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Surgical Management of Adrenal Tumors: Experience of Three Tertiary Hospitals in Yaounde, Cameroon
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作者 Junior Barthelemy Mekeme Mekeme Etoa Ndzie +10 位作者 Agbor Orock Tanyi Jean Cedrick Fouda Achille Aurele Mbassi Philip Owon Abessolo Bright Che Awondo Marcel Junior Yon Mekeme Pierre Ongolo Zogo Pierre Joseph Fouda Eugene Sobngwi Zachary Sando Angwafo III Fru 《Open Journal of Urology》 2023年第11期495-516,共22页
Introduction: Surgical management of adrenal tumors has greatly improved over the past years, with laparoscopic adrenalectomy being the gold standard. However, Open adrenalectomy is indicated in large adrenal tumors, ... Introduction: Surgical management of adrenal tumors has greatly improved over the past years, with laparoscopic adrenalectomy being the gold standard. However, Open adrenalectomy is indicated in large adrenal tumors, malignant tumors and large phaeochromocytomas. We report surgical outcomes of 18 cases of functional adrenal tumors from 2007 to 2022. Methods: We conducted a retrospective cross-sectional and descriptive study in three tertiary hospitals in Yaounde, Cameroon. We reviewed files of patients who underwent adrenalectomy over a period of 15 years from July 2007 to July 2022. Clinical and diagnostic components of adrenal tumors, indications and surgical outcomes were analyzed. Results: A total of 18 patients were included in our study. The average age of patients was 38.33 years, with a female-to-male sex ratio of 2:1. Weight gain (72.2%) was the most represented clinical sign. The secretory nature of tumor and malignancy represented 55.5% and 33.3% of the operative indications and all 18 (100%) of the patients had open adrenalectomy. Vascular injury was the most common intraoperative complication with 5.63%, while acute adrenal insufficiency (16.7%) was the most common post-operative complication. The average tumor size was 6.22 cm and the mean duration of hospitalization was 11.61 days. Adenoma 7 (38.9%) and adrenocortical carcinoma 5 (27.8%) were the frequent histological types. One patient died two months post-surgery from anemia-related complications. Conclusion: The success of adrenal surgery is linked to multidisciplinary patient care and the experience of the surgeon. Conventional surgery still has indications with satisfactory short- and medium-term results in our context. 展开更多
关键词 adrenal tumors Surgical Management OUTCOME Yaounde
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Association of erythropoietin gene rs576236 polymorphism and risk of adrenal tumors in a Chinese population 被引量:2
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作者 Chao Zhang Zhongxing Li +6 位作者 Qiang Cao Chao Qin Hongzhou Cai Hai Zhou Jian Qian Xiaobing Ju Changjun Yin 《The Journal of Biomedical Research》 CAS 2014年第6期456-461,共6页
Erythropoietin(EPO) is a circulating glycosylated protein hormone and has been implicated in the development and progression of non-hematopoietic tissue tumors.The objective of the present study was to determine if ... Erythropoietin(EPO) is a circulating glycosylated protein hormone and has been implicated in the development and progression of non-hematopoietic tissue tumors.The objective of the present study was to determine if the EPO rs576236 polymorphism was associated with the risk of adrenal tumors.We genotyped the EPO rs576236 polymorphism in a case-control study of 288 adrenal tumor patients and 456 cancer-free controls by using the TaqMan method,and assessed the association between the polymorphism and the adrenal tumor risk by logistic regression.Furthermore,95%confidence interval(CI) was used to assess the genetic association between the polymorphism and the risk of adrenal tumor.Compared with the TT genotype,the TC genotype had a significantly increased risk of adrenal tumor[adjusted odds ratio(OR) = 1.24,95%CI = 1.12-2.22].Furthermore a significantly increased risk of adrenal tumor was found in the combined variant genotypes TC+CC compared with the TT genotype(adjusted OR = 1.17,95%CI = 1.12-2.21).Our present study suggests that the rs576236 polymorphism of EPO confers susceptibility to adrenal tumor in the Chinese population. 展开更多
关键词 POLYMORPHISM genetic susceptibility ERYTHROPOIETIN adrenal tumor
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Giant adrenal tumor presenting as Cushing’s syndrome and pheochromocytoma:A case report
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作者 Puskal Kumar Bagchi Somor Jyoti Bora +1 位作者 Sasanka Kumar Barua Rajeev Thekumpadam Puthenveetil 《Asian Journal of Urology》 2015年第3期182-184,共3页
