Wang You’s thoughts on the compilation of Wu Zi Jin Si Lu reflect the thoughts of the scholars who took Zhu Xi as their mentor in the late Ming and early Qing Dynasties.Wang You combined four scholars in the Northern...Wang You’s thoughts on the compilation of Wu Zi Jin Si Lu reflect the thoughts of the scholars who took Zhu Xi as their mentor in the late Ming and early Qing Dynasties.Wang You combined four scholars in the Northern Song Dynasty(Zhou Dunyi,Zhang Zai,Cheng Yi,and Cheng Hao)and Zhu Xi into a whole,so that readers could grasp their thoughts as a whole.This also enabled the scholars of the time to access to the sages.His books were widely circulated in East Asia and were well received by Ly Dynasty,North Korea,with many copies printed.Inspired by Wang You’s compiling ideas,Ly Dynasty scholars in North Korea have compiled new documents reflecting the local Xing-li of learning,such as Li Duzhong’s Li Zi Jin Si Lu and Song Bingxuan’s Jin Si Xu Lu.The Huizhou scholars,represented by Wang You,spared no effort to construct the Jin Si Lu documents to adapt to the development of the times and to explain the essence of Jin Si Lu.It played a certain role in the dissemination of Neo-Confucianism in East Asia.展开更多
Objective:To observe the clinical effect of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in the treatment of granulomatous lobular mastitis in the mass stage and the effect on cellu...Objective:To observe the clinical effect of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in the treatment of granulomatous lobular mastitis in the mass stage and the effect on cellular pyroptosis-related proteins.Methods:Forty patients with granulomatous lobular mastitis were randomly divided into 20 cases in the observation group and 20 cases in the control group.Both groups were given dexamethasone ointment for treatment,and the observation group was treated with external application of Zi Cao Yang He Tang on the basis of the control group.Breast lump vol-ume changes,breast pain and pus symptoms,pathology and histology and immunohistochemistry,cellular death-related indicators expression were compared between the two groups.Results:After treatment,the difference in mass volume of the observation group was significantly greater than that of the control group(16.7±21.5 in the control group and 32.9±27.4 in the experimental group)and the difference between the two groups was statistically significant(P<0.05);the objective remission rate of the patients in the observation group(ORR=85%)was significantly higher than that of the treatment group(ORR=50%,P<0.05).In terms of pus formation rate and pain level,the breast pain score of the observation group was significantly lower than that of the control group after two weeks or three weeks of treatment(P<0.05);the pus formation rate of the observation group was 30%,and the pus formation rate of the control group was 20%,and the difference was not statistically significant(P>0.05).The immunohistochemical expression levels of caspase-1 and GSDMD in the observation group were significantly lower than those in the control group(P<0.05);and in terms of the expression of cellular pyroptosis-related indexes,the expression of GSDMD,cas-pase-1,and NLRP3 in the observation group was significantly lower compared with that in the control group(P<0.05).Conclusion:The efficacy of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in treating granulomatous lobular mastitis in the mass stage is remarkable,which can effectively reduce breast pain,reduce the size of the mass,de-crease the expression of cellular pyroptosisrelated indexes,and have a good anti-inflammatory effect.展开更多
Based on the brief introduction of western contemporary eco-philosophies and Lao Zi’s eco-philosophy,there will be an analysis of the differences according to historical context and critical target and their converge...Based on the brief introduction of western contemporary eco-philosophies and Lao Zi’s eco-philosophy,there will be an analysis of the differences according to historical context and critical target and their convergence.The analysis leads to the conclusion that eco-philosophies,whether contemporary or ancient,are against any form of domination and centrism.展开更多
This review summarizes the process of the discovery,research,and development of a cardioactive component,mesaconine,from the lateral roots of Aconitum carmichaelii(“Fu Zi”).To date,pre-clinical showed that mesaconin...This review summarizes the process of the discovery,research,and development of a cardioactive component,mesaconine,from the lateral roots of Aconitum carmichaelii(“Fu Zi”).To date,pre-clinical showed that mesaconine is a novel type of cardiotonic lead drug with relatively high potency,low toxicity,and a new mechanism.展开更多
