Asymmetric 1,3-Dipolar Cycloaddition of the Chiral Nitronic Esters with Acrylate

Asymmetric 1,3-dipolar cycloaddihon of the chiral nitronic esters with acrylate giving the enantiomerically pure novel chiral bisheterocyclic compounds is describcd

Synthesis and Application of a New Acrylic Ester Resin for Recycling SIPA from its Water Solution

A new acrylic ester polymer YWB-7 resin was prepared and characterized. The properties of YWB-7 resin were compared with those of the commercial Amberlite XAD-7, Diaion HP2MG and hypercrosslinked macroporous polymer NDA-150 resins. Both surface area and micropore area of YWB-7 resin were bigger than those of XAD-7 resin and HP2MG resin. The YWB-7 resin was successfully employed to recycle 5-sodiosulfoisophthalic acids （SIPA） from its solutions with and without methanol.

Synthesis of 12-alkoxycarbonylmethylene-1,15-pentadecanolides

Six novel 12-alkoxycarbonylmethylene-1,15-pentadecanolides （3） were synthesized from 2-nitrocyclo-dodecanone by the Michael addition with acrolein followed by ring enlargement, Nef reaction and Wittig-Homer reaction. Their structures were confirmed bv 1H NMR, IR and elemental analysis. The preliminary bioassay showed that they have some fungicidal activity.

Superabsorbent poly(acrylic acid) and antioxidant poly(ester amide) hybrid hydrogel for enhanced wound healing

Wound healing dressing is increasingly needed in clinical owing to the large quantity of skin damage annually.Excessive reactive oxygen species(ROS)produced through internal or external environmental influences can lead to lipid peroxidation,protein denaturation,and even DNA damage,and ultimately have harmful effects on cells.Aiming to sufficiently contact with the wound microenvironment and scavenge ROS,superabsorbent poly(acrylic acid)and antioxidant poly(ester amide)(PAA/PEA)hybrid hydrogel has been developed to enhance wound healing.The physical and chemical properties of hybrid hydrogels were studied by Fourier-transform infrared(FTIR)absorption spectrum,compression,swelling,degradation,etc.Besides,the antioxidant properties of hybrid hydrogels can be investigated through the free radical scavenging experiment,and corresponding antioxidant indicators have been tested at the cellular level.Hybrid hydrogel scaffolds supported the proliferation of human umbilical vein endothelial cells and fibroblasts,as well as accelerated angiogenesis and skin regeneration in wounds.The healing properties of wounds in vivo were further assessed on mouse skin wounds.Results showed that PAA/PEA hybrid hydrogel scaffolds significantly accelerated the wound healing process through enhancing granulation formation and re-epithelialization.In summary,these superabsorbent and antioxidative hybrid hydrogels could be served as an excellent wound dressing for full-thickness wound healing.

Synergistic scale inhibition of polyaspartic acid composite with magnetic field

Polyaspartic acid(PASP)composite,a scale inhibitor,was prepared from PASP,itaconic acid—acrylic acid—acrylic ester(IA-AA-AE)terpolymer and 2-phosphonobutane-1,2,4-tricarboxylic acid(PBTCA).The scale inhibition of PASP composite and the effect of its synergism with a magnetic field on scale inhibition were investigated.Calcium carbonate crystals in scale samples were characterized by means of SEM and XRD.The static and dynamic experiments show that the chelating function of PASP composite for Ca2+can be enhanced by synergism with a magnetic field.Under Ca2+650 mg/L,HCO3-1,300 mg/L and PASPcomposite 4 mg/L,the scale inhibition rate of PASP composite in magnetic water can increase by 10%in static state and by 20%in dynamic experiments.Scanning electron microscope(SEM)and X-ray diffraction(XRD)results show that calcite and aragonite can be completely transformed into vaterite by using PASP composite.

Environmental Friendly Synthesis of Novel Isatin Ketal and Isatin Schiff Base Derivatives Using Michael Addition Reaction under Solvent-Free Conditions

An efficient and simple procedure for the synthesis of novel isatin derivatives is described. Michael addition of aniline Schiff bases of isatin or p-toluidine Schiff bases of isatin to fumaric esters affords the Michael adduct com- pounds in good to high yields in the presence of K2CO3 and tetrabutylammonium bromide （TBAB） under sol- vent-free conditions. Repeating of this reaction about spiro[l,3-dioxolane-2,3＇-indol]-2＇（l＇H）-one, as a Michael do- nor, in the presence of 1,4-diazabicyclo[2.2.2]octane （DABCO） gives Michael adducts in remarkable yields under the same conditions.