The Opinions on Acceleration of Implementation of Free Trade Zone Strategy,which was issued by the State Council in the end of 2015,clearly proposed the establishment of high standard global FTA(free trade zone)networ...The Opinions on Acceleration of Implementation of Free Trade Zone Strategy,which was issued by the State Council in the end of 2015,clearly proposed the establishment of high standard global FTA(free trade zone)network that is based on surrounding countries regions and covers the'Belt and Road'region.As of now,China has signed 14 FTA agreements with 22 countries and regions,including ASEAN(Association of Southeast展开更多
The results from a recent s tudy show that in the past five years,the transfer of rural labourers from agri-cultural work to non-agricultural sectors has accelerated and some 50 million rural labourers have made the s...The results from a recent s tudy show that in the past five years,the transfer of rural labourers from agri-cultural work to non-agricultural sectors has accelerated and some 50 million rural labourers have made the switch.This figure was produced by the State Statistical Bureau(SSB)based on data from Chind s 1%popu-1ation sample survey and annual popu-lation statistics.展开更多
Scientific progress has greatly improved the technical level of China’s highway and waterway transport in the past ten years. In order to modernize communications and transport and raise competitive power of enterpri...Scientific progress has greatly improved the technical level of China’s highway and waterway transport in the past ten years. In order to modernize communications and transport and raise competitive power of enterprises as early as possible, the Ministry of Communications has decided to add more scientific investment, planning to double the annual expense on scientific investment during the Ninth Five-year Plan period compared to the Eighth Five-year展开更多
Background Cellular repressor of ElA-stimulated genes(CREG) is homeostatic modulated gene,which regulate a number of cellular processes,including cell differentiation, motility and survival.Previous studies have demon...Background Cellular repressor of ElA-stimulated genes(CREG) is homeostatic modulated gene,which regulate a number of cellular processes,including cell differentiation, motility and survival.Previous studies have demonstrated that CREG was expressed in all three germ layers,suggesting that it might act as a vital regulator during embryonic developing.The aim of the present study was to investigate the role of CREG in an embryonic stem cell(ESC) differentiation model that recapitulates the developmental steps of vasculogenesis.Methods The ES cells were stably transfected either pCXN2-FLAG-CREG-IRES-EGFP plasmid or pDS1- shRNA-CREG plasmid to produce the CREG+/ES cells and CREG-siRNA/ES cells,respectively.Vasculogenesis was detected by whole mount immunostainings for CD31.Dil labeled acLDL staining assay was used to detect branching pseudopods in cultures in Matrigel.Real-time PCR and Western blot analysis were employed to determine expressions of VEGF and Flk-1.Results CREG +/ES-derived embryoid bodies(EBs) were found to form spontaneously a primitive vascular network after 6 days of differentiation.In contrast, wildtype EBs exhibit theirs vasculogenesis until 13 days of differentiation by whole mount immunostainings for CD31. CREG +/EBs developed more rapidly branching pseudopods at 9 days compared with that of wildtype EBs by Dil labeled acLDL staining assay.In contrast,CREG-siRNA/ES exhibits an undifferentiated morphogenesis associated with an increase in apoptotic cells in spite of being derived from LIF and feeder layers.Administration of CREG-siRNA/ES cells with recombinant CREG protein rescued the phenomena that CREG boosted vasculogenesis in a dose-dependent fasion. Mechanically,Real-time PCR and Western blot analysis revealed the expressions both VEGF and Flk-1 significantly in- creased in CREG+/EBs.Moreover,after treatment of CREG+ /EBs with neurtralizing antibody against VEGF,the rapid vasculogenesis was significantly repressed.Conclusions Our data strongely demonstrate that CREG play a pivotal role in accelerating vasculogenesis in development of ES cells. VEGF,as its important downstream effector,mediated this bio-function.展开更多
