Survival benefit of younger gastric cancer patients in China and the United States:A comparative study

BACKGROUND The impact of racial and regional disparity on younger patients with gastric cancer(GC) remains unclear.AIM To investigate the clinicopathological characteristics, prognostic nomogram, and biological analysis of younger GC patients in China and the United States.METHODS From 2000 to 2018, GC patients aged less than 40 years were enrolled from the China National Cancer Center and the Surveillance Epidemiology and End Results database. Biological analysis was performed based on the Gene Expression Omnibus database. Survival analysis was conducted via Kaplan-Meier estimates and Cox proportional hazards models.RESULTS A total of 6098 younger GC patients were selected from 2000 to 2018, of which 1159 were enrolled in the China National Cancer Center, and 4939 were collected from the Surveillance Epidemiology and End Results database. Compared with the United States group, younger patients in China revealed better survival outcomes(P < 0.01). For race/ethnicity, younger Chinese cases also enjoyed a better prognosis than that in White and Black datasets(P < 0.01). After stratification by pathological Tumor-Node-Metastasis(pTNM) stage, a survival advantage was observed in China with pathological stage Ⅰ, Ⅲ, and Ⅳ(all P < 0.01), whereas younger GC patients with stage Ⅱ showed no difference(P = 0.16). In multivariate analysis, predictors in China involved period of diagnosis, linitis plastica, and pTNM stage, while race, diagnostic period, sex, location, differentiation, linitis plastica, signet ring cell, pTNM stage, surgery, and chemotherapy were confirmed in the United States group. Prognostic nomograms for younger patients were established, with the area under the curve of 0.786 in the China group and of 0.842 in the United States group. Moreover, three gene expression profiles(GSE27342, GSE51105, and GSE38749) were enrolled in further biological analysis, and distinctive molecular characteristics were identified in younger GC patients among different regions.CONCLUSION Except for younger cases with pTNM stage Ⅱ, a survival advantage was observed in the China group with pathological stage Ⅰ, Ⅲ, and Ⅳ compared to the United States group, which might be partly due to differences in surgical approaches and the improvement of the cancer screening in China. The nomogram model provided an insightful and applicable tool to evaluate the prognosis of younger patients in China and the United States. Furthermore, biological analysis of younger patients was performed among different regions, which might partly explain the histopathological behavior and survival disparity in the subpopulations.

Younger Dryas事件与北黄海泥炭层的形成

形成于海平面变化处于停滞阶段和湿润气候条件下的泥炭层是古环境变化信息的重要载体。对北黄海4个含泥炭层的沉积剖面进行研究后发现,其均集中在渤海海峡入口处,水深变化在50～54m。泥炭层的AMS14C年龄在10650～1010014 CaBP,与发生在11000～1000014 CaBP间的末次冰消气候回冷事件——Younger Dryas(YD)事件在年代上非常吻合,表明北黄海泥炭层的形成可能与YD事件的全球效应密切相关,可作为YD事件在北黄海陆架响应的一个重要证据。泥炭层在北黄海的集中出现说明,冰后期的海平面上升过程中在YD事件期间存在停滞阶段,这一时期海面已经达到渤海海峡外侧,并可能在此徘徊了近千年。此外,泥炭层的大量出现和孢粉记录表明YD事件发生期间约为10600～1020014 CaBP,此时北黄海可能处在寒冷而湿润的环境。这一发现与全球范围内大部分YD事件的海陆记录存在明显差异,说明不同地区对YD事件的响应存在差异,不能简单地利用单一的干冷模式来分析YD事件在区域上的响应特征和过程。

东亚地区YoungerDryas气候突变的数值模拟研究

Younger Dryas (YD)气候突变事件是近两万年中一次全球性的气候急剧变冷事件。文章试图在东亚地区YD事件的若干证据基础上,从海洋、冰盖和大气的热力学以及动力学角度出发,利用气候模拟方法就东亚地区YD气候突变的机制和一些成因假说进行敏感性试验。模拟结果表明,因淡水通量异常引起的海洋表面温度降低是YD形成的直接原因。海洋大气耦合作用对于YD传播强度及时间不同步具有重要作用。除北大西洋淡水通量异常的作用外,南半球海洋的淡水通量异常可能对东亚地区的YD事件有着更重要的贡献。海洋耦合大气环流模式模拟表明,东亚与欧洲降温具有不同步性,最大变化速率欧洲达到-0.122℃/a,东亚地区为-0.067℃/a。模拟结果与东亚地区YD时期的气候记录在特征上能够进行对比,反映了模拟试验的边界和强迫条件的设计接近东亚古气候状况,因而模拟结果对分析海洋、冰盖和大气的热力学以及动力学探讨揭示YD气候事件的物理机制和动力原因具有可靠的依据。