We report a case of a 35-year-old lady who presented with Cushingoid features and associated raised urinary metanephrine.The patient underwent open adrenelectomy.Histopathological examination revealed adreno-cortical ... We report a case of a 35-year-old lady who presented with Cushingoid features and associated raised urinary metanephrine.The patient underwent open adrenelectomy.Histopathological examination revealed adreno-cortical carcinoma with microscopic lymphovascular invasion.Postoperative period was uneventful and is on follow-up for the last one year and is doing well. 展开更多
关键词 Giant adrenal tumor Cushing’s syndrome PHEOCHROMOCYTOMA
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Application of retroperitoneal laparoscopy and robotic surgery in complex adrenal tumors
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作者 Kai Huang Ye-Hua Wang 《Artificial Intelligence in Cancer》 2021年第3期42-48,共7页
As a surgical method for the treatment of adrenal surgical diseases,laparoscopy has the advantages of small trauma,short operation time,less bleeding,and fast postoperative recovery.It is considered as the gold standa... As a surgical method for the treatment of adrenal surgical diseases,laparoscopy has the advantages of small trauma,short operation time,less bleeding,and fast postoperative recovery.It is considered as the gold standard for the treatment of adrenal surgical diseases.Retroperitoneal laparoscopy is widely used because it does not pass through the abdominal cavity,does not interfere with internal organs,and has little effect on gastrointestinal function.However,complex adrenal tumors have the characteristics of large volume,compression of adjacent tissues,and invasion of surrounding tissues,so they are rarely treated by retroperitoneal laparoscopy.In recent years,with the development of laparoscopic technology and the progress of surgical technology,robotic surgery has been gradually applied to the surgical treatment of complex adrenal tumors.This paper reviews the clinical application of retroperitoneal laparoscopic surgery and robotic surgery in the treatment of complex adrenal tumors. 展开更多
关键词 Retroperitoneal laparoscopic Robotic surgical procedures Complex adrenal tumors Clinical application ROBOTIC
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Surgical approaches of adrenal tumors( report of 1077 cases)
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作者 刘定益 《外科研究与新技术》 2003年第2期124-124,共1页
Objective To identify the optimal surgical approaches for the resection of adrenal tumors. Methods The choices and effects of surgical approaches in 1 077 patients with adrenal tumors of varying sizes and types were a... Objective To identify the optimal surgical approaches for the resection of adrenal tumors. Methods The choices and effects of surgical approaches in 1 077 patients with adrenal tumors of varying sizes and types were analyzed. Results An 11th or 10th intercostal incision was used for 567 cases of aldosterone-producing adrenocortical tumors (APA) and Cushing syndrome (CUS). An llth or 10th incision was used in 173 cases of pheochromocytomas and 136 cases of incidental tumors. Transabdominal approach was performed in 136 cases of pheochromocytomas and 22 cases of incidental tumors. Twenty-five patients recieving thoracoabdominal approach were all those with pheochromocytomas or incidental tumors. Nine patients with adrenal tomors less than 4 cm in diameter received laparoscopic surgery. Surgeries included 1 060 cases of tumor resection and 17 cases of biopsies, and splenectomy was procedured in 9 patients simultaneously. The main complication of 11th or 10th intercostal incision approach was pleural 展开更多
关键词 of Surgical approaches of adrenal tumors report of 1077 cases
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Primary adrenal Ewing sarcoma:A systematic review of the literature
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作者 Dimitrios K Manatakis Ioannis Tsouknidas +5 位作者 Emmanouil Mylonakis Nikolaos Tasis Maria Ioanna Antonopoulou Vasileios Acheimastos Aikaterini Mastoropoulou Dimitrios P Korkolis 《World Journal of Clinical Cases》 SCIE 2023年第28期6782-6791,共10页
BACKGROUND Ewing sarcoma(ES)is a malignant neoplasm of neuroectodermal origin and is commonly observed in children and young adults.The musculoskeletal system is the main body system impacted and ES is rarely seen in ... BACKGROUND Ewing sarcoma(ES)is a malignant neoplasm of neuroectodermal origin and is commonly observed in children and young adults.The musculoskeletal system is the main body system impacted and ES is rarely seen in the visceral organs particularly the adrenal gland.AIM To present a comprehensive review of primary adrenal ES,with emphasis on diagnosis,therapy and oncological outcomes.METHODS A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses 2020.PubMed/MEDLINE,EMBASE and Google Scholar bibliographic databases were searched to identify articles