Scientific progress has greatly improved the technical level of China’shighway and waterway transport in the past decade.In order tomodernize communications and transport and raise competitivepower of enterprises as ...Scientific progress has greatly improved the technical level of China’shighway and waterway transport in the past decade.In order tomodernize communications and transport and raise competitivepower of enterprises as early as possible,the Ministry of Communicationshas decided to add more scientific investment,planning to double theannual expense on scientific investment during the Ninth Five-yearPlan period compared to the Eighth Five-year Plan period.Theministry will also conduct cooperative research,development,designand production with foreign scientific institutions and internationalorganizations.展开更多
A cosmological model with both acceleration and deceleration is proposed, rewriting and reinterpreting Einstein's Field Equations, with a variable cosmological parameter A denoting energy due to space-time, which may...A cosmological model with both acceleration and deceleration is proposed, rewriting and reinterpreting Einstein's Field Equations, with a variable cosmological parameter A denoting energy due to space-time, which may be considered as "vacuum energy" at the "beginning" of the universe. The cosmological constant is replaced by a variable cosmological parameter, which is a measure of the energy of space-time that could be converted to energy of matter and radiation and vice versa.展开更多
The rapid expansion of lake area in the Tibetan Plateau(TP)has attracted a considerable amount of concern in recent decades.Limited evidence has suggested that climate warming and the cryosphere change are the most pr...The rapid expansion of lake area in the Tibetan Plateau(TP)has attracted a considerable amount of concern in recent decades.Limited evidence has suggested that climate warming and the cryosphere change are the most prominent contributors to lake expansion.The widespread changes in lake area result from a combination of increased precipitation,melting glaciers,permafrost degradation,and changes in other components of terrestrial water.However,debate remains as to whether melting glaciers or increased precipitation have a greater impact on lake expansion.Varied topography and limited datasets hinder the ability to perform extensive research,and there is currently no definitive conclusion on the issue.展开更多
From May to July, an American-style Texas barbecue will be jointly held by Unilever and Huajiayiyuan Restaurant at SOHO Shangdu, located at the center of Beijing’s Central Business District.
With the support by the National Natural Science Foundation of China and the'Strategic Priority Research Program'of the Chinese Academy of Sciences,a collaborative study by the research groups led by Professor...With the support by the National Natural Science Foundation of China and the'Strategic Priority Research Program'of the Chinese Academy of Sciences,a collaborative study by the research groups led by Professors Tian Zhixi(田志喜),Wang Guodong(王国栋),and Zhu Baoge(朱保葛)from the展开更多
Zhongjin Lingnan’s main business is mining,smelting and sales of non-ferrous metals such as lead,zinc,copper and silver.In its nonpublic offering scheme released earlier,a total of about 658 million yuan,including 46...Zhongjin Lingnan’s main business is mining,smelting and sales of non-ferrous metals such as lead,zinc,copper and silver.In its nonpublic offering scheme released earlier,a total of about 658 million yuan,including 460million yuan of raised funds will be invested in a new materials project.The construction projects include a high-performance展开更多
Chengtun Mining recently released its financial report,recording a rapid growth in both operating income and net profit.In 2016,the company achieved operating income of RMB 12.710 billion,up by 90.78%year-on-year,
