Introduction: Indicators of maternal health are often used to evaluate the social development and overall health of a population, as well as the accessibility of health services. Among these indicators, the Potential ...Introduction: Indicators of maternal health are often used to evaluate the social development and overall health of a population, as well as the accessibility of health services. Among these indicators, the Potential Years of Life Lost, which is associated with maternal deaths, is useful for the definition of priorities, monitoring, evaluation, and intervention, identifying the highest risk groups. Objective: To analyze the Potential Years of Life Lost by maternal death in Santa Catarina in 2000 and 2014. Method: An Ecological study with exploratory spatial analysis was conducted with data obtained from the Information System on Mortality and Live Births. Results: In the Information System, 35 maternal deaths in the year 2000 were identified and 24 in 2014. The total estimated years of life lost were 845 years in 2000 and 780 years in 2014, dominated by direct obstetric causes. In 2000, women who died lost, on average, 39.8 years of life;and 41.5 years in 2014. Conclusion: The spatial pattern observed in 2000 highlights areas of high risk in different regions of Santa Catarina. The greatest loss of years occurred in younger women, confirming the need to prevent and control maternal mortality and review strategies for compliance with public policies in the State.展开更多
The magnitude of the overall prevalence and racial disparity in induced abortion suggests that it is a major influence on the demographic and socioeconomic composition of the population of the United States (US). Howe...The magnitude of the overall prevalence and racial disparity in induced abortion suggests that it is a major influence on the demographic and socioeconomic composition of the population of the United States (US). However, the years of potential lives averted by induced abortion have not been systematically studied. We applied race-specific intra-uterine death estimates to the induced abortions occurring to non-Hispanic (NH) white and non-Hispanic (NH) black women in the US state of North Carolina in 2008. The resultant estimate of births averted by induced abortion was used to project years of potential life lost. All-cause detailed mortality data were used to compare induced abortion with other contributing causes of years of potential life lost before age 75 (YPLL 75). For NH whites, induced abortions in 2008 contributed 59% of total YPLL 75, and 1.5 times the total YPLL 75 from all other causes combined. For NH blacks, induced abortions in 2008 contributed 76% of total YPLL 75 and 3.2 times the total YPLL 75 from all other causes combined. Induced abortion is the overwhelmingly predominant contributing cause of preventable potential lives lost in the North Carolina population, and NH blacks are disproportionately affected.展开更多
目的分析江西省死因监测地区居民肝癌死亡水平及其疾病负担情况,为针对性开展肝癌防控措施提供建议。方法利用2014—2021年江西省20个国家级死因监测地区报告的居民肝癌死亡数据,计算肝癌死亡率、标化死亡率、年龄别死亡率、早死所致的...目的分析江西省死因监测地区居民肝癌死亡水平及其疾病负担情况,为针对性开展肝癌防控措施提供建议。方法利用2014—2021年江西省20个国家级死因监测地区报告的居民肝癌死亡数据,计算肝癌死亡率、标化死亡率、年龄别死亡率、早死所致的寿命损失年(years of life lost,YLL)率、平均寿命损失年(average years of life lost,AYLL)等指标,2014—2021年趋势分析采用平均年度变化百分比(average annual percent change,AAPC)表示。结果2014—2021年,江西省死因监测地区肝癌死亡率为21.41/10万,标化死亡率为20.01/10万,男性死亡率高于女性,农村死亡率高于城市(P<0.05)。肝癌年龄别死亡率随年龄增长而上升,死亡率从30岁开始快速上升。2014—2021年男性、女性、农村居民死亡率AAPC分别为2.60%、5.58%、3.55%(P<0.05);城市居民死亡率、各人群标化死亡率变化趋势均无统计学意义(P>0.05)。男性、女性、城市、农村居民AYLL的AAPC分别为-1.75%、-2.88%、-2.46%、-1.94%(P<0.05);女性YLL率呈上升趋势(AAPC=2.56%,P<0.05)。结论江西省肝癌死亡水平较高,但早死导致的疾病负担有下降趋势,男性与农村居民是肝癌防控的重点人群。展开更多
