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Preparation of AChE Inhibitors From Jujubogenin
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作者 Yu ZHAO Yuan Ling KU Shoei Sheng LEE 《Chinese Chemical Letters》 SCIE CAS CSCD 2000年第8期671-674,共4页
A dammarane derivative dihydrojujubogenin-2-en-1-one, which possesses a skeleton and pharmacophore partially similar to those of Territrem B, a potent AChE inhibitor, was synthesized via three different paths. The ant... A dammarane derivative dihydrojujubogenin-2-en-1-one, which possesses a skeleton and pharmacophore partially similar to those of Territrem B, a potent AChE inhibitor, was synthesized via three different paths. The anti-AChE activity of this compound and related analogue was measured. 展开更多
关键词 Alzheimer disease (AD) acetylcholinesterase ache inhibitor pharmaceutical chemistry jujubogenin Territrem B analogues
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Two Series of Synthetic Territrem B Analogues and their Biological Activities
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作者 FengZHAO JinHaoZHAO +5 位作者 HaiBoLI LeiXiangYANG HuaBAI YanGuangWANG ShoeiShengLEE YuZHAO 《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第4期457-460,共4页
Two series of territrem B analogues (6, 11) were designed and synthesized from jujubogenin 2. Compound 11c inhibited AChE with the ratio of 70% at 10-4 mol/L. Compounds 5a, 5b, 6a and 11b showed moderate cytotoxicit... Two series of territrem B analogues (6, 11) were designed and synthesized from jujubogenin 2. Compound 11c inhibited AChE with the ratio of 70% at 10-4 mol/L. Compounds 5a, 5b, 6a and 11b showed moderate cytotoxicity on cultured KB cells at 10-6 mol/L. Compounds 5c and 6b alleviated injury arising from oxygen-glucose deprivation (OGD). 展开更多
关键词 Territrem B analogues acetylcholinesterase (ache) inhibitor cytotoxicity on KB cells oxygen-glucose deprivation (OGD).
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Synthesis of 2-En-1-one-ebelactonyl Benzoates of Territrem B Analogues from Jujubogenin
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作者 JinHaoZHAO YanGuangWANG +5 位作者 HaiBoLI FengZHAO LeiXiangYANG HuaBAI ShoeiShengLEE YuZHAO 《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第1期11-14,共4页
Two series of territrem B analogues (10a-10c and 18) have been designed and synthesized from jujubogenin 5a which was prepared from jujubogenin glycosides 5b obtained from the leaves of Zizyphus jujuba. The structur... Two series of territrem B analogues (10a-10c and 18) have been designed and synthesized from jujubogenin 5a which was prepared from jujubogenin glycosides 5b obtained from the leaves of Zizyphus jujuba. The structures of the new compounds were confirmed by H-, 1 13C-NMR and MS data. Compounds 10c and 18 showed weak inhibitory effect on AChE at 10-4 mol/L. 展开更多
关键词 Territrem B analogues acetylcholinesterase (ache) inhibitor jujubogenin.
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