In vitro experiments have shown that subtle fluid flow environment plays a significant role in living biological tissues, while there is no in vivo practical dynamical measurement of the interstitial fluid flow veloci...In vitro experiments have shown that subtle fluid flow environment plays a significant role in living biological tissues, while there is no in vivo practical dynamical measurement of the interstitial fluid flow velocity. On the basis of a new finding that capillaries and collagen fibrils in the interosseous membrane form a parallel array, we set up a porous media model simulating the flow field with FLUENT software, studied the shear stress on interstitial cells＇ surface due to the interstitial fluid flow, and analyzed the effect of flow on protein space distribution around the ceils. The numerical simulation results show that the parallel nature of capillaries could lead to directional interstitial fluid flow in the direction of capillaries. Interstitial fluid flow would induce shear stress on the membrane of interstitial cells, up to 30 Pa or so, which reaches or exceeds the threshold values of cells＇ biological response observed in vitro. Interstitial fluid flow would induce nonuniform spacial distribution of secretion protein of mast cells. Shear tress on cells could be affected by capillary parameters such as the distance between the adjacent capillaries, blood pressure and the permeability coefficient of capillary＇s wall. The interstitial pressure and the interstitial porosity could also affect the shear stress on cells. In conclusion, numerical simulation provides an effective way for in vivo dynamic interstitial velocity research, helps to set up the vivid subtle interstitial flow environment of cells, and is beneficial to understanding the physiological functions of interstitial fluid flow.展开更多
目的:分析基于子午流注理论运用揿针联合脐疗治疗糖尿病便秘的效果。方法:选择无锡市中医医院2022年2月—2024年1月诊治的106例糖尿病便秘患者,将其随机分为两组,各53例。对比组给予大黄、肉苁蓉脐疗贴治疗,观察组在对比组基础上给予基...目的:分析基于子午流注理论运用揿针联合脐疗治疗糖尿病便秘的效果。方法:选择无锡市中医医院2022年2月—2024年1月诊治的106例糖尿病便秘患者,将其随机分为两组,各53例。对比组给予大黄、肉苁蓉脐疗贴治疗,观察组在对比组基础上给予基于子午流注理论的揿针治疗。比较两组临床疗效、血糖指标、便秘症状积分。结果:观察组临床总有效率(96.23%)高于对比组(75.47%),差异有统计学意义(P<0.05)。观察组治疗后空腹血糖(FPG)、餐后2 h血糖(2 h PG)均低于对比组,差异均有统计学意义(P<0.05)。观察组治疗后排便频率、腹胀、排便不尽、排便时间、粪便性状、排便困难积分均低于对比组,差异均有统计学意义(P<0.05)。结论:基于子午流注理论运用揿针联合脐疗可有效缓解糖尿病便秘患者便秘症状,调控血糖,临床疗效显著。展开更多
目的:分析温阳补肾贴穴位贴敷治疗对老年性夜尿频症患者最大尿流率(The Maximum urine flow rate, Qmax)、中医症候积分及睡眠质量的影响。方法:选取2021年3月~2023年3月本院收治的131例老年性夜尿频症患者为研究对象,按照治疗方式的不...目的:分析温阳补肾贴穴位贴敷治疗对老年性夜尿频症患者最大尿流率(The Maximum urine flow rate, Qmax)、中医症候积分及睡眠质量的影响。方法:选取2021年3月~2023年3月本院收治的131例老年性夜尿频症患者为研究对象,按照治疗方式的不同分为64例对照组(常规治疗)和67例观察组(温阳补肾贴穴位贴敷治疗),疗程为4周。对比两组临床疗效、治疗前后膀胱残余尿量、最大尿流率(Qmax)、夜间排尿次数、中医症候积分、匹兹堡睡眠质量指数评定量表(Pittsburgh Sleep Quality Index, PSQI)、生活质量综合评定问卷(Generic Quality of Life Inventory-74,GQOLI-74)及不良反应。结果:对照组临床总疗效率为75.00%,观察组临床总疗效率为94.02%,观察组总疗效率高于对照组(P<0.05)。观察组治疗后膀胱残余尿量、夜间排尿次数均少于对照组,且Qmax高于对照组(P<0.05)。两组治疗后中医症候积分均降低,且观察组治疗后中医症候积分低于对照组(P<0.05)。两组治疗后睡眠障碍、睡眠时间、日间功能障碍、睡眠效率、睡眠质量、入睡时间及催眠药物评分均降低,且观察组治疗后PSQI评分低于对照组(P<0.05)。治疗后两组心理功能、社会功能、生活态度、躯体功能四维度评分均升高,且对照组GQOL-74量表评分低于观察组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:温阳补肾贴穴位贴敷治疗应用于老年性夜尿频症患者中,可有效改善其临床症状,提高夜间最大尿流率,进而改善其睡眠质量,安全性高。展开更多
