During the three decades after the adoption of the Declaration on the Right to Development, the right to development has received wider acknowledgement throughout the international community, and has become a typical ...During the three decades after the adoption of the Declaration on the Right to Development, the right to development has received wider acknowledgement throughout the international community, and has become a typical example of 'third-generation rights.' The 2030 Agenda for Sustainable Development, which puts forward 17 goals of sustainable development, was adopted at the UN Sustainable Development Summit on September 25, 2015. From the contents of the agenda, we can see that the 2030 Agenda for Sustainable Development highly conforms to the right to development. Both match, not only in purpose and content, but also in object and subject, as well as in demands for countries and the foundations needed. We may regard the 2030 Agenda for Sustainable Development as setting action targets for the realization of the right to development in the new era. Meanwhile, to realize the right to development in the new situation is to accomplish the aim of the 2030 Agenda for Sustainable Development. The two adopt different approaches that lead to the same destination.展开更多
In April 2009, after receiving ap- proval from the State Council, the Information Office of the State Council published the NationalHuman Rights Action Plan of China （2009-2010）. It is China＇s first national plan o...In April 2009, after receiving ap- proval from the State Council, the Information Office of the State Council published the NationalHuman Rights Action Plan of China （2009-2010）. It is China＇s first national plan on the theme of human rights, and serves as a policy document of the current stage for advancing China＇s human rights in a comprehensive way. It is an important move to implement the constitutional principle of respect- ing and safeguarding human rights, and to promote sustainable development and social harmony. It is also a solemn commitment to the world made by the Chinese government on human rights.展开更多
针对人体动作识别任务中特征值选取不当导致识别率低、使用多模态数据导致训练成本高等问题,提出一种轻量级人体动作识别方法。首先使用OpenPose、PoseNet提取出人体骨架信息,使用BWT69CL传感器提取姿势信息;其次对数据进行预处理、特...针对人体动作识别任务中特征值选取不当导致识别率低、使用多模态数据导致训练成本高等问题,提出一种轻量级人体动作识别方法。首先使用OpenPose、PoseNet提取出人体骨架信息,使用BWT69CL传感器提取姿势信息;其次对数据进行预处理、特征融合,对人体动作进行深度学习分类识别;最后,为验证此方法的有效性,在公开数据集WISDM、UCIHAR、HASC和自建的人体动作数据集上进行实验验证,并使用改进的目标引导注意力机制(target-guided attention,TGA)–长短期记忆(long short term memory,LSTM)网络输出最终的分类结果。实验结果表明,在自建数据集下融合姿势和骨架特征达到99.87%准确率,相比于只使用姿势信息特征,识别准确率提高了约5.31个百分点;相比于只使用人体骨架特征,识别准确率提高了约1.87个百分点;在识别时间上相比于只使用姿势信息,识别时间降低了约29.73 s;相比于只使用人体骨架数据,识别时间降低了约9 s。使用该方法能及时有效地反映人体的运动意图,有助于提高人体动作和行为的识别准确率和训练效率。展开更多
胃癌是最常见的恶性肿瘤之一,患者多采用手术、放化疗及免疫治疗,但临床疗效及预后欠佳。去整合素⁃金属蛋白酶(a disintegrin and metalloproteinase,ADAM)17作为ADAMs家族的重要成员,在胃癌组织中的表达显著高于癌旁组织,并通过介导EGF...胃癌是最常见的恶性肿瘤之一,患者多采用手术、放化疗及免疫治疗,但临床疗效及预后欠佳。去整合素⁃金属蛋白酶(a disintegrin and metalloproteinase,ADAM)17作为ADAMs家族的重要成员,在胃癌组织中的表达显著高于癌旁组织,并通过介导EGFR和TNF⁃α、TGF⁃β/Smad、Notch和Wnt、FoxM1⁃ADAM17以及EGFR/ERK/SP1等信号通路参与胃癌的发生发展,其高表达与预后不良密切相关,提示ADAM17可作为胃癌的生物学指标,预测胃癌发展,有望成为胃癌新的治疗靶点。本文就ADAM17在胃癌发展中的作用机制、治疗及预测研究进展作一综述,以期为胃癌临床诊疗提供新思路。展开更多
目的:研究治疗便血方剂的用药规律及其“核心配伍-作用靶点”的关联性。方法:从《中医方剂大辞典》中筛选治疗便血的方剂,录入数据库,进行频数、聚类和关联分析,从中发现配伍组方规律。找到核心配伍组合后,再使用中药分子机制的生物信...目的:研究治疗便血方剂的用药规律及其“核心配伍-作用靶点”的关联性。方法:从《中医方剂大辞典》中筛选治疗便血的方剂,录入数据库,进行频数、聚类和关联分析,从中发现配伍组方规律。找到核心配伍组合后,再使用中药分子机制的生物信息学分析工具(Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine,BATMAN-TCM)对核心配伍组合进行活性成分-靶点预测,从而分析核心配伍组合的共同作用靶点。结果:共收录便血方剂616首,涉及中药340味;排名前10的高频药物依次是当归、甘草、黄连、芍药、枳壳、生地黄、黄芩、地榆、槐花、黄芪;主要使用的中药类别依次是补虚药、清热药、止血药。发现生地黄、黄芩、赤芍,人参、白术、茯苓,侧柏叶、地榆、槐花,当归和川芎等是治疗便血的四组核心配伍组合;经分析发现这四组核心配伍组合均有AR、ESR1、NR3C1、PGR、VDR这5个共同作用靶点,即治疗便血的11个核心药物有5个共同作用靶点。结论:《中医方剂大辞典》所载便血方剂的核心配伍组合关联的AR、NR3C1、PGR、VDR等靶点与肠炎、结直肠癌、胃癌等常导致便血的相关疾病密切相关,提示其“核心配伍-作用靶点”的关联性对于指导临床用药以及相关基础研究和新药开发有一定参考意义。展开更多
文摘During the three decades after the adoption of the Declaration on the Right to Development, the right to development has received wider acknowledgement throughout the international community, and has become a typical example of 'third-generation rights.' The 2030 Agenda for Sustainable Development, which puts forward 17 goals of sustainable development, was adopted at the UN Sustainable Development Summit on September 25, 2015. From the contents of the agenda, we can see that the 2030 Agenda for Sustainable Development highly conforms to the right to development. Both match, not only in purpose and content, but also in object and subject, as well as in demands for countries and the foundations needed. We may regard the 2030 Agenda for Sustainable Development as setting action targets for the realization of the right to development in the new era. Meanwhile, to realize the right to development in the new situation is to accomplish the aim of the 2030 Agenda for Sustainable Development. The two adopt different approaches that lead to the same destination.
