Acupoint catgut-embedding therapy ameliorates DNCB-induced atopic dermatitis in BALB/c mice by regulating Th2 type immune response and reducing infiltration of CD4^(+)and CD8^(+)cells

Background:This study aimed to assess how acupoint catgut-embedding therapy influences Th2-type immune response and the infiltration of CD4^(+)and CD8^(+)cells in DNCB-induced atopic dermatitis in BALB/c mice.It also conducted an initial examination of the underlying molecular mechanisms.Methods:Seventy-two mice were randomly divided into four groups:normal control,DNCB-induced atopic dermatitis model(AD),AD with acupoint catgut-embedding treatment(ADA),and AD with sham-acupoint catgut-embedding treatment.After DNCB challenge to induce AD,the ADA group received acupoint catgut-embedding therapy treatment at Zusanli(ST 36)and Quchi(LI 11)acupoints every other week from day 8.Mice in the AD with sham-acupoint catgut-embedding treatment group underwent the same procedure as the ADA group but without catgut implantation.Severity was assessed using SCORAD on treatment days 1,10,and 20.On day 18,nine mice per group were euthanized,and the remaining on day 28.Histopathological changes were observed using hematoxylin-eosin and immunohistochemistry staining.TNF-α,IL-4,IL-6,and IL-13 levels were analyzed by ELISA,and GATA3 and STAT6 protein levels by western blot.Results:After 20 days of acupoint catgut-embedding therapy treatment,mice showed reduced dermatitis scores compared to DNCB-induced AD-like mice.Significant decreases occurred in serum IL-4,IL-6,IL-13,and TNF-αlevels.Skin analysis revealed marked reductions in CD4^(+)and CD8^(+)cell infiltration,as well as GATA3 and STAT6 protein levels.Conclusion:Acupoint catgut-embedding therapy may effectively alleviate atopic dermatitis by suppressing Th2 immune responses via the STAT6-GATA3 pathway and reducing CD4^(+)and CD8^(+)T cell infiltration in skin lesions.

Effects of acupoint thread-embedding therapy on serum apelin and GLP-1 in type 2 diabetes mellitus patients with obesity due to dampness-heat encumbering spleen

Objective:To observe the effects of acupoint thread-embedding therapy on serum apelin and glucagon-like peptide-1(GLP-1)in type 2 diabetes mellitus patients with obesity due to dampness-heat encumbering spleen.Methods:Sixty-six patients were randomly divided into a control group and an observation group according to the random number table method,with 33 cases in each group.Patients in the control group were treated with exenatide and metformin,while patients in the observation group were treated with additional acupoint thread-embedding.After 12-week treatment,the obesity-related indicators,including body mass index(BMI),waist circumference and body fat rate,the glycometabolism indicators,including fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin,and the lipid metabolism indicators,including total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C),as well as serum apelin and GLP-1 levels were observed in patients of the two groups.Results:After treatment,the BMI,waist circumference and body fat rate of patients in the two groups were all reduced(all P<0.05),and were lower in the observation group than in the control group(all P<0.05);the fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin levels of patients in both groups were all decreased(all P<0.05),and were significantly lower in the observation group than in the control group(all P<0.05);the TC level was decreased(P<0.05),while the TG and LDL-C levels did not change significantly in the control group(both P>0.05);the TC,TG and LDL-C levels were all significantly reduced in the observation group(all P<0.05),lower than those in the control group(all P<0.05);the serum apelin level was decreased(P<0.05)and the serum GLP-1 level was increased(P<0.05)in the observation group,statistically different from those in the control group(both P<0.05).Conclusion:Combined with the conventional medication,acupoint thread-embedding therapy can significantly improve the obesity-related indicators,glycometabolism and lipid metabolism in type 2 diabetes mellitus patients with obesity due to dampness-heat encumbering spleen.This may be achieved by regulating the serum apelin and GLP-1 levels.

