Objective： To systematically evaluate the efficacy and safety of Yiyiren Decoction combined with western medicine and western medicine alone in the treatment of rheumatoid arthritis. Methods： Databases of CNKI, VIP...Objective： To systematically evaluate the efficacy and safety of Yiyiren Decoction combined with western medicine and western medicine alone in the treatment of rheumatoid arthritis. Methods： Databases of CNKI, VIP, Wanfang Data, PubMed, Medline, Cochrane Library, and Embase were retrieved by computers. The references of the included studies, relevant dissertations, and conference proceedings were manually retrieved. The search intervals were from the database inception until July 2017. The retrieval and screening of studies were carried out respectively by 2 researchers, and the quality and data were evaluated and extracted according to Jadad quality scale. Meta-analysis was performed with RevMan5.3 software. Results： （1） A total of 7 randomized controlled trials and 485 patients were enrolled, among which 262 cases were in experimental group and 223 cases were in control group. The point of 2 studies was 3, other studies were 1-2. The studies included indicated that the group baselines were comparable. （2）The total effective rate of Yiyiren Decoction with western medicine group was higher than that of western medicine group （RR = 0.85, 95%CI [0.78, 0.92]. Improved Conditions of tender joint count （MD = -2.79, 95%CI [-3.47, -2.12]）; erythrocyte sedimentation rate （MD = -9.5, 95%CI [15.67, -3.33]）; and C-reactive protein （MD = -3.36, 95%CI [-5.45, -1.27]） were superior to control group. There was no significant difference on the side effects of drugs and the rheumatoid factor between the two groups. Conclusion： Yiyiren Decoction with western medicine had advantages in alleviating clinical symptoms and laboratory index of rheumatoid arthritis patients. While, the quality of included studies was low and possible publication bias was present, further multi-center double-blind randomized control trials with larger sample are needed.展开更多
文摘Objective： To systematically evaluate the efficacy and safety of Yiyiren Decoction combined with western medicine and western medicine alone in the treatment of rheumatoid arthritis. Methods： Databases of CNKI, VIP, Wanfang Data, PubMed, Medline, Cochrane Library, and Embase were retrieved by computers. The references of the included studies, relevant dissertations, and conference proceedings were manually retrieved. The search intervals were from the database inception until July 2017. The retrieval and screening of studies were carried out respectively by 2 researchers, and the quality and data were evaluated and extracted according to Jadad quality scale. Meta-analysis was performed with RevMan5.3 software. Results： （1） A total of 7 randomized controlled trials and 485 patients were enrolled, among which 262 cases were in experimental group and 223 cases were in control group. The point of 2 studies was 3, other studies were 1-2. The studies included indicated that the group baselines were comparable. （2）The total effective rate of Yiyiren Decoction with western medicine group was higher than that of western medicine group （RR = 0.85, 95%CI [0.78, 0.92]. Improved Conditions of tender joint count （MD = -2.79, 95%CI [-3.47, -2.12]）; erythrocyte sedimentation rate （MD = -9.5, 95%CI [15.67, -3.33]）; and C-reactive protein （MD = -3.36, 95%CI [-5.45, -1.27]） were superior to control group. There was no significant difference on the side effects of drugs and the rheumatoid factor between the two groups. Conclusion： Yiyiren Decoction with western medicine had advantages in alleviating clinical symptoms and laboratory index of rheumatoid arthritis patients. While, the quality of included studies was low and possible publication bias was present, further multi-center double-blind randomized control trials with larger sample are needed.
