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Differentiability of the Pritchard-Salamon systems with admissible state-feedback
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作者 于欣 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2005年第4期311-314,共4页
Many papers on a wide range of control problems for Pritchard-Salamon systems have appeared and many of its important mathematical and system theoretical properties have been revealed. This paper deals with the differ... Many papers on a wide range of control problems for Pritchard-Salamon systems have appeared and many of its important mathematical and system theoretical properties have been revealed. This paper deals with the differentiability of the Pritchard-Salamon system with admissible state-feedback. Spectrum analysis showed that under definite condition, the unbounded perturbation semigroup of the Pritchard-Salamon system is eventually differentiable. 展开更多
关键词 C_0-semigroup DIFFERENTIABILITY admissible operator Pritchard-Salamon systems PERTURBATION
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Components Admissible Solution of Algebraic Differential Equations Systems
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作者 LI Guo-wang GAO Ling-yun 《Chinese Quarterly Journal of Mathematics》 CSCD 2011年第3期457-461,共5页
Using the Nevanlinna value distribution theory of meromorphic function,we investigate the existence problem of admissible solutions of higher-order algebraic differential equations systems,and obtain a result concerni... Using the Nevanlinna value distribution theory of meromorphic function,we investigate the existence problem of admissible solutions of higher-order algebraic differential equations systems,and obtain a result concerning admissible components of solution. 展开更多
关键词 value distribution differential equation components admissible solution
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Robust Admissible Analyse of Uncertain Singular Systems via Delta Operator Method
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作者 WANG Wen WANG Hui 《科技视界》 2016年第9期244-245,共2页
This paper investigates the problem of robust admissible analysis for uncertain singular delta operator systems(SDOSs).Firstly,we introduce the definition of generalized quadratic admissibility to ensure robust admiss... This paper investigates the problem of robust admissible analysis for uncertain singular delta operator systems(SDOSs).Firstly,we introduce the definition of generalized quadratic admissibility to ensure robust admissibility.Then,by means of LMI,a necessary and sufficient condition is given to prove a uncertain SDOS is generalized quadratic admissible.Finally,a numerical example is provided to demonstrate the effectiveness of the results in this paper. 展开更多
关键词 SDOSs ROBUST ADMISSIBILITY LMI
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An Ontology-Based Question Answering System for University Admissions Advising
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作者 Thi Thanh Sang Nguyen Dang Huu Trong Ho Ngoc Tram Anh Nguyen 《Intelligent Automation & Soft Computing》 SCIE 2023年第4期601-616,共16页
Question-Answer systems are now very popular and crucial to support human in automatically responding frequent questions in manyfields.However,these systems depend on learning methods and training data.Therefore,it is ... Question-Answer systems are now very popular and crucial to support human in automatically responding frequent questions in manyfields.However,these systems depend on learning methods and training data.Therefore,it is necessary to prepare such a good dataset,but it is not an easy job.An ontol-ogy-based domain knowledge base is able to help to reason semantic information and make effective answers given user questions.This study proposes a novel chatbot model involving ontology to generate efficient responses automatically.A case study of admissions advising at the International University–VNU HCMC is taken into account in the proposed chatbot.A domain ontology is designed and built based on the domain knowledge of university admissions using Protégé.The Web user interface of the proposed chatbot system is developed as a prototype using NetBeans.It includes a search engine reasoning the ontology and generat-ing answers to users’questions.Two experiments are carried out to test how the system reacts to different questions.Thefirst experiment examines questions made from some templates,and the second one examines normal questions taken from frequent questions.Experimental results have shown that the ontology-based chatbot can release meaningful and long answers.The results are analysed to prove the proposed chatbot is usable and promising. 展开更多
关键词 ONTOLOGY chatbots answer-question systems domain knowledge base admissions advising
