Efficacy of Cyanoacrylate Tissue Adhesive Application in the Management of Corneal Perforations at Preah Ang Duong Hospital in Cambodia

Purpose: The study was to evaluate the efficacy of cyanoacrylate tissue adhesive (CTA) application in corneal perforations. Method: This was a prospective study on 20 patients of corneal perforations who received cyanoacrylate tissue adhesive application as treatment between March 2021 and March 2022 at Preah Ang Duong Hospital. The primary outcome measure was success rate of CTA application, while the secondary outcome was to measure postoperative best-corrected visual acuity (BCVA) and ocular complications. Results: The mean age of patients was 44.15 ± 16.05 years old and 7 (35%) were female. Causes of perforation were microbial infection in 12 patients (60%), trauma in 5 patients (25%), and sterile melting in 3 patients (15%). The perforation of size smaller than 1.5 mm was in 8 patients (40%) while 12 patients (60%) had perforated size between 1.5 mm to 3 mm. The perforation was 60% (12 patients) central, 25% (5 patients) paracentral, and 15% (3 patients) peripherally. Out of 20 patients, 5 patients (25%) received CTA application more than 1 time. The mean glue retention was 57.60 ± 31.84 days. Success rate of glue application (defined as intact globe without surgical intervention regardless of number of CTA applications) was 85%. At the last visit, 7 patients (35%) had BCVA of 6/120 or better. Common complications were uveitis (45%), ocular hypertension (30%), cataract (25%) and neovascularization (20%). No serious complications were found. Conclusion: Cyanoacrylate tissue adhesive is an effective treatment option in sealing corneal perforations with no serious complications. .

Study on Modification of Octyl-α-Cyanoacrylate Medical Adhesive

Objective:In order that the adhesive character could be improved to modify the octyl-α-cyanoacrylate(OCA) medical adhesive.Methods:Suitable modifiers involving polycaprolactone(PCL),dibutyl phthalate (DBP),dioctyl phthalate(DOP) and poly octyl methacrylat(POMA) have been chosen to modify the OCA adhesive,then tensile shear strength and adhesive strength are tested to evaluate the bond character of adhesives.Results:The PCL group's tensile shear strength and adhesive strength in normal temperature are descended while the other groups'are all enhanced.Conclusion:The modification of properties of the other groups is effectively promoted in the aspect of the bond character,except the PCL group treated in normal temperature and the PCL modified group treated by rectification get a best improvement in the agglutinate intention, while the stability is expected to be improved.

2-Octyl-Cyanoacrylate Skin Adhesive Used as a Splinting Material in Auricular Surgery

In cases of auricular surgery, postoperative dressings are thought to be important for keeping auricular contour and in helping to prevent from dressing failures due to edema or subcutaneous hematoma, which may result in fibrous or cartilaginous proliferation. However, it is often difficult to achieve success with standard dressings because of the complicated shape of the auricle. We used 2-octyl-cyanoacrylate skin adhesive to dress the auricle after different types of auricular procedures (five cases of cryptotia, two of prominent ear, two of severe auricular laceration, two of skin grafting and one of flap repair of the partial auricle defect). The 2-octyl-cyanoacrlaate skin adhesive was applied to the suture line and the operated and peripheral areas for wider coverage. No dressing materials were placed over the surface. In all cases, the desired outcome was achieved, without subcutaneous hematoma, wound dehiscence, and wound infection. Contact dermatitis caused by the skin adhesive was not observed in any of the cases. Dressing and splinting after auricular surgery can be simply and successfully achieved using 2-octyl-cyanoacrylate skin adhesive. There is no need for more complicated dressings and post-surgical dressing changes, resulting in higher patient satisfaction.

