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<sup>13</sup>C NMR and Raman Studies of Fullerene-Based Poly (Acrylamides) 被引量:2
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作者 Supriya Porwal Ashutosh Diwedi Meet Kamal 《International Journal of Organic Chemistry》 2012年第4期377-386,共10页
A new classification of the different types of fullerene-containing polymers is presented according to their different properties and applications they exhibit in a variety of fields. 13C NMR and Raman studies of a se... A new classification of the different types of fullerene-containing polymers is presented according to their different properties and applications they exhibit in a variety of fields. 13C NMR and Raman studies of a series of polymeric samples of fullerene-grafted poly (acrylamide), which were prepared by systematic variation of concentration of fullerene and acrylamide, are described. 13C NMR spectral analysis of the polymeric samples showed a peak for fullerene at 143 δppm and for poly (acrylamide) between 170 and 180 δppm and Raman spectral analysis of the poly-meric samples gave the Raman band for fullerene between 1470 cm-1 and poly (acrylamide) at 2800 cm-1. The Tg value, obtained from DSC results, showed a high glass transition temperature at 100.94°C revealing the presence of fullerene in the polymeric matrix. TGA analysis shows that polymer is thermally stable up to 340°C. 展开更多
关键词 FULLERENE Glass Transition Temperature POLY (Acrylamide)
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Copper-catalyzed α-selective C–H trifluoromethylation of acrylamides with TMSCF3 被引量:1
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作者 Shang-Zheng Sun Hui Xu Hui-Xiong Dai 《Chinese Chemical Letters》 SCIE CAS CSCD 2019年第5期969-972,共4页
A copper-catalyzedα-selective C–H trifluoromethylation of acrylamides with TMSCF3 is described.A wide range of arenes and heteroarenes at theβ-position of acrylamides are compatible with the reaction,affording the ... A copper-catalyzedα-selective C–H trifluoromethylation of acrylamides with TMSCF3 is described.A wide range of arenes and heteroarenes at theβ-position of acrylamides are compatible with the reaction,affording the corresponding(E)-trifluoromethylated products in moderate to good yields.The reaction proceeded fast and can be completed within 30 min. 展开更多
关键词 α-Selectivity C–H trifluoromethylation Copper acrylamides HETEROCYCLE
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Bio-rational design of photosystem Ⅱ inhibitors (Ⅷ)——Molecular design, synthesis and inhibitory activity of acrylates (acrylamides)
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作者 刘华银 沙印林 +2 位作者 谭惠芬 杨华铮 来鲁华 《Science China Chemistry》 SCIE EI CAS 1999年第3期326-331,共6页
Molecular modeling of acrylates (acrylamides) with D1 protein of Pisum sativum is presented. Studies show that the binding force mainly includes H-bond interaction, Van der Waals and π-ring stacking interaction. It w... Molecular modeling of acrylates (acrylamides) with D1 protein of Pisum sativum is presented. Studies show that the binding force mainly includes H-bond interaction, Van der Waals and π-ring stacking interaction. It was found that SER 268 in Dl protein might be an important binding site. It is important for high inhibitory activity of compounds whether an electronegative atom in alkyl of ester linkage could make H-bond interaction with SER 268 in Dl protein. Thus some new acrylates (acrylamides) were designed and synthesized, Bioassay indicated that these new compounds showed expected Hill reaction inhibitory activity. 展开更多
关键词 PHOTOSYSTEM ACRYLATES (acrylamides) MOLECULAR modeling MOLECULAR design HILL reaction INHIBITORY activity.