Younger Dryas时期东亚季风气候和中国东部沙区沙漠变化

位于沙漠／黄土过渡带的杨桃峁剖面，高分辨率地记录了ＹｏｕｎｇｅｒＤｒｙａｓ时期东亚季风气候和沙漠变化历史。在ＡＭＳ１４Ｃ测年基础上，磁化率、粒度和有机质含量等替代性气候指标的测试结果分析表明，ＹｏｕｎｇｅｒＤｒｙａｓ时期东亚季风气候在全球气候变化的影响下，总的表现为与北半球高纬度地区相同的干寒特征，即沙漠总的具有扩大的趋势；但又与南北半球大气相互作用，特别是赤道太平洋地区气压异常引起亚洲季风气候的不稳定有关，表现出降水变化特点，沙漠出现逆过程变化，存在短暂成壤固定时期。

The Younger Dryas Event and Holocene Climate Fluctuations Recorded in a Stalagmite from the Panlong Cave of Guilin

Comprehensive studies on a stalagmite from the Panlong cave, Guilin, have shown that the isotopic records and sedimentary characteristics can reflect the changes of both palaeotemperatures and palaeorainfall, that is to say, it is possible to get some information about the changes in climate of the area from the speleothem. The results suggest that: (1) the Younger Dryas event might have persisted in the area from 11 300 to 10 800 a B.P.; (2) from 9000 to 7000 a B.P., the climate got warmer and wetter, and the summer monsoon was gradually enhanced; (3) from 7000 to 4500 a B.P., the climate was warm and wet, and the summer monsoon prevailed; and (4) from 4500 a B.P. on, the summer monsoon was weakened and the modern climate pattern appeared, but there were several cold and dry periods, namely, from 4000 to 2500 a B.P., ca. 2400 a B.P. and 【 1000 a B.P.

Analysis of prognostic factors and outcomes of gastric cancer in younger patients:A case control study using propensity score methods

AIM:To understand the clinicopathological and prognostic features of gastric cancer in younger and older patients.METHODS:Between January 2002 and December2008,1667 patients underwent curative gastric surgery.For comparative purposes,the patients were divided into two groups:younger patients who were less than 40 years old(112 patients),and older patients who were 40 years old and older(1555 patients).In both groups,propensity scoring methods were used to select patients with similar disease statuses.A total of224 matched cases,with 112 patients in each group,were included in the final analysis.RESULTS:Compared to the older group,the younger group with gastric cancer had a significantly higher percentage of females(P=0.007),poorly differentiated or signet ring cell carcinoma(P<0.001),advanced T stage gastric cancer(P=0.045),and advanced tumornode-metastasis stage cancer(P=0.036).The older group with gastric cancer had more comorbidities(P<0.001).With the exception of the number of lymph node dissection(P<0.001)and retrieved lymph node(P=0.010),there were no statistically significant differences between the postoperative outcomes of the two groups.During the follow-up period,there were19 recurrences in the younger group and 11 recurrences in the older group.The overall five-year survival rates in the younger and older groups were 84.3%and89.6%,respectively(P=0.172).There were no significant differences(P=0.238)in the overall survival of patients with advanced T stage gastric cancer in the two groups,with five-year survival rates of 70.8%in the younger group and 79.5%in the older group.With regard to the age-adjusted survival rate,there was significant difference between the two groups(P=0.225).CONCLUSION:In spite of aggressive cancer patterns in the younger group with gastric cancer,the younger group did not have a worse prognosis than the older group in our study.

Risk factors and natural history of breast cancer in younger Chinese women

AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts.

