目的:运用数据挖掘技术,分析阴陵泉穴的优势病症与配伍处方,总结其主治特点与配伍规律。方法:在中国知网、万方学术期刊全文、维普中文期刊资源、SinoMed、Web of Science和PubMed等数据库中检索阴陵泉在1949-10-1到2022-3-31期间的相...目的:运用数据挖掘技术,分析阴陵泉穴的优势病症与配伍处方,总结其主治特点与配伍规律。方法:在中国知网、万方学术期刊全文、维普中文期刊资源、SinoMed、Web of Science和PubMed等数据库中检索阴陵泉在1949-10-1到2022-3-31期间的相关资料,建立SQL Server数据库,运用“五输穴主治与配伍数据挖掘软件V1.0”及Gephi可视化软件对数据进行复杂网络、复合关联和聚类分析。结果:共纳入文献548篇。阴陵泉共6种单穴主治病症,优势病症包括肩关节周围炎和尿潴留;133种配伍主治病症,优势病症包括尿潴留、膝关节炎、糖尿病和脑卒中后遗症等19种。高频腧穴包括三阴交、足三里、血海、阳陵泉和关元等30穴。配伍经脉以足阳明胃经、足太阴脾经和任脉等为主。复合关联经筛选后得出45条阴陵泉配伍的腧穴-病症关联规则。聚类分析产生了3类7组高频配伍穴类组合。结论:阴陵泉主治方面主要以腧穴所在部位之膝关节炎、经脉所过部位之肢体关节病症、脾胃系及肾系相关脏腑病症和湿邪所致病症等为主,腧穴配伍主要以本经、交接经和表里经等方式为主,其结果可为临床和科研提供参考。展开更多
目的 :通过穴位注射徐长卿注射液改善痔结扎术后尿潴留情况,以寻求一种安全、快捷和有效的方法 ,减轻患者痛苦。方法:采取随机、对照的研究方法,将90例患者分为3组,例数比为1∶1∶1。治疗组:阴陵泉穴位注射徐长卿注射液2 m L,对照1组:...目的 :通过穴位注射徐长卿注射液改善痔结扎术后尿潴留情况,以寻求一种安全、快捷和有效的方法 ,减轻患者痛苦。方法:采取随机、对照的研究方法,将90例患者分为3组,例数比为1∶1∶1。治疗组:阴陵泉穴位注射徐长卿注射液2 m L,对照1组:阴陵泉穴位注射新斯的明2 m L,对照2组:阴陵泉穴位注射生理盐水2 m L。观察各组患者治疗前后症状改善情况及不良反应。结果:治疗组在总有效率及治疗后症状改善方面均优于两个对照组,差异有统计学意义(P<0.05)。结论:阴陵泉穴位注射徐长卿可明显改善痔病术后尿潴留,从而减轻术后患者的痛苦。展开更多
[Objectives] This study aimed to explore the effects of moxibustion at the Yanglingquan and Yinlingquan points on thickness of the left foot and synovial tissue inflammation of collagen-induced arthritis( CIA) rats,an...[Objectives] This study aimed to explore the effects of moxibustion at the Yanglingquan and Yinlingquan points on thickness of the left foot and synovial tissue inflammation of collagen-induced arthritis( CIA) rats,and to explore the therapeutic effect of moxibustion at complementary acupoints on rheumatoid arthritis( RA). [Methods] Total 32 Wistar rats were selected. Among them,8 rats were selected randomly using the randomized digital method as the blank control( K),and the remaining were subjected to modeling. After the successful establishment of the CIA model,the 24 rats were randomly and evenly divided into model group( M),Yanglingquan and Yinlingquan group( AB) and Shenshu and Zusanli group( CD). The rats in the moxibustion groups were subjected to bilateral synchronous moxibustion once every two days( 2 mg refined moxa/cone,5 cones/( point·d)),for total 10 times. The left plantar thickness of each rat was measured before modeling,after modeling,and after the last intervention,respectively. After the last intervention,the situation of synovial tissue inflammation in each rat of the treatment group was inspected. [Results] Compared with that of the control group,the left foot thickness of each group of rats that were modeled all increased significantly( P < 0. 05). And the synovial tissue showed different degrees of inflammatory infiltration,fibrous hyperplasia,and angiogenes. After the intervention ended,compared with that in the M group,the left foot thickness in the AB and CD treatment groups reduced significantly( P < 0. 05). The inflammatory infiltration,fibrous hyperplasia,and angiogenes of the synovial tissue decreased. Between the two moxibustion groups,the thickness of the left foot in group AB decreased compared with group CD( P < 0. 05). The inflammatory infiltration,fibrous hyperplasia and angiogenes in group AB decreased compared with those in group CD. [Conclusions] Moxibustion at the complementary acupoints of Yanglingquan and Yinlingquan,Shenshu and Zusanli both showed good improvement effect on CIA rats. In terms of left foot thickness and synovial tissue inflammation,the treatment group AB was superior to the group CD,and the specific mechanism needs further study.展开更多