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Michael addition reactions of cyclanones with acrylamides:Producing 2-carbamoylethyl derivatives or ene-lactams
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作者 DAI WeiFeng WANG ChaoHua +2 位作者 ZHANG Xi ZHANG JinMing LANG MeiDong 《Science China Chemistry》 SCIE EI CAS 2008年第11期1044-1050,共7页
The electron-withdrawing groups (EWGs) in the electrophilic alkenes employed in the Michael addition reaction are almost only CO2R, CN, COR, NO2, and SO2Ph. Although amides (CONR1R2) are also typical electron-withdraw... The electron-withdrawing groups (EWGs) in the electrophilic alkenes employed in the Michael addition reaction are almost only CO2R, CN, COR, NO2, and SO2Ph. Although amides (CONR1R2) are also typical electron-withdrawing groups and are of great importance in organic synthesis, they are scarcely em-ployed as the EWGs of the electrophilic alkenes in the Michael addition reaction. In this work, the Mi-chael reactions of acrylamide and its derivatives with cyclanones were successfully carried out in the presence of enough radical inhibitors. The amide groups play a key role in producing the preferred products. The N-substituted acrylamides, including N-monosubstituted and N,N-disubstituted acryla-mides could react with cyclohexanone (CHn) to give the expected 2-carbamoylethyl derivatives; how-ever, acrylamide reacting with cyclohexanone only produced ene-lactam. Cyclanones also have effects on the products, while the ring size of cyclanones influences the reaction yield and the α-substituent decides the ratio of resulting isomeric ene-lactams. 展开更多
关键词 MICHAEL addition reaction cyclanone ACRYLAMIDE ene-lactam 2-carbamoylethyl derivative
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A Polyvinyl Alcohol/Acrylamide Hydrogel with Enhanced Mechanical Properties Promotes Full-Thickness Skin Defect Healing by Regulating Immunomodulation and Angiogenesis Through Paracrine Secretion 被引量:1
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作者 Peng Wang Liping Qian +9 位作者 Huixin Liang Jianhao Huang Jing Jin Chunmei Xie Bin Xue Jiancheng Lai Yibo Zhang Lifeng Jiang Lan Li Qing Jiang 《Engineering》 SCIE EI CAS CSCD 2024年第6期138-151,共14页
Hydrogel-based tissue-engineered skin has attracted increased attention due to its potential to restore the structural integrity and functionality of skin.However,the mechanical properties of hydrogel scaffolds and na... Hydrogel-based tissue-engineered skin has attracted increased attention due to its potential to restore the structural integrity and functionality of skin.However,the mechanical properties of hydrogel scaffolds and natural skin are substantially different.Here,we developed a polyvinyl alcohol(PVA)/acrylamide based interpenetrating network(IPN)hydrogel that was surface modified with polydopamine(PDA)and termed Dopa-gel.The Dopa-gel exhibited mechanical properties similar to native skin tissue and a superior ability to modulate paracrine functions.Furthermore,a tough scaffold with tensile resistance was fabricated using this hydrogel by three-dimensional printing.The results showed that the interpenetration of PVA,alginate,and polyacrylamide networks notably enhanced the mechanical properties of the hydrogel.Surface modification with PDA endowed the hydrogels with increased secretion of immunomodulatory and proangiogenic factors.In an in vivo model,Dopa-gel treatment accelerated wound closure,increased vascularization,and promoted a shift in macrophages from a proinflammatory M1 phenotype to a prohealing and anti-inflammatory M2 phenotype within the wound area.Mechanistically,the focal adhesion kinase(FAK)/extracellular signal-related kinase(ERK)signaling pathway may mediate the promotion of skin defect healing by increasing paracrine secretion via the Dopa-gel.Additionally,proangiogenic factors can be induced through Rho-associated kinase-2(ROCK-2)/vascular endothelial growth factor(VEGF)-mediated paracrine secretion under tensile stress conditions.Taken together,these findings suggest that the multifunctional Dopa-gel,which has good mechanical properties similar to those of native skin tissue and enhanced immunomodulatory and angiogenic properties,is a promising scaffold for skin tissue regeneration. 展开更多