Recent information about Jinwang Bismuth Industrial reveals that the company has developed the world’s first oxygen-rich sideblown redox duplex furnace technology,solving the long-standing problems of environmental p...Recent information about Jinwang Bismuth Industrial reveals that the company has developed the world’s first oxygen-rich sideblown redox duplex furnace technology,solving the long-standing problems of environmental protection and resource recycling in bismuth smelting.It’s learned that the company recovers up to100,000 tons of bismuth-containing lead-展开更多
On June 27,China(Qinghai)Lithium Industry and Power Battery International Summit Forum2018 was officially held in Xining,Qinghai.Wang Liming,vice-governor of Qinghai,noted at the forum that Qinghai boasts advantaged s...On June 27,China(Qinghai)Lithium Industry and Power Battery International Summit Forum2018 was officially held in Xining,Qinghai.Wang Liming,vice-governor of Qinghai,noted at the forum that Qinghai boasts advantaged salt lake resources,the proved lithium resources reserve here accounts for over 1/3 of the global resources reserve and over展开更多
Background and aims:Drug-induced liver injury(DILI)is one of the most serious adverse drug reactions and its incidence has been increasing rapidly.Accumulating evidence suggests that immune activation and systemic inf...Background and aims:Drug-induced liver injury(DILI)is one of the most serious adverse drug reactions and its incidence has been increasing rapidly.Accumulating evidence suggests that immune activation and systemic inflammatory responses are very important in the progression of DILI.Corticosteroids are often used in DILI,but their clinical usefulness remains controversial.We therefore conducted a prospective,randomized controlled study to investigate whether corticosteroid therapy can accelerate recovery and reduce mortality in severe DILI(SDILI).Methods:SDILI patients with total bilirubin?171μmol/L who presented to the Fifth Medical Center of Chinese PLA General Hospital,Beijing from 2016 to 2019 were randomly allocated to prednisolone and control groups.The endpoints were resolution of SDILI,defined as a decrease in total bilirubin of at least 35μmol/L to<171μmol/L,and overall survival at 6 months.Patients in the prednisolone group received prednisolone 60 mg/day therapy for the first 7 days.Patients with a decrease in total bilirubin of more than 35μmol/L on day 8 continued on tapering doses of prednisolone;otherwise,prednisolone was discontinued.Results:On day 8,50.75%(34/67)and 26.47%(18/68)of the participants in the prednisolone and control groups,respectively,achieved the primary endpoint(p¼0.002).However,there was no significant difference in overall survival at 6 months:95.52%(64/67)vs.91.18%(62/68)in the prednisolone and control groups,respectively(p¼0.3).All deaths in both groups occurred in patients who failed to achieve SDILI resolution on day 8.Conclusion:Prednisolone therapy may accelerate the recovery of SDILI.展开更多
西南艰险山区分布着大量的不同倾向的层状碎裂结构斜坡,地震作用下极易发生崩塌、滑坡等灾害,对在建的川藏铁路造成严重威胁。通过大型振动台模型试验,研究了强震条件下顺倾、反倾层状碎裂结构斜坡的动力响应、失稳破坏模式以及能量传...西南艰险山区分布着大量的不同倾向的层状碎裂结构斜坡,地震作用下极易发生崩塌、滑坡等灾害,对在建的川藏铁路造成严重威胁。通过大型振动台模型试验,研究了强震条件下顺倾、反倾层状碎裂结构斜坡的动力响应、失稳破坏模式以及能量传递规律。试验结果表明:反倾斜坡的抗震性能显著优于顺倾斜坡;顺倾斜坡的破坏模式主要为拉裂-剪切-隆起-滑移型破坏,反倾斜坡的破坏模式主要为拉伸-弯曲-倾倒-崩塌型破坏;反倾斜坡的自振频率高于顺倾斜坡,顺倾斜坡的自振频率随震级的增加而逐渐降低,而反倾斜坡的自振频率在地震波幅值为0.4g~0.7g时出现反复震荡现象;顺倾斜坡存在明显的高程放大效应和趋表效应,反倾斜坡存在高程放大效应,其内部的加速度响应大于坡表。边际谱识别显示:顺倾斜坡的边际谱幅值(peak of marginal spectrum amplitude,简称PMSA)突变在坡腰上部最显著,说明该位置附近地震波的能量损失最大,反映出顺倾斜坡在坡腰上部附近形成了滑动破坏面;反倾斜坡的PMSA在坡肩处降低得最为显著,反映出坡肩部位损伤最为严重,易发生局部崩塌破坏。分析结果与试验现象能够较好地吻合,进一步揭示了不同结构类型层状碎裂结构斜坡在强震作用下的动力响应与失稳破坏模式,为川藏铁路的安全建设提供了依据。展开更多
文摘The Opinions on Acceleration of Implementation of Free Trade Zone Strategy,which was issued by the State Council in the end of 2015,clearly proposed the establishment of high standard global FTA(free trade zone)network that is based on surrounding countries regions and covers the'Belt and Road'region.As of now,China has signed 14 FTA agreements with 22 countries and regions,including ASEAN(Association of Southeast
文摘The results from a recent s tudy show that in the past five years,the transfer of rural labourers from agri-cultural work to non-agricultural sectors has accelerated and some 50 million rural labourers have made the switch.This figure was produced by the State Statistical Bureau(SSB)based on data from Chind s 1%popu-1ation sample survey and annual popu-lation statistics.