Background The rise in suicides among children aged 10–14 years demands urgent attention globally.This study aims to assess the global burden of suicide-related deaths in this age group from 1990 to 2019,considering ...Background The rise in suicides among children aged 10–14 years demands urgent attention globally.This study aims to assess the global burden of suicide-related deaths in this age group from 1990 to 2019,considering factors such as sex,geography,and sociodemographics,to inform prevention strategies and interventions.Methods The data from Global Burden of Disease 2019,encompassing 204 countries and territories,were analyzed to investigate deaths and years of life lost(YLLs)due to suicide among children aged 10–14 years.Statistical analyses,including mortality rates,YLLs,and the sociodemographic index(SDI),were conducted using standardized tools.Results In 2019,a total of 8327[95%uncertainty interval(UI)=7073–9685]children aged 10–14 years died globally due to suicide,with a mortality rate of 1.30(95%UI=1.10–1.51)per 100,000.The rates varied across countries/territories ranging between 0.05(95%UI=0.02–0.10)in South Africa and 7.49(95%UI=5.13–10.57)in Greenland.The contribution of suicide-related deaths to all-cause mortality ranged from 0.07%(95%UI=0.04%–0.15%)in South Africa to 33.02%(95%UI=24.36%–41.53%)in Greenland.Worldwide,there were approximately 636,196(95%UI=540,383–740,009)YLLs due to suicide,with a rate of 99.07(95%UI=84.15–115.23)per 100,000.The association between SDI and suicide-related deaths was evident,with higher contributions observed in countries with higher SDI.Conclusions This study reveals a concerning global burden of suicide-related deaths among children aged 10–14 years.Despite progress in reducing mortality rates,suicide remains a significant issue.While overall rates have declined,the percentage of deaths caused by suicide in this age group is increasing.展开更多
Background:Colorectal cancer(CRC)is the fourth cause of cancer death in China.We aimed to provide national and subnational estimates and changes of CRC premature mortality burden during 2005–2020.Methods:Data from mu...Background:Colorectal cancer(CRC)is the fourth cause of cancer death in China.We aimed to provide national and subnational estimates and changes of CRC premature mortality burden during 2005–2020.Methods:Data from multi-source on the basis of the national surveillance mortality system were used to estimate mortality and years of life lost(YLL)of CRC in the Chinese population during 2005–2020.Estimates were generated and compared for 31 provincial-level administrative divisions in China.Results:Estimated CRC deaths increased from 111.41 thousand in 2005 to 178.02 thousand in 2020;age-standardized mortality rate decreased from 10.01 per 100,000 in 2005 to 9.68 per 100,000 in 2020.Substantial reduction in CRC premature mortality burden,as measured by age-standardized YLL rate,was observed with a reduction of 10.20%nationwide.Marked differences were observed in the geographical patterns of provincial units,and they appeared to be obvious in areas with higher economic development.Population aging was the dominant driver which contributed to the increase in CRC deaths,followed by population growth and age-specific mortality change.Conclusions:Substantial discrepancies were observed in the premature mortality burden of CRC across China.Targeted considerations were needed to promote a healthy lifestyle,expand cost-effective CRC early screening and diagnosis,and improve medical treatment to reduce CRC mortality among high-risk populations and regions with inadequate healthcare resources.展开更多