关键词 Polyvinyl alcohol/acrylamide hydrogel Mechanical property enhancement Paracrine effect Skin regeneration Signaling pathways
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Probiotic microorganisms affect the reproductive and nervous systems of male rats treated with acrylamide
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作者 Seyedhossein Hekmatimoghaddam Maryam Yadegari +2 位作者 Fateme Zare Fatemeh Zakizadeh Seyed Mohammad Seifati 《Asian pacific Journal of Reproduction》 CAS 2024年第4期178-186,共9页
Objective:To evaluate the protective effects of probiotic microorganisms on the reproductive and nervous systems of male rats treated with acrylamide.Methods:Thirty-two rats were randomly divided into 4 groups and rec... Objective:To evaluate the protective effects of probiotic microorganisms on the reproductive and nervous systems of male rats treated with acrylamide.Methods:Thirty-two rats were randomly divided into 4 groups and received normal saline through gavage(control),acrylamide 20 mg/kg body weight,acrylamide plus probiotic microorganisms(Lactobacillus acidophilus,Lactobacillus casei,Lactobacillus bulgaricus,Lactobacillus rhamnosus,Bifidobacterium breve,Bifidobacterium infantis,Streptococcus thermophilus and fructooligosaccharides,all mixed in sachets)20 or 200 mg/kg body weight,respectively.After 30 days,the testis,prostate,seminal vesicle and cerebellum were removed,fixed and stained with hematoxylin-eosin(H&E).The Johnsen score was used to classify spermatogenesis.Cavalieri's principle method was used to evaluate the total volume(in mm3)of the testes.The number of each intratubular cell type as well as intertubular Leydig cells in whole samples was measured using the physical dissector counting techniques.Stereological analysis and the grids were used to determine the volume of cerebellar layers as well as the Purkinje cell number.Results:The testis weight decreased significantly in the acrylamide-treated group compared to the other groups(P<0.001).The number of spermatogonia,spermatocytes,spermatids and Leydig cells in the acrylamide-treated group were significantly less compared to the control group(P<0.05),while they were increased significantly in the acrylamide+200 mg/kg probiotic group(P<0.05;P<0.01).The mean Johnsen score in the acrylamide-treated group was lower than in the control group(P<0.001).Acrylamide-induced changes including congestion,vacuolization in the secretory epithelial cells,and epithelial rupture were observed in the prostate and seminal vesicle.The volumes of cerebellar layers were decreased in the acrylamide group compared to the control group while recovered in both probiotic treated groups.Conclusions:Probiotic microorganisms alleviate acrylamide-induced toxicities against the reproductive and cerebellar tissues in rats. 展开更多
关键词 ACRYLAMIDE CEREBELLUM MICROORGANISMS PROBIOTICS Prostate Rats TESTIS
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Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity
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作者 Linzi Li Xueying Lei +6 位作者 Lin Chen Ya Ma Jun Luo Xuebo Liu Xinglian Xu Guanghong Zhou Xianchao Feng 《Food Science and Human Wellness》 SCIE CSCD 2024年第1期225-240,共16页
Quercetin compounds have antioxidant,anti-inflammatory and anticancer pharmacological functions.Longterm exposure to acrylamide(AA)can cause liver injury and endanger human health.However,whether quercetin compounds c... Quercetin compounds have antioxidant,anti-inflammatory and anticancer pharmacological functions.Longterm exposure to acrylamide(AA)can cause liver injury and endanger human health.However,whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not clear.Here,we studied the mechanism and structure-activity relationship of quercetin compounds in reducing AA-induced hepatotoxicity in vivo and in vitro.In vivo studies found that quercetin-like compounds protect against AAinduced liver injury by reducing oxidative stress levels,activating the Akt/m TOR signaling pathway to