文摘Scientific progress has greatly improved the technical level of China’s highway and waterway transport in the past ten years. In order to modernize communications and transport and raise competitive power of enterprises as early as possible, the Ministry of Communications has decided to add more scientific investment, planning to double the annual expense on scientific investment during the Ninth Five-year Plan period compared to the Eighth Five-year
文摘Background Cellular repressor of ElA-stimulated genes(CREG) is homeostatic modulated gene,which regulate a number of cellular processes,including cell differentiation, motility and survival.Previous studies have demonstrated that CREG was expressed in all three germ layers,suggesting that it might act as a vital regulator during embryonic developing.The aim of the present study was to investigate the role of CREG in an embryonic stem cell(ESC) differentiation model that recapitulates the developmental steps of vasculogenesis.Methods The ES cells were stably transfected either pCXN2-FLAG-CREG-IRES-EGFP plasmid or pDS1- shRNA-CREG plasmid to produce the CREG+/ES cells and CREG-siRNA/ES cells,respectively.Vasculogenesis was detected by whole mount immunostainings for CD31.Dil labeled acLDL staining assay was used to detect branching pseudopods in cultures in Matrigel.Real-time PCR and Western blot analysis were employed to determine expressions of VEGF and Flk-1.Results CREG +/ES-derived embryoid bodies(EBs) were found to form spontaneously a primitive vascular network after 6 days of differentiation.In contrast, wildtype EBs exhibit theirs vasculogenesis until 13 days of differentiation by whole mount immunostainings for CD31. CREG +/EBs developed more rapidly branching pseudopods at 9 days compared with that of wildtype EBs by Dil labeled acLDL staining assay.In contrast,CREG-siRNA/ES exhibits an undifferentiated morphogenesis associated with an increase in apoptotic cells in spite of being derived from LIF and feeder layers.Administration of CREG-siRNA/ES cells with recombinant CREG protein rescued the phenomena that CREG boosted vasculogenesis in a dose-dependent fasion. Mechanically,Real-time PCR and Western blot analysis revealed the expressions both VEGF and Flk-1 significantly in- creased in CREG+/EBs.Moreover,after treatment of CREG+ /EBs with neurtralizing antibody against VEGF,the rapid vasculogenesis was significantly repressed.Conclusions Our data strongely demonstrate that CREG play a pivotal role in accelerating vasculogenesis in development of ES cells. VEGF,as its important downstream effector,mediated this bio-function.
文摘Scientific progress has greatly improved the technical level of China’shighway and waterway transport in the past decade.In order tomodernize communications and transport and raise competitivepower of enterprises as early as possible,the Ministry of Communicationshas decided to add more scientific investment,planning to double theannual expense on scientific investment during the Ninth Five-yearPlan period compared to the Eighth Five-year Plan period.Theministry will also conduct cooperative research,development,designand production with foreign scientific institutions and internationalorganizations.
文摘A cosmological model with both acceleration and deceleration is proposed, rewriting and reinterpreting Einstein's Field Equations, with a variable cosmological parameter A denoting energy due to space-time, which may be considered as "vacuum energy" at the "beginning" of the universe. The cosmological constant is replaced by a variable cosmological parameter, which is a measure of the energy of space-time that could be converted to energy of matter and radiation and vice versa.
基金supported by the National Natural Science Foundation of China(41421004,41825010)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA19070201)+1 种基金the Open Program of Joint Laboratory of Climate and Environment Change,Chengdu University of Information Technology(JLCEC201801)the CAS-PKU(Chinese Academy of Science-Peking University)Joint Research Program
文摘The rapid expansion of lake area in the Tibetan Plateau(TP)has attracted a considerable amount of concern in recent decades.Limited evidence has suggested that climate warming and the cryosphere change are the most prominent contributors to lake expansion.The widespread changes in lake area result from a combination of increased precipitation,melting glaciers,permafrost degradation,and changes in other components of terrestrial water.However,debate remains as to whether melting glaciers or increased precipitation have a greater impact on lake expansion.Varied topography and limited datasets hinder the ability to perform extensive research,and there is currently no definitive conclusion on the issue.
文摘From May to July, an American-style Texas barbecue will be jointly held by Unilever and Huajiayiyuan Restaurant at SOHO Shangdu, located at the center of Beijing’s Central Business District.
