The paper reports results of investigation on the harmonic detection technique of a complicated power supply system such as an AC excited generation system, which has a variable fundamental frequency and low order har...The paper reports results of investigation on the harmonic detection technique of a complicated power supply system such as an AC excited generation system, which has a variable fundamental frequency and low order harmonics with rich sub-harmonics whose frequencies are lower than the fundamental one. The in-phase correlation filtering technique, based on the frequency shifting principle, is proposed in this paper.Theoretical analysis and experimental results validate the effectiveness of this technique for the harmonic detections of AC excited generation systems.展开更多
We theoretically investigate the contribution of the excited state to the ellipticity of the harmonics from H+ at different orientation angles irradiated by a linearly polarized laser pulse. It is found that the firs...We theoretically investigate the contribution of the excited state to the ellipticity of the harmonics from H+ at different orientation angles irradiated by a linearly polarized laser pulse. It is found that the first excited state has a significant influence to the ellipticity of the harmonics, and the contribution of higher excited states to the ellipticity can be neglected. Moreover, the conclusion is not dependent on the laser intensity.展开更多
Dynamic nonlinearities of C70/toluene solution are measured and analysed by an improved picosecond timeresolved pump-probe system based on a nonlinear imaging technique with phase object. The photophysical parameters ...Dynamic nonlinearities of C70/toluene solution are measured and analysed by an improved picosecond timeresolved pump-probe system based on a nonlinear imaging technique with phase object. The photophysical parameters are determined by the five-level model, which is adopted to interpret the experimental data. The change of refraction index per unit density of the excited state obtained by a numerically simulation is a critical factor to determine the nonlinear behaviour of C70 in picosecond time regime.展开更多
It is proposed that the Generation Model (GM) of particle physics, which describes the elementary particles, the six leptons, the six quarks and the three weak bosons, of the Standard Model (SM) as composite particles...It is proposed that the Generation Model (GM) of particle physics, which describes the elementary particles, the six leptons, the six quarks and the three weak bosons, of the Standard Model (SM) as composite particles in terms of three kinds of rishons and their antiparticles may be mimicking a simpler model, employing only two kinds of rishons and their antiparticles.展开更多
We theoretically investigate high-order harmonic generation(HHG) of helium(He), lithium cation(Li+), and beryllium dication(Be2+) using the time-dependent Hartree–Fock method to solve the three-dimensional time-depen...We theoretically investigate high-order harmonic generation(HHG) of helium(He), lithium cation(Li+), and beryllium dication(Be2+) using the time-dependent Hartree–Fock method to solve the three-dimensional time-dependent Schr ¨odinger equation. It is found that the intensity of the HHG increases significantly from a certain harmonic order below the ionization threshold, and the initial position of the enhancement does not depend on the intensity or the wavelength of the driving laser field. Further analysis shows that excited states play an important role on this enhancement,consistent with the excited-state tunneling mechanism [Phys. Rev. Lett. 116 123901(2016)]. Our results unambiguously show that excited-state tunneling is essential for understanding the enhancement of HHG. Accordingly, a four-step model is herein proposed to illustrate the multiphoton excitation effect in helium-like ions, which enriches the physics of HHG enhancement.展开更多
Multiphoton microscopy(MPM),based on two-photon excited fuorescence and second harmonic generation,enables direct noninvasive visualization of tissue architecture and cell morphology in live tissues without the admini...Multiphoton microscopy(MPM),based on two-photon excited fuorescence and second harmonic generation,enables direct noninvasive visualization of tissue architecture and cell morphology in live tissues without the administration of exogenous contrast agents.In this paper,we used MPM to image the microstructures of the mucosa in fresh,unfixed,and unstained intestinal tissue of mouse.The morphology and distribution of the main components in mucosa layer such as columnar cells,goblet cells,intestinal glands,and a little collagen fibers were clearly observed in MPM images,and then compared with standard H&:E images from paired specimens.Our results indicate that MPM combined with endoscopy and miniaturization probes has the potential application in the clinical diagnosis and in vivo monitoring of early intestinal cancer.展开更多
