目的:探讨c-Myc、SIRT1及acetyl-p53蛋白在乳腺癌中的表达及其对预后的影响。方法:应用免疫组织化学方法检测90例乳腺癌和30例乳腺增生症中的c-Myc、SIRT1(Sirtuin type 1)、acetyl-p53蛋白表达,结合临床病理资料和随访资料,进行预后分...目的:探讨c-Myc、SIRT1及acetyl-p53蛋白在乳腺癌中的表达及其对预后的影响。方法:应用免疫组织化学方法检测90例乳腺癌和30例乳腺增生症中的c-Myc、SIRT1(Sirtuin type 1)、acetyl-p53蛋白表达,结合临床病理资料和随访资料,进行预后分析。结果:c-Myc阳性组乳腺癌患者的5年无瘤生存率和5年总生存率(分别为5 9.0%/6 7.2%)低于c-M y c阴性组(分别为8 6.2%/8 6.2%),S I RT 1阳性组乳腺癌患者的5年无瘤生存率和5年总生存率(分别为5 6.1%/6 4.9%)低于S I RT 1阴性组(87.9%/87.9%);acetyl-p53阳性组乳腺癌患者的5年无瘤生存率和5年总生存率(分别为86.7%/86.7%)高于acetyl-p53阴性组(分别为58.3%/66.7%),差异均有统计学意义(P<0.05)。结论:c-Myc及SIRT1蛋白高表达的乳腺癌患者预后差,而acetyl-p53蛋白高表达的乳腺癌患者预后好。展开更多
BACKGROUND The high prevalence of human papillomavirus(HPV)infection in oropharyngeal squamous cell carcinoma(SCC)is well established,and p16 expression is a strong predictor.HPV-related tumors exhibit unique mechanis...BACKGROUND The high prevalence of human papillomavirus(HPV)infection in oropharyngeal squamous cell carcinoma(SCC)is well established,and p16 expression is a strong predictor.HPV-related tumors exhibit unique mechanisms that target p16 and p53 proteins.However,research on HPV prevalence and the combined predictive value of p16 and p53 expression in head and neck cutaneous SCC(HNCSCC),particularly in Asian populations,remains limited.This retrospective study surveyed 62 patients with HNSCC(2011-2020),excluding those with facial warts or other skin cancer.AIM To explore the prevalence of HPV and the predictive value of p16 and p53 expression in HNCSCC in Asian populations.METHODS All patients underwent wide excision and biopsy.Immunohistochemical staining for HPV,p16,and p53 yielded positive and negative results.The relevance of each marker was investigated by categorizing the tumor locations into high-risk and middle-risk zones based on recurrence frequency.RESULTS Of the 62 patients,20(32.26%)were male,with an average age of 82.27 years(range 26-103 years).High-risk included 19 cases(30.65%),with the eyelid and lip being the most common sites(five cases,8.06%).Middle-risk included 43 cases(69.35%),with the cheek being the most common(29 cases,46.77%).The p16 expression was detected in 24 patients(38.71%),p53 expression in 42 patients(72.58%),and HPV in five patients(8.06%).No significant association was found between p16 expression and the presence of HPV(P>0.99),with a positive predictive value of 8.33%.CONCLUSION This study revealed that p16,a surrogate HPV marker in oropharyngeal SCC,is not reliable in HNCSCC,providing valuable insights for further research in Asian populations.展开更多
文摘目的:探讨c-Myc、SIRT1及acetyl-p53蛋白在乳腺癌中的表达及其对预后的影响。方法:应用免疫组织化学方法检测90例乳腺癌和30例乳腺增生症中的c-Myc、SIRT1(Sirtuin type 1)、acetyl-p53蛋白表达,结合临床病理资料和随访资料,进行预后分析。结果:c-Myc阳性组乳腺癌患者的5年无瘤生存率和5年总生存率(分别为5 9.0%/6 7.2%)低于c-M y c阴性组(分别为8 6.2%/8 6.2%),S I RT 1阳性组乳腺癌患者的5年无瘤生存率和5年总生存率(分别为5 6.1%/6 4.9%)低于S I RT 1阴性组(87.9%/87.9%);acetyl-p53阳性组乳腺癌患者的5年无瘤生存率和5年总生存率(分别为86.7%/86.7%)高于acetyl-p53阴性组(分别为58.3%/66.7%),差异均有统计学意义(P<0.05)。结论:c-Myc及SIRT1蛋白高表达的乳腺癌患者预后差,而acetyl-p53蛋白高表达的乳腺癌患者预后好。
基金Supported by the National Research Foundation of Korea,No.2020R1A2C1100891Soonchunhyang University Research Fund,No.2024-05-014.
文摘BACKGROUND The high prevalence of human papillomavirus(HPV)infection in oropharyngeal squamous cell carcinoma(SCC)is well established,and p16 expression is a strong predictor.HPV-related tumors exhibit unique mechanisms that target p16 and p53 proteins.However,research on HPV prevalence and the combined predictive value of p16 and p53 expression in head and neck cutaneous SCC(HNCSCC),particularly in Asian populations,remains limited.This retrospective study surveyed 62 patients with HNSCC(2011-2020),excluding those with facial warts or other skin cancer.AIM To explore the prevalence of HPV and the predictive value of p16 and p53 expression in HNCSCC in Asian populations.METHODS All patients underwent wide excision and biopsy.Immunohistochemical staining for HPV,p16,and p53 yielded positive and negative results.The relevance of each marker was investigated by categorizing the tumor locations into high-risk and middle-risk zones based on recurrence frequency.RESULTS Of the 62 patients,20(32.26%)were male,with an average age of 82.27 years(range 26-103 years).High-risk included 19 cases(30.65%),with the eyelid and lip being the most common sites(five cases,8.06%).Middle-risk included 43 cases(69.35%),with the cheek being the most common(29 cases,46.77%).The p16 expression was detected in 24 patients(38.71%),p53 expression in 42 patients(72.58%),and HPV in five patients(8.06%).No significant association was found between p16 expression and the presence of HPV(P>0.99),with a positive predictive value of 8.33%.CONCLUSION This study revealed that p16,a surrogate HPV marker in oropharyngeal SCC,is not reliable in HNCSCC,providing valuable insights for further research in Asian populations.