文摘With the support by the National Natural Science Foundation of China and the'Strategic Priority Research Program'of the Chinese Academy of Sciences,a collaborative study by the research groups led by Professors Tian Zhixi(田志喜),Wang Guodong(王国栋),and Zhu Baoge(朱保葛)from the
文摘Zhongjin Lingnan’s main business is mining,smelting and sales of non-ferrous metals such as lead,zinc,copper and silver.In its nonpublic offering scheme released earlier,a total of about 658 million yuan,including 460million yuan of raised funds will be invested in a new materials project.The construction projects include a high-performance
文摘Chengtun Mining recently released its financial report,recording a rapid growth in both operating income and net profit.In 2016,the company achieved operating income of RMB 12.710 billion,up by 90.78%year-on-year,
文摘Recent information about Jinwang Bismuth Industrial reveals that the company has developed the world’s first oxygen-rich sideblown redox duplex furnace technology,solving the long-standing problems of environmental protection and resource recycling in bismuth smelting.It’s learned that the company recovers up to100,000 tons of bismuth-containing lead-
文摘On June 27,China(Qinghai)Lithium Industry and Power Battery International Summit Forum2018 was officially held in Xining,Qinghai.Wang Liming,vice-governor of Qinghai,noted at the forum that Qinghai boasts advantaged salt lake resources,the proved lithium resources reserve here accounts for over 1/3 of the global resources reserve and over
基金This work was supported by the Capital Clinical Characteristic Application Research on Funded Projects(No:Z161100000516172)the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine(No:ZYYCXTD-C-202005).
文摘Background and aims:Drug-induced liver injury(DILI)is one of the most serious adverse drug reactions and its incidence has been increasing rapidly.Accumulating evidence suggests that immune activation and systemic inflammatory responses are very important in the progression of DILI.Corticosteroids are often used in DILI,but their clinical usefulness remains controversial.We therefore conducted a prospective,randomized controlled study to investigate whether corticosteroid therapy can accelerate recovery and reduce mortality in severe DILI(SDILI).Methods:SDILI patients with total bilirubin?171μmol/L who presented to the Fifth Medical Center of Chinese PLA General Hospital,Beijing from 2016 to 2019 were randomly allocated to prednisolone and control groups.The endpoints were resolution of SDILI,defined as a decrease in total bilirubin of at least 35μmol/L to<171μmol/L,and overall survival at 6 months.Patients in the prednisolone group received prednisolone 60 mg/day therapy for the first 7 days.Patients with a decrease in total bilirubin of more than 35μmol/L on day 8 continued on tapering doses of prednisolone;otherwise,prednisolone was discontinued.Results:On day 8,50.75%(34/67)and 26.47%(18/68)of the participants in the prednisolone and control groups,respectively,achieved the primary endpoint(p¼0.002).However,there was no significant difference in overall survival at 6 months:95.52%(64/67)vs.91.18%(62/68)in the prednisolone and control groups,respectively(p¼0.3).All deaths in both groups occurred in patients who failed to achieve SDILI resolution on day 8.Conclusion:Prednisolone therapy may accelerate the recovery of SDILI.
文摘西南艰险山区分布着大量的不同倾向的层状碎裂结构斜坡,地震作用下极易发生崩塌、滑坡等灾害,对在建的川藏铁路造成严重威胁。通过大型振动台模型试验,研究了强震条件下顺倾、反倾层状碎裂结构斜坡的动力响应、失稳破坏模式以及能量传递规律。试验结果表明:反倾斜坡的抗震性能显著优于顺倾斜坡;顺倾斜坡的破坏模式主要为拉裂-剪切-隆起-滑移型破坏,反倾斜坡的破坏模式主要为拉伸-弯曲-倾倒-崩塌型破坏;反倾斜坡的自振频率高于顺倾斜坡,顺倾斜坡的自振频率随震级的增加而逐渐降低,而反倾斜坡的自振频率在地震波幅值为0.4g~0.7g时出现反复震荡现象;顺倾斜坡存在明显的高程放大效应和趋表效应,反倾斜坡存在高程放大效应,其内部的加速度响应大于坡表。边际谱识别显示:顺倾斜坡的边际谱幅值(peak of marginal spectrum amplitude,简称PMSA)突变在坡腰上部最显著,说明该位置附近地震波的能量损失最大,反映出顺倾斜坡在坡腰上部附近形成了滑动破坏面;反倾斜坡的PMSA在坡肩处降低得最为显著,反映出坡肩部位损伤最为严重,易发生局部崩塌破坏。分析结果与试验现象能够较好地吻合,进一步揭示了不同结构类型层状碎裂结构斜坡在强震作用下的动力响应与失稳破坏模式,为川藏铁路的安全建设提供了依据。