The calibration model for simultaneous deter-mination of chlorogenic acid and baicalin in heat-clearing and detoxicating oral liquid was built by partial least squares and near infrared spectroscopy, and the method of...The calibration model for simultaneous deter-mination of chlorogenic acid and baicalin in heat-clearing and detoxicating oral liquid was built by partial least squares and near infrared spectroscopy, and the method of spectral pre-treatment was discussed. Building model from calibration set obtained good results, and vali-dated by prediction. According to heat-clearing and detoxicating oral liquid from 30 batches of 6 factories, the correlation coefficient of chloro-genic acid and baicalin model are 0.9993 and 0.9923, The root mean square error of cross validation (RMSECV) are 0.467 and 0.480, and the standard Error of prediction (SEP) of chloro- genic acid and baicalin are 0.356 and 0.370 re-spectively. The correlation coefficients in pre-diction set are 0.9997 and 0.9969, prediction results are accurate and reliable. This method can be applied in rapid analysis of heat- clearing and detoxicating oral liquid, and it is fit for on-line detection and has a wide application prospect.展开更多
The heat capacities of 3-（ 2,2-dichloroethenyl）-2,2-dimethylcyclopropanecarboxylic acid （a racemic mixture, molar ratio of cis-/trans-structure is 35/65） in a temperature range from 78 to 389 K were measured with ...The heat capacities of 3-（ 2,2-dichloroethenyl）-2,2-dimethylcyclopropanecarboxylic acid （a racemic mixture, molar ratio of cis-/trans-structure is 35/65） in a temperature range from 78 to 389 K were measured with a precise automatic adiabatic calorimeter. The sample was prepared with a purity of 98.75% （ molar fraction）. A solid-liquid fusion phase transition was observed in the experimental temperature range. The melting point, Tm, enthalpy and en- tropy of fusion, △fusHm, △fusSm, of the acid were determined to be （331.48±0.03 ） K, （16.321±0.031） kJ/mol, and （49.24±0.19） J/（ K·mol）, respectively. The thermodynamic functions of the sample, Ht-H298.15, Sr-S298.15 and Gr-G298.15, were reported at a temperature intervals of 5 K. The thermal decomposition of the sample was studied using thermogravimetric（TG） analytic technique, the thermal decomposition starts at ca. 418 K and ends at ca. 544 K, the maximum decomposition rate was obtained at 510 K. The order of reaction, preexponential factor and activation energy are n =0.23, A =7.3 ×10^7 min^-1 , E =70.64 kJ/mol, respectively.展开更多
Corrosion of metal components constitutes a major challenge in many engineering systems, with appropriate design, proper material selection, and heat treatment as commonly used control strategies. In this study, the c...Corrosion of metal components constitutes a major challenge in many engineering systems, with appropriate design, proper material selection, and heat treatment as commonly used control strategies. In this study, the corrosion behaviour of heat-treated (annealed, normalised, hardened, and tempered) NST 37-2 steel in three concentrations (1.0, 1.5 and 2.0 M) of hydrochloric acid solution was investigated using weight loss and electrode-potential methods. Results showed that corrosion rate increased with increase in acid concentration. The decreasing order of corrosion resistance was Tempered > Annealed > Normalised > Hardened > Untreated. The surface pictures of the heat-treated and untreated samples showed uniform and pitting corrosion with the latter becoming more pronounced as concentration increased.展开更多
In this paper,a compact difference scheme is established for the heat equations with multi-point boundary value conditions.The truncation error of the difference scheme is O(τ2+h^4),where t and h are the temporal ste...In this paper,a compact difference scheme is established for the heat equations with multi-point boundary value conditions.The truncation error of the difference scheme is O(τ2+h^4),where t and h are the temporal step size and the spatial step size.A prior estimate of the difference solution in a weighted norm is obtained.The unique solvability,stability and convergence of the difference scheme are proved by the energy method.The theoretical statements for the solution of the difference scheme are supported by numerical examples.展开更多
Objective:To investigate the expression of HSP90 and HIF-1αin human colorectal cancer tissue,the influence of HSP90 and HIF-1αon human colorectal cancer biological behavior and their related factors.Methods:The expr...Objective:To investigate the expression of HSP90 and HIF-1αin human colorectal cancer tissue,the influence of HSP90 and HIF-1αon human colorectal cancer biological behavior and their related factors.Methods:The expression of HSP90 and HIF-1 a protein in human colorectal cancer as well as normal tissue were detected by imnmnohistochemical method.Results:The positive expression rates of HSP90 and HIF-1αprotein in normal human colorectal tissue as well as colorectal cancer tissue were 30%vs.63.0%,15.0%vs.71.7%,respectively.There were significant difference(P=0.035 and P=0.005 respectively).The expression of HSP90 was significantly correlated with the differentiation,Dukes stages and lymph node metastasis(P<0.05),while the expression of HIF-1 a was significantly correlated with the Dukes stages and lymph node metastasis(P<0.05).Association analysis showed that the expression of HSF90 protein was significantly correlated with that of HIF-1αprotein(P<0.01).Conclusions:The expression of HSP90 and HIF—1αprotein may be related to the development,metastasis and invasion of human colorectal cancer,and their synergistic effects may participate in the development of the colorectal carcinoma.展开更多
文摘The calibration model for simultaneous deter-mination of chlorogenic acid and baicalin in heat-clearing and detoxicating oral liquid was built by partial least squares and near infrared spectroscopy, and the method of spectral pre-treatment was discussed. Building model from calibration set obtained good results, and vali-dated by prediction. According to heat-clearing and detoxicating oral liquid from 30 batches of 6 factories, the correlation coefficient of chloro-genic acid and baicalin model are 0.9993 and 0.9923, The root mean square error of cross validation (RMSECV) are 0.467 and 0.480, and the standard Error of prediction (SEP) of chloro- genic acid and baicalin are 0.356 and 0.370 re-spectively. The correlation coefficients in pre-diction set are 0.9997 and 0.9969, prediction results are accurate and reliable. This method can be applied in rapid analysis of heat- clearing and detoxicating oral liquid, and it is fit for on-line detection and has a wide application prospect.
