Membrane proteins are an important kind of proteins embedded in the membranes of cells and play crucial roles in living organisms, such as ion channels,transporters, receptors. Because it is difficult to determinate t...Membrane proteins are an important kind of proteins embedded in the membranes of cells and play crucial roles in living organisms, such as ion channels,transporters, receptors. Because it is difficult to determinate the membrane protein's structure by wet-lab experiments,accurate and fast amino acid sequence-based computational methods are highly desired. In this paper, we report an online prediction tool called Mem Brain, whose input is the amino acid sequence. Mem Brain consists of specialized modules for predicting transmembrane helices, residue–residue contacts and relative accessible surface area of a-helical membrane proteins. Mem Brain achieves aprediction accuracy of 97.9% of ATMH, 87.1% of AP,3.2 ± 3.0 of N-score, 3.1 ± 2.8 of C-score. Mem BrainContact obtains 62%/64.1% prediction accuracy on training and independent dataset on top L/5 contact prediction,respectively. And Mem Brain-Rasa achieves Pearson correlation coefficient of 0.733 and its mean absolute error of13.593. These prediction results provide valuable hints for revealing the structure and function of membrane proteins.Mem Brain web server is free for academic use and available at www.csbio.sjtu.edu.cn/bioinf/Mem Brain/.展开更多
The National Institute of Standards and Technology(NIST)has identified natural language policies as the preferred expression of policy and implicitly called for an automated translation of ABAC natural language access...The National Institute of Standards and Technology(NIST)has identified natural language policies as the preferred expression of policy and implicitly called for an automated translation of ABAC natural language access control policy(NLACP)to a machine-readable form.To study the automation process,we consider the hierarchical ABAC model as our reference model since it better reflects the requirements of real-world organizations.Therefore,this paper focuses on the questions of:how can we automatically infer the hierarchical structure of an ABAC model given NLACPs;and,how can we extract and define the set of authorization attributes based on the resulting structure.To address these questions,we propose an approach built upon recent advancements in natural language processing and machine learning techniques.For such a solution,the lack of appropriate data often poses a bottleneck.Therefore,we decouple the primary contributions of this work into:(1)developing a practical framework to extract authorization attributes of hierarchical ABAC system from natural language artifacts,and(2)generating a set of realistic synthetic natural language access control policies(NLACPs)to evaluate the proposed framework.Our experimental results are promising as we achieved-in average-an F1-score of 0.96 when extracting attributes values of subjects,and 0.91 when extracting the values of objects’attributes from natural language access control policies.展开更多
The National Institute of Standards and Technology(NIST)has identified natural language policies as the preferred expression of policy and implicitly called for an automated translation of ABAC natural language access...The National Institute of Standards and Technology(NIST)has identified natural language policies as the preferred expression of policy and implicitly called for an automated translation of ABAC natural language access control policy(NLACP)to a machine-readable form.To study the automation process,we consider the hierarchical ABAC model as our reference model since it better reflects the requirements of real-world organizations.Therefore,this paper focuses on the questions of:how can we automatically infer the hierarchical structure of an ABAC model given NLACPs;and,how can we extract and define the set of authorization attributes based on the resulting structure.To address these questions,we propose an approach built upon recent advancements in natural language processing and machine learning techniques.For such a solution,the lack of appropriate data often poses a bottleneck.Therefore,we decouple the primary contributions of this work into:(1)developing a practical framework to extract authorization attributes of hierarchical ABAC system from natural language artifacts,and(2)generating a set of realistic synthetic natural language access control policies(NLACPs)to evaluate the proposed framework.Our experimental results are promising as we achieved-in average-an F1-score of 0.96 when extracting attributes values of subjects,and 0.91 when extracting the values of objects’attributes from natural language access control policies.展开更多
基金supported by the National Natural Science Foundation of China(Nos.61671288,91530321,61603161)Science and Technology Commission of Shanghai Municipality(Nos.16JC1404300,17JC1403500,16ZR1448700)
文摘Membrane proteins are an important kind of proteins embedded in the membranes of cells and play crucial roles in living organisms, such as ion channels,transporters, receptors. Because it is difficult to determinate the membrane protein's structure by wet-lab experiments,accurate and fast amino acid sequence-based computational methods are highly desired. In this paper, we report an online prediction tool called Mem Brain, whose input is the amino acid sequence. Mem Brain consists of specialized modules for predicting transmembrane helices, residue–residue contacts and relative accessible surface area of a-helical membrane proteins. Mem Brain achieves aprediction accuracy of 97.9% of ATMH, 87.1% of AP,3.2 ± 3.0 of N-score, 3.1 ± 2.8 of C-score. Mem BrainContact obtains 62%/64.1% prediction accuracy on training and independent dataset on top L/5 contact prediction,respectively. And Mem Brain-Rasa achieves Pearson correlation coefficient of 0.733 and its mean absolute error of13.593. These prediction results provide valuable hints for revealing the structure and function of membrane proteins.Mem Brain web server is free for academic use and available at www.csbio.sjtu.edu.cn/bioinf/Mem Brain/.
文摘The National Institute of Standards and Technology(NIST)has identified natural language policies as the preferred expression of policy and implicitly called for an automated translation of ABAC natural language access control policy(NLACP)to a machine-readable form.To study the automation process,we consider the hierarchical ABAC model as our reference model since it better reflects the requirements of real-world organizations.Therefore,this paper focuses on the questions of:how can we automatically infer the hierarchical structure of an ABAC model given NLACPs;and,how can we extract and define the set of authorization attributes based on the resulting structure.To address these questions,we propose an approach built upon recent advancements in natural language processing and machine learning techniques.For such a solution,the lack of appropriate data often poses a bottleneck.Therefore,we decouple the primary contributions of this work into:(1)developing a practical framework to extract authorization attributes of hierarchical ABAC system from natural language artifacts,and(2)generating a set of realistic synthetic natural language access control policies(NLACPs)to evaluate the proposed framework.Our experimental results are promising as we achieved-in average-an F1-score of 0.96 when extracting attributes values of subjects,and 0.91 when extracting the values of objects’attributes from natural language access control policies.
基金supported by Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.
文摘The National Institute of Standards and Technology(NIST)has identified natural language policies as the preferred expression of policy and implicitly called for an automated translation of ABAC natural language access control policy(NLACP)to a machine-readable form.To study the automation process,we consider the hierarchical ABAC model as our reference model since it better reflects the requirements of real-world organizations.Therefore,this paper focuses on the questions of:how can we automatically infer the hierarchical structure of an ABAC model given NLACPs;and,how can we extract and define the set of authorization attributes based on the resulting structure.To address these questions,we propose an approach built upon recent advancements in natural language processing and machine learning techniques.For such a solution,the lack of appropriate data often poses a bottleneck.Therefore,we decouple the primary contributions of this work into:(1)developing a practical framework to extract authorization attributes of hierarchical ABAC system from natural language artifacts,and(2)generating a set of realistic synthetic natural language access control policies(NLACPs)to evaluate the proposed framework.Our experimental results are promising as we achieved-in average-an F1-score of 0.96 when extracting attributes values of subjects,and 0.91 when extracting the values of objects’attributes from natural language access control policies.