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Robust admissibility analysis of uncertain switched singular systems:a switched Lyapunov function approach
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作者 林金星 费树岷 +1 位作者 沈炯 于建江 《Journal of Southeast University(English Edition)》 EI CAS 2009年第2期208-212,共5页
The robust admissibility analysis of a class of uncertain discrete-time switched linear singular(SLS) systems for arbitrary switching laws is addressed. The parameter uncertainty is assumed to be norm-bounded. First... The robust admissibility analysis of a class of uncertain discrete-time switched linear singular(SLS) systems for arbitrary switching laws is addressed. The parameter uncertainty is assumed to be norm-bounded. First, by using the switched Lyapunov function approach, some new sufficient conditions ensuring the nominal discrete-time SLS system to be regular, casual and asymptotically stable for arbitrary switching laws are derived in terms of linear matrix inequalities. Then, the robust admissibility condition for the uncertain discrete-time SLS systems is presented. The obtained results can be viewed as an extension of previous works on the switched Lyapunov function approach from the regular switched linear systems to the switched linear singular cases. Numerical examples show the reduced conservatism and effectiveness of the proposed conditions. 展开更多
关键词 switched singular systems robust admissibility switched Lyapunov function parameter uncertainty
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Admission Control Based on QoS for Third Generation Broadband Mobile Communication Systems
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作者 侯春萍 常倩 +1 位作者 曹达仲 范仲方 《Transactions of Tianjin University》 EI CAS 2002年第2期110-113,共4页
In this paper, a novel admission scheme is proposed which provides high degrees of quality of service (QoS) guarantees for multimedia traffic carried in mobile networks. The proposed scheme combines the admission cont... In this paper, a novel admission scheme is proposed which provides high degrees of quality of service (QoS) guarantees for multimedia traffic carried in mobile networks. The proposed scheme combines the admission control and bandwidth reservation to guarantee QoS requirements. It considers both local information and remote information to determine whether to accept or reject a connection. In order to embody the characteristics of the algorithms proposed in the article, two traditional algorithms of admission control are used for comparison. In the end of the paper the simulation analyses are given and the results show that the proposed algorithm can adjust the bandwidth according to the current status of networks and decrease the probability of connections forcibly dropped. The most important thing is that the algorithm is based on the multimedia communications and can guarantee the QoS of real time connections through decreasing the bandwidth of non real time connections. 展开更多
关键词 broadband mobile networks admission control quality of service guarantee
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Trends of autoimmune liver disease inpatient hospitalization and mortality from 2011 to 2017:A United States nationwide analysis
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作者 Ali Wakil Yasameen Muzahim +4 位作者 Mina Awadallah Vikash Kumar Natale Mazzaferro Patricia Greenberg Nikolaos Pyrsopoulos 《World Journal of Hepatology》 2024年第7期1029-1038,共10页
BACKGROUND Autoimmune liver diseases(AiLD)encompass a variety of disorders that target either the liver cells(autoimmune hepatitis,AIH)or the bile ducts[primary biliary cholangitis(PBC),and primary sclerosing cholangi... BACKGROUND Autoimmune liver diseases(AiLD)encompass a variety of disorders that target either the liver cells(autoimmune hepatitis,AIH)or the bile ducts[primary biliary cholangitis(PBC),and primary sclerosing cholangitis(PSC)].These conditions can progress to chronic liver disease(CLD),which is characterized by fibrosis,cirrhosis,and hepatocellular carcinoma.Recent studies have indicated a rise in hospitalizations and associated costs for CLD in the US,but information regarding inpatient admissions specifically for AiLD remains limited.AIM To examine the trends and mortality of inpatient hospitalization of AiLD from 2011 to 2017.METHODS This study is a retrospective analysis utilizing the National Inpatient Sample(NIS)databases.All subjects admitted between 2011 and 2017 with a diagnosis of AiLD(AIH,PBC,PSC)were identified using the International Classification of Diseases(ICD-9)and ICD-10 codes.primary AiLD admission was defined if the first admission code was one of the AiLD codes.secondary AiLD admission was defined as having the AiLD diagnosis anywhere in the admission diagnosis(25 diagnoses).Subjects aged 21 years and older were included.The national estimates of hospitalization were derived using sample weights provided by NIS.