Purpose: Traffic injuries are among the leading causes of mortality and morbidity worldwide. Pedestrians have been considered as a high-risk group among road users, especially in middle- or low-income communities. Th...Purpose: Traffic injuries are among the leading causes of mortality and morbidity worldwide. Pedestrians have been considered as a high-risk group among road users, especially in middle- or low-income communities. This study attempted to determine the burden of pedestrians' fatalities in Fars, the southern province of Iran using years of life lost (YLL) approach. Methods: The data used in this study were retrieved from Fars Forensic Medicine Organization database on pedestrian traffic accidents. The YLL from 2009 to 2013 was estimated using the method presented by World Health organization. Some epidemiological characteristics of pedestrians' fatalities were analyzed by SPSS. Results: Although YLL among 1000 male pedestrians decreased from 2.5 in 2009 to 1.5 in 2013, it increased from 0.9 to 2.1 among 1000 females during the same period. Higher proportion of death was found in female, illiterate, and married pedestrians {p 〈 0.001 ). In addition, mortality was higher in pedestrians living the cities, during daytime, at home, and in hospitals (p 〈 0.001 ). Conclusion: Consistent with the global trends, burden of pedestrian accidents in Fats was also excep- tionally high. Considering the national and cultural aspects of different countries, improving the safety of pedestrians demands a multi-dimensional approach with interventional factors concerning policies, rules, pedestrians, motor vehicles and environmental conditions taken into consideration.展开更多
Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and q...Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics.展开更多
目的分析2007-2019年南京市胃癌死亡率及早死寿命损失年(Years of life lost,YLL)变化趋势。方法利用南京市居民全死因监测系统,收集2007年1月1日-2019年12月31日南京市户籍居民胃癌死亡病例。计算胃癌的死亡率、标化死亡率、YLL和YLL率...目的分析2007-2019年南京市胃癌死亡率及早死寿命损失年(Years of life lost,YLL)变化趋势。方法利用南京市居民全死因监测系统,收集2007年1月1日-2019年12月31日南京市户籍居民胃癌死亡病例。计算胃癌的死亡率、标化死亡率、YLL和YLL率;采用Joinpoint回归分析胃癌死亡率和YLL率的变化趋势,计算平均年度变化百分比(Average annual percentage change,AAPC)。结果2007-2019年南京市胃癌死亡共32187例,其中男性死亡22296例,女性死亡9891例,男性死亡率高于女性(52.64/10万vs.23.61/10万),差异有统计学意义(u=2.281,P<0.05);城市地区居民因胃癌死亡10591例,农村地区居民死亡21596例,城区地区居民胃癌死亡率低于农村地区居民(26.02/10万vs.49.56/10万),差异有统计学意义(u=55.257,P<0.05)。南京市胃癌年龄别死亡率随着年龄的增加而上升,在40岁之前较低,40岁后开始上升,男性至80岁达最高之后下降,女性至85岁达到最高峰。2007-2019年南京市胃癌死亡率、标化死亡率均呈下降趋势(死亡率AAPC为-2.65%,标化死亡率AAPC为-7.69%,P<0.05)。2007-2019年南京市因胃癌导致的YLL合计为681511人年,YLL率为8.09‰,2007-2019年南京市YLL率呈下降趋势(AAPC为-3.86%,P<0.05),YLL率均随年龄的增加而上升(AAPC为52.43%,P<0.05),且男性增长速度快于女性(男性AAPC为54.90%,女性AAPC为49.70%,P<0.05)。结论南京市胃癌死亡有明显的性别、年龄和城乡分布差异,可根据高危人群特征逐步推进南京市胃癌早诊早治工作,提高胃癌患者生活质量,减轻个人和社会的癌症负担。展开更多
目的了解2019年中国乙型肝炎的疾病负担情况并对2020—2030年乙型肝炎的疾病负担发展趋势进行预测。方法在2019全球疾病负担研究数据库(Global Burden of Disease 2019,GBD 2019)中下载中国乙型肝炎数据。利用患病率、发病率、死亡率、...目的了解2019年中国乙型肝炎的疾病负担情况并对2020—2030年乙型肝炎的疾病负担发展趋势进行预测。方法在2019全球疾病负担研究数据库(Global Burden of Disease 2019,GBD 2019)中下载中国乙型肝炎数据。利用患病率、发病率、死亡率、伤残调整寿命年(disability-adjusted life year,DALY)、早死损失寿命年(years of life lost,YLL)、伤残损失寿命年(years lived with disability,YLD)及年龄标化率等指标描述2019年中国乙型肝炎的疾病负担情况,利用估计年百分比变化(estimated annual percentage change,EAPC)描述中国乙型肝炎疾病负担1990—2019年的变化趋势。采用R4.2.1构建贝叶斯年龄-时期-队列模型对2020—2030年中国乙型肝炎总体发病、死亡、DALY和YLD情况进行预测。结果1990—2019年中国乙型肝炎的总体疾病负担呈下降趋势,中国乙型肝炎的总体标化患病率为6566.1/10万、标化发病率为1397.3/10万、标化死亡率为8.1/10万、标化DALY率为247.7/10万、标化YLL率为241.5/10万、标化YLD率为6.2/10万,与1990年相比分别下降2.34%、2.35%、4.92%、5.15%、5.20%、2.71%。女性居民的疾病负担指标均低于同时期的男性居民。乙型肝炎的患病率在20~24岁最高,发病率在25~29岁最高,死亡率随着年龄增长而升高。根据贝叶斯模型预测,2020—2030年中国乙型肝炎发病人数约为1486.56万人,死亡人数约为11.18万人,DALY约为634.9万人年,YLD约为12.1万人年。结论尽管在1990—2019年之间中国乙型肝炎疾病负担呈下降趋势,但在2030年消除乙型肝炎病毒这一公共威胁的目标仍然面临挑战。因此,有必要扩大诊断覆盖范围、减轻患者经济负担,进一步推进健康中国建设。展开更多
基金financed in part by the Coordenacao de Aperfeicoamento de Pessoal de Nível Superior-Brasil(CAPES)-Finance Code 001.