Meta-analysis of the acupoint application therapy for stable chronic obstructive pulmonary disease

Objective:To systematically evaluate the clinical efficacy and safety of acupoint application in the treatment of stable chronic obstructive pulmonary disease.Methods:A comprehensive search of domestic and international databases,the search time is limited to nearly ten years,collecting traditional Chinese medicine acupoint application in the treatment of chronic obstructive pulmonary disease in stable phase of randomized controlled trials.Literature screening,information extraction and literature quality evaluation were carried out independently by two researchers,and Meta analysis was carried out by Revman software.Results:A total of 42 RCTs with a total of 4192 patients were included.The results of Meta analysis showed that:Compared with the routine treatment of western medicine,the addition of acupoint application therapy can significantly increase the effective rate[RR=1.23,95%CI(1.19,1.27),P<0.00001]and FEV1/FVC[MD=4.46,95%CI(3.17,5.76),P<0.00001].Significantly improved BODE index[MD=-0.63,95%CI(-0.87,-0.40),P<0.00001],SGRQ score[MD=-6.77,95%CI(-9.81,-3.72),P<0.00001],CAT score[MD=-3.33,95%CI(-3.87,-2.79),P<0.00001]and TCM syndrome integral[MD=-3.51,95%CI(-3.96,-3.06),P<0.00001].The differences is statistically significant and the safety profile is good.Conclusion:On the basis of routine treatment of COPD western medicine,acupoint application therapy can significantly improve the clinical symptoms of patients with less adverse reactions.However,due to the limitations of the research,high-quality research is still needed to provide further evidence.

Clinical Study on the Therapeutic Effect of Combined Traditional Chinese Medicine with Acupoint Injection and Herbal Paste Application in Treating Ovulatory Dysfunction in Polycystic Ovary Syndrome (PCOS)

Objective: To observe the therapeutic effect of combined traditional Chinese medicine (TCM) therapy with acupoint injection and herbal patch application on patients with ovulatory dysfunction associated with polycystic ovary syndrome (PCOS). Methods: A total of 80 PCOS patients who received treatment at the First Affiliated Hospital of Guangxi University of Chinese Medicine between October 2022 and March 2024 were enrolled in this study. They were randomly divided into a control group (n = 40) and an observation group (n = 40). The control group received conventional Western medical treatments, while the observation group was administered TCM combined with acupoint injection and herbal patch application. Pre- and post-treatment conditions were compared between the two groups. Results: After treatment, the overall effective rate was significantly higher in the observation group compared to the control group (P 0.05). Following treatment, both ovulation and pregnancy rates increased in both groups, but the increase was more evident in the observation group, showing a statistically significant difference (P < 0.01). Conclusion: For patients with oligoovulation or anovulation due to PCOS, the combined use of TCM, acupoint injection, and herbal patch application appears to be effective in improving systemic symptoms and achieving notable clinical outcomes.

Preventing Lower Extremity Deep Vein Thrombosis After Hip Fracture Surgery in Elderly Patients by Acupoint Application Combined with Pneumatic Compression Therapy

Objective:To investigate and analyze the long-term clinical effects of acupoint application combined with pneumatic compression therapy in the prevention of deep venous thrombosis after hip fracture surgery among the elderly.Methods:Sixty elderly patients who had undergone hip fracture surgery from February 2021 to February 2022 were selected as the research subjects.The patients were divided into two groups via drawing lots.Both the groups received nursing care,but the patients in the observation group were treated with TCM acupoint application combined with pneumatic compression therapy,whereas the control group received pneumatic compression therapy.The evaluation indicators included the patients’quality of life and complications.Results:The incidence of lower extremity deep vein thrombosis in the observation group was more than twice(0.3%),whereas the incidence of lower extremity complications in the control group was more than 6 times(20%).There was a significant difference between the two groups(p<0.05).Conclusion:Traditional Chinese medicine acupoint application combined with pneumatic compression therapy is beneficial for the prevention of postoperative lower extremity deep vein thrombosis among elderly patients.In addition,the patients’overall quality-of-life scores in both physiological and psychological aspects improved significantly,which carries significant clinical reference value.