Study of glue extrusion after endoscopic N-butyl-2-cyanoacrylate injection on gastric variceal bleeding

AIM:To investigate glue extrusion after endoscopic N-butyl-2-cyanoacrylate injection on gastric variceal bleeding and to evaluate the long-term efficacy and safety of this therapy.METHODS:A total of 148 cirrhotic patients in our hospital with esophagogastric variceal bleeding(EGVB) were included in this study.N-butyl-2-cyanoacrylate was mixed with lipiodol in a 1:1 ratio and injected as a bolus of 1-3 mL according to variceal size.Patients underwent endoscopic follow-up the next week,fourth week,second month,fourth month,and seventh month after injection and then every 6 mo to determine the cast shape.An abdominal X-ray fi lm and ultrasound or computed tomographic scan were also carried out in order to evaluate the time of variceal disappearance and complete extrusion of the cast.The average follow-up time was 13.1 mo.RESULTS:The instantaneous hemostatic rate was 96.2%.Early re-bleeding after injection in 9 cases(6.2%) was estimated from rejection of adhesive.Late re-bleeding occurred in 12 patients(8.1%) at 2-18 mo.The glue cast was extruded into the lumen within one month in 86.1% of patients and eliminated within one year.Light erosion was seen at the injection position and mucosa edema in the second week.The glue casts were extruded in 18 patients(12.1%) after one week and in 64 patients(42.8%) after two weeks.All kinds of glue clumping shapes and colors on endoscopic examination were observed in 127 patients(86.1%) within one month,including punctiform,globular,pillar and variform.Forty one patients(27.9%) had glue extrusion after 3 mo and 28 patients(28.9%) after six months.The extrusion time was not related to the injection volume of histoacryl.Obliteration was seen in 70.2%(104 cases) endoscopically.The main complication was re-bleeding resulting from extrusion.The prognosis of the patients depended on the severity of the underlying liver disease.CONCLUSION:Endoscopic injection of cyanoacrylate is highly effective for gastric varices bleeding.The glue clump shape is correlated with anatomic structure of vessels.The time of extrusion was not related to dosage of the glue.

Sciatic nerve repair using adhesive bonding and a modified conduit

When repairing nerves with adhesives, most researchers place glue directly on the nerve stumps, but this method does not fix the nerve ends well and allows glue to easily invade the nerve ends. In this study, we established a rat model of completely transected sciatic nerve injury and re- paired it using a modified 1 cm-length conduit with inner diameter of 1.5 mm. Each end of the cylindrical conduit contains a short linear channel, while the enclosed central tube protects the nerve ends well Nerves were repaired with 2-octyl-cyanoacrylate and suture, which complement the function of the modified conduit. The results demonstrated that for the same conduit, the av- erage operation time using the adhesive method was much shorter than with the suture method. No significant differences were found between the two groups in sciatic function index, motor evoked potential latency, motor evoked potential amplitude, muscular recovery rate, number of medullated nerve fibers, axon diameter, or medullary sheath thickness. Thus, the adhesive method for repairing nerves using a modified conduit is feasible and effective, and reduces the operation time while providing an equivalent repair effect.

粘鼠板产品的质量分析及正确使用

粘鼠板是一种采用物理方法灭鼠的产品,简便易行,不污染环境,在一些特殊场所的灭鼠工作中具有特殊优势。目前市场上粘鼠板产品种类繁多,质量参差不齐,为便于相关人士更好地选择和使用粘鼠板,基于多年的工作经验,对粘鼠板产品的质量和使用方法进行了分析和说明。

气相色谱法测定医用胶中α-氰基丙烯酸正丁酯和柠檬酸三乙酯的含量

目的:建立医用胶中α-氰基丙烯酸正丁酯和柠檬酸三乙酯含量的气相色谱测定方法。方法:气相色谱法:HP-5毛细管色谱柱;检测器:氢火焰离子化检测器;程序升温:初始温度100℃保持2min,以10℃/min的速率升温至180℃,保持3min;进样口温度:230℃;检测器温度:250℃;柱流速:2mL/min;进样量:1.0μL,分流比30:1。结果:α-氰基丙烯酸正丁酯在浓度0.10~0.60mg/mL范围内线性良好,线性方程为y=373.54589x+1.08702,线性相关系数为0.9997,准确度为98.8%~100.3%,精密度RSD为0.572%,定量限为1.20ug/mL;柠檬酸三乙酯在浓度0.02~0.12mg/mL范围内线性良好,线性方程为y=259.92943x-0.12898,线性相关系数为0.9995,准确度为100.1%~100.3%,精密度RSD为1.016%,定量限为3.0ug/mL。结论:本法可用于医用胶中α-氰基丙烯酸正丁酯和柠檬酸三乙酯含量的测定。

