Causal relationship between feelings and cognitive decline:An univariable and multivariable Mendelian randomization study

BACKGROUND While the impact of depression on cognition is well-documented,the relationship between feelings and cognition has received limited attention.AIM To explore the potential association between feelings and cognition with a twosample Mendelian randomization(MR)analysis.METHODS Our analysis utilized genome-wide association data on various feelings(fed-up feelings,n=453071;worrier/anxious feelings,n=450765;guilty feelings,n=45-0704;nervous feelings,n=450700;sensitivity/hurt feelings,n=449419;miserableness,n=454982;loneliness/isolation,n=455364;happiness,n=152348)in the European population and their impact on cognitive functions(intelligence,n=269867).Conducting a univariable MR(UVMR)analysis to assess the relationship between feelings and cognition.In this analysis,we applied the inverse variance weighting(IVW),weighted median,and MR Egger methods.Additionally,we performed sensitivity analysis(leave-one-out analysis),assessed heterogeneity(using MR-PRESSO and Cochran’s Q test),and conducted multiple validity test(employing MR-Egger regression).Subsequently,a multivariable MR(MVMR)analysis was employed to examine the impact of feelings on cognition.IVW served as the primary method in the multivariable analysis,complemented by median-based and MR-Egger methods.RESULTS In this study,UVMR indicated that sensitivity/hurt feelings may have a negative causal effect on cognition(OR=0.63,95%CI:0.43-0.92,P=0.017).After adjustment of other feelings using MVMR,a direct adverse causal effect on cognition was observed(OR_(MVMR)=0.39,95%CI:0.17-0.90,P_(MVMR)=0.027).While a potential increased risk of cognitive decline was observed for fed-up feelings in the UVMR analysis(ORUVMR=0.64,95%CI:0.42-0.97,PUVMR=0.037),this effect disappeared after adjusting for other feelings(OR_(MVMR)=1.42,95%CI:0.43-4.74,P_(MVMR)=0.569).These findings were generally consistent across MV-IVW,median-based,and MR-Egger analyses.MR-Egger regression revealed pleiotropy in the impact of worrier/anxious feelings on cognition,presenting a challenge in identifying the effect.Notably,this study did not demonstrate any significant impact of guilty feelings,nervous feelings,miserableness,or loneliness/isolation on cognition.Due to a limited number of instrumental variables for happiness,this study was unable to analyze the relationship between happiness and cognition.CONCLUSION This MR study finds that sensitivity/hurt feelings are associated with cognitive decline,while the link between worrier/anxious feelings and cognition remains inconclusive.Insufficient evidence supports direct associations between happiness,guilty feelings,nervous feelings,miserableness,loneliness/isolation,and cognition.

Common Emulsifier Combination Skin Feeling Research and Recommendation

Emulsifier is an important component of emulsified skin care BASE(matrix),and the common influencing factors affecting the skin feel of BASE are:emollient,thickeners,and emulsifier.The choice of emulsifier is crucial to the skin feel of cosmetics.In this paper,12 classical emulsifiers were selected and 13 combinations of them were made.Thirteen creams were designed using the same formulation structure,their physicochemical indexes were determined,and their skin feel was tested and evaluated using five expert panel scores,with the test site being the hand.Physicochemical parameters included pH and viscosity.Skin feel indicators include:stickiness,silkiness,whiteheads,greasiness at the end of application,absorption,softness after use,etc.The BASE formulations of the creams were tested and evaluated by five experts.Recommendations were also made for the selection of emulsifier combinations in the design of cream BASE formulations.

An extended state observer with adjustable bandwidth for measurement noise

In this paper,a bandwidth-adjustable extended state observer(ABESO)is proposed for the systems with measurement noise.It is known that increasing the bandwidth of the observer improves the tracking speed but tolerates noise,which conflicts with observation accuracy.Therefore,we introduce a bandwidth scaling factor such that ABESO is formulated to a 2-degree-of-freedom system.The observer gain is determined and the bandwidth scaling factor adjusts the bandwidth according to the tracking error.When the tracking error decreases,the bandwidth decreases to suppress the noise,otherwise the bandwidth does not change.It is proven that the error dynamics are bounded and converge in finite time.The relationship between the upper bound of the estimation error and the scaling factor is given.When the scaling factor is less than 1,the ABESO has higher estimation accuracy than the linear extended state observer(LESO).Simulations of an uncertain nonlinear system with compound disturbances show that the proposed ABESO can successfully estimate the total disturbance in noisy environments.The mean error of total disturbance of ABESO is 15.28% lower than that of LESO.

