The effect of Shengmaisan (SMS) on coronary heart disease (CHD) patients, 30 anginapectoris and 68 acute myocardial infarction (AMI) and its peroxidation damage was studied. It was shownthat the activities of superoxi...The effect of Shengmaisan (SMS) on coronary heart disease (CHD) patients, 30 anginapectoris and 68 acute myocardial infarction (AMI) and its peroxidation damage was studied. It was shownthat the activities of superoxide dismutase (SOD) and glutathione peroxidase ( GSH-Px) in blood decreasedand the content of malondialdehyde (MDA) in plasma increased in CHD patients in comparison with thehealthy controls (P < 0. 001 ) . When SMS was orally administered in 38 AMI patients, both SOD and GSH-Pxactivities were increased and the level of MDA decreased (P < 0. 05) , and these changes were even moresignificant when SMS was further ingested for another two weeks (P < 0. 001 ) . AT the same time, it wasfound that the changes of SOD. GSH-Px and MDA in the control group (30 AMI patients not taking SMS) werenot significantly different (P >0. 05 ) . It could be assumed that the pathogenesis of CHD is associated withfree radical (FR) triggering a chain reaction of the lipid peroxidation, and that SMS is acting as an effectivefree radical scavenger, which would ameliorate the lipid peroxidation damage . Thus, SMS could be adminis-tered in the prevention and the treatment of CHD.展开更多
Dynamic observations for 4 weeks were made on left ventricular function and oxygen freeradicals (OFR) in 43 patients who suffered the first attack of acute myocardial intarction and was hospitalizedin Coronary Care Un...Dynamic observations for 4 weeks were made on left ventricular function and oxygen freeradicals (OFR) in 43 patients who suffered the first attack of acute myocardial intarction and was hospitalizedin Coronary Care Unit within 36 hours. The results showed that Radix Astragali (RA) could strenthen the leftventricicular function and had an effect of scavenging OFR. After administration of RA, the ratio of pre-ejectionperiod/ left ventricular ejection time (PEP/LVET) was decreased , the superoxide dismutase (SOD) activitiesof erythrocytes were increased, and the lipid peroxidation (LPO) concentration of plasma was reduced.There was a significant difference between the RA group and the control group in the parameters mentionedabove. The study demonstrated that the PEP/LVET ratio was closely correlated with SOD and LPO. It sug-gested that the scavenging effect of RA on OFR was one of its mechanisms of cardiotonic action.展开更多
文摘The effect of Shengmaisan (SMS) on coronary heart disease (CHD) patients, 30 anginapectoris and 68 acute myocardial infarction (AMI) and its peroxidation damage was studied. It was shownthat the activities of superoxide dismutase (SOD) and glutathione peroxidase ( GSH-Px) in blood decreasedand the content of malondialdehyde (MDA) in plasma increased in CHD patients in comparison with thehealthy controls (P < 0. 001 ) . When SMS was orally administered in 38 AMI patients, both SOD and GSH-Pxactivities were increased and the level of MDA decreased (P < 0. 05) , and these changes were even moresignificant when SMS was further ingested for another two weeks (P < 0. 001 ) . AT the same time, it wasfound that the changes of SOD. GSH-Px and MDA in the control group (30 AMI patients not taking SMS) werenot significantly different (P >0. 05 ) . It could be assumed that the pathogenesis of CHD is associated withfree radical (FR) triggering a chain reaction of the lipid peroxidation, and that SMS is acting as an effectivefree radical scavenger, which would ameliorate the lipid peroxidation damage . Thus, SMS could be adminis-tered in the prevention and the treatment of CHD.
文摘Dynamic observations for 4 weeks were made on left ventricular function and oxygen freeradicals (OFR) in 43 patients who suffered the first attack of acute myocardial intarction and was hospitalizedin Coronary Care Unit within 36 hours. The results showed that Radix Astragali (RA) could strenthen the leftventricicular function and had an effect of scavenging OFR. After administration of RA, the ratio of pre-ejectionperiod/ left ventricular ejection time (PEP/LVET) was decreased , the superoxide dismutase (SOD) activitiesof erythrocytes were increased, and the lipid peroxidation (LPO) concentration of plasma was reduced.There was a significant difference between the RA group and the control group in the parameters mentionedabove. The study demonstrated that the PEP/LVET ratio was closely correlated with SOD and LPO. It sug-gested that the scavenging effect of RA on OFR was one of its mechanisms of cardiotonic action.