丁基自粘TPO防水卷材在金属屋面修缮中的应用

某方舱医院项目系利用既有建筑改造而建,原有压型金属板屋面经多年使用,出现锈蚀、变形,致使屋面呈现大面积无规律渗漏。该项目在充分考虑维修工期、造价后,选用在原金属压型板上满粘一层耐候型(TPO)丁基自粘防水卷材,利用TPO片材优异的耐候、防水性能实现屋面渗漏治理和长期外露使用的需求。本文介绍了耐候型(TPO)丁基自粘卷材在压型板金属屋面上应用的特点、优势以及施工流程和细部处理。

汽车后感应器装饰条注射模的改良和应用

塑件出现不良缺陷对产品存在很大的影响,不少模具因为设计不合理出现不良缺陷,实际生产一段时间后就会出现各种问题。塑件出现不良缺陷不仅会影响塑件的外观、而且对塑件强度等方面也有很大的影响,所以,如何对不良塑件模具进行改良始终都是一直无法避免的问题,如何对塑件的不良缺陷进行设计改造以及对塑件不良缺陷制定塑件改良方案是模具行业中都需要面对和解决的问题。主要针对汽车后感应器塑件在注射生产中存在不良缺陷,对塑件不良缺陷进行改良并制定塑件改良方案。

基于视觉识别技术的铁路自粘防排水板的涂胶工艺研究

随着铁路建设品质的不断提升,自粘防排水板在铁路隧道工程中的应用日益广泛。本文聚焦于提升自粘防排水板的涂胶效率与精度,介绍了一种基于视觉识别技术的自动化点涂胶工艺,通过对产品本体涂胶区域进行精确定位,配合矩阵式胶枪,实现对其凸壳顶部的精准涂胶,提高了涂胶质量和生产效率,同时降低了单位产品的用胶量和整体能耗。

Procedure-related complications in gastric variceal obturation with tissue glue

AIM To focus on procedure-related complications,evaluate their incidence,analyze the reasons and discuss the solutions.METHODS Overall,628 endoscopic gastric variceal obturation(EGVO) procedures(case-times) with NBC were performed in 519 patients in the Department of Endoscopy of the Third Affiliated Hospital of Sun Yat-Sen University from January 2011 to December 2016. The clinical data of patients and procedure-related complications of EGVO were retrospectively analyzed.RESULTS In the 628 EGVO procedures,sticking of the needle to the varix occurred in 9 cases(1.43%),including 1 case that used lipiodol-diluted NBC and 8 cases that used undiluted NBC(P = 0.000). The needle was successfully withdrawn in 8 cases. Large spurt bleeding occurred in one case,and hemostasis was achieved by two other injections of undiluted glue. The injection catheter became blocked in 17 cases(2.71%) just during the injection,and 4 cases were complicated with the needle sticking to the varix. Large glue adhesion to the endoscope resulted in difficulty withdrawing the endoscope in 1 case. Bleeding from multiple sites was observed in the esophagus and gastric cardia after the endoscope was withdrawn. Hemostasis was achieved by 1% aethoxysklerol injection and intravenous somatostatin. The ligation device stuck to the varices in two cases during the subsequent endoscopic variceal ligation. In one case,the ligation device was successfully separated from the esophageal varix after all bands were released. In another case,a laceration of the vein and massive bleeding were observed. The bleeding ceased after 1% aethoxysklerol injection.CONCLUSION Although EGVO with tissue glue is usually safe and effective,a series of complications can occur during the procedure that may puzzle endoscopists. There is no standard operating procedure for addressing these complications. The cases described in the current study can provide some reference for others.