from 1989 to 2022 and included patients with ES/primitive neuroectodermal tumor(PNET)of the adrenal gland.PubMed,Google Scholar and EMBASE medical databases were searched,combining the terms“adrenal”,“ES”and“PNET”.Demographic,clinical,pathological and oncological data of patients were analyzed by SPSS version 29.0.RESULTS A total of 52 studies were included for review(47 case reports and 5 case series)with 66 patients reported to have primary adrenal ES.Mean age at diagnosis was 26.4±15.4 years(37.9%males,57.6%females,sex not reported in 3 cases).The most frequent complaint was abdominal/flank pain or discomfort(46.4%)followed by a palpable mass(25.0%),and the average duration of symptoms was 2.6±3.1 mo.The imaging modality of choice was computed tomography scan(81.5%),followed by magnetic resonance imaging(20.4%).Preoperative staging revealed that 17 tumors(27.9%)were metastatic and 14 patients had inferior vena cava or renal vein neoplastic thrombus at initial diagnosis.Open adrenalectomy was performed in the majority of cases(80.0%),of which 27.9%required more extensive resection.Minimally invasive surgery was attempted in 8.2%of tumors.Complete surgical resection was achieved in 89.4%of the patients.Adjuvant therapy was administered to 32 patients,in the form of chemotherapy(62.5%),radiotherapy(3.1%)or combination(34.4%).Median overall survival was 15 mo and 24-mo overall survival was 40.5%.Median disease-free survival was 10 mo and 24-mo disease-free survival was 33.3%.CONCLUSION The significant progress in molecular biology and genetics of ES does not reflect on patient outcomes.ES remains an aggressive tumor with a poor prognosis and high mortality. 展开更多
关键词 Ewing sarcoma Primary adrenal tumor adrenalECTOMY
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Corticosurrenaloma: About a Pediatric Case
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作者 Thierry Mukenge Wa Mukengeshay Fatoumata Binta Balde +6 位作者 Zineb Benmassaoud Priscilla Kinsala Othmane Allaoui Abdelhalim Mahmoudi Khalid Khattala Sara Benmilloud Youssef Bouabdallah 《Open Journal of Pediatrics》 2022年第2期449-452,共4页
Introduction: This study aims to describe the outcome of adrenocortical cancer in children through observation. Observation: A 10-year-old girl with no previous pathological history. She presented headaches and severe... Introduction: This study aims to describe the outcome of adrenocortical cancer in children through observation. Observation: A 10-year-old girl with no previous pathological history. She presented headaches and severe hypertension with clinical and biological signs of hyperandrogenism for 6 months. An abdominal CT scan showed an encapsulated left adrenal mass without local or regional invasion or secondary location. A pheochromocytoma or adrenal neuroblastoma was first suspected. The blood pressure was stable at 130/65 mmHg under antihypertensive drugs. She underwent a complete tumor resection without any intraoperative incident. The pathologic study confirmed the adrenocortical carcinoma scored Weiss 7. The severe high blood pressure reappeared 2-year later despite antihypertensive drugs. The thoracic abdominal and pelvic CT scan showed a locally advanced tumor recurrence in the left adrenal gland with parenchymal nodes in the lungs and liver. The outcome was fatal despite medical and surgical management. Conclusion: Adrenocortical cancer is a rare tumor. It is important to hormonal testing in the presence of Cushing’s syndrome in children. It can give a strong indication of the diagnostic possibilities. Histology confirms the diagnosis. The evolution is covered by complications, in particular recurrence with life-threatening metastases. 展开更多
关键词 adrenal tumor adrenal Cortex HYPERANDROGENISM CHILD
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Myxoid adrenal cortical tumor: report of four cases 被引量:2
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作者 SHENG Jia-yan HE Hong-chao +5 位作者 ZHU Yu WU Yu-xuan SHEN Zhou-jun ZHAO Ju-ping MA Gui XU Yun-ze 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第9期1672-1674,共3页
Myxoid adrenocortical neoplasms are rare. Surgical resection of the mass is the first-line therapy. Here we reported a total of four patients, aged 44-66 years, diagnosed with myxoid adrenocortical tumor. The clinical... Myxoid adrenocortical neoplasms are rare. Surgical resection of the mass is the first-line therapy. Here we reported a total of four patients, aged 44-66 years, diagnosed with myxoid adrenocortical tumor. The clinical characteristics and immunohistochemical features of the tumor are discussed in the current literature. 展开更多
关键词 myxoid adrenal cortical tumor endocrine metabolic clinicopathological and immunohistochemical feature prognosis
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