An investigation of the influence of intestinal flora in external traditional Chinese medicine therapy

External therapy,which has been used for millennia to treat disease,has now become the newest member of complementary and alternative therapies.A growing number of clinical studies and animal experiments have shown that external therapy exerts a positive effect on the intestinal flora.In this paper,we review the research related to external therapy on various systemic diseases and focus on changes in the intestinal flora.We found that studies on external therapy are dominated by acupuncture and tuina,primarily aimed at the treatment of digestive and neurological diseases.However,the deeper mechanism of regulation of the intestinal flora by external therapy has not yet been experimentally confirmed.

CLINICAL OBSERVATION ON TREATMENT OF ALLERGIC BRONCHIAL ASTHMA WITH ACUPOINT APPLICATION THERAPY

In the present paper, the therapeutic effect of acupoint application of Chinese Materia Medica in the treatment of allergic asthma was observed. The results revealed that topical application of drug paste [mixture of powder of Mahuang (Herba Ephedrae), Xixin (Herba Asari), Baijiezi (Semen Sinapis Albae), etc.] at the acupuncture points could improve symptoms and signs of allergic asthma patients, with the total effective rate being 69.57% (16/23) for the short term effect, and 52.17%(12/23) for the long term effect. In medication (Aminophylline) group, of the 25 cases of allergic asthma, 16 (64.0%) were effective after 4 weeks of treatment, while 6 (24.0%) were still effective that was shown by 6 months’ follow up. The therapeutic effect of acupoint application group was significantly better than that of medication group in the long term effect. Results also showed that no obvious interrelation between the short term therapeutic effect and the duration or the severity of the disease. Results also display that acupoint application therapy is an effective, safe and handy method with fewer side effects for asthma.

CLINICAL OBSERVATION ON THE ACUPOINT INTRADERMAL EMBEDDING OF RINGHEADED THUMBTACK-NEEDLE THERAPY FOR HYPERPLASIA OF MAMMARY GLANDS

In the present paper, the author used acupoint intradermal embedding of ringheaded thumbtack-needle therapy combined with herbal medicine therapy to treat 110 cases of hyperplasia of mammary glands, and compared its therapeutic effect with that of herbal therapy alone. The observed indexes of the treatment were pain relief degree, the size of hyperplasic glands and the time of occurrence of marked effect. Following 3 courses of treatment,the results showed the therapeutic effect of the ringheaded thumbtack-needle needle plus herbal medicine therapy was superior to that of herbal medicine therapy alone in the above-mentioned 3 indexes (P ＜ 0.01 ).

Research on mechanism of Jin-Shui-Liu-Jun-Jian and Acupoint Application combined therapy for chronic bronchitis

