The law of anti-VCAM-1 targeted microbubbles adhesion to activated endothelial cells under controlled shear flow

Microbubbles can enhance the detection in noninvasive ultrasound imaging.Recently,targeted microbubbles have been developed to selectively adhere to specific and overexpressed p molecules in endothelial cells in some pathologic conditions.However,the law of

Antimicrobial silicone skin adhesives facilitated by controlled octenidine release from glycerol compartments

For improved wound healing,antimicrobial adhesives are one path forward.However,with the current challenge of bacterial resistance,it is essential to choose the included drug carefully.Octenidine is an obvious choice due to its broad antimicrobial efficacy and no reported bacterial resistance.In its pure form,octenidine complexes efficiently with the platinum catalyst in the silicone composition,inhibiting the targeted hydrosilyla-tion reaction and hindering curing.This obstacle is overcome by screening octenidine with cyclodextrins in homogeneously dispersed glycerol droplets,suppressing Pt inhibition in the silicone phase.Curing efficiency is demonstrated using rheol-ogy,which shows that it is possible to incorporate one wt%of octenidine into glycerol–silicone adhesives in the presence of(2-hydroxypropyl)-β-cyclodextrin without affecting the adhe-sives’mechanical properties.The interaction between octeni-dine and(2-hydroxypropyl)-β-cyclodextrin through an inclusion complex is confirmed by ROESY spectroscopy.Despite this screening,octenidine is still released efficiently from the glycerol–silicone adhesives upon contact with water,and the resulting antimicrobial action is subsequently demonstrated.This new technology constitutes a simple and efficient method for preparing wound care adhesives that actively inhibit the growth of four bacteria strains and one fungus.