attenuate autophagy,and improving mitochondrial apoptosis and endoplasmic reticulum stress-mediated apoptosis.In vitro studies found that quercetin compounds protected Hep G2 cells from AA by attenuating the activation of AA-induced autophagy,lowering reactive oxygen species(ROS)levels by exerting antioxidant effects and thus attenuating oxidative stress,increasing mitochondrial membrane potential(MMP),and improving apoptosis-related proteins,thus attenuating AA-induced apoptosis.Furthermore,the conformational differences between quercetin compounds correlated with their protective capacity against AA-induced hepatotoxicity,with quercetin showing the best protective capacity due to its strongest antioxidant activity.In conclusion,quercetin compounds can protect against AA-induced liver injury through multiple pathways of oxidative stress,autophagy and apoptosis,and their protective capacity correlates with antioxidant activity. 展开更多
关键词 Quercetin compounds ACRYLAMIDE Protection mechanism Oxidative stress Antioxidant activity
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Procyanidin A_1 and its digestive products alleviate acrylamide-induced IPEC-J2 cell damage through regulating Keap1/Nrf2 pathway
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作者 Fangfang Yan Qun Lu +1 位作者 Chengming Wang Rui Liu 《Food Science and Human Wellness》 SCIE CSCD 2024年第3期1475-1484,共10页
Our previous study has revealed that procyanidin A_(1)(A_(1))and its simulated digestive product(D-A,)can alleviate acrylamide(ACR)-induced intestine cell damage.However,the underlying mechanism remains unknown.In thi... Our previous study has revealed that procyanidin A_(1)(A_(1))and its simulated digestive product(D-A,)can alleviate acrylamide(ACR)-induced intestine cell damage.However,the underlying mechanism remains unknown.In this study,we elucidated the molecular mechanism for and D-A_(1) to alleviate ACR-stimulated IPEC-J2 cell damage.ACR slightly activated nuclear factor erythroid 2-related factor 2(Nrf2)signaling and its target genes,but this activation could not reduce intestine cell damage.A_(1) and D-A_(1) could alleviate ACR-induced cell damage,but the effect was abrogated in cells transiently transfected with Nrf2 small interfering RNA(siRNA).Further investigation confirmed that A_(1) and D-A_(1) interacted with Ketch-like ECH-associated protein 1(Keapl),which boosted the stabilization of Nrf2,subsequently promoted the translocation of Nrf2 into the nucleus,and further increased the expression of antioxidant proteins,thereby inhibiting glutathione(GSH)consumption,maintaining redox balance and eventually alleviating ACR-induced cell damage.Importantly,there was no difference between A_(1) and D-A_(1) treated groups,indicating that A_(1) can tolerate gastrointestinal digestion and may be a potential compound to limit the toxicity of ACR. 展开更多
关键词 Procyanidin A_1 Digestive products Acrylamide Nuclear factor erythroid 2-related factor 2(Nrf2) Intestinal cell damage
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ZnO Incorporated Acrylamide Grafted Chitosan Based Composite Film for Advanced Wound Healing Applications
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作者 Khodeja Afrin Kaniz Fatema +6 位作者 Fariha Afrose Md. Abdus Samad Azad Md. Shamim Akter Md. Saiful Alam Papia Haque Yeasmin Akter Newaz Mohammed Bahadur 《Open Journal of Applied Sciences》 2024年第4期1034-1051,共18页
This study was carried out to prepare ZnO nanoparticles incorporated acrylamide grafted chitosan composite film for possible biomedical application especially drug loading in wound healing. ZnO nanoparticles were prep... This study was carried out to prepare ZnO nanoparticles incorporated acrylamide grafted chitosan composite film for possible biomedical application especially drug loading in wound healing. ZnO nanoparticles were prepared by co-precipitation method from zinc acetate di-hydrate and incorporated in acrylamide grafted chitosan. FT-IR and TGA of the prepared composite film confirmed the successful incorporation of ZnO nanoparticles in the acrylamide-grafted polymer matrix. SEM images showed that the ZnO nanoparticles