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Effect of Ligustrazine on Expression of Adherent Molecule CD_(49)d and Cyclin D_2 in Hematopoietic Cells in Acute Radiation Injured Mice
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作者 董凌莉 孙汉英 +3 位作者 刘文励 陶德定 张悦 徐慧珍 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1999年第2期20-22,共3页
After irradiation by 8.0 Gy γ ray, each mouse was stomach fed by 4 mg ligustrazine injection twice a day. On the 7th day after irradiation, CD 49 d expression in ligustrazine treated group was significantly h... After irradiation by 8.0 Gy γ ray, each mouse was stomach fed by 4 mg ligustrazine injection twice a day. On the 7th day after irradiation, CD 49 d expression in ligustrazine treated group was significantly higher than that in control group ( P <0.01), and showed no difference from that in normal group ( P > 0.05). On the 14th day after irradiation, CD 49 d expression was increased in control group, but decreased significantly in ligustrazine treated group ( P <0.01). The expression of Cyclin D 2 in spleen mononuclear cells (MNC) in ligustrazine treated group was significantly higher than that in control group, but the ratio of G 0+G 1 phase cells was significantly lower in ligustrazine treated group ( P <0.01). This finding indicated that ligustrazine could increase the expression of adherent molecule on bone marrow hematopoietic cells and Cyclin D 2 in spleen MNC, thereby promoting the growth of hematopoietic cells. 展开更多
关键词 LIGUSTRAZINE adherent molecule CYCLINS
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Expression of Adherent Molecule and Cyclin by Ligustrazine in Bone Marrow of Mice with Immune-Induced Aplastic Anemia 被引量:1
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作者 董凌莉 孙汉英 +2 位作者 刘文励 徐慧珍 陶德定 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1999年第1期32-34,共3页
Summary: Mice with immune induced aplastic anemia (AA) were given 5 mg ligustrazine intraperitoneally twice a day. On the 14th day, the expression of CD 49d , CD 49e , cyclinD 2 in bone marrow mononuclear ... Summary: Mice with immune induced aplastic anemia (AA) were given 5 mg ligustrazine intraperitoneally twice a day. On the 14th day, the expression of CD 49d , CD 49e , cyclinD 2 in bone marrow mononuclear cells (MNC) was examined by flow cytometry, and VCAM 1 on stromal cells was immunohistochemically measured by Strept Avidin Biotin Complex (SABC). The expression of CD 49d , CD 49e , VCAM 1 and cyclinD 2 in ligustrazine treated group was significantly higher than that in AA group ( P <0 01), but the ratio of G 0+G 1 phase cells was significantly lower than that in AA group ( P <0.01).The results showed that ligustrazine could improve the expression of adherent molecule and cyclin D 2 in the bone marrow of mice with immune induced aplastic anemia, thereby promoting the growth of hematopoietic cells. 展开更多
关键词 ANEMIA anemia aplastic adherent molecules LIGUSTRAZINE CYCLIN
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