Synthesis, characterization, and biological properties of nano-rare earth complexes with L-glutamic acid and imidazole

Four nano-rare earth ternary complexes of L-glutamic acid and imidazole RE（Glu）3ImCl3·3H2O （RE=Ce^3＋, Pr^3＋, Sm^3＋, Dy^3＋, Glu= L-glutamic acid, and Im=imidazole） were synthesized. Their composition was characterized with elemental analysis, IR, and molar conductance. The TEM image indicated that the complexes were regular shaped and the length was about 30-60 nm. The antibacterial activity test showed that all these complexes exhibited better antibacterial ability against Escherichia coli, Staphylociccus aureus, and Candida albican （MIC were about 180, 100, and 310 μg/mi, respectively） and could be considered as broad-spectral antimicrobial. Their antitumor activity in vitro against leukemia K562 cells was measured using the MTr method. The results indicate that the four complexes possess strong inhibi- tion effect on leukemia K562 cells. An approximately linear relationship is discovered between the relative inhibition rate and concentration, with the correlation coefficients R〉0.7 and P〈0.05, which is considered statistically significant.

NEW POLY(METHACRYLATE)S CONTAINING OXIME ESTERS MOIETIES BASED ON CYCLOHEXANON AND CYCLOPENTANON

The synthesis of two new methacrylates such as 2-[(cyclohexylideneamino)oxy]-2-oxoethyl methylacrylate (CHOEMA)and 2-[(cyclopentylideneamino)oxy]-2-oxoethyl methylacrylate(CPOEMA)are described.The monomers produced from the reaction of corresponding cyclohexanone O-(2-chloroacetyl)oxime and cyclopentanone O-(2- chloroacetyl)oxime with sodium methacrylate was polymerized in 1,4-dioxane solution at 65℃using AIBN as an initiator. The monomers and their polymers were characterized by IR,~1H- and ^(13)C-NMR spec...

STUDY ON THE NON－STOICHIOMETRIC METALLURGICAL PROCESS－A MODEL FOR THE BATH－SMELTING PROCESS

model based on the bath-smelting process for the production of quality steels has been developed considering non-stoichiometric system. The thermodynamic function of slag has been used to calculat the activities a(i) of components present in the slag and metal.To determine the valency of the elements in bath slag and metal phase, an experimental method has been suggested.

Structurally Diverse Matrine-Based Alkaloids with Anti-inflam-matory Effects from Sophora alopecuroides

A phytochemical investigation on the seeds of Sophora alopecuroides led to obtaining fourteen structurally diverse matrine-based alkaloids(1-14),including eight new ones(1,6,8-12,14).Notably,alopecuroide F(1)represents the first dimeric matrine-type skeleton assembled via unprecedent C-13-C-12'connection.The new structures were determined through extensive spectroscopic data(UV,OR,HRESIMS,1D,and 2D NMR),ECD calculations,and three instances,verified by X-ray crystallography.Biologically,all alkaloids were evaluated for cytotoxicity against four human cancer cell lines(HepG2,A549,THP-1,and MCF-7)and anti-inflammatory activities for two pro-inflammatory cytokines(TNF-αand IL-6).Alopecuroide F(1)can inhibit TNF-αand IL-6 productions in a dose-dependent manner with IC50 values of 35.6±0.5 and 41.7±0.8μmol/L,respectively.

Synthesis and insecticidal bioactivities of 2,3-dihydroimidazo[1,2-a] pyridin-5(1H)-one derivatives

A novel synthesis of 2,3-dihydroimidazo[1,2-a]pyridin-5 (1H)-one 4 and its derivatives were described.Preliminary bioassays showed that some of the target compounds exhibited excellent insecticidal activities against brown planthopper (Nilaparvata lugens), cowpea aphids (Aphis craccivora) (4,5 a, 5 c, 5 g,5 h, 5 j, 5 r, 6 b, 6 e) and carmine spider mite (Tetranychus cinnabarinus (5 f, 5 s, 6 a) at 500 mg/L. Among them,compound 4 was still active against brown planthopper and cowpea aphids at 4 mg/L. The insecticidal activities were influenced by the types and position of the substituents, which provided guidance for the structure modifications.

Secondary metabolites from a deep-sea-derived Aspergillus versicolor F77

Chemical examination of fermentation products of a deep-sea-derived fungus Aspergillus versicolor F77 led to the isolation of two new compounds acetyl-sydonol(1)and 2-hydroxydiorcinol D(2),a new natural product 1-(2,4-dimethoxyphenyl)-1,2-dihydro-3 H-pyrazol-3-one(3),together with four known compounds sydonol(4),(S)-sydonic acid(5),aspergillusene A(6)and diorcinol D(7).Their structures were determined through the extensive spectroscopic analysis and comparison with the reported data in literature.Compound 6 showed moderate NF-κB inhibitory activity.

SESQUITERPENES AND MONOTERPENOID WITH ACETYLCHOLINESTERASE(ACHE) INHIBITORY ACTIVITIY FROM VALERIANA OFFICINALIS VAR.LATIOFOLIA

Four new sesquiterpenoids,volvalerenal H-J(1-3)and Volvalerenic Acid K(4),along with a new monoterpenoid named Densispicnins C(5),were isolated from the ethanol extract of the root of Valeriana officinalis var.latiofolia.The structures of new compounds were determined on the basis of ID and 2D NMR,and HRESIMS.And the isolations