were homogeneously distributed on the porous matrix of the composite film. Water uptake and buffer uptake analysis revealed that the composite film could hold water and buffer sufficiently, which facilitated the absorption of exudate from the wound site. Amoxicillin was loaded in the prepared composite film and the maximum loading efficiency was found to be 67.33% with drug concentration of 300 ppm. In vitro studies showed greater antimicrobial activity of drug-loaded composite film compared to both pure film and standard antibiotic disc. Finally, the In vivo mouse model showed maximum healing efficiency compared to conventional gauge bandages because the loading of antibiotic in the film produced a synergistic effect and healing time was reduced. 展开更多
关键词 CHITOSAN ZnO Nanoparticles Wound Management Acrylamide Grafting Bacterial Resistance Drug Loading
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Enhance of Grafting Reaction of Acrylic Acid and Acrylamide onto Preirradiated Polypropylene Film 被引量:1
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作者 杨黎明 陈捷 +2 位作者 吴明红 刘昊晟 吕霞娟 《Advances in Manufacturing》 SCIE CAS 2000年第S1期189-192,共4页
Grafting of acrylic acid (AAc) and acrylamide (AAm) onto preirradiated PP film was performed in aqueous solution of AAc and AAm, respectively. Electron beam accelerator was used as irradiation source. The effect of f... Grafting of acrylic acid (AAc) and acrylamide (AAm) onto preirradiated PP film was performed in aqueous solution of AAc and AAm, respectively. Electron beam accelerator was used as irradiation source. The effect of ferrous sulfate, sodium nitrate, methanol and glucose on the degree of grafting was demonstrated. The function of the different additives was compared by the grafting of different monomers (AAc and AAm). The results show that the four of these additives are elective on the grafting of AAc. Only two of these additives, ferrous sulfate and methanol were effective on the grafting of AAm. 展开更多
关键词 Radiation grafting POLYPROPYLENE acrylic acid ACRYLAMIDE
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An Approach to the Flame Retardancy of EVA Copolymer by Plasma Treatmentc2
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作者 施来顺 王建祺 《Journal of Beijing Institute of Technology》 EI CAS 1997年第4期17-24,共8页
An attempt was made in the paper aiming at imparting flame retardancy to polymers by plasma grafting technique Based on EVA copolymers with different VA contents the author tried to use the Ar plasma followed by graf... An attempt was made in the paper aiming at imparting flame retardancy to polymers by plasma grafting technique Based on EVA copolymers with different VA contents the author tried to use the Ar plasma followed by grafting with/without subsequent saponification and metal ion exchange expediting the charring of polymers upon heationg Characterization of the flammability of the plasma treated EVA copolymers grafted with acrylic monomers(MAA,AA and AAm)indicates that this approach turns out to be a promising way and worthy doing whatever in research and/or applications 展开更多
关键词 flame retardancy surface grafting plasma EVA copolymer methylacrylic acid acrylic acid ACRYLAMIDE
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暴露丙烯酰胺对Wistar大鼠学习记忆及海马CA1区c-Fos表达的影响 被引量:2
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作者 方桦 刘合玉 +2 位作者 朱宁 赵钢 岳屹立 《神经解剖学杂志》 CAS CSCD 北大核心 2018年第6期699-704,共6页
目的:探讨丙烯酰胺(ACR)暴露对Wistar大鼠学习记忆能力、大脑海马CA1区c-Fos蛋白和c-fos mRNA表达的影响。方法:健康雄性Wistar大鼠40只,体重180~220g,随机分为对照组、腹腔注射ACR9mg/kg组、18mg/kg组和36mg/kg组,每组各8只,对照组以... 目的:探讨丙烯酰胺(ACR)暴露对Wistar大鼠学习记忆能力、大脑海马CA1区c-Fos蛋白和c-fos mRNA表达的影响。方法:健康雄性Wistar大鼠40只,体重180~220g,随机分为对照组、腹腔注射ACR9mg/kg组、18mg/kg组和36mg/kg组,每组各8只,对照组以同样方式腹腔注射等量生理盐水。1周后用Morris水迷宫法检测大鼠学习记忆功能,HE染色观察海马CA1区神经细胞形态,用免疫组化法检测海马CA1区c-Fos蛋白表达,RT-PCR法检测c-fos基因表达。结果:ACR组大鼠表现为海马CA1区神经纤维稀疏、神经细胞减少,可见空泡样变性等。与对照组比较,ACR作用后大鼠学习记忆功能明显降低(P<0.05),且具有剂量依赖性(r=0.820~0.891,P均<0.05)。ACR中、高剂量组海马区c-Fos蛋白和c-fosmRNA表达水平明显低于对照组(P<0.01),同时随ACR剂量增加,c-Fos蛋白和c-fosmRNA表达水平降低,与ACR剂量明显相关(r=-0.824,0.857,P均<0.05)。结论:模型大鼠暴露于ACR可以损害学习记忆功能,同时有海马区c-Fos蛋白和c-fosmRNA表达水平下降,其机制可能是ACR造成大鼠海马区神经细胞功能减弱所致。 展开更多