Objective:To investigate the influencing mechanism of Jin-Shui-Liu-Jun-Jian and Acupoint Application combined therapy on hemorheology, inflammatory factors and pulmonary functions in patients with chronic bronchitis, thus to offer relevant help for clinical therapies on patients with chronic bronchitis. Methods:120 cases of patients with chronic bronchitis treated in our hospital were selected and randomly divided to be the therapeutic group and the control group, 60 cases each. Patients in control group were provided some basic treatments, such as spasmolysis, anti-inflammation, asthma relieving, oxygen inhalation and dissolve phlegm. For therapeutic group on this basis, Jin-Shui-Liu-Jun-Jian and Acupoint Application combined therapy was provided. Hemorheology, inflammatory factors and pulmonary functions in the two groups of patients were detected before and after treatment. Results:Differences of hemorheology indexes, inflammatory factors and pulmonary function relevant indexes between the two groups of patients with chronic bronchitis before treatment showed no statistical significance (P>0.05). Compared with prior treatment, hemorheology relevant indexes [whole blood high shear viscosity (WHV), whole blood low shear viscosity (WLV), packed cell volume (PCV), plasma viscosity (PV) and red cell assembling index (RCAI)], inflammatory factors [IL-8 (interleukin-8) and TNF-α(tumor necrosis factor-α)] were significantly decreased and pulmonary function relevant indexes [forced vital capacity (FVC), forced expiratory volume in one second (FEV1.0), peak expiratory flow (PEF), maximal voluntary ventilation (MVV) and expiratory flow rate when exhale vital capacity was 0.50], inflammatory factors (IL-4, IL-2) were significantly increased in the two groups of patients with chronic bronchitis after relevant treatments;The differences between the groups showed statistical significance (P<0.05). After combined therapy provided, pulmonary function relevant indexes (FVC, FEV1.0, PEF, MVV and V0.50) and inflammatory factors (IL-4, IL-2) in therapeutic group were significantly higher than control group after basic therapy. Hemorheology relevant indexes (WHV, WLV, PV, PCV and RCAI) and inflammatory factors (IL-8 and TNF-α) in therapeutic group were significantly lower than control group;Differences between the two groups showed statistical significance (P<0.05). Conclusions: Combination of Jin-Shui-Liu-Jun-Jian and Acupoint Application significantly improved the levels of hemorheology, inflammatory factors and pulmonary functions in patients with chronic bronchitis. It has a great important clinical significance on therapies for patients with chronic bronchitis.

子午流注纳子法穴位贴敷联合穴位药熨治疗脾胃虚寒型功能性消化不良临床观察

目的观察子午流注纳子法穴位贴敷联合穴位药熨治疗脾胃虚寒型功能性消化不良(FD)的临床疗效。方法将120例脾胃虚寒型FD患者按照随机数字表法分为2组,治疗组60例予子午流注纳子法穴位贴敷联合穴位药熨治疗,对照组60例予多潘立酮片治疗,2组均治疗28天。比较2组疗效;比较2组治疗前后主要症状评分变化;比较2组治疗前后焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分变化。结果治疗组总有效率96.67%(58/60),对照组总有效率76.67%(46/60),治疗组疗效优于对照组(P<0.05)。2组治疗后各项主要症状评分及总积分均较本组治疗前降低(P<0.05),治疗后治疗组各项主要症状评分及总积分均低于对照组(P<0.05)。2组治疗后SAS评分、SDS评分均较本组治疗前降低(P<0.05),治疗后治疗组SAS评分、SDS评分均低于对照组(P<0.05)。结论子午流注纳子法穴位贴敷联合穴位药熨治疗脾胃虚寒型FD疗效显著,可改善患者主要症状及焦虑、抑郁状态。

耳穴贴压联合针灸对高血压病患者血压血脂的影响

目的 探析高血压病患者采用耳穴贴压联合针灸治疗对血压与血脂的影响。方法 选择枣庄市立医院2021年3月—2022年3月接诊的90例高血压病患者,按照随机数字表法分为2组,每组45例。对照组口服药物治疗,观察组耳穴贴压联合针灸治疗。比较2组患者血压、血脂、中医证候积分和治疗总有效率。结果 治疗后,观察组舒张压、收缩压均低于对照组,差异有统计学意义(P<0.05);观察组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)低于对照组,高密度脂蛋白胆固醇(HDL-C)高于对照组,差异均有统计学意义(P<0.05);观察组主症(头痛、眩晕)与次症(心悸、胸闷、畏寒肢冷)中医证候积分均低于对照组,差异有统计学意义(P<0.05)。观察组的治疗总有效率为97.78%(44/45),高于对照组的80.00%(36/45),差异有统计学意义(P<0.05)。结论 高血压病患者采用耳穴贴压联合针灸治疗可以更好地改善血压与血脂,值得推广。