文摘Wang You’s thoughts on the compilation of Wu Zi Jin Si Lu reflect the thoughts of the scholars who took Zhu Xi as their mentor in the late Ming and early Qing Dynasties.Wang You combined four scholars in the Northern Song Dynasty(Zhou Dunyi,Zhang Zai,Cheng Yi,and Cheng Hao)and Zhu Xi into a whole,so that readers could grasp their thoughts as a whole.This also enabled the scholars of the time to access to the sages.His books were widely circulated in East Asia and were well received by Ly Dynasty,North Korea,with many copies printed.Inspired by Wang You’s compiling ideas,Ly Dynasty scholars in North Korea have compiled new documents reflecting the local Xing-li of learning,such as Li Duzhong’s Li Zi Jin Si Lu and Song Bingxuan’s Jin Si Xu Lu.The Huizhou scholars,represented by Wang You,spared no effort to construct the Jin Si Lu documents to adapt to the development of the times and to explain the essence of Jin Si Lu.It played a certain role in the dissemination of Neo-Confucianism in East Asia.
基金Hubei Chen Xiaoping Science and Technology Development Foundation Special Fund Project (No.CXPJJH12000002-2020010)Education Science Research Project,Beijing University of Chinese Medicine (No.XJY21056)Beijing University of Chinese Medicine New Teachers Start-up Fund Project (No.2022-BUCMXJKY010)。
文摘Objective:To observe the clinical effect of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in the treatment of granulomatous lobular mastitis in the mass stage and the effect on cellular pyroptosis-related proteins.Methods:Forty patients with granulomatous lobular mastitis were randomly divided into 20 cases in the observation group and 20 cases in the control group.Both groups were given dexamethasone ointment for treatment,and the observation group was treated with external application of Zi Cao Yang He Tang on the basis of the control group.Breast lump vol-ume changes,breast pain and pus symptoms,pathology and histology and immunohistochemistry,cellular death-related indicators expression were compared between the two groups.Results:After treatment,the difference in mass volume of the observation group was significantly greater than that of the control group(16.7±21.5 in the control group and 32.9±27.4 in the experimental group)and the difference between the two groups was statistically significant(P<0.05);the objective remission rate of the patients in the observation group(ORR=85%)was significantly higher than that of the treatment group(ORR=50%,P<0.05).In terms of pus formation rate and pain level,the breast pain score of the observation group was significantly lower than that of the control group after two weeks or three weeks of treatment(P<0.05);the pus formation rate of the observation group was 30%,and the pus formation rate of the control group was 20%,and the difference was not statistically significant(P>0.05).The immunohistochemical expression levels of caspase-1 and GSDMD in the observation group were significantly lower than those in the control group(P<0.05);and in terms of the expression of cellular pyroptosis-related indexes,the expression of GSDMD,cas-pase-1,and NLRP3 in the observation group was significantly lower compared with that in the control group(P<0.05).Conclusion:The efficacy of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in treating granulomatous lobular mastitis in the mass stage is remarkable,which can effectively reduce breast pain,reduce the size of the mass,de-crease the expression of cellular pyroptosisrelated indexes,and have a good anti-inflammatory effect.
文摘Based on the brief introduction of western contemporary eco-philosophies and Lao Zi’s eco-philosophy,there will be an analysis of the differences according to historical context and critical target and their convergence.The analysis leads to the conclusion that eco-philosophies,whether contemporary or ancient,are against any form of domination and centrism.
基金Chemical Biology Program,Memorial Sloan Kettering Cancer Center,New York.USA。
文摘This review summarizes the process of the discovery,research,and development of a cardioactive component,mesaconine,from the lateral roots of Aconitum carmichaelii(“Fu Zi”).To date,pre-clinical showed that mesaconine is a novel type of cardiotonic lead drug with relatively high potency,low toxicity,and a new mechanism.