关键词 丙烯酰胺(acrylamide ACR) 海马 学习记忆 C-FOS蛋白 C-FOSMRNA WISTAR大鼠
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Synthesis and Flocculation Property of Chitosan-Acrylamide Graft Copolymer 被引量:11
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作者 LILiu-zhu MAOLu-yuan WANGXiu-li YANGYong ZHUANGYin-feng 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2004年第2期221-224,共4页
Chitosan, as a kind of natural polymer, has many advantages, such as abundant sources, biological degradation, no secondary contamination and facile modification. In this work, we prepared modified chitosan flocculant... Chitosan, as a kind of natural polymer, has many advantages, such as abundant sources, biological degradation, no secondary contamination and facile modification. In this work, we prepared modified chitosan flocculants with double electrical behavior via polymerizing chitosan, acrylamide and sodium carboxymethyl cellulose together by using ammonium persulfate as the indicator in water. The product is a comb-type of chitosan copolymer and a polymeric ampholyte. And then we studied the product by FTIR, UV-Vis, TG, DSC spectrometeries and viscometry, etc. We also performed CACM′s water treat experiment. The effects of pH values, reaction time and dose of the new floccalant on treating various of waste water have been investigated, too. 展开更多
关键词 Organic flocculant CHITOSAN ACRYLAMIDE COPOLYMER
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Dietary Exposure of the Chinese Population to Acrylamide 被引量:8
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作者 ZHOU Ping Ping ZHAO Yun Feng +4 位作者 LIU Hua Liang MA Yong Jian LI Xiao Wei YANG Xin WU Yong Ning 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2013年第6期421-429,共9页
Objective To assess the current status of the acrylamide in the Chinese food supply, the dietary acrylamide exposure in the Chinese population and to estimate the public health risks of the current consumption. Method... Objective To assess the current status of the acrylamide in the Chinese food supply, the dietary acrylamide exposure in the Chinese population and to estimate the public health risks of the current consumption. Methods The acrylamide content in the total diet study (TDS) food samples was analyzed using an LC-MS/MS method. Based on the analytical results, the dietary exposure calculations were performed using a deterministic method, combining mean acrylamide concentrations from the food group composite with their associated food consumptions. Results Acrylamide was detected in 43.7% of all samples collected and acrylamide concentration varied from ND to 526.6 I^g/kg. The estimated dietary intakes of acrylamide among Chinese general population given as the mean and the 95th percentile (P95) were 0.286 and 0.490 iJg.kg1 bw.day1, respectively. The margins of exposure (MOEs) for the population calculated using both benchmark dose lower confidence limit for a 10% extra risk of tumors in animals (BMDL10) 0.31 and 0.18 i^g.k8-1 bw-dayz, were 1069 and 621 for the mean dietary exposure, and 633 and 367 for the high dietary exposure respectively. Conclusion These MOE values might indicate a human health concern on acrylamide for Chinese population. Efforts should continue to reduce acrylamide levels in food in order to reduce the dietary risks to the human health. 展开更多
关键词 ACRYLAMIDE Dietary exposure ASSESSMENT Health risk Total diet study
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Research on a novel composite gel system for CO_2 breakthrough 被引量:7
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作者 Hou Yongli Xiang'an 《Petroleum Science》 SCIE CAS CSCD 2010年第2期245-250,共6页