[Objectives]To explore the moxibustion effect and mechanism of"Complementary Acupoints"on rheumatoid arthritis(RA).[Methods]A total of 32 Wistar rats were randomly divided into 4 group:normal control(K),mode...[Objectives]To explore the moxibustion effect and mechanism of"Complementary Acupoints"on rheumatoid arthritis(RA).[Methods]A total of 32 Wistar rats were randomly divided into 4 group:normal control(K),model group(M group),"the Complementary Acupoints"Yanglingquan and Yinlingquan group(AB group),Shenshu and Zusanli group(CD group),with 8 rats in each group.Moxibustion was performed using refined moxa floss(2 mg/pc)on acupoints in both sides every other day,5 pieces for each acupoint,and implemented for 10 times.Before and after the modeling and after the intervention,the left foot sole thermal pain threshold of each group was measured.After the intervention,the rats'left paws were examined by X-ray to detect the number of mast cells(MCs)and degranulation in the affected area of the foot.[Results]The thermal pain threshold of the model group was lower than that of the K group(P<0.05).The number of MC in the affected area and the degranulation were increased.After the moxibustion intervention,the thermal pain threshold of the AB and CD groups was higher than that of the M group(P<0.05);the number of MCs and degranulation were decreased compared with M group,and the degree of reduction was better than that of CD group.The data of foot and claw showed that the foot and paw soft tissue swelling,bone and joint deformity and bone destruction were better in AB and CD groups were more relieved than that in M group.[Conclusions]The moxibustion of Complementary Acupoints can effectively intervene with RA of rats,and its mechanism may be closely related to the MC degranulation.展开更多
文摘目的:运用数据挖掘技术,分析阴陵泉穴的优势病症与配伍处方,总结其主治特点与配伍规律。方法:在中国知网、万方学术期刊全文、维普中文期刊资源、SinoMed、Web of Science和PubMed等数据库中检索阴陵泉在1949-10-1到2022-3-31期间的相关资料,建立SQL Server数据库,运用“五输穴主治与配伍数据挖掘软件V1.0”及Gephi可视化软件对数据进行复杂网络、复合关联和聚类分析。结果:共纳入文献548篇。阴陵泉共6种单穴主治病症,优势病症包括肩关节周围炎和尿潴留;133种配伍主治病症,优势病症包括尿潴留、膝关节炎、糖尿病和脑卒中后遗症等19种。高频腧穴包括三阴交、足三里、血海、阳陵泉和关元等30穴。配伍经脉以足阳明胃经、足太阴脾经和任脉等为主。复合关联经筛选后得出45条阴陵泉配伍的腧穴-病症关联规则。聚类分析产生了3类7组高频配伍穴类组合。结论:阴陵泉主治方面主要以腧穴所在部位之膝关节炎、经脉所过部位之肢体关节病症、脾胃系及肾系相关脏腑病症和湿邪所致病症等为主,腧穴配伍主要以本经、交接经和表里经等方式为主,其结果可为临床和科研提供参考。
文摘目的 :通过穴位注射徐长卿注射液改善痔结扎术后尿潴留情况,以寻求一种安全、快捷和有效的方法 ,减轻患者痛苦。方法:采取随机、对照的研究方法,将90例患者分为3组,例数比为1∶1∶1。治疗组:阴陵泉穴位注射徐长卿注射液2 m L,对照1组:阴陵泉穴位注射新斯的明2 m L,对照2组:阴陵泉穴位注射生理盐水2 m L。观察各组患者治疗前后症状改善情况及不良反应。结果:治疗组在总有效率及治疗后症状改善方面均优于两个对照组,差异有统计学意义(P<0.05)。结论:阴陵泉穴位注射徐长卿可明显改善痔病术后尿潴留,从而减轻术后患者的痛苦。
基金Supported by Natural Science Foundation of Hebei Province(H2014406047)Natural Science Project of Chengde Medical University(201812)
文摘[Objectives] This study aimed to explore the effects of moxibustion at the Yanglingquan and Yinlingquan points on thickness of the left foot and synovial tissue inflammation of collagen-induced arthritis( CIA) rats,and to explore the therapeutic effect of moxibustion at complementary acupoints on rheumatoid arthritis( RA). [Methods] Total 32 Wistar rats were selected. Among them,8 rats were selected randomly using the randomized digital method as the blank control( K),and the remaining were subjected to modeling. After the successful establishment of the CIA model,the 24 rats were randomly and evenly divided into model group( M),Yanglingquan and Yinlingquan