医用环氧胶生产设备自动化控制系统设计与应用技术探究

环氧胶是一种有着优异绝缘性能和力学性能的粘胶剂,在医学、体育、化工等行业应用广泛。随着对医用双组分环氧胶使用需求的上升,环氧胶产业机械设备的自动化控制成为研究重点。以双组分环氧胶粘剂自动灌胶机为例,探索电气自动化控制技术与环氧胶产业设备的结合。阐述了环氧树脂在医用领域应用现状,重点对环氧胶粘剂自动灌胶机控制系统进行设计。控制系统由PLC控制器、步进电机、齿轮计量泵、触摸屏等组成,在PLC控制下将2种组分混合,并以持续、稳定的速度完成自动灌胶。

橡胶基球拍专用胶水的制备及粘接强度对比研究

专业运动员乒乓球拍根据自己的打法进行自行粘接,这种粘接胶水的弹性会直接影响乒乓球拍最终的性能。研究以天然橡胶为基质材料制备了一种专门应用于乒乓球拍面粘合的胶水,胶水通过不同程度的机械塑炼,能够在一定程度上改变原有的平均分子量,在经过有机溶剂环己烷进行溶解以后的溶解度高于原有的橡胶,最高溶解度可达29%左右。结果表明:该胶水的粘合性较好,能够有效粘接乒乓球底板、海绵、胶片,且在相同量胶水使用条件下,能够为乒乓球拍提供更好的弹性。

施胶方式对不同密度刨花层积材性能的影响

以辐射松(Pinus radiata)窄长薄平刨花和酚醛树脂为原料制备刨花层积材(laminated strand lumber,LSL),研究浸胶和喷胶两种施胶方式对LSL中树脂分布、剖面密度、耐水性能和弯曲性能的影响。结果表明:采用两种不同施胶方式时,树脂在刨花表面和刨花内部渗透深度存在差异。浸胶方式时树脂渗入刨花内部,有利于增强刨花单元;喷胶方式时刨花单元表面树脂含量高,有利于刨花单元间形成良好的胶合界面。LSL的密度从0.80 g/cm^(3)增大到1.00 g/cm^(3),施胶方式对LSL的抗弯性能和吸水率影响显著,对吸水厚度膨胀率没有显著影响。当密度为1.00 g/cm^(3)时,浸胶方式制备的LSL具有较高的MOE(19.9 GPa),但在耐水试验中易因胶合失效出现刨花间胶层剥离的现象;喷胶方式制备的LSL则具有较高的MOR(126.8 MPa),在耐水试验中刨花间胶层不易剥离。

建筑施工中的新型环保复合胶工艺分析

针对环保复合胶会对建筑施工环保造成影响,提出了建筑施工中的新型环保复合胶工艺。以淀粉和聚乙烯醇作为基胶添加氧化剂、交联剂等提升复合胶性能,并通过调整淀粉、聚乙烯醇、双氧水等原料及添加剂的用量,试验制备出质量较好的新型环保复合胶。结果表明,淀粉用量为40%,1.2 mL双氧水,质量分数1.2%聚乙烯醇,硼砂用量为8 mL,过硫酸铵用量为0.33%,12%羧基丁腈胶乳配比下,新型环保复合胶的胶合强度较好,同时干燥时间与剥离强度都较高,硼砂用量与羧基丁腈胶乳用量还能有效提升新型环保复合胶的耐水性能。

单组分瓷砖背胶及粘结剂体系与玻化砖粘结强度试验研究

试验通过设计不同初粘性背胶、瓷砖胶粘剂厚度以及浸水时间,研究了瓷砖背胶与瓷砖胶粘剂的匹配机制和破坏机理。结果表明,使用初粘性较低或玻璃化温度较高的背胶,可有效提高胶粘剂与瓷砖的粘结强度;瓷砖胶粘剂厚度过大会导致内聚粘结强度降低,影响背胶对瓷砖胶粘结体系的增益效果,最佳施工厚度应该控制在8 mm左右;背胶膜吸水后内聚力降低,会导致粘结失效,玻璃化温度较高的背胶具有较好的耐水性,但浸水时间达到21 d时相差不大。理想施工环境下应尽量追求更高的界面破坏占比,减小瓷砖胶粘剂内聚破坏占比。