A composite gel was prepared for plugging CO2 channeling, which is a serious problem for enhanced oil recovery with CO2. A composite gel which is one of the materials for successful control of CO2 channeling during CO... A composite gel was prepared for plugging CO2 channeling, which is a serious problem for enhanced oil recovery with CO2. A composite gel which is one of the materials for successful control of CO2 channeling during CO2 injection process was studied in this paper. SEM and nano particle size analysis were used to describe this material’s microstructure. Its effect on CO2 channeling control was evaluated with core flow experiments. Both the rheological test and core plugging experiments indicated that both acrylamide monomer concentration and reaction pressure had positive influences on gel properties. The gel system with an acrylamide monomer concentration of 2% and 5% sodium silicate was proved to have excellent strength, elastic and plugging efficiency, which confirmed huge development potential and wide application of the composite gel system. The high-pressure acid environment arising from the CO2 injection not only reacts with solid silicate to form silicic acid gel, but also facilitates efficient polymerization. 展开更多
关键词 Enhanced oil recovery CO2 CHANNELING composite gel acrylamide monomer
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SWELLING BEHAVIOR OF ACRYLAMIDE HYDROGEL IN DIFFERENT SOLVENTS AND pHs 被引量:7
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作者 M.F.Mina M.M.Alam 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2005年第3期269-274,共6页
Swelling property of acrylamide hydrogels,prepared from aqueous solutions of acrylamide monomer havingconcentrations in the range of 10-60 wt% by ray irradiation method using a Co-60 gamma radiation source at dosesran... Swelling property of acrylamide hydrogels,prepared from aqueous solutions of acrylamide monomer havingconcentrations in the range of 10-60 wt% by ray irradiation method using a Co-60 gamma radiation source at dosesranging 1-30.0 kGy,has been investigated under various swelling media.These swelling media were basically solvents(solutions),produced by dissolving methanol,ethanol,glucose,sucrose,sodium chloride and sodium persulfate individuallywith distilled water,and solutions prepared with pHs=3,7 and 10.The investigation was performed in order to observe theeffect of these solvents and pHs as well as the influence of monomer concentrations,radiation doses and times on swellingbehavior of hydrogels.Swelling values were found higher for hydrogels prepared with lower monomer concentrations(ca.20 wt%)and radiation doses(ca.5 kGy)and showed a leveling off tendency within 24 h.The glucose solvent and the buffersolution of pH=10 revealed significant increase of swelling of hydrogels as compared to other solutions.Results areexplained based on crosslinking density in hydrogel,polymer-solvent/polymer-polymer interactions in solutions,permeability of molecules in solutions and ionization capacity of hydrogel in pH. 展开更多
关键词 ACRYLAMIDE HYDROGEL Co-60 gamma radiation source Swelling.
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Synthesis and application of lignin-based copolymer LSAA on controlling non-point source pollution resulted from surface runoff 被引量:8
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作者 LIU Chen WU Guangxia MU Huanzhen 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2008年第7期820-826,共7页
In this article,alkali lignin separated from paper pulp waste was grafted into a novel copolymer LSAA (a copolymer of lignin,starch, acrylamide,and acrylic acid).Its practical application effect and environmental safe... In this article,alkali lignin separated from paper pulp waste was grafted into a novel copolymer LSAA (a copolymer of lignin,starch, acrylamide,and acrylic acid).Its practical application effect and environmental safety were studied.The results of field simulation experiment indicated that the application of LSAA significantly affected the output of the runoff and pollutants.The runoff quantity was decreased by 16.67%-47.00%and the loads of total suspended solids (TSS),chemical oxygen demand (COD),total nit... 展开更多
关键词 application COPOLYMER a copolymer of lignin STARCH acrylamide and acrylic acid (LSAA) non-point source pollution (NPS) surface runoff
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Studies on LCST of poly (N-isopropylacrylamide-co-acrylic acid-co-N-diacetone acrylamide) 被引量:5
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作者 Cai Hua Ni Xiao Xia Zhu +1 位作者 Qing Lan Wang Xian Yu Zeng 《Chinese Chemical Letters》 SCIE CAS CSCD 2007年第1期79-80,共2页