基金supported by Shanghai Leading Academic Disci-pline Project (B112 and T0302)Shanghai Science & Technology Development Foundation (09DZ1976600)Shanghai Rising-Star Program (10QA1406100)
文摘In vitro experiments have shown that subtle fluid flow environment plays a significant role in living biological tissues, while there is no in vivo practical dynamical measurement of the interstitial fluid flow velocity. On the basis of a new finding that capillaries and collagen fibrils in the interosseous membrane form a parallel array, we set up a porous media model simulating the flow field with FLUENT software, studied the shear stress on interstitial cells＇ surface due to the interstitial fluid flow, and analyzed the effect of flow on protein space distribution around the ceils. The numerical simulation results show that the parallel nature of capillaries could lead to directional interstitial fluid flow in the direction of capillaries. Interstitial fluid flow would induce shear stress on the membrane of interstitial cells, up to 30 Pa or so, which reaches or exceeds the threshold values of cells＇ biological response observed in vitro. Interstitial fluid flow would induce nonuniform spacial distribution of secretion protein of mast cells. Shear tress on cells could be affected by capillary parameters such as the distance between the adjacent capillaries, blood pressure and the permeability coefficient of capillary＇s wall. The interstitial pressure and the interstitial porosity could also affect the shear stress on cells. In conclusion, numerical simulation provides an effective way for in vivo dynamic interstitial velocity research, helps to set up the vivid subtle interstitial flow environment of cells, and is beneficial to understanding the physiological functions of interstitial fluid flow.
文摘目的:分析基于子午流注理论运用揿针联合脐疗治疗糖尿病便秘的效果。方法:选择无锡市中医医院2022年2月—2024年1月诊治的106例糖尿病便秘患者,将其随机分为两组,各53例。对比组给予大黄、肉苁蓉脐疗贴治疗,观察组在对比组基础上给予基于子午流注理论的揿针治疗。比较两组临床疗效、血糖指标、便秘症状积分。结果:观察组临床总有效率(96.23%)高于对比组(75.47%),差异有统计学意义(P<0.05)。观察组治疗后空腹血糖(FPG)、餐后2 h血糖(2 h PG)均低于对比组,差异均有统计学意义(P<0.05)。观察组治疗后排便频率、腹胀、排便不尽、排便时间、粪便性状、排便困难积分均低于对比组,差异均有统计学意义(P<0.05)。结论:基于子午流注理论运用揿针联合脐疗可有效缓解糖尿病便秘患者便秘症状,调控血糖,临床疗效显著。
文摘目的:分析温阳补肾贴穴位贴敷治疗对老年性夜尿频症患者最大尿流率(The Maximum urine flow rate, Qmax)、中医症候积分及睡眠质量的影响。方法:选取2021年3月~2023年3月本院收治的131例老年性夜尿频症患者为研究对象,按照治疗方式的不同分为64例对照组(常规治疗)和67例观察组(温阳补肾贴穴位贴敷治疗),疗程为4周。对比两组临床疗效、治疗前后膀胱残余尿量、最大尿流率(Qmax)、夜间排尿次数、中医症候积分、匹兹堡睡眠质量指数评定量表(Pittsburgh Sleep Quality Index, PSQI)、生活质量综合评定问卷(Generic Quality of Life Inventory-74,GQOLI-74)及不良反应。结果:对照组临床总疗效率为75.00%,观察组临床总疗效率为94.02%,观察组总疗效率高于对照组(P<0.05)。观察组治疗后膀胱残余尿量、夜间排尿次数均少于对照组,且Qmax高于对照组(P<0.05)。两组治疗后中医症候积分均降低,且观察组治疗后中医症候积分低于对照组(P<0.05)。两组治疗后睡眠障碍、睡眠时间、日间功能障碍、睡眠效率、睡眠质量、入睡时间及催眠药物评分均降低,且观察组治疗后PSQI评分低于对照组(P<0.05)。治疗后两组心理功能、社会功能、生活态度、躯体功能四维度评分均升高,且对照组GQOL-74量表评分低于观察组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:温阳补肾贴穴位贴敷治疗应用于老年性夜尿频症患者中,可有效改善其临床症状,提高夜间最大尿流率,进而改善其睡眠质量,安全性高。
