Core acupoints of acupuncture for hyperplasia of mammary gland: a network analysis

Backgroud:Clinical studies on acupuncture treatment of hyperplasia of mammary gland(HMG)have proved its effectiveness,but most studies have paid little attention to acupoints prescription and acupoint compatibility.The clinical prescription is not identical,the curative effect also has the difference.Therefore,through data mining and network analysis,this study explored the core acupoints and the compatibility law of acupoints in acupuncture treatment of HMG.Methods:To search and select qualified literature according to inclusion and exclusion criteria for relevant clinical research literature on acupuncture treatment of HMG in CNKI,VIP database,WanFang database and PubMed,etc.Then extract relevant information and establish a database.Using the method of statistical and complex network analysis,this paper studies the core acupoints and the law of acupoint compatibility.Results:A total of 104 Chinese literatures and 0 English literatures were included and 106 acupuncture prescriptions were extracted.The core acupoints in the treatment of HMG are Danzhong(CV 17),Wuyi(ST 15),Zusanli(ST 36),Jianjing(GB 21).Danzhong(CV 17)and Zusanli(ST 36),Danzhong(CV 17)and Wuyi(ST 15),Jianjing(GB 21)and Tianzong(SI 11),Jianjing(GB 21)and Wuyi(ST 15)have the highest correlation degree.The method of acupoint matching mainly consists of local-remote acupoints,upper-lower acupoints and front-rear acupoints.Conclusion:The results of a network analysis substantially accord with the general rules of acupuncture theories in traditional Chinese medicine,able to reflect the points-selection principles and features in acupuncture treatment of HMG and provide evidence for the acupoints selection in the treatment of HMG in acupuncture clinic.

A Study on the Basic Drugs and Points for Point Application in Summer to Treat the Diseases with Attacks in Winter

Objective: To study the basic prescriptions of drugs and points for point application in summer to treat the diseases with attacks in winter and the law governing their compatibility. Methods: A database was set up by collecting and sorting out the relevant literature, and the analysis was made with the complex network. Results: It was found that Bai Jie Zi (白芥子 Semen Sinapis Albae), Xi Xin (细辛 Herba Asari), Gan Sui (甘遂 Radix Euphorbiae Kansui) and Yan Hu Suo (延胡索 Rhizoma Corydalis) were used as the basic prescriptions of drugs, Feishu (BL 13), Dazhui (GV 14) and Shanzhong (CV 17) were selected as the basic prescription of points. Conclusion: The knowledge obtained from the complex networks on the basic prescriptions of drugs and points for point-application in summer to treat diseases with attacks in winter can provide a data support for working out operation norms and carrying on verification research.

耳穴疗法治疗原发性失眠的现代文献研究

Objective By sorting and analyzing pertinent modern studies targeting auricular point therapy treating primary insomnia(PI),to summarize the point selection rules and clinical efficacy of using auricular points alone or combining it with other therapies in treating PI.Methods A search on China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP),PubMed,Springer and Ovid were conducted from January 1,1998 till January 31,2020.Point selection,diagnostic criteria and Pittsburgh sleep quality index(PSQI)in the eligible studies were analyzed and summarized.Results The difference in PSQI before and after using auricular point therapy alone was more significant than that of using Chinese medication alone(P<0.05),but less significant than that of combining auricular point therapy and acupuncture-moxibustion and Chinese therapeutic massage(tuina)(P<0.05).In the included studies,Shenmen(TF_(4))was the most commonly used(370 times),followed by Heart(CO_(15)),which was 344 times,and Subcortex(AT_(4)),which was 325 times.In terms of auricular points distribution,points in the auricular concha were the most commonly used(1500 times),followed by those in the antitragus(474 times)and triangular fossa(387 times).Correlation analysis showed that Shenmen(TF_(4))and Liver(CO_(12)),Sympathetic(AH6a)and Heart(CO_(15))were used together more often,followed by Shenmen(TF_(4)),Liver(CO_(12)),Spleen(CO_(13)),Kidney(CO_(10))and Subcortex(AT_(4)),and then Shenmen(TF_(4)),Liver(CO_(12)),Sympathetic(AH6a),Subcortex(AT_(4))and Heart(CO_(15)).Cluster analysis showed that the auricular points used for PI can be divided into 6 clusters in 2 major groups.One group was Heart(CO_(15)),Subcortex(AT_(4)),Shenmen(TF_(4)),Sympathetic(AH6a),Spleen(CO_(13)),Kidney(CO_(10)),Liver(CO_(12))and Endocrine(CO_(18));the other was Occiput(AT3),Stomach(CO_(4)),Pancrease-gallbladder(CO_(11)),Chuiqian(LO_(4)),Small Intestine(CO_(6)),Central Rim(AT_(2,3,4i))and Sanjiao(CO_(17)).In terms of patterns in traditional Chinese medicine,the pattern of dual deficiency of heart and spleen accounted for the largest proportion in the studies of using auricular points alone or combining it with other treatments to treatment PI,and then it was the pattern of liver depression transforming into fire.Conclusion In treatment of PI with auricular points alone or combo therapy involving auricular points,Shenmen(TF_(4))was commonly used,and the commonly used point group consisted of Shenmen(TF_(4)),Liver(CO_(12)),Sympathetic(AH_(6a))and Heart(CO_(15)).Auricular point therapy can be taken as a complementary therapy in treating PI.