Erosion–corrosion behavior of austenitic cast iron in an acidic slurry medium

A series of austenitic cast iron samples with different compositions were cast and a part of nickel in the samples was replaced by manganese for economic reason. Erosion–corrosion tests were conducted under 2wt% sulfuric acid and 15wt% quartz sand. The results show that the matrix of cast irons remains austenite after a portion of nickel is replaced with manganese.（Fe,Cr）3C is a common phase in the cast irons, and nickel is the main alloying element in high-nickel cast iron; whereas,（Fe,Mn）3C is observed with the increased manganese content in low-nickel cast iron. Under erosion–corrosion tests, the weight-loss rates of the cast irons increase with increasing time. Wear plays a more important role than corrosion in determining the weight loss. It is indicated that the processes of weight loss for the cast irons with high and low nickel contents are different. The erosion resistance of the cast iron containing 7.29wt% nickel and 6.94wt% manganese is equivalent to that of the cast iron containing 13.29wt% nickel.

Analyses of concrete microcosmic structure in multi-media environment

The structure of concrete generally serves in multi-media environments; various environments act differently on concrete. The compound action of some severe environments will threaten the duration of concrete and decrease the service life of a concrete structure if improperly handled. In this paper the microstructure of concrete is observed by using Scanned Electric Microscope (SEM) through contrasting experiments in media of acid, alkali and salt with that of freezing-thawing in the same medium environment. This study is to supply a certain basis for changing traditional thinking of mechanical design and to combine construction reliability design with durability of concrete design.

Mechanism of Wumei Pill in the Treatment of Non-Erosive reflux disease from the Perspective of Network Pharmacology and Molecular docking

Objective:Based on network pharmacology and molecular docking to explore the mechanism of Wumei Pill in the treatment of non-erosive reflux disease(NERD).Method:We collected the active ingredients and targets of Wumei Pill by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),and collected NERD related targets through Genecards,PharmGKB,Drugbank,DisGeNET,OMIM,CTD and TTD databases.Intersection targets of Wumei Pill targets and NERD related targets were the potential targets of Wumei Pill in the treatment of NERD.We imported the intersection targets into the STRING database to obtain the PPI network,and obtained the hub targets.The network diagram of"Drugs-Potential active ingredients-Potential targets"was constructed by Cytoscape 3.7.2 software.We used R software to perform Gene Ontology function enrichment analysis(GO)and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis(KEGG)on hub targets,and then performed molecular docking verification.Results:There were 129 active ingredients and 213 drug targets of Wumei Pill of which 114 were the intersection targets.1587 GO enrichment items were identified(P<0.05),including 1,491 biological processes,11 cell components,and 85 molecular functions.143 KEGG pathways(P<0.05),mainly related to Kaposi sarcoma-associated herpesvirus infection,IL-17 signaling pathway,the TNF signaling pathway,MAPK signaling pathway.Results of molecular docking showed that the potential active ingredients in Wumei Pill had relatively stable binding activity to the key targets.Conclusion:Wumei pill for the treatment of non-erosive reflux disease are main active ingredients quercetin,kaempferol,beta sitosterol,Isocorypalmine,Stigmasterol,rutaecarpine,etc,the main targets is JUN,TP53,AKT1,may inhibit excessive inflammation,antioxidant therapy effect into full play.This provided a certain theoretical basis for clinical application.