Objective To explore the mechanisms of cyclosporin-induced chronic nephrotoxicity. Methods Radioimmunoassay was used to study the changes of plasma renin activity (PRA) ,plasma angiotensin Ⅱ(Ang Ⅱ),and Aldosterone a...Objective To explore the mechanisms of cyclosporin-induced chronic nephrotoxicity. Methods Radioimmunoassay was used to study the changes of plasma renin activity (PRA) ,plasma angiotensin Ⅱ(Ang Ⅱ),and Aldosterone after rats were given low salt diet and 30 mg?kg-1?d-1of CsAfor 28 days. The protective effects of Radix Salviae Miltiorrhizae or benazepril on these changes were also studied. Results In CsA-treated rats, PRA and Ang Ⅱ levels were significantly elevated as compared with control groups. The elevation was not influenced by injection of Radix Salviae Miltiorrhizae,but could be blocked markedly by benazepril. There was significant difference in Aldosterone levels among the groups except benazepril-treated group showing a decreased Aldosterone level. Conclusion Chronic cyclosporone nephropathy may be related to activation of renin-angiotensin system, especially to the elevation of Ang Ⅱ levels. The different effects of Radix Salviae Miltiorrhizae or benazepril on RAS suggest the different展开更多
The thermal failure of airborne avionics equipment is not optimistic.It is very necessary to establish relatively accurate thermal models for predicting thermal response of avionics equipment under different flight co...The thermal failure of airborne avionics equipment is not optimistic.It is very necessary to establish relatively accurate thermal models for predicting thermal response of avionics equipment under different flight conditions.Traditional thermal modeling methods are often difficult to obtain accurate temperature response in complex conditions.This has severely restricted the application of these models.However,the Stochastic Configuration Network(SCN)model based on random algorithm can weaken the heat transfer mechanism and pay attention to the mining of experimental data,so that a more accurate thermal relationship might be obtained.In this paper,the SCN was used to analyze the experimental data of the avionics pod with a Ram Air Turbine(RAT)cooling system.The thermal models based on the SCN were finally built for avionics pod.Compared with the commonly used Random Vector Functional Link Network(RVFLN)thermal models,the SCN thermal models not only inherit the advantages of simple network structure and low computational complexity,but also have some merits,such as the better learning performance and the less human intervention.The presented SCN models provide a way to predict the thermal response of avionics pod cabin under the full flight envelope for a fighter.展开更多
文摘Objective To explore the mechanisms of cyclosporin-induced chronic nephrotoxicity. Methods Radioimmunoassay was used to study the changes of plasma renin activity (PRA) ,plasma angiotensin Ⅱ(Ang Ⅱ),and Aldosterone after rats were given low salt diet and 30 mg?kg-1?d-1of CsAfor 28 days. The protective effects of Radix Salviae Miltiorrhizae or benazepril on these changes were also studied. Results In CsA-treated rats, PRA and Ang Ⅱ levels were significantly elevated as compared with control groups. The elevation was not influenced by injection of Radix Salviae Miltiorrhizae,but could be blocked markedly by benazepril. There was significant difference in Aldosterone levels among the groups except benazepril-treated group showing a decreased Aldosterone level. Conclusion Chronic cyclosporone nephropathy may be related to activation of renin-angiotensin system, especially to the elevation of Ang Ⅱ levels. The different effects of Radix Salviae Miltiorrhizae or benazepril on RAS suggest the different
基金This work was funded by the National Key R&D Program of China(2017YFB1201100)the Liao Ning Revitalization Talents Program(XLYC1802092).
文摘The thermal failure of airborne avionics equipment is not optimistic.It is very necessary to establish relatively accurate thermal models for predicting thermal response of avionics equipment under different flight conditions.Traditional thermal modeling methods are often difficult to obtain accurate temperature response in complex conditions.This has severely restricted the application of these models.However,the Stochastic Configuration Network(SCN)model based on random algorithm can weaken the heat transfer mechanism and pay attention to the mining of experimental data,so that a more accurate thermal relationship might be obtained.In this paper,the SCN was used to analyze the experimental data of the avionics pod with a Ram Air Turbine(RAT)cooling system.The thermal models based on the SCN were finally built for avionics pod.Compared with the commonly used Random Vector Functional Link Network(RVFLN)thermal models,the SCN thermal models not only inherit the advantages of simple network structure and low computational complexity,but also have some merits,such as the better learning performance and the less human intervention.The presented SCN models provide a way to predict the thermal response of avionics pod cabin under the full flight envelope for a fighter.