χ^(2)tests for categorical data were used.The primary trend characteristics were in-hospital mortality,hospital charges,and length of stay.RESULTS From 2011 to 2017,hospitalization rates witnessed a significant decline,dropping from 83263 admissions to 74850 admissions(P<0.05).The patients hospitalized were predominantly elderly(median 53%for age>65),mostly female(median 59%)(P<0.05),and primarily Caucasians(median 68%)(P<0.05).Medicare was the major insurance(median 56%),followed by private payer(median 27%)(P<0.05).The South was the top geographical distribution for these admissions(median 33%)(P<0.05),with most admissions taking place in big teaching institutions(median 63%)(P<0.05).Total charges for admissions rose from 66031 in 2011 to 78987 in 2017(P<0.05),while the inpatient mortality rate had a median of 4.9%(P<0.05),rising from 4.67%in 2011 to 5.43%in 2017.The median length of stay remained relatively stable,changing from 6.94 days(SD=0.07)in 2011 to 6.51 days(SD=0.06)in 2017(P<0.05).Acute renal failure emerged as the most common risk factor associated with an increased death rate,affecting nearly 68%of patients(P<0.05).CONCLUSION AiLD-inpatient hospitalization showed a decrease in overall trends over the studied years,however there is a significant increase in financial burden on healthcare with increasing in-hospital costs along with increase in mortality of hospitalized patient with AiLD. 展开更多
关键词 Autoimmune hepatitis Autoimmune liver disease Epidemiology Cost-Effective care Admissions trend Mortality rate
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Fever assessment in children under five: Are we following the guidelines?
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作者 Hasan M Isa Ahmed J Isa +1 位作者 Murtadha A Alnasheet Mahmood M Mansoor 《World Journal of Clinical Pediatrics》 2024年第1期62-72,共11页
BACKGROUND Fever is a common cause of medical consultation and hospital admission,particularly among children.Recently,the United Kingdom’s National Institute for Health and Care Excellence(NICE)updated its guideline... BACKGROUND Fever is a common cause of medical consultation and hospital admission,particularly among children.Recently,the United Kingdom’s National Institute for Health and Care Excellence(NICE)updated its guidelines for assessing fever in children under five years of age.The efficient assessment and management of children with fever are crucial for improving patient outcomes.AIM To evaluate fever assessment in hospitalized children and to assess its adherence with the NICE Fever in under 5s guideline.METHODS We conducted a retrospective cohort review of the electronic medical records of children under five years of age at the Department of Pediatrics,Salmaniya Medical Complex,Bahrain,between June and July 2023.Demographic data,vital signs during the first 48 h of admission,route of temperature measurement,and indications for admission were gathered.Fever was defined according to the NICE guideline.The children were divided into five groups according to their age(0-3 months,>3-6 months,>6-12 months,>12-36 months,and>36-60 months).Patients with and without fever were compared in terms of demography,indication for admission,route of temperature measurement,and other vital signs.Compliance with the NICE Fever in the under 5s guideline was assessed.Full compliance was defined as>95%,partial compliance as 70%-95%,and minimal compliance as≤69%.Pearson’sχ^(2),Student’s t test,the Mann-Whitney U test,and Spearman’s correlation coefficient(rs)were used for comparison.RESULTS Of the 136 patients reviewed,80(58.8%)were boys.The median age at admission was 14.2[interquartile range(IQR):1.7-44.4]months,with the most common age group being 36-60 months.Thirty-six(26.4%)patients had fever,and 100(73.6%)were afebrile.The commonest age group for febrile patients(>12-36 months)was older than the commonest age group for afebrile patients(0-3 months)(P=0.027).The median weight was 8.3(IQR:4.0-13.3)kg.Patients with fever had higher weight than those without fever[10.2(IQR:7.3-13.0)vs 7.1(IQR:3.8-13.3)kg,respectively](P=0.034).Gastrointestinal disease was the leading indication for hospital admission(n=47,34.6%).Patients with central nervous system diseases and fever of unknown etiology were more likely to be febrile(P=0.030 and P=0.011,respectively).The mean heart rate was higher in the febrile group than the afebrile group(140±24 vs 126±20 beats per minute,respectively)[P=0.001(confidence interval:5.8-21.9)]with a positive correlation between body temperature and heart rate,r=0.242,n=136,P=0.004.A higher proportion of febrile patients received paracetamol(n=35,81.3%)compared to the afebrile patients(n=8,18.6%)(P<0.001).The axillary route was the most commonly used for temperature measurements(n=40/42,95.2%),followed by the rectal route(n=2/42,4.8%).The department demonstrated full