文摘Introduction: Indicators of maternal health are often used to evaluate the social development and overall health of a population, as well as the accessibility of health services. Among these indicators, the Potential Years of Life Lost, which is associated with maternal deaths, is useful for the definition of priorities, monitoring, evaluation, and intervention, identifying the highest risk groups. Objective: To analyze the Potential Years of Life Lost by maternal death in Santa Catarina in 2000 and 2014. Method: An Ecological study with exploratory spatial analysis was conducted with data obtained from the Information System on Mortality and Live Births. Results: In the Information System, 35 maternal deaths in the year 2000 were identified and 24 in 2014. The total estimated years of life lost were 845 years in 2000 and 780 years in 2014, dominated by direct obstetric causes. In 2000, women who died lost, on average, 39.8 years of life;and 41.5 years in 2014. Conclusion: The spatial pattern observed in 2000 highlights areas of high risk in different regions of Santa Catarina. The greatest loss of years occurred in younger women, confirming the need to prevent and control maternal mortality and review strategies for compliance with public policies in the State.
文摘The magnitude of the overall prevalence and racial disparity in induced abortion suggests that it is a major influence on the demographic and socioeconomic composition of the population of the United States (US). However, the years of potential lives averted by induced abortion have not been systematically studied. We applied race-specific intra-uterine death estimates to the induced abortions occurring to non-Hispanic (NH) white and non-Hispanic (NH) black women in the US state of North Carolina in 2008. The resultant estimate of births averted by induced abortion was used to project years of potential life lost. All-cause detailed mortality data were used to compare induced abortion with other contributing causes of years of potential life lost before age 75 (YPLL 75). For NH whites, induced abortions in 2008 contributed 59% of total YPLL 75, and 1.5 times the total YPLL 75 from all other causes combined. For NH blacks, induced abortions in 2008 contributed 76% of total YPLL 75 and 3.2 times the total YPLL 75 from all other causes combined. Induced abortion is the overwhelmingly predominant contributing cause of preventable potential lives lost in the North Carolina population, and NH blacks are disproportionately affected.
文摘目的分析江西省死因监测地区居民肝癌死亡水平及其疾病负担情况,为针对性开展肝癌防控措施提供建议。方法利用2014—2021年江西省20个国家级死因监测地区报告的居民肝癌死亡数据,计算肝癌死亡率、标化死亡率、年龄别死亡率、早死所致的寿命损失年(years of life lost,YLL)率、平均寿命损失年(average years of life lost,AYLL)等指标,2014—2021年趋势分析采用平均年度变化百分比(average annual percent change,AAPC)表示。结果2014—2021年,江西省死因监测地区肝癌死亡率为21.41/10万,标化死亡率为20.01/10万,男性死亡率高于女性,农村死亡率高于城市(P<0.05)。肝癌年龄别死亡率随年龄增长而上升,死亡率从30岁开始快速上升。2014—2021年男性、女性、农村居民死亡率AAPC分别为2.60%、5.58%、3.55%(P<0.05);城市居民死亡率、各人群标化死亡率变化趋势均无统计学意义(P>0.05)。男性、女性、城市、农村居民AYLL的AAPC分别为-1.75%、-2.88%、-2.46%、-1.94%(P<0.05);女性YLL率呈上升趋势(AAPC=2.56%,P<0.05)。结论江西省肝癌死亡水平较高,但早死导致的疾病负担有下降趋势,男性与农村居民是肝癌防控的重点人群。
基金This research received no specific grants from any funding agency in the public,commercial,or not-for-profit sectors.
