A novel magnetic weak acid resin NDMC-1 was prepared in the presence of methyl acrylate （MA）, divinylbenzene （DVB） and titanate coupling agent （TCA） coated γ-Fe203 particles. To evaluate the adsorption of Cu^2...A novel magnetic weak acid resin NDMC-1 was prepared in the presence of methyl acrylate （MA）, divinylbenzene （DVB） and titanate coupling agent （TCA） coated γ-Fe203 particles. To evaluate the adsorption of Cu^2＋ on the obtained resin NDMC- 1, another two magnetic resins NDMC-0 （the precursor of NDMC-1 without hydrolyzation） and NDMO-1 （the synthesized weak acid resin using oleic acid coated γ-Fe2O3） were chosen for comparison. The results showed that the carboxyl groups were formed after hydrolyzation, and NDMC-1 exhibited a greater adsorption capacity to Cu2~. The desorption experiment demonstrated that the desorption ratio at pH 2 （95.14%） was greatly higher than pH 3 （25.97%）. Moreover, the magnetic resin NDMC-1 was proved to be stable at pH 2, extending the application of magnetic materials which were always considered to be acid-nor, resistant.展开更多
Drug-loaded micelles for oral administration are desired for its conve nience,low cost and flexibility,but current designs rely on introducing pH responsiveness,leaving problems like drug leakage and low accuracy of t...Drug-loaded micelles for oral administration are desired for its conve nience,low cost and flexibility,but current designs rely on introducing pH responsiveness,leaving problems like drug leakage and low accuracy of targeted delivery un-solved.Herein,we reported an acid-resistant ROS-responsive hyperbranched polythioether which can self-assemble into micellar structure and pass through the gastrointestinal tract without leaking drugs.At the inflammatory lesions,the thioester bonds are oxidized to sulphone groups to significantly increase the hydrophilicity in response to accumulated ROS species and efficiently release the encapsulated drugs.Animal experiments,including the evaluation of bodyweight,colon length,MPO activity,spleen index,histology and quantitative reverse transcription PCR,evidenced that the drug-loaded micelles have improved therapeutic efficiency compared to bare drug administration for the treatment of DSS-induced colitis in mice.This study provides an example of oral administrated micellar system can be extended for the treatment of other intestinal tract diseases.展开更多
基金support provided by Program for Changjiang Scholars,NSFC(Nos. 51178215 and 51208249)Jiangsu Nature Science Fund(Nos.BK2010006 and BK2011032)Joint Innovation Project for Production-Study-Research in Jiangsu Province(No.BY2012155) China
文摘A novel magnetic weak acid resin NDMC-1 was prepared in the presence of methyl acrylate （MA）, divinylbenzene （DVB） and titanate coupling agent （TCA） coated γ-Fe203 particles. To evaluate the adsorption of Cu^2＋ on the obtained resin NDMC- 1, another two magnetic resins NDMC-0 （the precursor of NDMC-1 without hydrolyzation） and NDMO-1 （the synthesized weak acid resin using oleic acid coated γ-Fe2O3） were chosen for comparison. The results showed that the carboxyl groups were formed after hydrolyzation, and NDMC-1 exhibited a greater adsorption capacity to Cu2~. The desorption experiment demonstrated that the desorption ratio at pH 2 （95.14%） was greatly higher than pH 3 （25.97%）. Moreover, the magnetic resin NDMC-1 was proved to be stable at pH 2, extending the application of magnetic materials which were always considered to be acid-nor, resistant.
基金the National Nature Science Foundation of China(NSFC,Nos.51803115,21636006,81773686)Nature Science Foundation of Shaanxi Province(No.2019JQ-528)+2 种基金the Fundamental Research Funds for the Central Universities(Nos.GK201801003,GK201802009,GK201901001)Young Talent Fund of University Association for Science and Technology in Shaanxi,China(No.20180602)the Program of Introducing Talents of Discipline to Universities(No.B14041)。
文摘Drug-loaded micelles for oral administration are desired for its conve nience,low cost and flexibility,but current designs rely on introducing pH responsiveness,leaving problems like drug leakage and low accuracy of targeted delivery un-solved.Herein,we reported an acid-resistant ROS-responsive hyperbranched polythioether which can self-assemble into micellar structure and pass through the gastrointestinal tract without leaking drugs.At the inflammatory lesions,the thioester bonds are oxidized to sulphone groups to significantly increase the hydrophilicity in response to accumulated ROS species and efficiently release the encapsulated drugs.Animal experiments,including the evaluation of bodyweight,colon length,MPO activity,spleen index,histology and quantitative reverse transcription PCR,evidenced that the drug-loaded micelles have improved therapeutic efficiency compared to bare drug administration for the treatment of DSS-induced colitis in mice.This study provides an example of oral administrated micellar system can be extended for the treatment of other intestinal tract diseases.