compliance with the NICE guideline for five criteria:the type of thermometer used,route and frequency of temperature measurement,frequency of heart rate measurement,and use of antipyretics as needed.Partial compliance was noted for two criteria,the threshold of fever at 38°C or more,and the respiratory rate assessment in febrile patients.Minimal compliance or no record was observed for the remaining three criteria;routine assessment of capillary refill,temperature reassessment 1-2 h after each antipyretic intake,and refraining from the use of tepid sponging.CONCLUSION This study showed that fever assessment in hospitalized children under five years of age was appropriate,but certain areas of adherence to the NICE guideline still need to be improved. 展开更多
关键词 FEVER PEDIATRICS Admission patterns Temperature measurement GUIDELINES Bahrain
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Long-term follow-up of kidney transplant recipients admitted to a tertiary care transplant center with SARS-CoV-2
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作者 Emily E Zona Mina L Gibes +4 位作者 Asha S Jain Jeannina A Smith Jacqueline M Garonzik-Wang Didier A Mandelbrot Sandesh Parajuli 《World Journal of Virology》 2024年第2期87-95,共9页
BACKGROUND Kidney transplant recipients(KTR)are at risk of severe coronavirus disease 2019(COVID-19)disease and mortality after severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.We predicted that ho... BACKGROUND Kidney transplant recipients(KTR)are at risk of severe coronavirus disease 2019(COVID-19)disease and mortality after severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.We predicted that hospitalization for COVID-19 and subsequent admission to the intensive care unit(ICU)would yield worse outcomes in KTRs.cohort was stratified by ICU admission.Outcomes of interest included risk factors for ICU admission and mortality,length of stay(LOS),respiratory symptoms at admission,all-cause graft failure at the last follow-up,and death related to COVID-19.RESULTS 96 KTRs were hospitalized for SARS-COV-2 infection.21(22%)required ICU admission.The ICU group had longer hospital LOS(21.8 vs 8.6 days,P<0.001)and were more likely to experience graft failure(81%vs 31%,P<0.001).Of those admitted to the ICU,76%had death at last-follow up,and 71%had death related to COVID-19.Risk factors for ICU admission included male sex(aHR:3.11,95%CI:1.04-9.34;P=0.04).Risk factors for all-cause mortality and COVID-19-related mortality included ICU admission and advanced age at SARS-CoV-2 diagnosis.Mortality was highest within a month of COVID-19 diagnosis,with the ICU group having increased risk of all-cause(aHR:11.2,95%CI:5.11-24.5;P<0.001)and COVID-19-related mortality(aHR:27.2,95%CI:8.69-84.9;P<0.001).CONCLUSION ICU admission conferred an increased risk of mortality,graft failure,and longer LOS.One-fifth of those hospit-alized died of COVID-19,reflecting the impact of COVID-19-related morbidity and mortality among KTRs. 展开更多
关键词 Kidney transplants SARS-CoV-2 Intensive care unit admission OUTCOMES Graft failure
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拟双曲度量空间中广义反演函数的性质
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作者 杨倩 梁茜 刘红军 《兰州工业学院学报》 2024年第2期97-101,共5页
基于一般度量空间中flattening函数和admission反演函数的概念,在拟双曲度量空间中引入拟对偶的概念,并借助于拟双曲度量作为工具,结合flattening函数和admission反演函数的性质来刻画了拟双曲度量空间中广义反演函数的几何特征。
关键词 拟双曲度量空间 flattening函数 admission反演函数 拟对偶性
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Oil Content Conversion between Ether-based and Ethanol-based Methods and Establishment of Admissible Error for Imported Wool
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作者 罗丽疆 徐新龙 +6 位作者 刘东 哈森 刘佳丽 徐静 叶尔买克 戴莉 王海珍 《Agricultural Science & Technology》 CAS 2016年第1期23-25,33,共4页
Due to various reasons, the inspection methods often need to be changed, and the detection reagents often need to be replaced. In this study, a comparative experiment was conducted between the ethanol-based and ether-... Due to various reasons, the inspection methods often need to be changed, and the detection reagents often need to be replaced. In this study, a comparative experiment was conducted between the ethanol-based and ether-based determination methods for oil content in imported wool. The determination results obtained from the two methods were treated as abscissa and ordinate respectively,and their linear relationship was analyzed. According to the linear regression analysis, the conversion equation of determination result between the two methods was obtained. In addition, the repeatability admissible error and reproducibility admissible error were established through analyzing the comparative experimental results by scientific software. This study will bring new ideas for further researches in this field, and provide reference for solving the similar problems in actual inspection work. 展开更多