文摘Background The rise in suicides among children aged 10–14 years demands urgent attention globally.This study aims to assess the global burden of suicide-related deaths in this age group from 1990 to 2019,considering factors such as sex,geography,and sociodemographics,to inform prevention strategies and interventions.Methods The data from Global Burden of Disease 2019,encompassing 204 countries and territories,were analyzed to investigate deaths and years of life lost(YLLs)due to suicide among children aged 10–14 years.Statistical analyses,including mortality rates,YLLs,and the sociodemographic index(SDI),were conducted using standardized tools.Results In 2019,a total of 8327[95%uncertainty interval(UI)=7073–9685]children aged 10–14 years died globally due to suicide,with a mortality rate of 1.30(95%UI=1.10–1.51)per 100,000.The rates varied across countries/territories ranging between 0.05(95%UI=0.02–0.10)in South Africa and 7.49(95%UI=5.13–10.57)in Greenland.The contribution of suicide-related deaths to all-cause mortality ranged from 0.07%(95%UI=0.04%–0.15%)in South Africa to 33.02%(95%UI=24.36%–41.53%)in Greenland.Worldwide,there were approximately 636,196(95%UI=540,383–740,009)YLLs due to suicide,with a rate of 99.07(95%UI=84.15–115.23)per 100,000.The association between SDI and suicide-related deaths was evident,with higher contributions observed in countries with higher SDI.Conclusions This study reveals a concerning global burden of suicide-related deaths among children aged 10–14 years.Despite progress in reducing mortality rates,suicide remains a significant issue.While overall rates have declined,the percentage of deaths caused by suicide in this age group is increasing.
基金the National Key Research&Development Program of the Ministry of Science and Technology of the People’s Republic of China(No.2018YFC1315301)Taikang Yicai Public Health and Epidemic Control Fund.
文摘Background:Colorectal cancer(CRC)is the fourth cause of cancer death in China.We aimed to provide national and subnational estimates and changes of CRC premature mortality burden during 2005–2020.Methods:Data from multi-source on the basis of the national surveillance mortality system were used to estimate mortality and years of life lost(YLL)of CRC in the Chinese population during 2005–2020.Estimates were generated and compared for 31 provincial-level administrative divisions in China.Results:Estimated CRC deaths increased from 111.41 thousand in 2005 to 178.02 thousand in 2020;age-standardized mortality rate decreased from 10.01 per 100,000 in 2005 to 9.68 per 100,000 in 2020.Substantial reduction in CRC premature mortality burden,as measured by age-standardized YLL rate,was observed with a reduction of 10.20%nationwide.Marked differences were observed in the geographical patterns of provincial units,and they appeared to be obvious in areas with higher economic development.Population aging was the dominant driver which contributed to the increase in CRC deaths,followed by population growth and age-specific mortality change.Conclusions:Substantial discrepancies were observed in the premature mortality burden of CRC across China.Targeted considerations were needed to promote a healthy lifestyle,expand cost-effective CRC early screening and diagnosis,and improve medical treatment to reduce CRC mortality among high-risk populations and regions with inadequate healthcare resources.
文摘Purpose: Traffic injuries are among the leading causes of mortality and morbidity worldwide. Pedestrians have been considered as a high-risk group among road users, especially in middle- or low-income communities. This study attempted to determine the burden of pedestrians' fatalities in Fars, the southern province of Iran using years of life lost (YLL) approach. Methods: The data used in this study were retrieved from Fars Forensic Medicine Organization database on pedestrian traffic accidents. The YLL from 2009 to 2013 was estimated using the method presented by World Health organization. Some epidemiological characteristics of pedestrians' fatalities were analyzed by SPSS. Results: Although YLL among 1000 male pedestrians decreased from 2.5 in 2009 to 1.5 in 2013, it increased from 0.9 to 2.1 among 1000 females during the same period. Higher proportion of death was found in female, illiterate, and married pedestrians {p 〈 0.001 ). In addition, mortality was higher in pedestrians living the cities, during daytime, at home, and in hospitals (p 〈 0.001 ). Conclusion: Consistent with the global trends, burden of pedestrian accidents in Fats was also excep- tionally high. Considering the national and cultural aspects of different countries, improving the safety of pedestrians demands a multi-dimensional approach with interventional factors concerning policies, rules, pedestrians, motor vehicles and environmental conditions taken into consideration.