Rigidloop Adjustable可调袢钢板治疗踝关节骨折并下胫腓联合损伤

目的比较Rigidloop Adjustable(RLA)可调袢钢板与螺钉治疗踝关节骨折合并下胫腓联合损伤的临床效果。方法回顾性分析2019年9月至2022年5月武汉市第三医院收治的44例踝关节骨折合并下胫腓联合损伤的患者。踝关节骨折行切开复位内固定后,下胫腓联合采用RLA可调袢钢板固定22例,2枚皮质骨螺钉三皮质骨固定22例。应用AOFAS踝与后足功能评分、术侧与健侧踝关节活动度平均差值及术前、术后随访时正位X线片下胫腓间隙(tibiofibular bottom clear space,TBCS)、下胫腓重叠距离(tibiofibular bottom overlap,TBOL)比较两组临床效果。结果患者均获得随访,随访时间12~18个月,平均(16.41±1.66)个月。患者踝关节功能满意,无伤口感染、皮肤激惹等并发症。术后3、6、12个月时,RLA可调袢钢板组双侧踝关节活动度差值均显著小于螺钉组,差异有统计学意义(P<0.05);术后3、6、12个月时,两组的AOFAS评分比较,差异无统计学意义(P>0.05);TBCS、TBOL术前、术后即刻、术后3个月及末次随访时,差异无统计学意义(P>0.05)。结论RLA可调袢钢板和螺钉均可有效固定下胫腓联合,与螺钉固定相比,RLA可调袢钢板组可早期功能锻炼,获得更好的踝关节活动度。

Cross-Cultural Adjustment and Coping:U.S.Students in Taiwan Residents Higher Education

The aim of this study was to investigate the adjustment problems of students from the United States enrolled in universities in the East,specifically in Taiwan,their problems related to cultural adaptation,and the process of adjustment to student life in Taiwan.Under investigation were cultural adjustment and coping skills as these students transitioned from West to East.Qualitative data were collected from interviews with participants and faculty members as well as participant observations.Results indicated that U.S.students found their own ways to acclimate to their new academic setting as well as to social relations,cross-cultural issues,and the linguistic environment in Taiwan to achieve effective adaptation.They made changes in themselves to cope with all situations they encountered.This study provides suggestions for international students abroad in Taiwan,for the Taiwan Residents government,and for universities or colleges in terms of what they should offer to current and future international students.

Optimized CUDA Implementation to Improve the Performance of Bundle Adjustment Algorithm on GPUs

The 3D reconstruction pipeline uses the Bundle Adjustment algorithm to refine the camera and point parameters. The Bundle Adjustment algorithm is a compute-intensive algorithm, and many researchers have improved its performance by implementing the algorithm on GPUs. In the previous research work, “Improving Accuracy and Computational Burden of Bundle Adjustment Algorithm using GPUs,” the authors demonstrated first the Bundle Adjustment algorithmic performance improvement by reducing the mean square error using an additional radial distorting parameter and explicitly computed analytical derivatives and reducing the computational burden of the Bundle Adjustment algorithm using GPUs. The naïve implementation of the CUDA code, a speedup of 10× for the largest dataset of 13,678 cameras, 4,455,747 points, and 28,975,571 projections was achieved. In this paper, we present the optimization of the Bundle Adjustment algorithm CUDA code on GPUs to achieve higher speedup. We propose a new data memory layout for the parameters in the Bundle Adjustment algorithm, resulting in contiguous memory access. We demonstrate that it improves the memory throughput on the GPUs, thereby improving the overall performance. We also demonstrate an increase in the computational throughput of the algorithm by optimizing the CUDA kernels to utilize the GPU resources effectively. A comparative performance study of explicitly computing an algorithm parameter versus using the Jacobians instead is presented. In the previous work, the Bundle Adjustment algorithm failed to converge for certain datasets due to several block matrices of the cameras in the augmented normal equation, resulting in rank-deficient matrices. In this work, we identify the cameras that cause rank-deficient matrices and preprocess the datasets to ensure the convergence of the BA algorithm. Our optimized CUDA implementation achieves convergence of the Bundle Adjustment algorithm in around 22 seconds for the largest dataset compared to 654 seconds for the sequential implementation, resulting in a speedup of 30×. Our optimized CUDA implementation presented in this paper has achieved a 3× speedup for the largest dataset compared to the previous naïve CUDA implementation.