关键词 WOOL Oil content Determination method Exchange admissible error
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An Improved Approach to Delay-dependent Robust Stabilization for Uncertain Singular Time-delay Systems 被引量:7
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作者 Xin Sun Qing-Ling Zhang +2 位作者 Chun-Yu Yang Zhan Su Yong-Yun Shao 《International Journal of Automation and computing》 EI 2010年第2期205-212,共8页
In this paper, delay-dependent stability analysis and robust stabilization for uncertain singular time-delay systems are addressed. By using Jensen integral inequality, an improved delay-dependent criterion of admissi... In this paper, delay-dependent stability analysis and robust stabilization for uncertain singular time-delay systems are addressed. By using Jensen integral inequality, an improved delay-dependent criterion of admissibility for singular time-delay systems is proposed in terms of linear matrix inequality (LMI). Our new proposed criterion is less conservative and the numerical complexity is smaller than the existing ones. Based on this criterion, a state feedback controller is designed to ensure that the uncertain singular time-delay system is admissible. Finally, three numerical examples are employed to illustrate the effectiveness of the proposed method. 展开更多
关键词 DELAY-DEPENDENT singular time-delay systems admissible robust stabilization.
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Robust Admissibility and Stabilization of Uncertain Singular Fractional-Order Linear Time-Invariant Systems 被引量:5
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作者 Saliha Marir Mohammed Chadli 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2019年第3期685-692,共8页
This paper addresses the robust admissibility problem in singular fractional-order continuous time systems. It is based on new admissibility conditions of singular fractional-order systems expressed in a set of strict... This paper addresses the robust admissibility problem in singular fractional-order continuous time systems. It is based on new admissibility conditions of singular fractional-order systems expressed in a set of strict linear matrix inequalities(LMIs). Then, a static output feedback controller is designed for the uncertain closed-loop system to be admissible. Numerical examples are given to illustrate the proposed methods. 展开更多
关键词 CONTROL FRACTIONAL-ORDER systemS linear matrix inequalities (LMIs) output feedback CONTROL robust ADMISSIBILITY SINGULAR systemS UNCERTAIN systemS
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A RESULT OF SYSTEMS OF NONLINEAR COMPLEX ALGEBRAIC DIFFERENTIAL EQUATIONS 被引量:3
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作者 高凌云 《Acta Mathematica Scientia》 SCIE CSCD 2010年第5期1507-1513,共7页
In this article, we mainly investigate the behavior of systems of complex differential equations when we add some condition to the quality of the solutions, and obtain an interesting result, which extends Gaekstatter ... In this article, we mainly investigate the behavior of systems of complex differential equations when we add some condition to the quality of the solutions, and obtain an interesting result, which extends Gaekstatter and Laine's result concerning complex differential equations to the systems of algebraic differential equations. 展开更多
关键词 admissible solution BEHAVIOR complex differential equations
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Admissibility analysis and control synthesis for switched linear singular systems 被引量:4
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作者 Lin Jinxing Fei Shumin Shen Jiong 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第5期1037-1044,共8页
The problem of admissibility analysis and control synthesis of discrete-time switched linear singular (SLS) systems for arbitrary switching laws is solved. By using the switched Lyapunov function approach, some new ... The problem of admissibility analysis and control synthesis of discrete-time switched linear singular (SLS) systems for arbitrary switching laws is solved. By using the switched Lyapunov function approach, some new sufficient conditions under which the SLS system is admissible for arbitrary switching laws are derived in terms of linear matrix inequalities (LMIs). Based on the admissibility results, control synthesis is then to design switched state feedback and static output feedback controllers, guaranteeing that the resulting closed-loop system is admissible. The presented results can be viewed as the extensions of previous works on switched Lyapunov function approach from the regular switched systems to singular switched cases. Examples are provided to demonstrate the reduced conservatism and effectiveness of the proposed conditions. 展开更多
关键词 switched singular systems ADMISSIBILITY switched Lyapunov function switched state feedback switched static output feedback.