基金We thank Professor Antonio Gasparrini for providing assistance during statistical analysis.This work was supported by the National Key Research and Development Program of China(2018YFA0606200)Guangzhou Science and Technology Project(201704020194)+3 种基金and the Guangdong Health Innovation Platform.The funders were not involved in the research and preparation of the article,including study designcollection,analysis,and interpretation of datawriting of the articleand the decision to submit it for publication.
文摘Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics.
文摘目的分析2007-2019年南京市胃癌死亡率及早死寿命损失年(Years of life lost,YLL)变化趋势。方法利用南京市居民全死因监测系统,收集2007年1月1日-2019年12月31日南京市户籍居民胃癌死亡病例。计算胃癌的死亡率、标化死亡率、YLL和YLL率;采用Joinpoint回归分析胃癌死亡率和YLL率的变化趋势,计算平均年度变化百分比(Average annual percentage change,AAPC)。结果2007-2019年南京市胃癌死亡共32187例,其中男性死亡22296例,女性死亡9891例,男性死亡率高于女性(52.64/10万vs.23.61/10万),差异有统计学意义(u=2.281,P<0.05);城市地区居民因胃癌死亡10591例,农村地区居民死亡21596例,城区地区居民胃癌死亡率低于农村地区居民(26.02/10万vs.49.56/10万),差异有统计学意义(u=55.257,P<0.05)。南京市胃癌年龄别死亡率随着年龄的增加而上升,在40岁之前较低,40岁后开始上升,男性至80岁达最高之后下降,女性至85岁达到最高峰。2007-2019年南京市胃癌死亡率、标化死亡率均呈下降趋势(死亡率AAPC为-2.65%,标化死亡率AAPC为-7.69%,P<0.05)。2007-2019年南京市因胃癌导致的YLL合计为681511人年,YLL率为8.09‰,2007-2019年南京市YLL率呈下降趋势(AAPC为-3.86%,P<0.05),YLL率均随年龄的增加而上升(AAPC为52.43%,P<0.05),且男性增长速度快于女性(男性AAPC为54.90%,女性AAPC为49.70%,P<0.05)。结论南京市胃癌死亡有明显的性别、年龄和城乡分布差异,可根据高危人群特征逐步推进南京市胃癌早诊早治工作,提高胃癌患者生活质量,减轻个人和社会的癌症负担。
文摘目的了解2019年中国乙型肝炎的疾病负担情况并对2020—2030年乙型肝炎的疾病负担发展趋势进行预测。方法在2019全球疾病负担研究数据库(Global Burden of Disease 2019,GBD 2019)中下载中国乙型肝炎数据。利用患病率、发病率、死亡率、伤残调整寿命年(disability-adjusted life year,DALY)、早死损失寿命年(years of life lost,YLL)、伤残损失寿命年(years lived with disability,YLD)及年龄标化率等指标描述2019年中国乙型肝炎的疾病负担情况,利用估计年百分比变化(estimated annual percentage change,EAPC)描述中国乙型肝炎疾病负担1990—2019年的变化趋势。采用R4.2.1构建贝叶斯年龄-时期-队列模型对2020—2030年中国乙型肝炎总体发病、死亡、DALY和YLD情况进行预测。结果1990—2019年中国乙型肝炎的总体疾病负担呈下降趋势,中国乙型肝炎的总体标化患病率为6566.1/10万、标化发病率为1397.3/10万、标化死亡率为8.1/10万、标化DALY率为247.7/10万、标化YLL率为241.5/10万、标化YLD率为6.2/10万,与1990年相比分别下降2.34%、2.35%、4.92%、5.15%、5.20%、2.71%。女性居民的疾病负担指标均低于同时期的男性居民。乙型肝炎的患病率在20~24岁最高,发病率在25~29岁最高,死亡率随着年龄增长而升高。根据贝叶斯模型预测,2020—2030年中国乙型肝炎发病人数约为1486.56万人,死亡人数约为11.18万人,DALY约为634.9万人年,YLD约为12.1万人年。结论尽管在1990—2019年之间中国乙型肝炎疾病负担呈下降趋势,但在2030年消除乙型肝炎病毒这一公共威胁的目标仍然面临挑战。因此,有必要扩大诊断覆盖范围、减轻患者经济负担,进一步推进健康中国建设。