The reduction reagents prepared from sodium borohydride, I2 and a catalytic amount of chiral ferrocenyl amino alcohols 2a-e have been successfully applied to the enantioselective reduction of ketones. The optically ac...The reduction reagents prepared from sodium borohydride, I2 and a catalytic amount of chiral ferrocenyl amino alcohols 2a-e have been successfully applied to the enantioselective reduction of ketones. The optically active secondary alcohols were obtained in moderate enantiomeric excess and high chemical yield.展开更多
Five novel chiral ferrocenyl amino alcohols were prepared from natural amino acids and used as catalysts in the asymmetric reduction of prochiral ketones with NaBH 4/I 2 combination. The incorporation of the ferroce...Five novel chiral ferrocenyl amino alcohols were prepared from natural amino acids and used as catalysts in the asymmetric reduction of prochiral ketones with NaBH 4/I 2 combination. The incorporation of the ferrocenyl moiety into the molecule of the chiral amino alcohols greatly improved their enantioselectivity in the catalysis. The optically active secondary alcohols were obtained in moderate to good enantiomeric excesses and high chemical yields.展开更多
The asymmetric reduction of prochiral ketones was catalyzed by a class of recoverable and highly stable chiral ferrocenyl amino alcohols derived from natural amino acids to yield optically active secondary alcohols in...The asymmetric reduction of prochiral ketones was catalyzed by a class of recoverable and highly stable chiral ferrocenyl amino alcohols derived from natural amino acids to yield optically active secondary alcohols in high chemical yields and moderate to good enantiomeric excesses.展开更多
文摘The reduction reagents prepared from sodium borohydride, I2 and a catalytic amount of chiral ferrocenyl amino alcohols 2a-e have been successfully applied to the enantioselective reduction of ketones. The optically active secondary alcohols were obtained in moderate enantiomeric excess and high chemical yield.
文摘Five novel chiral ferrocenyl amino alcohols were prepared from natural amino acids and used as catalysts in the asymmetric reduction of prochiral ketones with NaBH 4/I 2 combination. The incorporation of the ferrocenyl moiety into the molecule of the chiral amino alcohols greatly improved their enantioselectivity in the catalysis. The optically active secondary alcohols were obtained in moderate to good enantiomeric excesses and high chemical yields.
文摘The asymmetric reduction of prochiral ketones was catalyzed by a class of recoverable and highly stable chiral ferrocenyl amino alcohols derived from natural amino acids to yield optically active secondary alcohols in high chemical yields and moderate to good enantiomeric excesses.