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Passivity Control for Uncertain T-S Fuzzy Descriptor Systems 被引量:4
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作者 ZHU Bao-Yan ZHANG Qing-Ling TONG Shao-Cheng 《自动化学报》 EI CSCD 北大核心 2006年第5期674-679,共6页
By means of matrix decomposition method a criterion is presented for the admissibility of T-S fuzzy descriptor system. Then, the problem of passivity control is studied for a kind of T-S fuzzy descriptor system with u... By means of matrix decomposition method a criterion is presented for the admissibility of T-S fuzzy descriptor system. Then, the problem of passivity control is studied for a kind of T-S fuzzy descriptor system with uncertain parameters, and sufficient conditions which make the closed-loop system admissible and strictly passive are obtained based on linear matrix inequality (LMI). The nonstrict LMIs restricted conditions which characterize the descriptor system are transformed into strict ones, so testing admissibility and passivity of the system can be finished simultaneously. The design scheme of state feedback controller is also obtained. Finally, a numerical example is given to show the validity and feasibility of the proposed approach. 展开更多
关键词 Uncertain T-S fuzzy descriptor systems ADMISSIBILITY PASSIVITY linear matrix inequality (LMI)
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Improved methods for scheduling flexible manufacturing systems based on Petri nets and heuristic search 被引量:2
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作者 Bo HUANG Yamin SUN 《控制理论与应用(英文版)》 EI 2005年第2期139-144,共6页
This paper proposes and evaluates two improved Petri net (PN)-based hybrid search strategies and their applications to flexible manufacturing system (FMS) scheduling. The algorithms proposed in some previous paper... This paper proposes and evaluates two improved Petri net (PN)-based hybrid search strategies and their applications to flexible manufacturing system (FMS) scheduling. The algorithms proposed in some previous papers, which combine PN simulation capabilities with A* heuristic search within the PN reachability graph,may not find an optimum solution even with an admissible heuristic function. To remedy the defects an improved heuristic search strategy is proposed, which adopts a different method for selecting the promising markings and reserves the admissibility of the algorithm. To speed up the search process, another algorithm is also proposed which invokes faster termination conditions and still guarantees that the solution found is optimum. The scheduling results are compared through a simple FMS between our algorithms and the previous methods. They are also applied and evaluated in a set of randomly-generated FMSs with such characteristics as multiple resources and alternative routes. 展开更多
关键词 Heuristic search ADMISSIBILITY Petri net SCHEDULING
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New degradation call admission control for increasing WCDMA system capacity 被引量:2
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作者 Liu Ningqing Lu Zhi Gu Xuemai 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2006年第4期750-754,共5页
Propose a new degradation call admission control(DCAC)scheme, which can be used in wideband code division multiple access communication system. So-called degradation is that non-real time call has the characteristic... Propose a new degradation call admission control(DCAC)scheme, which can be used in wideband code division multiple access communication system. So-called degradation is that non-real time call has the characteristic of variable bit rate, so decreasing its bit rate can reduce the load of the system, consequently the system can admit new call which should be blocked when the system is close to full load, therefore new call's access probability increases. This paper brings forward design project and does system simulation, simulation proves that DCAC can effectively decrease calls' blocking probability and increase the total number of the on-line users. 展开更多
关键词 DEGRADATION call admission control WCDMA call block probability.