通络祛痛膏循经取穴贴敷对腰间盘突出患者止痛效果的随机对照研究

目的通过随机对照研究通络祛痛膏循经取穴贴敷对腰间盘突出患者止痛效果。方法110例腰间盘突出患者,采用随机数字表法分为观察组和对照组,每组55例。观察组采用循经取穴贴敷通络祛痛膏,对照组采用常规阿是穴贴敷通络祛痛膏。比较两组患者治疗前后及随访期间视觉模拟评分法(VAS)评分、伴随症状缓解效果、安全性。结果治疗前,观察组患者VAS评分(5.98±1.84)分与对照组的(6.10±2.20)分比较,无明显差异(P>0.05)。治疗后,两组患者VAS评分均低于治疗前,且观察组患者VAS评分(2.93±1.30)分低于对照组的(3.97±2.29)分(P<0.05)。观察组治疗后2周、1个月、3个月随访VAS评分分别为(2.79±1.68)、(2.67±1.38)、(2.37±1.95)分,均低于治疗前(P<0.05),略低于治疗后,但无明显差异(P>0.05)。对照组患者治疗后2周、1个月、3个月随访VAS评分分别为(3.67±2.54)、(4.67±2.63)、(4.59±2.98)分,治疗后2周随访VAS评分略低于治疗后,治疗后1、3个月随访VAS评分均高于治疗后,但均无明显差异(P>0.05)。观察组治疗后2周、1个月、3个月随访VAS评分均低于对照组(P<0.05)。观察组患者伴随症状缓解显效率94.6%高于对照组的76.4%(P<0.05)。观察组与对照组患者伴随症状缓解总有效率均为98.2%,无明显差异(P>0.05)。治疗过程中两组各发生轻度皮肤瘙痒3例,局部涂抹药膏后缓解,局部皮肤后期有轻微结痂,无感染及瘢痕产生。两组均未发生严重安全性问题,两组安全性比较无明显差异(P>0.05)。结论通络祛痛膏循经取穴贴敷疗法对腰间盘突出患者止痛效果及远期疗效优于常规阿是穴贴敷,且在改善伴随症状上循经取穴贴敷显效率高于阿是穴贴敷。

灸疗技术联合穴位按摩在脓毒症喂养不耐受患者中的应用效果

目的探讨灸疗技术联合穴位按摩在脓毒症喂养不耐受患者中的应用效果。方法选取江西中医药大学附属医院2022年1月至2024年1月收治的80例脓毒症喂养不耐受患者作为研究对象,其中将2022年1月至2023年1月收治的40例患者纳入对照组,将2023年2月至2024年1月收治的40例患者纳入研究组;对照组予常规干预,研究组基于常规干预予灸疗技术联合穴位按摩干预;比较两组干预效果、胃肠功能指标、营养指标及预后指标。结果研究组的总有效率高于对照组,差异有统计学意义(P<0.05);干预7 d,研究组的肠鸣音评分、胃肠功能障碍评分、腹腔压力均低于对照组,血清白蛋白、血清总蛋白水平均高于对照组,差异有统计学意义(P<0.05);研究组的ICU入住时间短于对照组,差异有统计学意义(P<0.05)。结论脓毒症喂养不耐受患者采用灸疗技术联合穴位按摩干预效果较好,可提高胃肠功能,改善营养状况与预后。

耳穴疗法联合普瑞巴林胶囊治疗气滞血瘀型带状疱疹后遗神经痛临床观察

目的分析耳穴疗法联合普瑞巴林胶囊治疗气滞血瘀型带状疱疹后遗神经痛(PHN)的临床效果。方法经随机方式把80例带状疱疹(HZ)住院患者归入对照组、治疗组,分别实施常规治护+普瑞巴林胶囊口服止痛疗法、常规治护+中医耳穴压豆+普瑞巴林胶囊口服止痛疗法,对比两组神经痛改善状况。结果在疼痛缓解方面,相较对照组,治疗组具有显著优势(P<0.05)。治疗组总有效率为90.00%(36/40),高于对照组的77.50%(31/40);治疗组的复发率为10.00%(4/40),低于对照组的22.50%(9/40)(P<0.05)。结论耳穴压豆+普瑞巴林胶囊疗法对于气滞血瘀型PHN的缓解有着积极作用,同时止痛效果相较单用普瑞巴林胶囊更具优势。