基金Supported by the Education Bureau Science Foundation of Liaoning Province,China(No.20040261).
文摘The heat capacities of 3-（ 2,2-dichloroethenyl）-2,2-dimethylcyclopropanecarboxylic acid （a racemic mixture, molar ratio of cis-/trans-structure is 35/65） in a temperature range from 78 to 389 K were measured with a precise automatic adiabatic calorimeter. The sample was prepared with a purity of 98.75% （ molar fraction）. A solid-liquid fusion phase transition was observed in the experimental temperature range. The melting point, Tm, enthalpy and en- tropy of fusion, △fusHm, △fusSm, of the acid were determined to be （331.48±0.03 ） K, （16.321±0.031） kJ/mol, and （49.24±0.19） J/（ K·mol）, respectively. The thermodynamic functions of the sample, Ht-H298.15, Sr-S298.15 and Gr-G298.15, were reported at a temperature intervals of 5 K. The thermal decomposition of the sample was studied using thermogravimetric（TG） analytic technique, the thermal decomposition starts at ca. 418 K and ends at ca. 544 K, the maximum decomposition rate was obtained at 510 K. The order of reaction, preexponential factor and activation energy are n =0.23, A =7.3 ×10^7 min^-1 , E =70.64 kJ/mol, respectively.
文摘Corrosion of metal components constitutes a major challenge in many engineering systems, with appropriate design, proper material selection, and heat treatment as commonly used control strategies. In this study, the corrosion behaviour of heat-treated (annealed, normalised, hardened, and tempered) NST 37-2 steel in three concentrations (1.0, 1.5 and 2.0 M) of hydrochloric acid solution was investigated using weight loss and electrode-potential methods. Results showed that corrosion rate increased with increase in acid concentration. The decreasing order of corrosion resistance was Tempered > Annealed > Normalised > Hardened > Untreated. The surface pictures of the heat-treated and untreated samples showed uniform and pitting corrosion with the latter becoming more pronounced as concentration increased.
基金The research is supported by the National Natural Science Foundation of China(No.11671081)the Fundamental Research Funds for the Central Universities(No.242017K41044).
文摘In this paper,a compact difference scheme is established for the heat equations with multi-point boundary value conditions.The truncation error of the difference scheme is O(τ2+h^4),where t and h are the temporal step size and the spatial step size.A prior estimate of the difference solution in a weighted norm is obtained.The unique solvability,stability and convergence of the difference scheme are proved by the energy method.The theoretical statements for the solution of the difference scheme are supported by numerical examples.
基金supported by Shaanxi province health department key funds:sx201227273
文摘Objective:To investigate the expression of HSP90 and HIF-1αin human colorectal cancer tissue,the influence of HSP90 and HIF-1αon human colorectal cancer biological behavior and their related factors.Methods:The expression of HSP90 and HIF-1 a protein in human colorectal cancer as well as normal tissue were detected by imnmnohistochemical method.Results:The positive expression rates of HSP90 and HIF-1αprotein in normal human colorectal tissue as well as colorectal cancer tissue were 30%vs.63.0%,15.0%vs.71.7%,respectively.There were significant difference(P=0.035 and P=0.005 respectively).The expression of HSP90 was significantly correlated with the differentiation,Dukes stages and lymph node metastasis(P<0.05),while the expression of HIF-1 a was significantly correlated with the Dukes stages and lymph node metastasis(P<0.05).Association analysis showed that the expression of HSF90 protein was significantly correlated with that of HIF-1αprotein(P<0.01).Conclusions:The expression of HSP90 and HIF—1αprotein may be related to the development,metastasis and invasion of human colorectal cancer,and their synergistic effects may participate in the development of the colorectal carcinoma.