The gas generation features of coals at different maturities were studied by the anhydrous pyrolysis of Jurassic coal from the Minhe Basin in sealed gold tubes at 50 MPa.The gas component yields(C1,C2,C3,i-C4,n-C4,i-C...The gas generation features of coals at different maturities were studied by the anhydrous pyrolysis of Jurassic coal from the Minhe Basin in sealed gold tubes at 50 MPa.The gas component yields(C1,C2,C3,i-C4,n-C4,i-C5,n-C5,and CO2);theδ13C of C1,C2,C3,and CO2;and the mass of the liquid hydrocarbons(C6+)were measured.On the basis of these data,the stage changes ofδ13C1,δ13C2,δ13C3,andδ13CO2 were calculated.The diagrams ofδ13C1–δ13C2 vs ln(C1/C2)andδ13C2–δ13C1 vsδ13C3–δ13C2 were used to evaluate the gas generation features of the coal maturity stages.At the high maturity evolution stage(T>527.6°C at 2°C/h),the stage change ofδ13C1 and the CH4 yield are much higher than that of CO2,suggesting that high maturity coal could still generate methane.When T<455°C,CO2 is generated by breaking bonds between carbons and heteroatoms.The reaction between different sources of coke and water may be the reason for the complicated stage change inδ13CCO2 when the temperature was higher than 455°C.With increasing pyrolysis temperature,δ13C1–δ13C2 vs ln(C1/C2)has four evolution stages corresponding to the early stage of breaking bonds between carbon and hetero atoms,the later stage of breaking bonds between carbon and hetero atoms,the cracking of C6+and coal demethylation,and the cracking of C2–5.Theδ13C2–δ13C1 vsδ13C3–δ13C2 has three evolution stages corresponding to the breaking bonds between carbon and hetero atoms,demethylation and cracking of C6+,and cracking of C2–5.展开更多
Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors arising in the digest tract.It brings a challenge to diagnosis because it is asymptomatic clinically.It is well known that tumor development...Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors arising in the digest tract.It brings a challenge to diagnosis because it is asymptomatic clinically.It is well known that tumor development is often accompanied by the changes in the morphology of collagen fibers.Nowadays,an emerging optical imaging technique,second-harmonic generation(SHG),can directly identify collagen fibers without staining due to its noncentrosymmetric properties.Therefore,in this study,we attempt to assess the feasibility of SHG imaging for detecting GISTs by monitoring the morphological changes of collagen fibers in tumor microenvironment.We found that collagen alterations occurred obviously in the GISTs by comparing with normal tissues,and furthermore,two morphological features from SHG images were extracted to quantitatively assess the morphological difference of collagen fibers between normal muscular layer and GISTs by means of automated image analysis.Quantitative analyses show a significant difference in the two collagen features.This study demonstrates the potential of SHG imaging as an adjunctive diagnostic tool for label-free identification of GISTs.展开更多
This paper proposes highly charged ions pumped by intense laser to produce very high order harmonics. Numerical simulations and full quantum theory of Ne^9+ ions driven by laser pulses at 1064 nm in the power range o...This paper proposes highly charged ions pumped by intense laser to produce very high order harmonics. Numerical simulations and full quantum theory of Ne^9+ ions driven by laser pulses at 1064 nm in the power range of 109 W/cm^2 1015 W/cm^2 show that the emission spectrum corresponds to the electronic transitions from the excited states to the ground state, which is very different from the spectrum of general high-order harmonic generation. In such situation, harmonic order as high as 1000 can be obtained without producing lower order harmonics and the energy conversion efficiency is close to general high order harmonic generation of hydrogen atom in the same laser field.展开更多