中药穴位贴敷联合音乐疗法对宫颈癌化疗所致恶心呕吐的干预效果分析

目的观察中药穴位贴敷联合音乐疗法对宫颈癌化疗所致恶心呕吐的干预效果。方法纳入宫颈癌化疗治疗所致恶心呕吐的患者76例,采用随机数字表法分为2组。对照组37例予音乐疗法,研究组39例予中药穴位贴敷联合音乐疗法干预。2组均21天为1个疗程,治疗4个疗程。比较2组治疗前后血小板计数、白细胞计数、血红蛋白水平、恶心及呕吐指数评估量表(INVR)和生活质量评分(QOL),记录2组恶心呕吐发生情况,统计对比2组疗效。结果研究组总有效率92.31%(36/39),对照组总有效率72.97%(27/37),研究组临床疗效优于对照组(P<0.05)。2组治疗后血小板计数、白细胞计数及血红蛋白水平均较本组治疗前降低(P<0.05),且研究组治疗后均低于对照组(P<0.05)。2组治疗前后INVR评分比较2组治疗后INVR各项评分均较本组治疗前降低(P<0.05),且研究组治疗后均低于对照组(P<0.05)。2组治疗后QOL各项评分均较本组治疗前升高(P<0.05),且研究组治疗后均高于对照组(P<0.05)。2组治疗当日恶心呕吐发生情况比较差异无统计学意义(P>0.05)。治疗结束后当日研究组恶心呕吐发生率均低于对照组(P<0.05)。结论经中药穴位贴敷联合音乐疗法对宫颈癌化疗所致恶心呕吐患者进行治疗,能显著改善患者恶心呕吐症状,提高患者生活质量,临床效果显著。

中药透皮术配合穴位手法治疗外阴色素减退性疾病的临床研究

目的 探讨中药透皮术联合穴位手法对外阴色素减退性疾病临床疗效。方法 将90例就诊于长春中医药大学附属医院妇产诊疗中心门诊,并符合纳入标准的外阴色素减退性疾病患者随机分为治疗组和对照组。治疗组采用中药透皮术配合穴位手法治疗,对照组采用竹红菌素软膏外涂。对2组的临床有效率与复发率进行详细比较。结果 治疗组的整体临床有效率高达95.56%,相比之下,对照组的总有效率仅为73.33%。通过比较2组数据可以发现,在有效性方面,治疗组优于对照组,差异具有统计学意义(P<0.05)。后续对2组患者进行为期一个月的随访,随访结果表明,治疗组的复发率相较于对照组更低。结论 中药透皮术配合穴位手法治疗外阴色素减退性疾病,其方法切实可行,疗效显著,复发率低,为中医治疗本病提供了新依据、新思路。

基于子午流注理论运用揿针联合脐疗治疗糖尿病便秘的效果

目的:分析基于子午流注理论运用揿针联合脐疗治疗糖尿病便秘的效果。方法:选择无锡市中医医院2022年2月—2024年1月诊治的106例糖尿病便秘患者,将其随机分为两组,各53例。对比组给予大黄、肉苁蓉脐疗贴治疗,观察组在对比组基础上给予基于子午流注理论的揿针治疗。比较两组临床疗效、血糖指标、便秘症状积分。结果:观察组临床总有效率(96.23%)高于对比组(75.47%),差异有统计学意义(P<0.05)。观察组治疗后空腹血糖(FPG)、餐后2 h血糖(2 h PG)均低于对比组,差异均有统计学意义(P<0.05)。观察组治疗后排便频率、腹胀、排便不尽、排便时间、粪便性状、排便困难积分均低于对比组,差异均有统计学意义(P<0.05)。结论:基于子午流注理论运用揿针联合脐疗可有效缓解糖尿病便秘患者便秘症状,调控血糖,临床疗效显著。