情绪与情绪调节策略对知晓感(Feeling-of-Knowing)判断的影响

本研究通过两个实验来研究情绪和情绪调节策略对知晓感判断的影响。在实验一中,通过让被试观看影片片段,激发相应的情绪状态,然后对不同情绪的词对做知晓感判断;在实验二中,通过观看影片诱发被试的负性情绪,然后采用不同情绪调节策略对被试的情绪状态进行调节并对不同情绪词对做知晓感判断。结果表明:1) 情绪状态和词对的情绪性质对FOK的判断等级和准确性存在影响,表现为在中性状态下,中性词对的判断等级和准确性均高于情绪词对;2) 情绪调节策略对FOK的判断等级产生影响,评价忽视策略和表情宣泄策略条件下被试的FOK判断值显著高于评价重视和表达抑制;3) 情绪调节策略对FOK判断准确性也存在影响,评价重视和评价忽视两种调节策略下被试的FOK判断准确性显著高于表情宣泄和表情抑制策略。

Detecting and Adjusting Temporal Inhomogeneity in Chinese Mean Surface Air Temperature Data

Adopting the Easterling-Peterson (EP) techniques and considering the reality of Chinese meteorological observations, this paper designed several tests and tested for inhomogeneities in all Chinese historical surface air temperature series from 1951 to 2001. The result shows that the time series have been widely impacted by inhomogeneities resulting from the relocation of stations and changes in local environment such as urbanization or some other factors. Among these factors, station relocations caused the largest magnitude of abrupt changes in the time series, and other factors also resulted in inhomogeneities to some extent. According to the amplitude of change of the difference series and the monthly distribution features of surface air temperatures, discontinuities identified by applying both the E-P technique and supported by China's station history records, or by comparison with other approaches, have been adjusted. Based on the above processing, the most significant temporal inhomogeneities were eliminated, and China's most homogeneous surface air temperature series has thus been created. Results show that the inhomogeneity testing captured well the most important change of the stations, and the adjusted dataset is more reliable than ever. This suggests that the adjusted temperature dataset has great value of decreasing the uncertaities in the study of observed climate change in China.

On Aesthetic Feelings of Synaesthesia

Synaesthesia is both a common daily life phenomenon and a controversial rhetoric one.Respective evidence may be found in 'Wounded fingers may cause pain in heart' and 'The breeze blows away birds' sweet voice from under the flower'.Other examples,like 'the liquid stillness of the night,noise color,sweet voice,icy look,sharp cry,sour remark,oily-tongued…' are so frequently seen in both Chinese and foreign poems especially classic poems.Without doubt,use of synaesthesia blows a fresh air into essay and poem writing,let alone the accurate and aesthetic feelings it arouses among readers.However,when people try to find out the reason why it can arouse such aesthetic feelings,they seem to encounter difficulties.This paper makes an attempt to offer a different explanation based on psychological analysis.

Simulating,adjusting and testing regional sustainable development──a case study of Jiangxi Province

Based on impact of human activities on regional information system, this paper focuses on sedating, adjusting and testing methodology adopted for the regional sustainable development. The case study of Jiangxi Province aims to show how to simulate, adjust and test regional sustainable development in all provinces.

Time-adjusting Acupuncture to Treat Neurosism

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Switching mechanism and optimisation research on a pressure-attitude adaptive adjusting coal seam water jet slotter

To investigate the attitude-switching mechanisms of existing jet slotters,which integrate drilling,punching and slotting operations,and to improve its fracture ability,we used the power bond diagram theory to analyse the dynamic flow pressure,and force of slotters.A mathematical model was developed for the dynamic characteristics of slotter systems.Furthermore,to study the effect of the main characteristic parameters on the ability of the nozzle to erode sandstone,multi-orthogonal experiments were carried out.And the optimised slots were applied in later practical operations.The research results show that the inlet fluid passed through the time-varying orifice to generate pressure differential thrust,which overcame the spring force,pushed the valve core to open the side nozzle,and closed the rear cavity channel thereby realising the switch of the slotter attitude.An optimal plan was established to balance the diameter,depth,and volume of punching,and a rock-breaking plan was developed for the slotter.Subsequently,the optimised water jet slotter was practically used in coal seam gas drainage.Compared with conventional dense drilling,water jet slotting technology significantly improves the ability,efficiency,and effect of increasing the permeability of the coal seam.

THE FEELING THOUGHT PROCESS DURING QIGONG

Setting one’s mind at complete rest dur-ing Qigong requires a process which includesadjustment of the body,breathing andmind,with adjustment of mind as most im-portant.As adjustment of the mind may beregarded as the thought process,we may saythat the thought process is the key to put-ring one’s mind at complete rest.

