Users leave their footprints about their interests while they are surfing on the Internet. Companies have the opportunity of capturing user＇s implicit data on the Intemet by behavioral targeting. So that they can del...Users leave their footprints about their interests while they are surfing on the Internet. Companies have the opportunity of capturing user＇s implicit data on the Intemet by behavioral targeting. So that they can deliver the advertisements of the products or services that appeals to those consumers. Users are being exposed to targeted advertisements according to their demographic characteristics or web site choices. Each online behavior gives a clue about the consumer＇s product interests for the advertisers. Targeted advertising services such as these are currently provided by many companies including Google and Amazon. There are differences between the users＇ level of awareness and attitudes towards targeted ads. In this study Internet users＇ attitudes and avoidance towards targeted ads were evaluated.展开更多
Objective To predict the main active ingredients,potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology.Methods A database of chemical constituents of Yuan...Objective To predict the main active ingredients,potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology.Methods A database of chemical constituents of Yuan Zhi powder was constructed by using databases and literatures.Potential targets were predicted by reverse molecular docking,and then a component-target network was constructed.The target network of Alzheimer's disease(AD)was mapped and analyzed to obtain the“active ingredient-AD target”network.The key targets were screened through network analysis.Finally,the rationality of the prediction was analyzed by comparing with the target reported in the literatures.Results There were180chemical constituents acting on the AD target,and the targets included three key targets(cyclooxygenase-2,muscarinic acetylcholine receptor M1,and muscarinic acetylcholine receptor M2)and an important target(acetylcholine esterase).Alzheimer's disease may be treated by regulating the activity of acetylcholine receptors and the binding toβ-amyloid protein,and its biological process may be concentrated in the acetylcholine receptor signal pathway,negative regulation of synaptic transmission and so on.Conclusion The fact that Yuan Zhi powder can treat AD is consistent with the characteristics of multi-components-multitargets-multiple pathways of traditional Chinese medicine.The important targets obtained from network analysis have a large proportion in literature research,so network analysis have some rationality.展开更多
文摘Users leave their footprints about their interests while they are surfing on the Internet. Companies have the opportunity of capturing user＇s implicit data on the Intemet by behavioral targeting. So that they can deliver the advertisements of the products or services that appeals to those consumers. Users are being exposed to targeted advertisements according to their demographic characteristics or web site choices. Each online behavior gives a clue about the consumer＇s product interests for the advertisers. Targeted advertising services such as these are currently provided by many companies including Google and Amazon. There are differences between the users＇ level of awareness and attitudes towards targeted ads. In this study Internet users＇ attitudes and avoidance towards targeted ads were evaluated.
基金funding support from the Major new drug creation project (2017ZX09101002-002-008)National Natural Science Foundation of China (81403171)Autonomous Program of China Academy of Chinese Medical Sciences (QZPT001 and 2014065)
文摘Objective To predict the main active ingredients,potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology.Methods A database of chemical constituents of Yuan Zhi powder was constructed by using databases and literatures.Potential targets were predicted by reverse molecular docking,and then a component-target network was constructed.The target network of Alzheimer's disease(AD)was mapped and analyzed to obtain the“active ingredient-AD target”network.The key targets were screened through network analysis.Finally,the rationality of the prediction was analyzed by comparing with the target reported in the literatures.Results There were180chemical constituents acting on the AD target,and the targets included three key targets(cyclooxygenase-2,muscarinic acetylcholine receptor M1,and muscarinic acetylcholine receptor M2)and an important target(acetylcholine esterase).Alzheimer's disease may be treated by regulating the activity of acetylcholine receptors and the binding toβ-amyloid protein,and its biological process may be concentrated in the acetylcholine receptor signal pathway,negative regulation of synaptic transmission and so on.Conclusion The fact that Yuan Zhi powder can treat AD is consistent with the characteristics of multi-components-multitargets-multiple pathways of traditional Chinese medicine.The important targets obtained from network analysis have a large proportion in literature research,so network analysis have some rationality.