Coherent electronic dynamics are of great significance in photo-induced processes and molecular magnetism.We theoretically investigate electronic dynamics of triatomic molecule H_(3)^(2+) by circularly polarized pulse...Coherent electronic dynamics are of great significance in photo-induced processes and molecular magnetism.We theoretically investigate electronic dynamics of triatomic molecule H_(3)^(2+) by circularly polarized pulses,including electron density distributions,induced electronic currents,and ultrafast magnetic field generation.By comparing the results of the coherent resonant excitation and direct ionization,we found that for the coherent resonant excitation,the electron is localized and the coherent electron wave packet moves periodically between three protons,which can be attributed to the coherent superposition of the ground A′state and excited E+state.Whereas,for the direct single-photon ionization,the induced electronic currents mainly come from the free electron in the continuum state.It is found that there are differences in the intensity,phase,and frequency of the induced current and the generated magnetic field.The scheme allows one to control the induced electronic current and the ultrafast magnetic field generation.展开更多
China,recognized as the world’s largest developing nation,displays considerably lower per capita consumption of dietary supplements in comparison to Asian nations such as Japan and South Korea.However,in recent years...China,recognized as the world’s largest developing nation,displays considerably lower per capita consumption of dietary supplements in comparison to Asian nations such as Japan and South Korea.However,in recent years,there has been a substantial surge in health consciousness among the Chinese populace.This trend is not confined to the middle-aged and elderly;even younger consumer demographics are exhibiting increased health awareness.Consequently,the target demographic for dietary supplements is transitioning towards a younger demographic.Within the Chinese dietary supplement industry,vitamin C has consistently held the largest market share,commanding a broad consumer base.This underscores the substantial role of vitamin C in the dietary supplement sector.In response to the trend towards a younger target demographic in the dietary supplement industry,adjustments are required to accommodate the preferences of this younger consumer group.This research,guided by Norman’s emotional design framework,executed a survey of over 200 respondents to investigate the preferences of Generation Z consumers in China.The research encompassed packaging,product forms,and brand imagery,corresponding to the emotional design’s visceral,behavioral,and reflective layers,with a primary focus on optimally meeting the emotional needs of Generation Z.The findings indicated that consumers favor products in capsule form,packaged in zip-lock.The predominant color scheme is clean white,accented by vibrant orange elements,while emphasizing the product’s health and scientific attributes.This study offers valuable insights for the continued evolution of the vitamin C dietary supplement market in China.展开更多
Background: The neutrophils (PMN) are our main blood cells to combat fungi, bacteria, and fibrin. For normal function, an activated PMN generates a certain concentration of reactive oxygen species (ROS). If the genera...Background: The neutrophils (PMN) are our main blood cells to combat fungi, bacteria, and fibrin. For normal function, an activated PMN generates a certain concentration of reactive oxygen species (ROS). If the generated blood ROS concentration is too low, then fungi, bacteria or fibrin might threaten the life of the patient, and it could be of great medical interest to stimulate PMN by physiologic drugs. Granulocyte-Colony Stimulating Factor (G-CSF) is a cell hormone that increases the cell number of PMN and that stimulates the individual PMN. The blood ROS generation assay (BRGA) is an innovative physiologic test to monitor the ROS generation of PMN in blood. Here the ROS generating action of G-CSF on normal PMN is quantified. Material and Methods: 40 μl 0 - 10.3 ng/ml (final conc.) G-CSF (in 5% human albumin) in black Brand? 781608 high quality polystyrene F-microwells was incubated in triplicate with 125 μl Hanks’ balanced salt solution (HBSS;modified without phenol red) and 10 μl normal citrated blood. Immediately (BRGA) or after 60 min (BRGA-60-) 10 μl 5 mM luminol sodium salt in 0.9% NaCl and 10 μl 0 or 36 μg/ml zymosan A in 0.9% NaCl was added. The photons were counted within 0 - 318 min (37°C) in a photons-multiplying microtiter plate luminometer. At about 0.5 t-maxn (0.5 fold the time to normal maximum) the approx. SC200 of G-CSF was determined. Results and Discussion: The approx. SC200 of G-CSF on normal blood ROS generation was 0.2 μg/l (=20 IU/ml). In clinical situations where an increased blood ROS generation is pharmacologically required, few micrograms of G-CSF could be a sufficient dosage for an adult patient. The BRGA helps to find out the correct stimulating G-CSF dosage for each individual. An enhanced PMN function could favor a better clinical outcome in situations of wanted increase of the innate immunology or in cellular fibrinolysis. G-CSF plasma concentrations of 0.1 - 1 μg/l might favor singlet oxygen generation without immunosuppression or cell fragment-induced thrombin generation.展开更多