文摘In April 2009, after receiving ap- proval from the State Council, the Information Office of the State Council published the NationalHuman Rights Action Plan of China （2009-2010）. It is China＇s first national plan on the theme of human rights, and serves as a policy document of the current stage for advancing China＇s human rights in a comprehensive way. It is an important move to implement the constitutional principle of respect- ing and safeguarding human rights, and to promote sustainable development and social harmony. It is also a solemn commitment to the world made by the Chinese government on human rights.
文摘针对人体动作识别任务中特征值选取不当导致识别率低、使用多模态数据导致训练成本高等问题,提出一种轻量级人体动作识别方法。首先使用OpenPose、PoseNet提取出人体骨架信息,使用BWT69CL传感器提取姿势信息;其次对数据进行预处理、特征融合,对人体动作进行深度学习分类识别;最后,为验证此方法的有效性,在公开数据集WISDM、UCIHAR、HASC和自建的人体动作数据集上进行实验验证,并使用改进的目标引导注意力机制(target-guided attention,TGA)–长短期记忆(long short term memory,LSTM)网络输出最终的分类结果。实验结果表明,在自建数据集下融合姿势和骨架特征达到99.87%准确率,相比于只使用姿势信息特征,识别准确率提高了约5.31个百分点;相比于只使用人体骨架特征,识别准确率提高了约1.87个百分点;在识别时间上相比于只使用姿势信息,识别时间降低了约29.73 s;相比于只使用人体骨架数据,识别时间降低了约9 s。使用该方法能及时有效地反映人体的运动意图,有助于提高人体动作和行为的识别准确率和训练效率。
文摘胃癌是最常见的恶性肿瘤之一,患者多采用手术、放化疗及免疫治疗,但临床疗效及预后欠佳。去整合素⁃金属蛋白酶(a disintegrin and metalloproteinase,ADAM)17作为ADAMs家族的重要成员,在胃癌组织中的表达显著高于癌旁组织,并通过介导EGFR和TNF⁃α、TGF⁃β/Smad、Notch和Wnt、FoxM1⁃ADAM17以及EGFR/ERK/SP1等信号通路参与胃癌的发生发展,其高表达与预后不良密切相关,提示ADAM17可作为胃癌的生物学指标,预测胃癌发展,有望成为胃癌新的治疗靶点。本文就ADAM17在胃癌发展中的作用机制、治疗及预测研究进展作一综述,以期为胃癌临床诊疗提供新思路。
文摘目的:研究治疗便血方剂的用药规律及其“核心配伍-作用靶点”的关联性。方法:从《中医方剂大辞典》中筛选治疗便血的方剂,录入数据库,进行频数、聚类和关联分析,从中发现配伍组方规律。找到核心配伍组合后,再使用中药分子机制的生物信息学分析工具(Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine,BATMAN-TCM)对核心配伍组合进行活性成分-靶点预测,从而分析核心配伍组合的共同作用靶点。结果:共收录便血方剂616首,涉及中药340味;排名前10的高频药物依次是当归、甘草、黄连、芍药、枳壳、生地黄、黄芩、地榆、槐花、黄芪;主要使用的中药类别依次是补虚药、清热药、止血药。发现生地黄、黄芩、赤芍,人参、白术、茯苓,侧柏叶、地榆、槐花,当归和川芎等是治疗便血的四组核心配伍组合;经分析发现这四组核心配伍组合均有AR、ESR1、NR3C1、PGR、VDR这5个共同作用靶点,即治疗便血的11个核心药物有5个共同作用靶点。结论:《中医方剂大辞典》所载便血方剂的核心配伍组合关联的AR、NR3C1、PGR、VDR等靶点与肠炎、结直肠癌、胃癌等常导致便血的相关疾病密切相关,提示其“核心配伍-作用靶点”的关联性对于指导临床用药以及相关基础研究和新药开发有一定参考意义。
