPOR;12 patients were re-rated with MSCPOR,Y-BOCS and HAMA.15 subjects were rated with MSCPOR and scored by two independent raters at the same time.Results:Test-retest reliability was 0.72～0.99;the homogeneity reliability(Chronbach’s α )in the OCD group were 0.82～0.88 and in phobias group 0.78～0.82;Spearman correlation coefficients were 0.35～0.94 in OCD group and 0.30～0.84 in phobias group;the inter-rater reliability(kappa index) were 0.53～1.For validity,correlation coefficients( γ )among different dimension of MSCPOR in OCD group was 0.36～0.92 and 0.10～0.80 in phobias group.Spearman correlation coefficients between MSCPOR vs Y-BOCS scores and MSCPOR vs HAMA were 0.62 and 0.41～0.44.The results of discriminate analysis showed that diagnosis error for MSCPOR was 40.1%.Conclusion:The reliability and validity of MSCPOR used in China were satisfactory;MSCPOR isn’t a suitable instrument for diagnosis but good for symptom assessment.