文摘The paper reports results of investigation on the harmonic detection technique of a complicated power supply system such as an AC excited generation system, which has a variable fundamental frequency and low order harmonics with rich sub-harmonics whose frequencies are lower than the fundamental one. The in-phase correlation filtering technique, based on the frequency shifting principle, is proposed in this paper.Theoretical analysis and experimental results validate the effectiveness of this technique for the harmonic detections of AC excited generation systems.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.91026021,11075068,10875054,11175076,and 10975065)the Fundamental Research Funds of the Central Universities of China(Grant No.lzujbky-2010-k08)
文摘We theoretically investigate the contribution of the excited state to the ellipticity of the harmonics from H+ at different orientation angles irradiated by a linearly polarized laser pulse. It is found that the first excited state has a significant influence to the ellipticity of the harmonics, and the contribution of higher excited states to the ellipticity can be neglected. Moreover, the conclusion is not dependent on the laser intensity.
基金Project supported by the National Natural Science Fundation of China(Grant No.90922007)
文摘Dynamic nonlinearities of C70/toluene solution are measured and analysed by an improved picosecond timeresolved pump-probe system based on a nonlinear imaging technique with phase object. The photophysical parameters are determined by the five-level model, which is adopted to interpret the experimental data. The change of refraction index per unit density of the excited state obtained by a numerically simulation is a critical factor to determine the nonlinear behaviour of C70 in picosecond time regime.
文摘It is proposed that the Generation Model (GM) of particle physics, which describes the elementary particles, the six leptons, the six quarks and the three weak bosons, of the Standard Model (SM) as composite particles in terms of three kinds of rishons and their antiparticles may be mimicking a simpler model, employing only two kinds of rishons and their antiparticles.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 12274294 and 12075036)。
文摘We theoretically investigate high-order harmonic generation(HHG) of helium(He), lithium cation(Li+), and beryllium dication(Be2+) using the time-dependent Hartree–Fock method to solve the three-dimensional time-dependent Schr ¨odinger equation. It is found that the intensity of the HHG increases significantly from a certain harmonic order below the ionization threshold, and the initial position of the enhancement does not depend on the intensity or the wavelength of the driving laser field. Further analysis shows that excited states play an important role on this enhancement,consistent with the excited-state tunneling mechanism [Phys. Rev. Lett. 116 123901(2016)]. Our results unambiguously show that excited-state tunneling is essential for understanding the enhancement of HHG. Accordingly, a four-step model is herein proposed to illustrate the multiphoton excitation effect in helium-like ions, which enriches the physics of HHG enhancement.
基金supported by the Program for Changjiang Scholars and Innovative Research Team in University(Grant No.IRT1115)the National Natural Science Foundation of China(Grant Nos.81271620,61275006,81101209,30970783).
文摘Multiphoton microscopy(MPM),based on two-photon excited fuorescence and second harmonic generation,enables direct noninvasive visualization of tissue architecture and cell morphology in live tissues without the administration of exogenous contrast agents.In this paper,we used MPM to image the microstructures of the mucosa in fresh,unfixed,and unstained intestinal tissue of mouse.The morphology and distribution of the main components in mucosa layer such as columnar cells,goblet cells,intestinal glands,and a little collagen fibers were clearly observed in MPM images,and then compared with standard H&:E images from paired specimens.Our results indicate that MPM combined with endoscopy and miniaturization probes has the potential application in the clinical diagnosis and in vivo monitoring of early intestinal cancer.