α-氰基丙烯酸酯类医用胶溶血试验相关影响因素的探讨

该研究探讨了α-氰基丙烯酸酯医用胶溶血试验的多个影响因素,结果显示浸提介质种类、试验方法、p H值、样品固化状态、浸提比例等对其溶血性能的评估有重要影响。选择磷酸缓冲盐溶液作为该医用胶溶血试验的浸提介质可能比生理盐水更加合适,同时用直接接触法和间接接触法进行试验能更全面地评估其溶血性能。

乒乓球拍用水性粘合剂的粘合性能与影响研究

乒乓球体育训练中,球拍的性能对竞技水平的表现影响巨大。粘合剂将球拍橡胶、海绵和底板粘合起来,为击球动作提供足够的弹性,而传统为氯丁胶粘合胶水毒性较大,不满足竞技体育要求。以天然橡胶为基材,通过加入环乙烷有机溶,进行通过不同材料配比获得环保无毒的粘合剂,并通过不同程度机械塑炼,改变分子量,对构性关系进行研究。结果表明:塑炼后的天然橡胶,分子量下降,塑性和溶解度、黏度上升。采用天然橡胶溶液进行乒乓球拍胶板和胶片粘接,增加了球拍弹性,且无毒,环保,性能明显优于传统无机胶水。

环保型大豆蛋白胶(J)制备及在户外景观设计中的应用研究

为了创造一种环保、低成本、性能良好的景观户外装置设计中艺术用胶,使用大豆蛋白在室温下与高碘酸钠(NaIO_(4))和高锰酸钾(KMnO_(4))进行氧化,制备大豆蛋白胶粘剂。试验结果表明,经NaIO_(4)氧化的胶粘剂表现出良好的干燥强度;经KMnO_(4)氧化处理的胶粘剂性能明显提高,特别是24 h冷水浸泡和3 h热水(63℃)浸泡的湿强度分别高达0.84、0.77 MPa。KMnO_(4)氧化剂在大豆蛋白氧化制备胶粘剂时可以起到较好的效果,最佳氧化剂添加量为12%。

普迪思单股可吸收缝线联合医用组织胶水在剖宫产切口缝合中的应用效果

目的探讨普迪思单股可吸收缝线联合医用组织胶水在剖宫产切口缝合中的应用效果。方法采用前瞻性研究,选取2023年1月~2023年4月中国人民解放军空军军医大学第一附属医院产科收治的360例剖宫产患者为研究对象,按照随机数字表法分为两组,每组180例。研究组剖宫产切口缝合时采用可吸收缝合线(普迪思单股缝线,美国强生公司)联合医用组织胶水(1×Histoacryl®,0.5 mL,美国强生公司);对照组剖宫产切口单纯采用可吸收缝合线(抗菌薇乔线,美国强生公司)缝合。比较两种缝合方式的切口愈合效果、愈合时间、伤口愈合等级、线结反应程度、伤口并发症等指标。结果等级资料秩和检验结果显示,两组缝合效果比较差异有统计学意义(Z=6.492,P=0.011),研究组总有效率高于对照组(χ^(2)=4.479,P=0.026);两组伤口愈合等级比较差异无统计学意义(Z=0.286,P=0.451);但研究组伤口愈合时间短于对照组(Z=4.479,P=0.034);两组线结反应比较差异有统计学意义(Z=11.989,P=0.001),研究组线结反应发生率明显低于对照组(χ^(2)=8.175,P=0.013)。实验组伤口并发症发生率(13.33%)明显低于对照组的38.89%(P<0.05)。结论普迪思单股可吸收缝线联合医用组织胶水缝合剖宫产切口具有较好的缝合效果,可有效促进创面愈合,减少线结反应,缓解炎性反应,降低伤口并发症发生率。