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Generalized Higher-Order Algebraic Differential Equations with Admissible Algebroid Solutions 被引量:4
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作者 高凌云 《Northeastern Mathematical Journal》 CSCD 2001年第2期159-168,共10页
Using the Nevanlinna theory of the value distribution of meromorphic functions, we investigate the existence problem of admissible algebroid solutions of generalized higher order algebraic differential equations.
关键词 algebroid functions admissible solution generalized higher order algebraic differential equations.
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Digestive system involvement and clinical outcomes among COVID-19 patients:A retrospective cohort study from Qatar 被引量:1
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作者 Muhammad Umair Khan Kamran Mushtaq +12 位作者 Deema Hussam Alsoub Phool Iqbal Fateen Ata Hammad Shabir Chaudhry Fatima Iqbal Girisha Balaraju Muna A Al Maslamani Betsy Varughese Rajvir Singh Khalid Al Ejji Saad Al Kaabi Yasser Medhat Kamel Adeel Ajwad Butt 《World Journal of Gastroenterology》 SCIE CAS 2021年第46期7995-8009,共15页
BACKGROUND Coronavirus disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2 virus most commonly presents with respiratory symptoms.While gastrointestinal(GI)manifestations either at pres... BACKGROUND Coronavirus disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2 virus most commonly presents with respiratory symptoms.While gastrointestinal(GI)manifestations either at presentation or during hospitalization are also common,their impact on clinical outcomes is controversial.Some studies have described worse outcomes in COVID-19 patients with GI symptoms,while others have shown either no association or a protective effect.There is a need for consistent standards to describe GI symptoms in COVID-19 patients and to assess their effect on clinical outcomes,including mortality and disease severity.AIM To investigate the prevalence of GI symptoms in hospitalized COVID-19 patients and their correlation with disease severity and clinical outcomes.METHODS We retrospectively reviewed 601 consecutive adult COVID-19 patients requiring hospitalization between May 1-15,2020.GI symptoms were recorded at admission and during hospitalization.Demographic,clinical,laboratory,and treatment data were retrieved.Clinical outcomes included all-cause mortality,disease severity at presentation,need for intensive care unit(ICU)admission,development of acute respiratory distress syndrome,and need for mechanical ventilation.Multivariate logistic regression model was used to identify independent predictors of the adverse outcomes.RESULTS The prevalence of any GI symptom at admission was 27.1%and during hospitalization was 19.8%.The most common symptoms were nausea(98 patients),diarrhea(76 patients),vomiting(73 patients),and epigastric pain or discomfort(69 patients).There was no difference in the mortality between the two groups(6.21%vs 5.5%,P=0.7).Patients with GI symptoms were more likely to have severe disease at presentation(33.13%vs 22.5%,P<0.001)and prolonged hospital stay(15 d vs 14 d,P=0.04).There was no difference in other clinical outcomes,including ICU admission,development of acute respiratory distress syndrome,or need for mechanical ventilation.Drugs associated with the development of GI symptoms during hospitalization were ribavirin(diarrhea 26.37%P<0.001,anorexia 17.58%,P=0.02),hydroxychloroquine(vomiting 28.52%,P=0.009)and lopinavir/ritonavir(nausea 32.65%P=0.049,vomiting 31.47%P=0.004,and epigastric pain 12.65%P=0.048).In the multivariate regression analysis,age>65 years was associated with increased mortality risk[odds ratio(OR)7.53,confidence interval(CI):3.09-18.29,P<0.001],ICU admission(OR:1.79,CI:1.13-2.83,P=0.012),and need for mechanical ventilation(OR:1.89,CI:1.94-2.99,P=0.007).Hypertension was an independent risk factor for ICU admission(OR:1.82,CI:1.17-2.84,P=0.008)and need for mechanical ventilation(OR:1.66,CI:1.05-2.62,P=0.028).CONCLUSION Patients with GI symptoms are more likely to have severe disease at presentation;however,mortality and disease progression is not different between the two groups. 展开更多
关键词 COVID-19 Gastrointestinal manifestations MORTALITY Intensive care unit admission Mechanical ventilation Disease severity
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