Linear copolymers from N-isopropylacrylamide (NIPA), acrylic acid (AA) and diacetone acrylamide (DAA) have been prepared. The effect of composition, ionic strength and pH on their lower critical solution tempera... Linear copolymers from N-isopropylacrylamide (NIPA), acrylic acid (AA) and diacetone acrylamide (DAA) have been prepared. The effect of composition, ionic strength and pH on their lower critical solution temperature (LCST) has been investigated. 展开更多
关键词 LCST THERMO-RESPONSIVE N-ISOPROPYLACRYLAMIDE N-Diacetone acrylamide
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Immunotoxicity of Acrylamide in Female BALB/c Mice 被引量:7
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作者 FANG Jin LIANG Chun Lai +1 位作者 JIA Xu Dong LI Ning 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2014年第6期401-409,共9页
Objective To investigate the immunotoxicity of acrylamide (ACR) in female BALB/c mice.Methods A total of 200 female mice weighing 18-22 g were randomly divided into four clusters based on body weight, and each weigh... Objective To investigate the immunotoxicity of acrylamide (ACR) in female BALB/c mice.Methods A total of 200 female mice weighing 18-22 g were randomly divided into four clusters based on body weight, and each weight-based cluster included five groups (10 mice per group): negative control, positive control (cyclophosphamide), low, intermediate, and high dose ACR groups, and all the groups were administered ACR by gavage for 30 days. At the end of the study, the immunotoxicological effects of the ACR were evaluated through immunopathology, humoral immunity, cellular immunity, and non-specific immunity. Results The terminal body weight, spleen and thymus weights, lymphocyte counts in the ACR-H group were decreased, pathological changes were observed in lymph glands, thymus and spleen. %T cells in blood lymphocytes were significantly increased in all ACR-treated groups, and a significant reduction of % natural killer(NK) cells and increase of %Th cells were observed in the ACR-H group. interleukin-6(IL-6), Concanavalin A(ConA)-induced splenocyte proliferation and serum half hemolysis value (HCso) were also significantly suppressed in the ACR-H group. Conclusion ACR elicited an inhibitory effect on cellular and humoral immunity of mice after 30 day feeding. 展开更多
关键词 Acrylamide(ACR) IMMUNOTOXICITY Female BALB/c mice
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A Temperature-sensitive Hydrogel Refolding System: Preparation of Poly(N-isopropyl acrylamide) and Its Application in Lysozyme Refolding 被引量:6
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作者 崔志芳 关怡新 姚善泾 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2004年第4期556-560,共5页
Temperature-sensitive hydrogel—poly(N-isopropyl acrylamide) (PNIPA) was prepared and applied to protein refolding. PNIPA gel disks and gel particles were synthesized by the solution polymerization and inverse suspens... Temperature-sensitive hydrogel—poly(N-isopropyl acrylamide) (PNIPA) was prepared and applied to protein refolding. PNIPA gel disks and gel particles were synthesized by the solution polymerization and inverse suspension polymerization respectively. The swelling kinetics of the gels was also studied. With these prepared PNIPA gels, the model protein lysozyme was renatured. Within 24h, PNIPA gel disks improved the yield of lysozyme activity by 49.3% from 3375.2U·mg^-1 to 5038.8U·mg^-1. With the addition of faster response PNIPA gel beads, the total lysozyme activity recovery was about 68.98% in 3h, as compared with 42.03% by simple batch dilution. The novel refolding system with PNIPA enables efficient refolding especially at high protein concentrations. Discussion about the mechanism revealed that when PNIPA gels were added into the refolding buffer, the hydrophobic interactions between denatured proteins and polymer gels could prevent the aggregation of refolding intermediates, thus enhanced the protein renaturation. 展开更多
关键词 poly(N-isopropyl acrylamide) hydrogel free radical polymerization protein refolding LYSOZYME
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