期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Effect of co-existent components in CO2 supercritical fluid extract of Angelica Sinensis Radix on metabolism of Z-ligustilide after oral administration in rats 被引量:2
1
作者 Bochen Zhao Qing Zhang +5 位作者 Hongmei Lin Qingguo Ru Qian Kang Hui Li Yewen Zhang Qing Wu 《Journal of Traditional Chinese Medical Sciences》 2014年第2期126-134,共9页
Objective:To establish a basis for Angelica Sinensis Radix(ASR)as a dietary supplement for colorectal cancer chemoprevention,the effect of co-existent components in supercritical fluid extract(SFE)of ASR on the pharma... Objective:To establish a basis for Angelica Sinensis Radix(ASR)as a dietary supplement for colorectal cancer chemoprevention,the effect of co-existent components in supercritical fluid extract(SFE)of ASR on the pharmacokinetics of Z-ligustilide after oral administration was investigated in vitro and in vivo.Methods:Incubation in gastrointestinal contents and incubation in rat liver tissue homogenates post-mitochondrial supernatant(PMS)experiments were used to study changes in the levels of Z-ligustilide in vitro.Results:Within 4 hours,the level of Z-ligustilide in SFE declined at a slower rate than in its pure form.Clearance of Z-ligustilide after administration in its pure form was significantly slower than that of SFE of ASR(CL,0.96±0.16 mL·min/kg versus 1.24±0.21 mL·min/kg P<0.05;AUC,243.37±16.84 versus 176.69±12.59 mg·min/L).Conclusion:These phenomena may be attributed to the interactions between the co-existent components in SFE of ASR and Z-ligustilide enhancing the stability of Z-ligustilide.These results suggest that the bioavailability of Z-ligustilide in SFE of ASR is improved.However,stabilization of plasma concentration was not sustained,so that the efficacy of active components could not be maintained.Thus,further processing of SFE of ASR is required. 展开更多
关键词 Angelica Sinensis Radix Supercritical fluid extract z-ligustilide METABOLISM
下载PDF
Adsorption equilibrium for Z-ligustilide on C18-bonded silica from supercritical carbon dioxide 被引量:1
2
作者 Huisheng Lü Shuangyan Liu +3 位作者 Yonghui Li Fanmei Meng Dawei Yao Xufei Mo 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2016年第12期1680-1686,共7页
Adsorption equilibrium is of great importance for the preparative supercritical fluid chromatography(pre-SFC) in defining supercritical adsorption behavior and the industrial amplification.This paper presents adsorpti... Adsorption equilibrium is of great importance for the preparative supercritical fluid chromatography(pre-SFC) in defining supercritical adsorption behavior and the industrial amplification.This paper presents adsorption isotherms of Z-ligustilide from supercritical carbon dioxide(SC-CO_2) on C18-bonded silica.Adsorption behavior was studied at 305.15 K,313.15 K and 323.15 K with SC-CO_2 density varying from 0.687 g·cm^(-3) to0.863 g·cm^(-3) with the elution by characteristic points(ECP) method.The adsorption amount of Z-ligustilide from SC-CO_2 on C18-bonded silica decreased with the increasing density of the mobile phase as well as the increasing temperature.Adsorption equilibrium data were fitted by Langmuir and Freundlich isotherm models,and the Langmuir isotherm model performed better for describing the whole adsorption process on the column.The monolayer saturation adsorption capacity of Z-ligustilide is in the range of 3.0 × 10^(-4) mg·cm^(-3) to5.5 × 10^(-4) mg·cm^(-3) with an average value of 4.0 × 10^(-4) mg·cm^(-3). 展开更多
关键词 z-ligustilide C18-bonded silica Pre-SFC Adsorption equilibrium Isotherm model
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部