group( AB) and Shenshu and Zusanli group( CD). The rats in the moxibustion groups were subjected to bilateral synchronous moxibustion once every two days( 2 mg refined moxa/cone,5 cones/( point·d)),for total 10 times. The left plantar thickness of each rat was measured before modeling,after modeling,and after the last intervention,respectively. After the last intervention,the situation of synovial tissue inflammation in each rat of the treatment group was inspected. [Results] Compared with that of the control group,the left foot thickness of each group of rats that were modeled all increased significantly( P < 0. 05). And the synovial tissue showed different degrees of inflammatory infiltration,fibrous hyperplasia,and angiogenes. After the intervention ended,compared with that in the M group,the left foot thickness in the AB and CD treatment groups reduced significantly( P < 0. 05). The inflammatory infiltration,fibrous hyperplasia,and angiogenes of the synovial tissue decreased. Between the two moxibustion groups,the thickness of the left foot in group AB decreased compared with group CD( P < 0. 05). The inflammatory infiltration,fibrous hyperplasia and angiogenes in group AB decreased compared with those in group CD. [Conclusions] Moxibustion at the complementary acupoints of Yanglingquan and Yinlingquan,Shenshu and Zusanli both showed good improvement effect on CIA rats. In terms of left foot thickness and synovial tissue inflammation,the treatment group AB was superior to the group CD,and the specific mechanism needs further study.
基金Natural Science Foundation of Hebei Province of China(H2014406047)Scientific and Technological Research Project for Institutions of Higher Education in Hebei Province of China(ZD2019085)Key Scientific Research Project of Chengde Medical University(201812).
文摘[Objectives]To explore the moxibustion effect and mechanism of"Complementary Acupoints"on rheumatoid arthritis(RA).[Methods]A total of 32 Wistar rats were randomly divided into 4 group:normal control(K),model group(M group),"the Complementary Acupoints"Yanglingquan and Yinlingquan group(AB group),Shenshu and Zusanli group(CD group),with 8 rats in each group.Moxibustion was performed using refined moxa floss(2 mg/pc)on acupoints in both sides every other day,5 pieces for each acupoint,and implemented for 10 times.Before and after the modeling and after the intervention,the left foot sole thermal pain threshold of each group was measured.After the intervention,the rats'left paws were examined by X-ray to detect the number of mast cells(MCs)and degranulation in the affected area of the foot.[Results]The thermal pain threshold of the model group was lower than that of the K group(P<0.05).The number of MC in the affected area and the degranulation were increased.After the moxibustion intervention,the thermal pain threshold of the AB and CD groups was higher than that of the M group(P<0.05);the number of MCs and degranulation were decreased compared with M group,and the degree of reduction was better than that of CD group.The data of foot and claw showed that the foot and paw soft tissue swelling,bone and joint deformity and bone destruction were better in AB and CD groups were more relieved than that in M group.[Conclusions]The moxibustion of Complementary Acupoints can effectively intervene with RA of rats,and its mechanism may be closely related to the MC degranulation.
