Electrochemical oxidation of paracetamol has been studied in the presence of malononitrile as a nucleophile in a phosphate buffer solution （0.15 tool/L, pH 7）, using cyclic voltammetric techniques. The results indic...Electrochemical oxidation of paracetamol has been studied in the presence of malononitrile as a nucleophile in a phosphate buffer solution （0.15 tool/L, pH 7）, using cyclic voltammetric techniques. The results indicated that the N-acetyl-p-benzoquinone-imine derived from paracetamol participates in a 1,4-Michael-ts, pe addition reaction with the malononitrile to form the corresponding paracetamol derivatives （6a, 7a）. The present study has led to the development of a simple, green, non-catalyst and one-pot electrochemical method with high atom economy under mild conditions.展开更多
基金Semnan University Research Council for financial supports of this work
文摘Electrochemical oxidation of paracetamol has been studied in the presence of malononitrile as a nucleophile in a phosphate buffer solution （0.15 tool/L, pH 7）, using cyclic voltammetric techniques. The results indicated that the N-acetyl-p-benzoquinone-imine derived from paracetamol participates in a 1,4-Michael-ts, pe addition reaction with the malononitrile to form the corresponding paracetamol derivatives （6a, 7a）. The present study has led to the development of a simple, green, non-catalyst and one-pot electrochemical method with high atom economy under mild conditions.