基金The authors would like to thank Prof.Liu Jinzhong and Dr.Xu An for their great help on experiments analysis.This work is financially supported by the Major science and technology projects of Shaanxi Coal Geology Group Co.,Ltd.(SMDZ-2019ZD-1)Independent subject of the Key Laboratory of Coal Exploration and Comprehensive Utilization,Ministry of Nature and Resources(ZP2019-3)+2 种基金the“Enterprise top innovative young talents support plan”(20190412)the“Shaanxi Provincial Postdoctoral Science Foundation(No.2018M633642XB)”China Postdoctoral Science Foundation(No.2018M633642XB).
文摘The gas generation features of coals at different maturities were studied by the anhydrous pyrolysis of Jurassic coal from the Minhe Basin in sealed gold tubes at 50 MPa.The gas component yields(C1,C2,C3,i-C4,n-C4,i-C5,n-C5,and CO2);theδ13C of C1,C2,C3,and CO2;and the mass of the liquid hydrocarbons(C6+)were measured.On the basis of these data,the stage changes ofδ13C1,δ13C2,δ13C3,andδ13CO2 were calculated.The diagrams ofδ13C1–δ13C2 vs ln(C1/C2)andδ13C2–δ13C1 vsδ13C3–δ13C2 were used to evaluate the gas generation features of the coal maturity stages.At the high maturity evolution stage(T>527.6°C at 2°C/h),the stage change ofδ13C1 and the CH4 yield are much higher than that of CO2,suggesting that high maturity coal could still generate methane.When T<455°C,CO2 is generated by breaking bonds between carbons and heteroatoms.The reaction between different sources of coke and water may be the reason for the complicated stage change inδ13CCO2 when the temperature was higher than 455°C.With increasing pyrolysis temperature,δ13C1–δ13C2 vs ln(C1/C2)has four evolution stages corresponding to the early stage of breaking bonds between carbon and hetero atoms,the later stage of breaking bonds between carbon and hetero atoms,the cracking of C6+and coal demethylation,and the cracking of C2–5.Theδ13C2–δ13C1 vsδ13C3–δ13C2 has three evolution stages corresponding to the breaking bonds between carbon and hetero atoms,demethylation and cracking of C6+,and cracking of C2–5.
基金supported by the National Natural Science Foundation of China(Grant Nos.82171991 and 82172800)Joint Funds for the Innovation of Science and Technology of Fujian Province(Grant No.2019Y9101)+1 种基金Fujian Major Scientific and Technological Special Project for"Social Development"(No.2020YZ016002)Special Funds of the Central Government Guiding Local Science and Technology Development(No.2020L3008).
文摘Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors arising in the digest tract.It brings a challenge to diagnosis because it is asymptomatic clinically.It is well known that tumor development is often accompanied by the changes in the morphology of collagen fibers.Nowadays,an emerging optical imaging technique,second-harmonic generation(SHG),can directly identify collagen fibers without staining due to its noncentrosymmetric properties.Therefore,in this study,we attempt to assess the feasibility of SHG imaging for detecting GISTs by monitoring the morphological changes of collagen fibers in tumor microenvironment.We found that collagen alterations occurred obviously in the GISTs by comparing with normal tissues,and furthermore,two morphological features from SHG images were extracted to quantitatively assess the morphological difference of collagen fibers between normal muscular layer and GISTs by means of automated image analysis.Quantitative analyses show a significant difference in the two collagen features.This study demonstrates the potential of SHG imaging as an adjunctive diagnostic tool for label-free identification of GISTs.
基金Project supported by the National Natural Science Foundation of China (Grant No. 10574030)
文摘This paper proposes highly charged ions pumped by intense laser to produce very high order harmonics. Numerical simulations and full quantum theory of Ne^9+ ions driven by laser pulses at 1064 nm in the power range of 109 W/cm^2 1015 W/cm^2 show that the emission spectrum corresponds to the electronic transitions from the excited states to the ground state, which is very different from the spectrum of general high-order harmonic generation. In such situation, harmonic order as high as 1000 can be obtained without producing lower order harmonics and the energy conversion efficiency is close to general high order harmonic generation of hydrogen atom in the same laser field.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12074146 and 12074142)。
文摘Coherent electronic dynamics are of great significance in photo-induced processes and molecular magnetism.We theoretically investigate electronic dynamics of triatomic molecule H_(3)^(2+) by circularly polarized pulses,including electron density distributions,induced electronic currents,and ultrafast magnetic field generation.By comparing the results of the coherent resonant excitation and direct ionization,we found that for the coherent resonant excitation,the electron is localized and the coherent electron wave packet moves periodically between three protons,which can be attributed to the coherent superposition of the ground A′state and excited E+state.Whereas,for the direct single-photon ionization,the induced electronic currents mainly come from the free electron in the continuum state.It is found that there are differences in the intensity,phase,and frequency of the induced current and the generated magnetic field.The scheme allows one to control the induced electronic current and the ultrafast magnetic field generation.