Selective Area Growth and Characterization of GaN Nanorods Fabricated by Adjusting the Hydrogen Flow Rate and Growth Temperature with Metal Organic Chemical Vapor Deposition

CaN nanorods are successfully fabricated by adjusting the flow rate ratio of hydrogen （H2）/nitrogen （N2） and growth temperature of the selective area growth （SAG） method with metal organic chemical vapor deposition （MOCVD）. The SAG template is obtained by nanospherical-lens photolithography. It is found that increasing the flow rate of 1-12 will change the CaN crystal shape from pyramid to vertical rod, while increasing the growth temperature will reduce the diameters of GaN rods to nanometer scale. Finally the CaN nanorods with smooth lateral surface and relatively good quality are obtained under the condition that the H2：N2 ratio is 1：1 and the growth temperature is 1030℃. The good crystal quality and orientation of GaN nanorods are confirmed by high resolution transmission electron microscopy. The cathodoluminescence spectrum suggests that the crystal and optical quality is also improved with increasing the temperature.

Benign Adjusting Effects of Long Tunnel on Environment and Slope Hazards:taking Erlang Mountain Tunnel as an example

The 21st century shall be a century of accelerated development of tunnel construction in China. But until now, what have been frequently stated in reports about influence of tunnels on environment are basically negative. In fact, this is not true. Tunnels, especially those extend across sensitive areas do exert some positive functions on improving environment and preventing local slope hazards. These positive effects, being new phenomena, are found and put forward by the authors after a series of careful observations have been carried out and in-depth analysis performed the first time. Meanwhile, it is a positive evaluation that the authors made upon tunnels. Many important phenomena and data are cited as evidence and their causative factors are analyzed in this paper as well.

CONTROLLING HYPERCHAOS IN PLANAR SYSTEMS BY ADJUSTING PARAMETERS

For the two_parameter family of planar mapping, a method to stabilize an unstable fixed point without stable manifold embedding in hyperchaos is introduced. It works by adjusting the two parameters in each iteration of the map. The explicit expressions for the parameter adjustments are derived, and strict proof of convergence for method is given.

Negative feelings experienced by people with mental disorder in the workplace: A qualitative study

Mental disorders are a significant cause of disability and loss of workplace productivity. Many people with mental illness want to work. Occupational health in the world has to face up to psychosocial risks to protect the health of employees. My study aims are to improve negative feelings in work place and work functioning and to stimulate better coping mechanisms. Participants were collected from “Mental health daycare facility”, “Regional living assistance center” and “B-type employment assistance office” in Japan. I took interviews with 25 members. The content of the interviews was categorized about negative feelings in work place. A total of 33 small category negative feelings of mental disorder were extracted and were classified into 11 subcategories. These subcategories were then classified into two higher-level categories: inward-directed feelings and outward-directed feelings. Inward-directed feelings include “reserve or timidity,” “hesitation about being open about the illness,” “anxiety about being dismissed,” “regrets about resigning,” “sense of isolation,” “feelings of remorse,” and “suffering.” Outward-directed feelings include “failure in interpersonal relationships,” “distrust,” “frustrations,” “negative feelings toward those with mental disorder.” Employment has been linked to having better social networks, to enhanced quality of life and to overall wellbeing. We will have to defend them legally. The legal and moral obligations placed on the employer require that it provides a healthy, harassment-free work environment.

Serum 17β-estradiol and oral dryness feeling in menopause

The aim of this study was to compare serum 17β-estradiol of menopausal women with/without Oral Dryness (OD) feeling, and evaluate the re-lationship between serum 17β-estradiol and severity of OD feeling. A case-control study was carried out on 70 selected menopausal women aged 40 - 77 years with or without OD feeling (35 as case, 35 as control) conducted at the Clinic of Oral Medicine, Tehran University of Medical Sciences. Xerostomia inventory (XI) score was used as an index of OD feeling severity. The serum 17β-estradiol concentration was measured by an enzyme immunoassay kit (ELISA). Statistical analysis of Student’s t-test and Spearman correlation coefficient was used. The mean serum concentration of 17β-estradiol was significantly lower in case than control. There was a significant negative correlation between XI score and concentration of 17β-estradiol in menopausal women (r = –0.311, P = 0.004). It seems that there is a negatively slight correlation between OD feeling severity and serum 17β-estradiol in menopausal women.

Incremental Training for SVM-Based Classification with Keyword Adjusting

This paper analyzed the theory of incremental learning of SVM (support vector machine) and pointed out it is a shortage that the support vector optimization is only considered in present research of SVM incremental learning. According to the significance of keyword in training, a new incremental training method considering keyword adjusting was proposed, which eliminates the difference between incremental learning and batch learning through the keyword adjusting. The experimental results show that the improved method outperforms the method without the keyword adjusting and achieve the same precision as the batch method. Key words SVM (support vector machine) - incremental training - classification - keyword adjusting CLC number TP 18 Foundation item: Supported by the National Information Industry Development Foundation of ChinaBiography: SUN Jin-wen (1972-), male, Post-Doctoral, research direction: artificial intelligence, data mining and system integration.