背俞穴指揉弹拨法改善老年社区获得性肺炎病人排痰的效果

目的:探讨背俞穴指揉弹拨法改善老年社区获得性肺炎(CAP)病人排痰的效果。方法:纳入2021年9月—2022年11月入住巴中市某三级甲等综合医院老年病科的老年CAP病人96例为研究对象,采用随机数字表法将病人分为试验组和对照组,每组48例,对照组接受常规背部叩击排痰护理,试验组在对照组基础上实施背俞穴指揉弹拨法。比较两组病人排痰费力改善情况、排痰有效率、经皮脉搏血氧饱和度(SpO2)、焦虑状况及住院时间。结果:干预开始后7 d,试验组病人排痰费力改善率为95.83%,高于对照组(81.25%);试验组病人干预后排痰总有效率为93.75%,高于对照组(79.17%);试验组病人干预后SpO2为(97.72±1.05)%,高于对照组[(95.23±1.27)%];试验组病人干预后焦虑程度低于对照组;试验组病人住院时间为(10.03±1.29)d,短于对照组[(12.94±1.22)d],差异均有统计学意义(P<0.05)。结论:背俞穴指揉弹拨法在一定程度上有利于改善老年CAP病人的排痰能力,提升病人血氧饱和度,改善病人焦虑状态,缩短病人住院时间。

基于正交设计的穴位埋线治疗脑卒中后便秘方案优选研究

目的基于正交设计对脑卒中后便秘穴位埋线进行初步方案优选。方法选取脑卒中后便秘患者80例,以每周完全自主排便次数为观察指标,应用正交设计法,观察间隔时间(A,2周、间隔4周)、埋线深度(B,25~40 mm、50~60 mm)、取穴(C,天枢、天枢+大肠俞)、线体(D,胶原蛋白线、PDO线)4因素两水平间的不同搭配组合对脑卒中后便秘的疗效,初步确定优选方案。结果治疗后,各组周完全自主排便(CSBM)次数较治疗前均有明显改善(P<0.05),直观分析:两水平差值之差(R)(B)>R(C)>R(A)>R(D),R(B)、R(C)明显大于R(A)、R(D),可知B、C是影响效果的主要因素,而A、D则是次要因素。结论间隔2周、埋线深度40~50 mm、PDO线体、天枢+大肠俞,为较优治疗方案。

温针配合穴位贴敷及药物干预乳腺癌化疗相关性恶心呕吐的临床研究

目的观察温针配合穴位贴敷及药物干预乳腺癌化疗相关性恶心呕吐(chemotherapy induced nausea and vomiting,CINV)的临床疗效。方法将110例乳腺癌术后辅助化疗患者随机分为观察组和对照组,每组55例。对照组于化疗前30 min接受静脉滴注注射用盐酸托烷司琼治疗,观察组在对照组基础上于化疗前1 d接受温针配合穴位贴敷治疗。观察两组化疗前后不同时间点恶心、呕吐反应症状评分及血清5-羟色胺(5-hydroxytryptamine,5-HT)水平的变化情况,并比较两组CINV发生率。结果观察组CINV发生率为34.5%,明显低于对照组的56.4%,差异具有统计学意义(P<0.05)。两组化疗后第3 d恶心、呕吐反应症状评分均较同组化疗前显著上升,化疗后第5、7 d恶心、呕吐反应症状评分均较同组化疗第3 d显著下降,差异均具有统计学意义(P<0.05)。观察组化疗后第3、5、7 d恶心、呕吐反应症状评分均明显低于对照组,差异均具有统计学意义(P<0.05)。两组化疗后第7 d血清5-HT水平均较同组化疗前显著上升(P<0.05)。观察组化疗后第7 d血清5-HT水平明显低于对照组,差异具有统计学意义(P<0.05)。结论温针配合穴位贴敷及药物干预能降低乳腺癌CINV的发生率,有助于缓解恶心、呕吐症状,其机制可能与降低5-HT水平有关。