内蒙古盐湖沉积物中YoungerDryas的确认及其重要意义

通过对内蒙古盐湖沉积物同位素、元素地球化学、古地磁、古生物、沉积岩石学等大量第一手资料的研究证实，中国内蒙古地区存在ＹｏｕｎｇｅｒＤｒｙａｓ气候期。所获之研究成果以其Ｙ．Ｄ．的高分辨率、冷湿型、持续时间、温度范围等属性特征而获得国内外的确认。

THE RECORD OF YOUNGER DRYAS EVENT IN EOLIAN SAND DEPOSIT IN QAIDAM BASIN

The Qaidam Basin is one of the main areas where the desert of the Qinghai-Xizang Plateau is distributed.According to the envirotunment records and the age of stratigraphy in Xiaxitai section in southeast part of Qaidam Basin,this paper reached the following conclusions: the desert development, formation of the cold-dry climate, evolution of natural environment and their reverse changes occurred frequently since the late glacial. In eolian sand deposits, the YoungerDryas event clearly appeared, which manifesed a dry-cold climatic period. Now there are two different opinions about theclimatic effect of Younger Dryas. According to the predecessors’ research and the field work of the authors, it is considered that the Younger Dryas event not only exists in different climatic zones of China, but the manifests the unitary drycold climatic effect.

晚冰期Younger Dryas环境灾变

新仙女木事件（ＹｏｕｎｇｅｒＤｒｙａｓＥｖｅｎｔ）是过去１５０００年里全球最为严重的环境灾变事件。它使得冰期气候急剧回返，陆地自然环境严重恶化，并且造成更新世末期的生物界大绝灭。该事件在深海沉积、大陆冰盖和湖泊沉积物剖面都有多种十分显著的记录。对其成因和机制的研究，将会深入揭示太阳辐射—大气—海洋—冰盖—陆地—生物圈相互作用系统中的非线性反馈现象，为探索人类面临的全球变化问题提供借鉴。

Intersection Related Crash Injuries: A Study on Factors Contributing to Injury Severity among Younger and Older Drivers in Summer and Winter

Older drivers and younger drivers are affected differently both in summer and winter. Different factors affect each level of severity differently;some factors affect a particular level of injury severity differently from when the same factor is analyzed for another injury severity. The goal of this study is to identify the factors that contribute to injury severity among older drivers (65+) and young drivers (16 - 25) considering two seasons namely, summer and winter at intersections. Binary ordered probit models were used to develop four models to identify the contributing factors, two models for each season, namely winter and summer. A statistical t-test has been done to identify the statistically significant variables @ 90% confidence interval. Based on the developed models, in summer, three contributing factors, driving too fast condition, rear-end crashes, and followed too close are associated with younger drivers injury severity, while two contributing factors, rear-end crashes and followed too close are associated with older drivers injury severity. In winter, five factors, made an improper turn, E Failed to Yield Right-of-Way from Traffic Signal, rear end (front to rear), gender like male and lighting condition like dark and dusk light condition, are associated with younger drivers injury severity, while three factors such as made improper turn, rear-end crashes, and followed too close are associated with older drivers injury severity. Contributing factors in summer are the same for both younger and older drivers, but different in winter for both younger and older drivers. This indicates that older drivers and younger drivers are affected differently both in summer and winter.

Younger Dryas气候突变事件及可能机理

国际地圈─生物圈计划（ＩＧＢＰ）的中心议题之一就是研究过去的全球变化（ＰＡＧＥＳ），而对过去短期气候突变事件特别是对末次冰期─间冰期过渡时期的ＹｏｕｎｇｅｒＤｒｙａｓ事件的研究更受全球变化研究者的关注．然而，到目前为止，对ＹｏｕｎｇｅｒＤｒｙａｓ的成因及是否为全球性事件等问题，依然争论不休。本文即是对近年来国际上对此事件研究的综述。

Younger Dryas Comet 12,900 BP

Deep troughs in Lake Superior support the hypothesis of Younger Dryas Boundary (YDB) comet impact 12,900 BP. The impact theory explains the megafauna extinction, a black mat across the Northern hemisphere, nanodiamonds, platinum and iridium, and the enigmatic Carolina Bays (CB). While the CB were thought to predate Clovis cultural remains, but this must now be seen as spurious as the CB occur on Long Island, an LGM terminal moraine & on end-glacial flood plains, according to Allen West. The CB sand rims are exceptionally pure quartz with large phenocrysts, and also they exude hydrogen (H). This suggests origin from deep granitic plutons, the granite typically being over-saturated with silica. When the Russian Kola Peninsula Superdeep Borehole had reached 40,000 ft, H was boiling from the borehole. This H is among volatiles copiously dissolved in the mantle, from the primitive solar nebula. The granite is from the Lake Superior Province. Lakes Superior, Michigan, Huron & Ontario have deep holes, reaching to below sea level. Bathymetry exhibits a ~145 km circular contour in Eastern L. Superior, where deep troughs occur, eroded in breccias infilling impact explosion cavities many kms deep, as much as 15 to 35 km, the comet fragments coming in from the NW, with the holes lined up along the trajectory. This was an oblique impact with an extremely low angle of incidence, so the ejected granite quartz sands ended up in the CB along the Eastern seaboard principally.