文摘China,recognized as the world’s largest developing nation,displays considerably lower per capita consumption of dietary supplements in comparison to Asian nations such as Japan and South Korea.However,in recent years,there has been a substantial surge in health consciousness among the Chinese populace.This trend is not confined to the middle-aged and elderly;even younger consumer demographics are exhibiting increased health awareness.Consequently,the target demographic for dietary supplements is transitioning towards a younger demographic.Within the Chinese dietary supplement industry,vitamin C has consistently held the largest market share,commanding a broad consumer base.This underscores the substantial role of vitamin C in the dietary supplement sector.In response to the trend towards a younger target demographic in the dietary supplement industry,adjustments are required to accommodate the preferences of this younger consumer group.This research,guided by Norman’s emotional design framework,executed a survey of over 200 respondents to investigate the preferences of Generation Z consumers in China.The research encompassed packaging,product forms,and brand imagery,corresponding to the emotional design’s visceral,behavioral,and reflective layers,with a primary focus on optimally meeting the emotional needs of Generation Z.The findings indicated that consumers favor products in capsule form,packaged in zip-lock.The predominant color scheme is clean white,accented by vibrant orange elements,while emphasizing the product’s health and scientific attributes.This study offers valuable insights for the continued evolution of the vitamin C dietary supplement market in China.
文摘Background: The neutrophils (PMN) are our main blood cells to combat fungi, bacteria, and fibrin. For normal function, an activated PMN generates a certain concentration of reactive oxygen species (ROS). If the generated blood ROS concentration is too low, then fungi, bacteria or fibrin might threaten the life of the patient, and it could be of great medical interest to stimulate PMN by physiologic drugs. Granulocyte-Colony Stimulating Factor (G-CSF) is a cell hormone that increases the cell number of PMN and that stimulates the individual PMN. The blood ROS generation assay (BRGA) is an innovative physiologic test to monitor the ROS generation of PMN in blood. Here the ROS generating action of G-CSF on normal PMN is quantified. Material and Methods: 40 μl 0 - 10.3 ng/ml (final conc.) G-CSF (in 5% human albumin) in black Brand? 781608 high quality polystyrene F-microwells was incubated in triplicate with 125 μl Hanks’ balanced salt solution (HBSS;modified without phenol red) and 10 μl normal citrated blood. Immediately (BRGA) or after 60 min (BRGA-60-) 10 μl 5 mM luminol sodium salt in 0.9% NaCl and 10 μl 0 or 36 μg/ml zymosan A in 0.9% NaCl was added. The photons were counted within 0 - 318 min (37°C) in a photons-multiplying microtiter plate luminometer. At about 0.5 t-maxn (0.5 fold the time to normal maximum) the approx. SC200 of G-CSF was determined. Results and Discussion: The approx. SC200 of G-CSF on normal blood ROS generation was 0.2 μg/l (=20 IU/ml). In clinical situations where an increased blood ROS generation is pharmacologically required, few micrograms of G-CSF could be a sufficient dosage for an adult patient. The BRGA helps to find out the correct stimulating G-CSF dosage for each individual. An enhanced PMN function could favor a better clinical outcome in situations of wanted increase of the innate immunology or in cellular fibrinolysis. G-CSF plasma concentrations of 0.1 - 1 μg/l might favor singlet oxygen generation without immunosuppression or cell fragment-induced thrombin generation.