The ring-opening copolymerization of adipic anhydride with propylene oxide was carried out with yttrium triflates as a catalyst. Poly（propylene adipate） could be synthesized by controlling the copolymerization condi...The ring-opening copolymerization of adipic anhydride with propylene oxide was carried out with yttrium triflates as a catalyst. Poly（propylene adipate） could be synthesized by controlling the copolymerization conditions. The copolymerization procedure was tracked by ^1H NMR analyses.展开更多
The ring-opening polymerization of adipic anhydride and the ring-opening copolymerization of adipic anhydride with ε-caprolactone catalyzed by single component rare earth trisphenolate have been reported. The structu...The ring-opening polymerization of adipic anhydride and the ring-opening copolymerization of adipic anhydride with ε-caprolactone catalyzed by single component rare earth trisphenolate have been reported. The structure of the copolymer poly（CL-b-AA） has been characterized by SEC, ^1H NMR and DSC.展开更多
This paper describes a formation of hybrid coatings on a Ti-2Ta-3Zr-36Nb surface.This is accomplished by plasma electrolytic oxidation and a dip-coating technique with poly(adipic anhydride)((C6H8O3)n)that is loaded w...This paper describes a formation of hybrid coatings on a Ti-2Ta-3Zr-36Nb surface.This is accomplished by plasma electrolytic oxidation and a dip-coating technique with poly(adipic anhydride)((C6H8O3)n)that is loaded with drugs:amoxicillin(C16H19N3O5S),cefazolin(C14H14N8O4S3)or vancomycin(C66H75Cl2N9O24·xHCl).The characteristic microstructure of the polymer was evaluated using scanning electron microscopy and confocal microscopy.Depending on the surface treatment,the surface roughness varied(between 1.53μm and 2.06μm),and the wettability was change with the over of time.X-ray photoelectron spectroscopy analysis showed that the oxide layer did not affect the polymer layer or loaded drugs.However,the drugs lose their stability in a phosphate-buffered saline solution after 6.5 h of exposure,and its decrease was greater than 7%(HPLC analysis).The stability,drug release and concentration of the drug loaded into the material were precisely analyzed by high-performance liquid chromatography.The results correlated with the degradation of the polymer in which the addition of drugs caused the percent of degraded polymer to be between 35.5%and 49.4%after 1 h of material immersion,depending on the mass of the loaded drug and various biological responses that were obtained.However,all of the coatings were cytocompatible with MG-63 osteoblast-like cells.The drug concentrations released from the coatings were sufficient to inhibit adhesion of reference and clinical bacterial strains(S.aureus).The coatings with amoxicillin showed the best results in the bacterial inhibition zone,whereas coatings with cefazolin inhibited adhesion of the above bacteria on the surface.展开更多
基金Supported by the National Natural Science Foundation of China(Nos.20704036, Key Program 20434020)the State Basic Research Projects of China(No.2005CB623802)
文摘The ring-opening copolymerization of adipic anhydride with propylene oxide was carried out with yttrium triflates as a catalyst. Poly（propylene adipate） could be synthesized by controlling the copolymerization conditions. The copolymerization procedure was tracked by ^1H NMR analyses.
基金Project supported by the National Natural Science Foundation of China （No. 020434020）, Special Fund for Major State Basic Research Projects （No 2005CB623800） and the Committee of Science and Technology of Zhejiang Province.
文摘The ring-opening polymerization of adipic anhydride and the ring-opening copolymerization of adipic anhydride with ε-caprolactone catalyzed by single component rare earth trisphenolate have been reported. The structure of the copolymer poly（CL-b-AA） has been characterized by SEC, ^1H NMR and DSC.
基金supported by the National Science Centre,Poland(UMO-2016/21/D/ST5/01652)supported by Rector's Grant in the field of research and development(Silesian University of Technology,Poland,04/010/RGJ19/0095).
文摘This paper describes a formation of hybrid coatings on a Ti-2Ta-3Zr-36Nb surface.This is accomplished by plasma electrolytic oxidation and a dip-coating technique with poly(adipic anhydride)((C6H8O3)n)that is loaded with drugs:amoxicillin(C16H19N3O5S),cefazolin(C14H14N8O4S3)or vancomycin(C66H75Cl2N9O24·xHCl).The characteristic microstructure of the polymer was evaluated using scanning electron microscopy and confocal microscopy.Depending on the surface treatment,the surface roughness varied(between 1.53μm and 2.06μm),and the wettability was change with the over of time.X-ray photoelectron spectroscopy analysis showed that the oxide layer did not affect the polymer layer or loaded drugs.However,the drugs lose their stability in a phosphate-buffered saline solution after 6.5 h of exposure,and its decrease was greater than 7%(HPLC analysis).The stability,drug release and concentration of the drug loaded into the material were precisely analyzed by high-performance liquid chromatography.The results correlated with the degradation of the polymer in which the addition of drugs caused the percent of degraded polymer to be between 35.5%and 49.4%after 1 h of material immersion,depending on the mass of the loaded drug and various biological responses that were obtained.However,all of the coatings were cytocompatible with MG-63 osteoblast-like cells.The drug concentrations released from the coatings were sufficient to inhibit adhesion of reference and clinical bacterial strains(S.aureus).The coatings with amoxicillin showed the best results in the bacterial inhibition zone,whereas coatings with cefazolin inhibited adhesion of the above bacteria on the surface.