Association of Erectile Dysfunction and Hypogonadism with Metabolic Syndrome in Men with Lower Urinary Tract Symptoms of Younger and Older Age Groups

The aim of this study was to evaluate the incidence and severity of erectile dysfunction (ED) and hypogonadism in 193 men presenting with lower urinary tract symptoms (LUTSs) in the younger (20 - 39 years old) and older (40 - 60 years old) age groups depending on the presence of metabolic syndrome (MetS). Triglycerides, glucose and high-density lipoprotein cholesterol, serum total testosterone (TT), sex hormone-binding globulin, prostate-specific antigen, pituitary hormones levels were measured in serum. Standardized criteria (2009) were used to determine the prevalence of MetS. Patients were assessed based on the International Prostate Symptom Score (IPSS) and the IPSS-Quality of Life (IPSS-QoL) for LUTSs and the International Index of Erectile Function (IIEF) for ED. Hypogonadism was determined in accordance with the ISA, ISSAM, EAU, EAA and ASA recommendations. In men with MetS in the younger age group the incidence of ED was 2.4 times higher, and that of low TT level and hypogonadism was 8.4 times higher compared to men without the syndrome. In the older age group, an increased incidence of ED and low TT level in men with MetS compared to men without the syndrome was on the trend level, but the incidence of hypogonadism was for sure higher (by 1.6 times). In conclusion, the study showed that ED and hypogonadism are associated with MetS by a high degree of certainty in young men with LUTSs. In men of the older age group with LUTSs, the presence of MetS is not so clearly associated with ED and hypogonadism due to the fact that the incidence of these urogenital diseases is also high in men without MetS.

The Automobile Consumption Market Welcomes Consumers of Younger Generations

According to data from the Traffic Administration Bureau of the Ministry of Public Security of the People’s Republic of China,as of the end of 2020,there were more than 40 million driving license holders aged 18 to 24,indicating the great potential in the auto consumption market in China.For auto manufacturers in China,they have to adapt to an inevitable trend that consumers are becoming younger.

The Spread of Younger House Buyer

Real estate has no doubt been a hottest topic during these years and the house price has also increased dramatically in China.Though,the government has taken measures to adjust the real estate market,the house price is still far from what we can afford.However,in such circumstance,more and more young people rushes to buy houses.According to a report released by the China Everbright Bank and a real estate research firm in 2010;those applying for housing loans in Beijing have an average age of 27 years old,which is younger as compared to developed countries.The average age of first-time house buyers in the United Kingdom rose from 33 to 37 years old.In Japan and Germany,it is 42 years old,while it is 30 years old in the United States (Baoru,2010).Thus,the purpose of this paper is to analyze the reasons of the first-time house buyers becoming younger in culture aspect,through paper reviews published studies found in relevant journals,books and databases that can be accessed online via Google Reader and Google Books.

How to hook the younger set on denim

Gen Z is nothing if not about authenticity. And perhaps no other piece of apparel has been linked more with the word “authentic” than denim jeans. But this young generation of shoppers also championed the rise of athleisure apparel. The question for denim brands becomes, how to stand out and appeal to this set of consumers whose purchasing power is increasing, whilje maintain-ing the genuineness that is the established hallmark of the denim categoiy.

Distribution and characteristics of initial PSA and PSA velocity in men younger than 50 years without prostate cancer

Objective To explore the distribution and characteristics of initial PSA and PSA velocity in men younger than years without prostate cancer. Methods PSA in men younger than 50 years without prostate cancer from January 2001 to November 2009 were retrieved retrospec-

Searching for a Younger Generation of Tibetan Minstrels to Sing the King Gesar

As time goes by,the development of epic performance cul-ture naturally fol-lows that the old blind minstrels who once specialized in singing the oral epic King Gesar(which they had memorized by their memories)are gradually dying out.Therefore, sooner or later,live performance of the oral epic King Gesar seems doomed to disappear.But does the successive loss of elite minstrels, such as the departure of Zhaba, Tsewang Jigme,Atak,Khetsa Zhaba,